SG11201707772RA - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number: SG11201707772RA
Authority: SG; Singapore
Prior art keywords: indole derivatives; indole; derivatives
Prior art date: 2015-04-15

Application number

SG11201707772RA

Other languages

English (en)

Inventor

Gyula Beke

János Éles

András Boros

Sándor Farkas

György Miklós Keserű

Original Assignee

Richter Gedeon Nyrt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-04-15

Filing date

2016-04-14

Publication date

2017-10-30

2016-04-14 Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt

2017-10-30 Publication of SG11201707772RA publication Critical patent/SG11201707772RA/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Addiction (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

SG11201707772RA 2015-04-15 2016-04-14 Indole derivatives SG11201707772RA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HUP1500169A HU230880B1 (hu)	2015-04-15	2015-04-15	Indol származékok
PCT/IB2016/052110 WO2016166684A1 (fr)	2015-04-15	2016-04-14	Dérivés d'indole

Publications (1)

Publication Number	Publication Date
SG11201707772RA true SG11201707772RA (en)	2017-10-30

Family

ID=89991787

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11201707772RA SG11201707772RA (en)	2015-04-15	2016-04-14	Indole derivatives

Country Status (34)

Country	Link
US (1)	US10329296B2 (fr)
EP (1)	EP3286193B1 (fr)
JP (1)	JP6783793B2 (fr)
KR (1)	KR102591750B1 (fr)
CN (1)	CN107466294B (fr)
AR (1)	AR104261A1 (fr)
AU (1)	AU2016248969B2 (fr)
CA (1)	CA2982232C (fr)
CL (1)	CL2017002605A1 (fr)
CO (1)	CO2017011511A2 (fr)
CU (1)	CU24451B1 (fr)
CY (1)	CY1123185T1 (fr)
DK (1)	DK3286193T3 (fr)
EA (1)	EA034427B1 (fr)
ES (1)	ES2804519T3 (fr)
GE (1)	GEP20207067B (fr)
HR (1)	HRP20201289T1 (fr)
HU (2)	HU230880B1 (fr)
IL (1)	IL254711B (fr)
LT (1)	LT3286193T (fr)
MX (1)	MX2017013201A (fr)
MY (1)	MY189372A (fr)
PE (1)	PE20180196A1 (fr)
PH (1)	PH12017501736B1 (fr)
PL (1)	PL3286193T3 (fr)
PT (1)	PT3286193T (fr)
RS (1)	RS60605B1 (fr)
SA (1)	SA517390161B1 (fr)
SG (1)	SG11201707772RA (fr)
SI (1)	SI3286193T1 (fr)
TW (1)	TWI703145B (fr)
UA (1)	UA121046C2 (fr)
UY (1)	UY36608A (fr)
WO (1)	WO2016166684A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP2200222A1 (hu)	2022-06-17	2023-12-28	Richter Gedeon Nyrt	MCHR1 antagonisták a Prader-Willi szindróma kezelésére
HUP2200221A1 (hu)	2022-06-17	2023-12-28	Richter Gedeon Nyrt	4-[(5-klór-piridin-2-il)metoxi]-1-[3-(propán-2-il)-1H,2H,3H,4H,5H-[1,4]diazepino [1,7-a]indol-9-il]-1,2-dihidropiridin-2-on kristályos formái és ezek sói, valamint elõállításuk és alkalmazásuk
HUP2300374A1 (hu) *	2023-11-03	2025-05-28	Richter Gedeon Nyrt	18F és 11C radioaktívan jelzett MCHR1 PET ligandumok

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU193083B (en) *	1984-02-22	1987-08-28	Sandoz Ag	Process for preparing diazepinoindole derivatives further pharmaceutical compositions containing such compounds
NZ521389A (en) *	2000-03-14	2005-06-24	Upjohn Co	2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole compounds
AU2004266228A1 (en)	2003-08-13	2005-03-03	Amgen, Inc.	Melanin concentrating hormone receptor antagonists
WO2007018248A1 (fr)	2005-08-10	2007-02-15	Banyu Pharmaceutical Co., Ltd.	Composé de pyridone
WO2008134480A1 (fr)	2007-04-25	2008-11-06	Bristol-Myers Squibb Company	Antagonistes du récepteur 1 de l'hormone de mélano-concentration non basiques
JP5514716B2 (ja)	2007-05-11	2014-06-04	コリア・リサーチ・インスティテュート・オブ・ケミカル・テクノロジー	アリールピペリジン置換基を有するイミダゾール誘導体、その製造方法及びこれを含む医薬組成物
US20090011994A1 (en)	2007-07-06	2009-01-08	Bristol-Myers Squibb Company	Non-basic melanin concentrating hormone receptor-1 antagonists and methods
KR101614723B1 (ko) *	2008-01-11	2016-04-22	알바니 몰레큘라 리써치, 인크.	Ｍｃｈ 길항물질로서 (1-아지논)-치환된 피리도인돌
SA110310332B1 (ar)	2009-05-01	2013-12-10	Astrazeneca Ab	مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل )
US20120083489A1 (en) *	2009-06-03	2012-04-05	Christensen Iv Siegfried Benjamin	Bis-pyridylpyridones as melanin-concentrating hormone receptor antagonists
JP2012532144A (ja) *	2009-07-01	2012-12-13	アルバニーモレキュラーリサーチ，インコーポレイテッド	アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
WO2011127643A1 (fr)	2010-04-12	2011-10-20	Merck Sharp & Dohme Corp.	Dérivés de pyridone
US20120316200A1 (en) *	2010-04-12	2012-12-13	Merck Sharp & Dohme Corp.	Pyridone derivatives
US8993765B2 (en) *	2010-12-21	2015-03-31	Albany Molecular Research, Inc.	Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
US8933079B2 (en)	2012-03-07	2015-01-13	Boehringer Ingelheim International Gmbh	Pyridone and pyridazinone derivatives as anti-obesity agents
WO2013149362A1 (fr)	2012-04-06	2013-10-10	Glaxosmithkline Llc	1-(dihydronaphtalényl)pyridones en tant qu'antagonistes du récepteur 1 de l'hormone de concentration de la mélanine
WO2014039411A1 (fr)	2012-09-05	2014-03-13	Bristol-Myers Squibb Company	Antagonistes du récepteur 1 de l'hormone de concentration de pyrrolone ou pyrrolidinone mélanine
US20140163012A1 (en) *	2012-12-11	2014-06-12	Albany Molecular Research, Inc.	Pyrido-/azepino-benzofuran and pyrido-/azepino-benzothiophene mch-1 antagonists, methods of making, and use thereof

2015
- 2015-04-15 HU HUP1500169A patent/HU230880B1/hu not_active IP Right Cessation
2016
- 2016-04-06 UY UY0001036608A patent/UY36608A/es active IP Right Grant
- 2016-04-12 TW TW105111384A patent/TWI703145B/zh active
- 2016-04-14 WO PCT/IB2016/052110 patent/WO2016166684A1/fr not_active Ceased
- 2016-04-14 MY MYPI2017703515A patent/MY189372A/en unknown
- 2016-04-14 AU AU2016248969A patent/AU2016248969B2/en active Active
- 2016-04-14 PH PH1/2017/501736A patent/PH12017501736B1/en unknown
- 2016-04-14 RS RS20200889A patent/RS60605B1/sr unknown
- 2016-04-14 EP EP16718017.3A patent/EP3286193B1/fr active Active
- 2016-04-14 KR KR1020177031700A patent/KR102591750B1/ko active Active
- 2016-04-14 HU HUE16718017A patent/HUE16718017T2/hu unknown
- 2016-04-14 PE PE2017001613A patent/PE20180196A1/es unknown
- 2016-04-14 JP JP2017554052A patent/JP6783793B2/ja active Active
- 2016-04-14 HR HRP20201289TT patent/HRP20201289T1/hr unknown
- 2016-04-14 AR ARP160101017A patent/AR104261A1/es active IP Right Grant
- 2016-04-14 CA CA2982232A patent/CA2982232C/fr active Active
- 2016-04-14 UA UAA201710857A patent/UA121046C2/uk unknown
- 2016-04-14 EA EA201792170A patent/EA034427B1/ru unknown
- 2016-04-14 DK DK16718017.3T patent/DK3286193T3/da active
- 2016-04-14 GE GEAP201614624A patent/GEP20207067B/en unknown
- 2016-04-14 PT PT167180173T patent/PT3286193T/pt unknown
- 2016-04-14 SI SI201630891T patent/SI3286193T1/sl unknown
- 2016-04-14 SG SG11201707772RA patent/SG11201707772RA/en unknown
- 2016-04-14 US US15/563,259 patent/US10329296B2/en active Active
- 2016-04-14 CU CU2017000128A patent/CU24451B1/es unknown
- 2016-04-14 PL PL16718017T patent/PL3286193T3/pl unknown
- 2016-04-14 LT LTEP16718017.3T patent/LT3286193T/lt unknown
- 2016-04-14 ES ES16718017T patent/ES2804519T3/es active Active
- 2016-04-14 MX MX2017013201A patent/MX2017013201A/es unknown
- 2016-04-14 CN CN201680021685.5A patent/CN107466294B/zh active Active
2017
- 2017-09-26 IL IL254711A patent/IL254711B/en active IP Right Grant
- 2017-10-13 CL CL2017002605A patent/CL2017002605A1/es unknown
- 2017-10-15 SA SA517390161A patent/SA517390161B1/ar unknown
- 2017-11-09 CO CONC2017/0011511A patent/CO2017011511A2/es unknown
2020
- 2020-08-06 CY CY20201100739T patent/CY1123185T1/el unknown

Also Published As

Publication number	Publication date
CA2982232A1 (fr)	2016-10-20
RS60605B1 (sr)	2020-08-31
SA517390161B1 (ar)	2021-07-12
JP2018511637A (ja)	2018-04-26
KR102591750B1 (ko)	2023-10-19
HU230880B1 (hu)	2018-11-29
HRP20201289T1 (hr)	2020-11-13
ES2804519T3 (es)	2021-02-08
AU2016248969A1 (en)	2017-11-09
PH12017501736A1 (en)	2018-03-12
KR20170137130A (ko)	2017-12-12
US10329296B2 (en)	2019-06-25
JP6783793B2 (ja)	2020-11-11
MX2017013201A (es)	2018-02-09
SI3286193T1 (sl)	2020-10-30
UY36608A (es)	2016-09-30
NZ736551A (en)	2024-08-30
GEAP201914624A (fr)	2019-10-10
PH12017501736B1 (en)	2022-07-22
PL3286193T3 (pl)	2020-11-16
AR104261A1 (es)	2017-07-05
CY1123185T1 (el)	2021-10-29
AU2016248969B2 (en)	2020-03-12
CO2017011511A2 (es)	2017-11-21
CN107466294A (zh)	2017-12-12
WO2016166684A1 (fr)	2016-10-20
EA201792170A1 (ru)	2018-03-30
US20180093989A1 (en)	2018-04-05
TW201708226A (zh)	2017-03-01
DK3286193T3 (da)	2020-08-24
EA034427B1 (ru)	2020-02-06
BR112017021843A2 (pt)	2018-07-10
HK1243705A1 (en)	2018-07-20
IL254711A0 (en)	2017-11-30
UA121046C2 (uk)	2020-03-25
PE20180196A1 (es)	2018-01-26
CU20170128A7 (es)	2018-01-10
TWI703145B (zh)	2020-09-01
EP3286193B1 (fr)	2020-05-27
CL2017002605A1 (es)	2018-03-16
HUE16718017T2 (hu)	2021-03-29
PT3286193T (pt)	2020-08-26
IL254711B (en)	2021-06-30
CN107466294B (zh)	2020-01-17
LT3286193T (lt)	2020-08-10
CA2982232C (fr)	2023-03-28
GEP20207067B (en)	2020-02-10
HUP1500169A2 (en)	2016-10-28
CU24451B1 (es)	2019-11-04
EP3286193A1 (fr)	2018-02-28
MY189372A (en)	2022-02-08

Publication	Publication Date	Title
ZA201800826B (en)	2021-08-25	Substituted oxopyridine derivatives
IL248550A0 (en)	2016-12-29	History of indolin-2-one or pyrrolo-pyridin-2-one
IL253381A0 (en)	2017-09-28	History of h9-pyrrolo-dipyridine
IL251798B (en)	2020-08-31	carbazole derivatives
ZA201802411B (en)	2019-01-30	Indolin-2-one derivatives
SG11201609205WA (en)	2016-12-29	Heterocyclyl-butanamide derivatives
PL3164393T3 (pl)	2019-03-29	Pochodne flawaglin
HUE050450T2 (hu)	2020-12-28	Fluoralkil-fluorén-származékok
IL248773A0 (en)	2017-01-31	History of naphthyridinedione
IL251005B (en)	2020-03-31	Pyrido-oxazinone derivatives
IL248629A0 (en)	2017-01-31	Substances containing diheteroaryl conjugated to cycloalkyl and their uses
PL3119744T3 (pl)	2019-07-31	Pochodne 2-cyjano-3-cyklopropylo-3-hydroksy-N-arylo-tioakryloamidu
IL254711A0 (en)	2017-11-30	History of Indole