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SG11201610594WA - Anti-il4-il 13 bispecific antibodies - Google Patents

Anti-il4-il 13 bispecific antibodies

Info

Publication number
SG11201610594WA
SG11201610594WA SG11201610594WA SG11201610594WA SG11201610594WA SG 11201610594W A SG11201610594W A SG 11201610594WA SG 11201610594W A SG11201610594W A SG 11201610594WA SG 11201610594W A SG11201610594W A SG 11201610594WA SG 11201610594W A SG11201610594W A SG 11201610594WA
Authority
SG
Singapore
Prior art keywords
bispecific antibodies
bispecific
antibodies
Prior art date
Application number
SG11201610594WA
Inventor
Corrine Esperet
Alexandre Jagerschmiet
Christina Soubrane
Arun Subramaniam
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SG11201610594WA publication Critical patent/SG11201610594WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/521Chemokines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/247IL-4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/521Chemokines
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
SG11201610594WA 2014-06-27 2015-06-26 Anti-il4-il 13 bispecific antibodies SG11201610594WA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462018253P 2014-06-27 2014-06-27
EP14306477 2014-09-24
US201562102097P 2015-01-11 2015-01-11
US201562102555P 2015-01-12 2015-01-12
PCT/IB2015/001377 WO2015198146A2 (en) 2014-06-27 2015-06-26 Anti-il4-il 13 bispecific antibodies

Publications (1)

Publication Number Publication Date
SG11201610594WA true SG11201610594WA (en) 2017-01-27

Family

ID=51663114

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201811562YA SG10201811562YA (en) 2014-06-27 2015-06-26 Anti-il4-il 13 bispecific antibodies
SG11201610594WA SG11201610594WA (en) 2014-06-27 2015-06-26 Anti-il4-il 13 bispecific antibodies

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201811562YA SG10201811562YA (en) 2014-06-27 2015-06-26 Anti-il4-il 13 bispecific antibodies

Country Status (18)

Country Link
US (2) US20170145089A1 (en)
EP (1) EP3160502A2 (en)
JP (1) JP2017530089A (en)
KR (1) KR102558891B1 (en)
CN (1) CN106573975A (en)
AU (1) AU2015278829B2 (en)
BR (1) BR112016030568B8 (en)
CA (1) CA2952902C (en)
CL (1) CL2016003317A1 (en)
CR (1) CR20170022A (en)
EA (1) EA201692495A8 (en)
MX (1) MX390942B (en)
NZ (1) NZ728020A (en)
PH (1) PH12016502569A1 (en)
SG (2) SG10201811562YA (en)
TN (1) TN2016000569A1 (en)
TW (2) TWI745962B (en)
WO (1) WO2015198146A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2050764A1 (en) * 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
TWI745962B (en) 2014-06-27 2021-11-11 法商賽諾菲公司 Methods of determining whether a dose comprising a dual-v-region antibody-like protein or a fragment thereof administered to a human subject specifically binds to il-4 or il-13 within the human subject
KR20240052871A (en) 2016-04-27 2024-04-23 애브비 인코포레이티드 Methods of treatment of diseases in which il-13 activity is detrimental using anti-il-13 antibodies
KR20220012894A (en) 2019-05-24 2022-02-04 사노피 How to treat systemic sclerosis
MX2024010773A (en) * 2022-03-03 2024-09-10 Pfizer Multispecific antibodies and uses thereof.

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EP0799244A1 (en) 1995-10-16 1997-10-08 Unilever N.V. A bifunctional or bivalent antibody fragment analogue
US6664227B1 (en) * 1996-03-01 2003-12-16 Genetics Institute, Llc Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains
WO2003035847A2 (en) 2001-10-26 2003-05-01 Centocor, Inc. Il-13 mutein proteins, antibodies, compositions, methods and uses
US20040023338A1 (en) 2001-10-26 2004-02-05 Heavner George A. IL-4 mutein proteins, antibodies, compositions, methods and uses
US20060148009A1 (en) 2004-10-12 2006-07-06 Xencor, Inc. Prediction and assessment of immunogenicity
EP1824886B1 (en) 2004-11-17 2010-12-22 Amgen Inc. Fully human monoclonal antibodies to il-13
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
JP2008087194A (en) 2006-09-29 2008-04-17 Brother Ind Ltd Inkjet printer
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
WO2009069355A1 (en) * 2007-11-28 2009-06-04 Riken Method for screening of therapeutic agent for allergic airway inflammation and/or airway hypersensitivity using il-17rb-positive nkt cell
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US20130344074A1 (en) * 2011-03-16 2013-12-26 Sanofi Uses of a dual v region antibody-like protein
TWI743461B (en) * 2011-03-28 2021-10-21 法商賽諾菲公司 Dual variable region antibody-like binding proteins having cross-over binding region orientation
KR102307248B1 (en) * 2012-08-21 2021-10-01 사노피 바이오테크놀로지 Methods for treating or preventing asthma by administering an il-4r antagonist
NZ630178A (en) * 2012-09-07 2017-06-30 Regeneron Pharma Methods for treating atopic dermatitis by administering an il-4r antagonist
TWI679019B (en) 2013-04-29 2019-12-11 法商賽諾菲公司 Anti-il-4/anti-il-13 bispecific antibody formulations
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TWI745962B (en) 2014-06-27 2021-11-11 法商賽諾菲公司 Methods of determining whether a dose comprising a dual-v-region antibody-like protein or a fragment thereof administered to a human subject specifically binds to il-4 or il-13 within the human subject

Also Published As

Publication number Publication date
CA2952902A1 (en) 2015-12-30
EP3160502A2 (en) 2017-05-03
NZ728020A (en) 2022-07-01
EA201692495A1 (en) 2017-05-31
TN2016000569A1 (en) 2018-04-04
BR112016030568B8 (en) 2023-12-05
JP2017530089A (en) 2017-10-12
CN106573975A (en) 2017-04-19
MX390942B (en) 2025-03-21
US20170145089A1 (en) 2017-05-25
MX2017000171A (en) 2017-04-25
CL2016003317A1 (en) 2017-08-11
SG10201811562YA (en) 2019-01-30
CR20170022A (en) 2017-04-04
BR112016030568B1 (en) 2023-10-17
AU2015278829B2 (en) 2021-03-25
AU2015278829A1 (en) 2017-02-02
US11136388B2 (en) 2021-10-05
KR102558891B1 (en) 2023-07-21
KR20170020519A (en) 2017-02-22
CA2952902C (en) 2024-02-13
TW202034954A (en) 2020-10-01
US20190359703A1 (en) 2019-11-28
EA201692495A8 (en) 2017-07-31
TWI745962B (en) 2021-11-11
PH12016502569A1 (en) 2017-04-17
BR112016030568A2 (en) 2018-02-20
WO2015198146A2 (en) 2015-12-30
TW201628647A (en) 2016-08-16
WO2015198146A3 (en) 2016-03-31

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