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SE9603285D0 - New compounds - Google Patents

New compounds

Info

Publication number
SE9603285D0
SE9603285D0 SE9603285A SE9603285A SE9603285D0 SE 9603285 D0 SE9603285 D0 SE 9603285D0 SE 9603285 A SE9603285 A SE 9603285A SE 9603285 A SE9603285 A SE 9603285A SE 9603285 D0 SE9603285 D0 SE 9603285D0
Authority
SE
Sweden
Prior art keywords
hydrogen
aminomethyl
amino
alkyl
new compounds
Prior art date
Application number
SE9603285A
Other languages
Swedish (sv)
Inventor
Haakan Bergstrand
Kostas Karabelas
Margareta Linden
Michael Lofthagen
Peter Sjoe
Mats Thelin
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9603285A priority Critical patent/SE9603285D0/en
Publication of SE9603285D0 publication Critical patent/SE9603285D0/en
Priority to ZA9707809A priority patent/ZA977809B/en
Priority to PCT/SE1997/001506 priority patent/WO1998011103A1/en
Priority to AU41433/97A priority patent/AU4143397A/en
Priority to ARP970104131A priority patent/AR009732A1/en
Priority to SA97180648A priority patent/SA97180648A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides compounds of formula (I) wherein each R20, which may be the same of different, is a hydrogen or halogen; R' is methyl, hydrogen or R; R is a group of formula (II) wherein Z is a single or a double bond; n is 1-3; R1 is hydroxy, hydroxymethyl, amino, N-((C1-C5)alkyl)amino, aminomethyl, N-((C1-C5)alkyl)aminomethyl, N,N-di((C1-C5)alkyl)aminomethyl, (C1-C5)acyloxy or N-((C1-C5)acyl)amino, and R2 and R3 are hydrogen and, when Z is a single bond, R4 and R5, which may be the same or different, are each hydrogen or hydroxy; and pharmaceutically acceptable salts thereof; and the use of such compounds in medical therapy.
SE9603285A 1996-09-10 1996-09-10 New compounds SE9603285D0 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
SE9603285A SE9603285D0 (en) 1996-09-10 1996-09-10 New compounds
ZA9707809A ZA977809B (en) 1996-09-10 1997-08-29 New pharmaceutically active compounds.
PCT/SE1997/001506 WO1998011103A1 (en) 1996-09-10 1997-09-08 New pharmaceutically active compounds
AU41433/97A AU4143397A (en) 1996-09-10 1997-09-08 New pharmaceutically active compounds
ARP970104131A AR009732A1 (en) 1996-09-10 1997-09-10 BISINDOLILMALEIMIDAS, PROCESS FOR ITS PREPARATION, ITS USE IN THE PREPARATION OF MEDICINES, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND INTERMEDIATE COMPOUNDS FOR ITS EXCLUSIVE USE IN THE ABOVE PROCESS
SA97180648A SA97180648A (en) 1996-09-10 1997-11-26 Novel bisindolylmaleimides, methods for their preparation and use, intermedlates therefor and pharmaceutical compositions comprising them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9603285A SE9603285D0 (en) 1996-09-10 1996-09-10 New compounds

Publications (1)

Publication Number Publication Date
SE9603285D0 true SE9603285D0 (en) 1996-09-10

Family

ID=20403830

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9603285A SE9603285D0 (en) 1996-09-10 1996-09-10 New compounds

Country Status (6)

Country Link
AR (1) AR009732A1 (en)
AU (1) AU4143397A (en)
SA (1) SA97180648A (en)
SE (1) SE9603285D0 (en)
WO (1) WO1998011103A1 (en)
ZA (1) ZA977809B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2233691T3 (en) 2000-07-27 2005-06-16 F. Hoffmann-La Roche Ag DERIVATIVES OF 3-INDOLIL-4-FENIL-1H-PIRROL-2,5-DIONA AS INHIBITORS OF THE GLINOGEN SINTASA KINASA-3BETA.
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US20050208151A1 (en) * 2003-10-30 2005-09-22 Entelos, Inc. Treatment of rheumatoid arthritis with FLIP antagonists
WO2007099385A1 (en) * 2006-03-01 2007-09-07 Glenmark Pharmaceuticals S.A. Dipeptidyl peptidase iv inhibitor compounds and compositions
TWI744723B (en) 2014-06-20 2021-11-01 美商基利科學股份有限公司 Synthesis of polycyclic-carbamoylpyridone compounds
EP3169337A1 (en) 2014-07-17 2017-05-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
CN113412258A (en) 2019-01-18 2021-09-17 阿斯利康(瑞典)有限公司 PCSK9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1449529B1 (en) * 1993-12-23 2010-01-27 Eli Lilly And Company Protein Kinase C Inhibitors

Also Published As

Publication number Publication date
AU4143397A (en) 1998-04-02
WO1998011103A1 (en) 1998-03-19
SA97180648A (en) 2005-12-03
ZA977809B (en) 1998-03-10
AR009732A1 (en) 2000-05-03

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