SG10201913807QA - Multivalent and multispecific gitr-binding fusion proteins - Google Patents
Multivalent and multispecific gitr-binding fusion proteinsInfo
- Publication number
- SG10201913807QA SG10201913807QA SG10201913807QA SG10201913807QA SG10201913807QA SG 10201913807Q A SG10201913807Q A SG 10201913807QA SG 10201913807Q A SG10201913807Q A SG 10201913807QA SG 10201913807Q A SG10201913807Q A SG 10201913807QA SG 10201913807Q A SG10201913807Q A SG 10201913807QA
- Authority
- SG
- Singapore
- Prior art keywords
- multivalent
- fusion proteins
- binding fusion
- gitr
- multispecific
- Prior art date
Links
- 101100425749 Mus musculus Tnfrsf18 gene Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562195822P | 2015-07-23 | 2015-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201913807QA true SG10201913807QA (en) | 2020-03-30 |
Family
ID=57835278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201913807QA SG10201913807QA (en) | 2015-07-23 | 2016-07-22 | Multivalent and multispecific gitr-binding fusion proteins |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10093742B2 (ru) |
| EP (1) | EP3325512B1 (ru) |
| JP (1) | JP6913682B2 (ru) |
| KR (1) | KR20180031728A (ru) |
| CN (1) | CN108650886B (ru) |
| AR (1) | AR105767A1 (ru) |
| AU (1) | AU2016297249B2 (ru) |
| BR (1) | BR112018001161A2 (ru) |
| CA (1) | CA2992298A1 (ru) |
| IL (1) | IL257030B2 (ru) |
| MX (1) | MX2018000948A (ru) |
| RU (1) | RU2753439C2 (ru) |
| SG (1) | SG10201913807QA (ru) |
| TW (1) | TWI745296B (ru) |
| WO (1) | WO2017015623A2 (ru) |
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| RU2753439C2 (ru) | 2015-07-23 | 2021-08-16 | Инхибркс, Инк. | Поливалетные и полиспецифичные gitr-связывающие слитые белки |
| JP7084870B2 (ja) | 2015-10-22 | 2022-06-15 | アブリンクス エン．ヴェー． | Ｇｉｔｒアゴニスト |
| EP3478721A1 (en) | 2016-07-01 | 2019-05-08 | Five Prime Therapeutics, Inc. | Combined anti tumor therapy with a gitr agonist and cpg |
| CN110709420A (zh) * | 2017-03-31 | 2020-01-17 | 戊瑞治疗有限公司 | 使用抗gitr抗体的癌症组合疗法 |
| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| TW202515920A (zh) | 2017-04-11 | 2025-04-16 | 美商因荷布瑞克斯生物科學公司 | 具有經受限cd3結合的多重特異性多肽構築體及使用其之方法 |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
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| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
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| CN111163798A (zh) | 2017-07-20 | 2020-05-15 | 诺华股份有限公司 | 用于抗lag-3抗体的给药方案及其用途 |
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-
2016
- 2016-07-22 RU RU2018106452A patent/RU2753439C2/ru active
- 2016-07-22 EP EP16828658.1A patent/EP3325512B1/en active Active
- 2016-07-22 BR BR112018001161A patent/BR112018001161A2/pt not_active IP Right Cessation
- 2016-07-22 WO PCT/US2016/043717 patent/WO2017015623A2/en not_active Ceased
- 2016-07-22 IL IL257030A patent/IL257030B2/en unknown
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- 2016-07-22 CN CN201680055497.4A patent/CN108650886B/zh not_active Expired - Fee Related
- 2016-07-22 CA CA2992298A patent/CA2992298A1/en active Pending
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2017
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2018
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| WO2017015623A2 (en) | 2017-01-26 |
| JP2018523493A (ja) | 2018-08-23 |
| BR112018001161A2 (pt) | 2018-09-18 |
| RU2018106452A3 (ru) | 2019-12-26 |
| US20190100594A1 (en) | 2019-04-04 |
| AR105767A1 (es) | 2017-11-08 |
| US20170320958A1 (en) | 2017-11-09 |
| CN108650886B (zh) | 2022-07-05 |
| NZ739130A (en) | 2023-08-25 |
| RU2018106452A (ru) | 2019-08-26 |
| JP6913682B2 (ja) | 2021-08-04 |
| MX2018000948A (es) | 2018-09-27 |
| TW201718630A (zh) | 2017-06-01 |
| IL257030B (en) | 2022-11-01 |
| RU2753439C2 (ru) | 2021-08-16 |
| US10093742B2 (en) | 2018-10-09 |
| EP3325512A4 (en) | 2019-03-06 |
| IL257030B2 (en) | 2023-03-01 |
| US20170022284A1 (en) | 2017-01-26 |
| IL257030A (en) | 2018-03-29 |
| EP3325512B1 (en) | 2023-09-06 |
| CA2992298A1 (en) | 2017-01-26 |
| TWI745296B (zh) | 2021-11-11 |
| KR20180031728A (ko) | 2018-03-28 |
| EP3325512A2 (en) | 2018-05-30 |
| CN108650886A (zh) | 2018-10-12 |
| WO2017015623A3 (en) | 2017-03-23 |
| AU2016297249B2 (en) | 2020-11-12 |
| AU2016297249A1 (en) | 2018-02-22 |
| US10844129B2 (en) | 2020-11-24 |
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