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AR009732A1 - BISINDOLILMALEIMIDAS, PROCESS FOR ITS PREPARATION, ITS USE IN THE PREPARATION OF MEDICINES, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND INTERMEDIATE COMPOUNDS FOR ITS EXCLUSIVE USE IN THE ABOVE PROCESS - Google Patents

BISINDOLILMALEIMIDAS, PROCESS FOR ITS PREPARATION, ITS USE IN THE PREPARATION OF MEDICINES, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND INTERMEDIATE COMPOUNDS FOR ITS EXCLUSIVE USE IN THE ABOVE PROCESS

Info

Publication number
AR009732A1
AR009732A1 ARP970104131A ARP970104131A AR009732A1 AR 009732 A1 AR009732 A1 AR 009732A1 AR P970104131 A ARP970104131 A AR P970104131A AR P970104131 A ARP970104131 A AR P970104131A AR 009732 A1 AR009732 A1 AR 009732A1
Authority
AR
Argentina
Prior art keywords
preparation
bisindolilmaleimidas
medicines
pharmaceutical composition
aminomethyl
Prior art date
Application number
ARP970104131A
Other languages
Spanish (es)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR009732A1 publication Critical patent/AR009732A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Bisindolilmaleimidas que comprenden la formula (I), en donde cada R20, que puede ser el mismo o diferente,es un hidrogeno o un halogeno; R es metilo, Ho R; R es un grupo de formula (II), en donde Z es un enlace simple o doble; n es 1 - 3; R1 es hidroxi, hidroximetilo, amino, N-((C1-C5)alquil)amino,aminometilo, N-((C1-C5)alquil)aminometilo, N,N-di((C1-C5)alquil)aminometilo, (C1-C5)alcoxi, o N-((C1-C5)acil)amino; y R2 y R3 son hidrogeno; y cuando Z esun enlace simple, R4 y R5, que pueden serlos mismos o diferentes, son cada uno hidrogeno o hidroxi; y sales farmacéuticamente aceptables, así como tambiénposibles estereoisomeros, ya sea puros o como racematos, o mezclas de estereoisomeros de los mismos, procesos para su preparacion, uso de dichoscompuestos para preparar medicamentos, compuestos intermdiarios para su exclusivo uso en dichos procedimientos y composiciones farmacéuticas que loscomprenden.Bisindolylmaleimides comprising formula (I), wherein each R20, which may be the same or different, is a hydrogen or a halogen; R is methyl, Ho R; R is a group of formula (II), where Z is a single or double bond; n is 1-3; R1 is hydroxy, hydroxymethyl, amino, N - ((C1-C5) alkyl) amino, aminomethyl, N - ((C1-C5) alkyl) aminomethyl, N, N-di ((C1-C5) alkyl) aminomethyl, ( C1-C5) alkoxy, or N - ((C1-C5) acyl) amino; and R2 and R3 are hydrogen; and when Z is a single bond, R4 and R5, which may be the same or different, are each hydrogen or hydroxy; and pharmaceutically acceptable salts, as well as possible stereoisomers, either pure or as racemates, or mixtures of stereoisomers thereof, processes for their preparation, use of said compounds to prepare drugs, intermediates for their exclusive use in said procedures and pharmaceutical compositions that understand them.

ARP970104131A 1996-09-10 1997-09-10 BISINDOLILMALEIMIDAS, PROCESS FOR ITS PREPARATION, ITS USE IN THE PREPARATION OF MEDICINES, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND INTERMEDIATE COMPOUNDS FOR ITS EXCLUSIVE USE IN THE ABOVE PROCESS AR009732A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9603285A SE9603285D0 (en) 1996-09-10 1996-09-10 New compounds

Publications (1)

Publication Number Publication Date
AR009732A1 true AR009732A1 (en) 2000-05-03

Family

ID=20403830

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104131A AR009732A1 (en) 1996-09-10 1997-09-10 BISINDOLILMALEIMIDAS, PROCESS FOR ITS PREPARATION, ITS USE IN THE PREPARATION OF MEDICINES, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND INTERMEDIATE COMPOUNDS FOR ITS EXCLUSIVE USE IN THE ABOVE PROCESS

Country Status (6)

Country Link
AR (1) AR009732A1 (en)
AU (1) AU4143397A (en)
SA (1) SA97180648A (en)
SE (1) SE9603285D0 (en)
WO (1) WO1998011103A1 (en)
ZA (1) ZA977809B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0301431A2 (en) 2000-07-27 2003-08-28 F. Hoffmann-La Roche Ag. 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivativas as inhibitors of glycogen synthase kinase-3betha, process for their preparation and pharmaceutical compositions containing them
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
WO2005042002A2 (en) * 2003-10-30 2005-05-12 Entelos, Inc. Treatment of rhematoid arthritis with flip antagonists
WO2007099385A1 (en) * 2006-03-01 2007-09-07 Glenmark Pharmaceuticals S.A. Dipeptidyl peptidase iv inhibitor compounds and compositions
TWI744723B (en) 2014-06-20 2021-11-01 美商基利科學股份有限公司 Synthesis of polycyclic-carbamoylpyridone compounds
EP3741375A1 (en) 2014-07-17 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
US11603523B2 (en) 2019-01-18 2023-03-14 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE456367T1 (en) * 1993-12-23 2010-02-15 Lilly Co Eli PROTEIN KINASE C INHIBITORS

Also Published As

Publication number Publication date
ZA977809B (en) 1998-03-10
SE9603285D0 (en) 1996-09-10
AU4143397A (en) 1998-04-02
SA97180648A (en) 2005-12-03
WO1998011103A1 (en) 1998-03-19

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