[go: up one dir, main page]

SG10201913045PA - A solid state form of pladienolide pyridine compounds and methods of use - Google Patents

A solid state form of pladienolide pyridine compounds and methods of use

Info

Publication number
SG10201913045PA
SG10201913045PA SG10201913045PA SG10201913045PA SG10201913045PA SG 10201913045P A SG10201913045P A SG 10201913045PA SG 10201913045P A SG10201913045P A SG 10201913045PA SG 10201913045P A SG10201913045P A SG 10201913045PA SG 10201913045P A SG10201913045P A SG 10201913045PA
Authority
SG
Singapore
Prior art keywords
methods
solid state
state form
pyridine compounds
pladienolide pyridine
Prior art date
Application number
SG10201913045PA
Other languages
English (en)
Inventor
Gregg F Keaney
John Wang
Baudouin Gerard
Kenzo Arai
Xiang Liu
Guo Zhu Zheng
Kazunobu Kira
Parcharee Tivitmahaisoon
Sudeep Prajapati
Nicholas C Gearhart
Yoshihiko Kotake
Satoshi Nagao
Sonabe Regina Mikie Kanada
Masayuki Miyano
Norio Murai
Silvia Buonamici
Lihua Yu
Eunice Sun Park
Betty Chan
Peter G Smith
Michael P Thomas
Ermira Pazolli
Kian Huat Lim
Arani Chanda
Atsushi Endo
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of SG10201913045PA publication Critical patent/SG10201913045PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG10201913045PA 2015-11-18 2016-11-17 A solid state form of pladienolide pyridine compounds and methods of use SG10201913045PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562257088P 2015-11-18 2015-11-18

Publications (1)

Publication Number Publication Date
SG10201913045PA true SG10201913045PA (en) 2020-02-27

Family

ID=57472076

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201913045PA SG10201913045PA (en) 2015-11-18 2016-11-17 A solid state form of pladienolide pyridine compounds and methods of use
SG11201803519YA SG11201803519YA (en) 2015-11-18 2016-11-17 A solid state form of pladienolide pyridine compounds and methods of use

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201803519YA SG11201803519YA (en) 2015-11-18 2016-11-17 A solid state form of pladienolide pyridine compounds and methods of use

Country Status (15)

Country Link
US (2) US10745387B2 (fr)
EP (1) EP3377485B1 (fr)
JP (2) JP6312282B2 (fr)
KR (1) KR20180083376A (fr)
CN (1) CN108473479B (fr)
AU (2) AU2016357433B2 (fr)
BR (1) BR112018009995B1 (fr)
CA (1) CA3004623C (fr)
ES (1) ES2757174T3 (fr)
IL (1) IL259198B2 (fr)
MD (1) MD3377485T2 (fr)
MX (2) MX379655B (fr)
RU (2) RU2743349C2 (fr)
SG (2) SG10201913045PA (fr)
WO (1) WO2017087667A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA128864C2 (uk) * 2018-04-09 2024-11-13 ЕйСей РендД МЕНЕДЖМЕНТ КО., ЛТД. Сполука пладієноліду та спосіб її застосування
EP3774760A1 (fr) 2018-04-12 2021-02-17 Eisai R&D Management Co., Ltd. Dérivés de pladiénolide en tant qu'agents ciblant un complexe d'épissage pour le traitement du cancer
MX2020012940A (es) * 2018-06-01 2021-03-25 Eisai R&D Man Co Ltd Metodos de uso de moduladores de empalme.
US20230022489A1 (en) * 2019-12-04 2023-01-26 Athma A. PAI Identifying non-productive splice sites
MX2022015374A (es) * 2020-06-05 2023-01-16 Eisai R&D Man Co Ltd Conjugados de anticuerpo anti antigeno de maduracion de linfocitos b (bcma)-farmaco y metodos de uso.
WO2022098712A1 (fr) 2020-11-04 2022-05-12 Eisai R&D Management Co., Ltd. Biomarqueurs pour le syndrome myélodysplasique (mds) et leurs méthodes d'utilisation
WO2023131866A1 (fr) 2022-01-05 2023-07-13 Eisai R&D Management Co., Ltd. Biomarqueurs pour le syndrome myélodysplasique (mds) et leurs méthodes d'utilisation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI312681B (en) * 2001-02-01 2009-08-01 Novel physiologically active substance
TWI334866B (en) 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
AU2003252299A1 (en) 2002-07-31 2004-02-16 Eisai Co., Ltd. Novel physiologically active substance
NZ537830A (en) 2002-07-31 2007-12-21 Mercian Corp Novel physiologically active substances
AU2003285012A1 (en) 2002-10-24 2004-05-13 Sepracor, Inc. Compositions comprising zopiclone derivatives and methods of making and using the same
RU2330069C2 (ru) 2002-11-29 2008-07-27 Мершан Корпорейшн Способ получения макролидного соединения и штаммы streptomyces sp., mortierella sp. и micromonosporaceae
EP1705247A4 (fr) 2003-11-27 2008-08-20 Mercian Corp Adn intervenant dans l'hydroxylation d'un compose macrolide
CA2552553C (fr) 2003-11-28 2015-01-06 Kanagawa Academy Of Science And Technology Methode de detection, diagnostic et remede contre le cancer du foie
EP1764592A4 (fr) 2004-07-02 2009-08-19 Plus One Techno & Co Ltd Appareil de pesage combiné
CN1977046A (zh) 2004-07-20 2007-06-06 卫材R&D管理有限公司 编码参与普拉地内酯生物合成的多肽的dna
TW200716744A (en) 2005-05-26 2007-05-01 Eisai R&D Man Co Ltd Genetically modified microorganism and process for production of macrolide compound using the microorganism
EP1935893A4 (fr) 2005-10-13 2009-07-22 Eisai R&D Man Co Ltd Synthèse totale de pladienolide b et de pladienolide d
EP2136209A4 (fr) * 2007-03-05 2010-10-27 Eisai R&D Man Co Ltd Procédé pour l'examen d'une action d'un agent anti-cancéreux utilisant un défaut d'épissage en tant que mesure
US20080312317A1 (en) 2007-04-12 2008-12-18 Eisai R&D Management Co., Ltd. 12 membered-ring macrolactam derivatives
JO3668B1 (ar) * 2014-05-15 2020-08-27 Eisai R&D Man Co Ltd مركبات بلاديينوليد البيريدين وطرق استعمالها

Also Published As

Publication number Publication date
JP2018502831A (ja) 2018-02-01
JP6312282B2 (ja) 2018-04-18
BR112018009995B1 (pt) 2024-04-30
IL259198B (en) 2022-12-01
ES2757174T3 (es) 2020-04-28
MX392475B (es) 2025-03-24
JP6353620B1 (ja) 2018-07-04
KR20180083376A (ko) 2018-07-20
CA3004623A1 (fr) 2017-05-26
MX2021001441A (es) 2022-05-19
RU2018121610A3 (fr) 2020-03-02
RU2018121610A (ru) 2019-12-18
CN108473479B (zh) 2024-05-07
SG11201803519YA (en) 2018-06-28
RU2743349C2 (ru) 2021-02-17
EP3377485A1 (fr) 2018-09-26
US10745387B2 (en) 2020-08-18
EP3377485B1 (fr) 2019-09-25
MX379655B (es) 2025-03-11
BR112018009995A2 (pt) 2018-11-21
WO2017087667A8 (fr) 2017-08-03
AU2021200974B2 (en) 2022-03-17
CN108473479A (zh) 2018-08-31
WO2017087667A9 (fr) 2017-10-12
JP2018111715A (ja) 2018-07-19
AU2016357433B2 (en) 2020-11-19
IL259198A (en) 2018-07-31
WO2017087667A1 (fr) 2017-05-26
AU2021200974A1 (en) 2021-03-11
US20200361915A1 (en) 2020-11-19
IL259198B2 (en) 2023-04-01
MD3377485T2 (ro) 2020-02-29
RU2021102393A (ru) 2021-03-17
MX2018006155A (es) 2018-08-01
CA3004623C (fr) 2024-05-14
AU2016357433A1 (en) 2018-05-17
US20190100513A1 (en) 2019-04-04

Similar Documents

Publication Publication Date Title
IL259433B (en) eif4-a inhibitory compounds and related methods
IL258768A (en) Compounds interacting with glycans and methods of use
SI3215147T1 (sl) Nevroatenuacijske spojine norketamina in postopki
IL256032A (en) Substituted pyridines and method of use
IL248529B (en) Palladianolide pyridine compounds and methods of use
HUE061672T2 (hu) Glikán-interakcióban lévõ vegyületek és felhasználási módszerek
IL257026A (en) Solid state forms of eluxadoline
LT3089971T (lt) Junginiai ir panaudojimo būdai
IL253234B (en) Methods for transdifferentiation and methods to use them
GB201514760D0 (en) Compounds and method of use
IL259198A (en) A solid form of paladinolide pyridine compound and methods of its use
IL251107A0 (en) Compounds and methods
ZA201701066B (en) Pyridine derivatives and anti-mycobacterial use thereof
GB201609584D0 (en) A de-oiler and a method of using the same
ZA201606450B (en) Compounds and their methods of use
TWI563431B (en) Touch devices and methods of forming the same
IL265180B (en) New polymorphs and new solid states of tiacomycin b
PT3263133T (pt) Composto de piridinona e a sua utilização
IL254666A0 (en) Crystalline forms of Aldecalcitol
GB201403697D0 (en) Compounds and methods of use
HUE050178T2 (hu) Piridinon vegyület és alkalmazása