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SG10201913006XA - Multipotent stem cells from the extrahepatic billary tree and methods of isolating same - Google Patents

Multipotent stem cells from the extrahepatic billary tree and methods of isolating same

Info

Publication number
SG10201913006XA
SG10201913006XA SG10201913006XA SG10201913006XA SG10201913006XA SG 10201913006X A SG10201913006X A SG 10201913006XA SG 10201913006X A SG10201913006X A SG 10201913006XA SG 10201913006X A SG10201913006X A SG 10201913006XA SG 10201913006X A SG10201913006X A SG 10201913006XA
Authority
SG
Singapore
Prior art keywords
billary
extrahepatic
tree
methods
stem cells
Prior art date
Application number
SG10201913006XA
Inventor
Lola Reid
Yunfang Wang
Vincenzo Cardinale
Eugenio Gaudio
Guido Carpino
Domenico Alvaro
Cai-Bin Cui
Original Assignee
Univ North Carolina Chapel Hill
Sapienza Univ Di Roma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43922533&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201913006X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ North Carolina Chapel Hill, Sapienza Univ Di Roma filed Critical Univ North Carolina Chapel Hill
Publication of SG10201913006XA publication Critical patent/SG10201913006XA/en

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/413—Gall bladder; Bile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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SG10201913006XA 2009-10-30 2010-10-28 Multipotent stem cells from the extrahepatic billary tree and methods of isolating same SG10201913006XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25684609P 2009-10-30 2009-10-30

Publications (1)

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SG10201913006XA true SG10201913006XA (en) 2020-02-27

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ID=43922533

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SG10201913006XA SG10201913006XA (en) 2009-10-30 2010-10-28 Multipotent stem cells from the extrahepatic billary tree and methods of isolating same
SG10201407102QA SG10201407102QA (en) 2009-10-30 2010-10-28 Multipotent stem cells from the extrahepatic billary tree and methods of isolating same

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Country Status (20)

Country Link
US (1) US20110135610A1 (en)
EP (2) EP3725874A1 (en)
JP (2) JP5936547B2 (en)
KR (4) KR20190065476A (en)
CN (2) CN105456292B (en)
AR (2) AR078849A1 (en)
AU (1) AU2016210783B2 (en)
BR (1) BR112012009848B1 (en)
CA (2) CA2779144C (en)
CL (1) CL2012001117A1 (en)
CR (1) CR20120254A (en)
ES (1) ES2819028T3 (en)
IL (2) IL219454A (en)
MX (1) MX2012005087A (en)
NZ (3) NZ622427A (en)
PH (1) PH12012500845A1 (en)
RU (2) RU2756584C2 (en)
SG (2) SG10201913006XA (en)
TW (3) TWI641688B (en)
WO (1) WO2011053690A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190065476A (en) * 2009-10-30 2019-06-11 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 Multipotent stem cells from the extrahepatic biliary tree and methods of isolating same
CA2840192A1 (en) 2011-06-23 2012-12-27 The Children's Hospital Of Philadelphia Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
CN103266084B (en) * 2013-05-27 2015-03-04 刘卫辉 Three-step separation method for enriching stem cells
JP6491671B2 (en) * 2014-03-17 2019-03-27 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ Method for predicting compound toxicity based on nuclear factor-κB translocation
GB201507894D0 (en) * 2015-05-08 2015-06-24 Imagen Biotech Ltd Personalised media
GB201510950D0 (en) * 2015-06-22 2015-08-05 Cambridge Entpr Ltd In vitro Production of Cholangiocytes
US10683486B2 (en) * 2015-10-30 2020-06-16 Biolamina Ab Methods for producing hepatocytes
GB201521179D0 (en) 2015-12-01 2016-01-13 Univ Leuven Kath Methods for differentiating cells into hepatic stellate cells
CN105807053B (en) * 2016-04-15 2019-04-02 苏州药明康德新药开发股份有限公司 A kind of application of the tumour dissociation reagent in FCM analysis
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
AU2018249853A1 (en) * 2017-04-06 2019-10-31 Sapienza Universita Di Roma Cryopreservation method
BR112020019773A2 (en) * 2018-03-29 2021-02-17 The University Of North Carolina At Chapel Hill stem / progenitor cells of the brunner duodenal glands, isolation methods and their uses
CN112126618B (en) * 2019-06-24 2023-09-12 上海拜羡生物科技有限公司 A method for obtaining and long-term in vitro culture of human gallbladder stem cells
CN113388569B (en) * 2020-08-28 2022-05-17 广东乾晖生物科技有限公司 Preparation method of liver organoid
AU2021453264A1 (en) * 2021-06-30 2023-12-14 Polbionica Sp. Z O.O. A medium for storing isolated pancreatic islets and a method for storing isolated pancreatic islets
CN115975913B (en) * 2023-02-03 2024-06-04 北京中医药大学深圳医院(龙岗) Method for inducing and differentiating cholecystokinin progenitor cells by utilizing pluripotent stem cells

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646197A (en) * 1969-05-14 1972-02-29 Zaidan Hojin Biseibutsu Novel process for removing copper from copper-containing bleomycin
US6069005A (en) * 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
US5660207A (en) * 1994-12-29 1997-08-26 Tylan General, Inc. Flow controller, parts of flow controller, and related method
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
GB9605808D0 (en) * 1996-03-20 1996-05-22 Isis Innovation CFTR gene regulator
US5830850A (en) * 1996-08-28 1998-11-03 Mount Sinai School Of Medicine Of The City Of New York Methods for the treatment of bone resorption disorders, including osteoporosis
EP1147179B1 (en) * 1999-01-19 2008-11-12 The University of North Carolina at Chapel Hill Human liver progenitors
US7456017B2 (en) * 1999-10-01 2008-11-25 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells
US20030211602A1 (en) * 2000-04-28 2003-11-13 Anthony Atala Isolation of mesenchymal stem cells and use thereof
US6828145B2 (en) * 2000-05-10 2004-12-07 Cedars-Sinai Medical Center Method for the isolation of stem cells by immuno-labeling with HLA/MHC gene product marker
JP3602038B2 (en) * 2000-07-24 2004-12-15 株式会社日立グローバルストレージテクノロジーズ Magnetic head and magnetic recording / reproducing device
DE10064804C2 (en) * 2000-12-22 2003-03-20 Schott Glas Alkali-free aluminoborosilicate glasses and their use
EP1425388A2 (en) * 2001-09-12 2004-06-09 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung A method for isolating, culturing and differentiating intestinal stem cells for therapeutic use
US7150990B2 (en) * 2002-03-06 2006-12-19 Reprocell, Inc. Self-renewing pluripotent hepatic stem cells
CN1742082B (en) * 2002-03-15 2015-01-21 北卡罗来纳大学查伯山分校 Primitive and proximal hepatic stem cells
WO2004071464A2 (en) * 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells
DE10336152B4 (en) * 2003-08-06 2007-02-15 Nephrogen LLC, Salt Lake City Purification method for human mesenchymal stem cells
EP1716167A4 (en) * 2003-10-09 2008-10-08 Univ Monash Cell surface marker
EP1685237A4 (en) * 2003-10-28 2007-12-26 Caritas St Elizabeths Boston NEW MULTIPOTENT STEM CELLS
US7081582B2 (en) * 2004-06-30 2006-07-25 Microsoft Corporation System and method for aligning and mixing songs of arbitrary genres
JP4824036B2 (en) * 2004-12-23 2011-11-24 ヴィアサイト，インコーポレイテッド Definitive endoderm cell proliferation
JP4773777B2 (en) * 2005-08-30 2011-09-14 グローバル・オーエルイーディー・テクノロジー・リミテッド・ライアビリティ・カンパニー Active matrix display device
EP1941032A2 (en) * 2005-10-14 2008-07-09 Regents Of The University Of Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
RU2008124158A (en) * 2005-11-16 2010-01-10 Юниверсити Оф Норт Каролина Эт Чепел Хилл (Us) EXTRACELLULAR MATRIX COMPONENTS FOR THE EXPANSION AND DIFFERENTIATION OF HEPATIC PRECEDENT CELLS
AU2007321928A1 (en) * 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
MX2009009582A (en) * 2007-03-06 2009-10-26 Univ North Carolina Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of cells.
JP2008307007A (en) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag Human pluripotent stem cell induced from human tissue-originated undifferentiated stem cell after birth
IN2010KN00157A (en) * 2007-06-15 2015-08-28 Univ North Carolina
CA3207103A1 (en) * 2007-07-31 2009-02-05 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to pancreatic endocrine
KR20190065476A (en) * 2009-10-30 2019-06-11 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 Multipotent stem cells from the extrahepatic biliary tree and methods of isolating same
US10135700B2 (en) 2014-03-10 2018-11-20 Softphone SRL Enterprise application integration on client computing devices
US10387547B2 (en) 2014-09-09 2019-08-20 Intentional Software Corporation Layout engine for creating a visual layout tree for a document

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