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SE9003665D0 - Morphine prodrugs - Google Patents

Morphine prodrugs

Info

Publication number
SE9003665D0
SE9003665D0 SE9003665A SE9003665A SE9003665D0 SE 9003665 D0 SE9003665 D0 SE 9003665D0 SE 9003665 A SE9003665 A SE 9003665A SE 9003665 A SE9003665 A SE 9003665A SE 9003665 D0 SE9003665 D0 SE 9003665D0
Authority
SE
Sweden
Prior art keywords
pct
morphine
date
sec
prodrugs
Prior art date
Application number
SE9003665A
Other languages
English (en)
Inventor
H Bundgaard
Original Assignee
Kabivitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabivitrum Ab filed Critical Kabivitrum Ab
Priority to SE9003665A priority Critical patent/SE9003665D0/sv
Publication of SE9003665D0 publication Critical patent/SE9003665D0/sv
Priority to IE368291A priority patent/IE913682A1/en
Priority to ZA918512A priority patent/ZA918512B/xx
Priority to NZ240349A priority patent/NZ240349A/en
Priority to IL9990591A priority patent/IL99905A/en
Priority to FI932212A priority patent/FI932212A7/sv
Priority to DE69129861T priority patent/DE69129861T2/de
Priority to CA002095223A priority patent/CA2095223C/en
Priority to DK91920399T priority patent/DK0557385T3/da
Priority to EP91920399A priority patent/EP0557385B1/en
Priority to AU89381/91A priority patent/AU655612B2/en
Priority to US08/050,336 priority patent/US5908846A/en
Priority to ES91920399T priority patent/ES2121793T3/es
Priority to PCT/SE1991/000760 priority patent/WO1992008459A1/en
Priority to AT91920399T priority patent/ATE168560T1/de
Priority to JP50056892A priority patent/JP3493434B2/ja
Priority to PT99513A priority patent/PT99513B/pt
Priority to NO931766A priority patent/NO931766D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
SE9003665A 1990-11-16 1990-11-16 Morphine prodrugs SE9003665D0 (sv)

Priority Applications (18)

Application Number Priority Date Filing Date Title
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs
IE368291A IE913682A1 (en) 1990-11-16 1991-10-21 Morphine prodrugs
ZA918512A ZA918512B (en) 1990-11-16 1991-10-25 Morphine prodrugs
NZ240349A NZ240349A (en) 1990-11-16 1991-10-25 Topical compositions for transdermal delivery of morphine prodrugs
IL9990591A IL99905A (en) 1990-11-16 1991-10-30 Topical compositions for transdermal delivery of morphine prodrugs
JP50056892A JP3493434B2 (ja) 1990-11-16 1991-11-11 モルヒネのプロドラッグ誘導体の経皮供給用の局所組成物
DK91920399T DK0557385T3 (da) 1990-11-16 1991-11-11 Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin
DE69129861T DE69129861T2 (de) 1990-11-16 1991-11-11 Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins
CA002095223A CA2095223C (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of prodrug derivatives of morphine
FI932212A FI932212A7 (sv) 1990-11-16 1991-11-11 Topikal kompositioner för transdermal transmission av morfinets prodru gderivat
EP91920399A EP0557385B1 (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of produg derivatives of morphine
AU89381/91A AU655612B2 (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of produg derivatives of morphine
US08/050,336 US5908846A (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of prodrug derivatives of morphine
ES91920399T ES2121793T3 (es) 1990-11-16 1991-11-11 Composiciones de uso local para la administracion transdermica de derivados profarmacos de morfina.
PCT/SE1991/000760 WO1992008459A1 (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of produg derivatives of morphine
AT91920399T ATE168560T1 (de) 1990-11-16 1991-11-11 Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins
PT99513A PT99513B (pt) 1990-11-16 1991-11-14 Processo para a preparacao de composicoes farmaceuticas contendo profarmacos de morfina para administracao topica por via transdermica
NO931766A NO931766D0 (no) 1990-11-16 1993-05-14 Topiske preparater for transdermal avlevering av forloeperlegemiddelderivater av morfin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs

Publications (1)

Publication Number Publication Date
SE9003665D0 true SE9003665D0 (sv) 1990-11-16

Family

ID=20380936

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs

Country Status (18)

Country Link
US (1) US5908846A (sv)
EP (1) EP0557385B1 (sv)
JP (1) JP3493434B2 (sv)
AT (1) ATE168560T1 (sv)
AU (1) AU655612B2 (sv)
CA (1) CA2095223C (sv)
DE (1) DE69129861T2 (sv)
DK (1) DK0557385T3 (sv)
ES (1) ES2121793T3 (sv)
FI (1) FI932212A7 (sv)
IE (1) IE913682A1 (sv)
IL (1) IL99905A (sv)
NO (1) NO931766D0 (sv)
NZ (1) NZ240349A (sv)
PT (1) PT99513B (sv)
SE (1) SE9003665D0 (sv)
WO (1) WO1992008459A1 (sv)
ZA (1) ZA918512B (sv)

Families Citing this family (47)

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US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
DE4403709A1 (de) * 1994-02-07 1995-08-10 Lohmann Therapie Syst Lts Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
JPH07267862A (ja) * 1994-03-29 1995-10-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
DE19508664C2 (de) * 1995-03-14 2001-08-23 Christian Mignat Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung
WO1996028451A1 (en) * 1995-03-14 1996-09-19 Euroceltique S.A. Morphine-3-esters
GB9519363D0 (en) 1995-09-22 1995-11-22 Euro Celtique Sa Pharmaceutical formulation
DE19602971A1 (de) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh Neue 7,8-Dihydromorphinderivate, Verfahren zu deren Herstellung und deren Verwendung
DE19923551A1 (de) * 1999-05-21 2000-11-30 Lohmann Therapie Syst Lts Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
CA2389235C (en) 1999-10-29 2007-07-17 Euro-Celtique, S.A. Controlled release hydrocodone formulations
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
KR100968128B1 (ko) 2000-10-30 2010-07-06 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
US6569449B1 (en) * 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
AUPR549901A0 (en) * 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
JP2004513183A (ja) * 2000-11-14 2004-04-30 バイタル　ヘルス　サイエンシズ　プロプライアタリー　リミティド リン酸誘導体の複合体
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
NZ529661A (en) * 2001-06-05 2006-03-31 Control Delivery Systems Sustained-release analgesic compounds
BR0211673A (pt) * 2001-07-27 2004-07-13 Vital Health Sciences Pty Ltd Terapia dermal utilizando derivados de fosfato de agentes de transferência de elétrons
AU2002350272B1 (en) * 2001-12-13 2003-06-23 Vital Health Sciences Pty Ltd Transdermal transport of compounds
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
US7084150B2 (en) * 2002-10-25 2006-08-01 Euro-Celtique S.A. Analogs and prodrugs of buprenorphine
AU2003285200A1 (en) * 2002-11-09 2004-06-03 Nobex Corporation Modified carbamate-containing prodrugs and methods of synthesizing same
ATE534384T1 (de) * 2003-01-17 2011-12-15 Vital Health Sciences Pty Ltd Verbindungen mit proliferationshemmenden eigenschaften
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
BRPI0412924A (pt) * 2003-07-25 2006-09-26 Euro Celtique Sa tratamento pré-operatório de dor pós-operatória
ES2313299T3 (es) * 2004-02-06 2009-03-01 Euro-Celtique S.A. Procedimientos para producir morfinonas 3 o protegidas y carboxilatos de morfinona dienol 3 o protegidos.
LT2351555T (lt) 2004-02-23 2016-12-27 Euro-Celtique S.A. Piktnaudžiavimui atspari priemonė, skirta transderminiam opoido įvedimui
DE602005025979D1 (de) * 2004-03-03 2011-03-03 Vital Health Sciences Pty Ltd Alkaloid-formulierungen
US9168216B2 (en) * 2005-06-17 2015-10-27 Vital Health Sciences Pty. Ltd. Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
BRPI0621081A2 (pt) * 2005-12-23 2011-11-29 Vital Health Sciences Pty Ltd método de modulação de uma ou mais citocinas imuno-reguladoras, uso de um ou mais derivados de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos, método de inibição de uma resposta inflamatória e/ou de estimulação de uma resposta anti-inflamatória, método de tratamento e/ou de profilaxia de distúbios imunológicos, distúrbios inflamatórios e/ou distúrbios proliferativos celulares, agente imuno-modulador, agente anti-inflamatório ou agente anti-cáncer e um ou mais derivado de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos
CA2679316C (en) 2007-03-02 2016-11-29 Teika Pharmaceutical Co., Ltd. Morphine composition for transdermal absorption, morphine composition storing unit and transdermal absorption preparation using the same
US9511016B2 (en) * 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
US8354116B2 (en) * 2007-06-18 2013-01-15 Biochemics, Inc. Bifunctional synthetic molecules
US8784872B2 (en) 2007-11-19 2014-07-22 Comgenrx, Inc. Formulation for decreasing tobacco, alcohol, drug or food consumption
US20090130048A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical Composition for Treating Pain
US20100104614A1 (en) * 2008-06-27 2010-04-29 Oronsky Bryan T Providone compositions for wound healing
WO2011002995A1 (en) 2009-07-02 2011-01-06 Kempharm, Inc. Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof
UA102916C2 (uk) * 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
ES2999020T3 (en) 2010-02-05 2025-02-24 Phosphagenics Ltd Carrier comprising non-neutralised tocopheryl phosphate
KR20130010473A (ko) 2010-03-30 2013-01-28 포스파제닉스 리미티드 경피 전달 패치
US11607407B2 (en) 2010-04-13 2023-03-21 Relmada Therapeutics, Inc. Dermal pharmaceutical compositions of 1-methyl-2′,6′-pipecoloxylidide and method of use
TWI520732B (zh) 2011-01-18 2016-02-11 輝瑞有限公司 固體分子分散液
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
WO2016086113A1 (en) 2014-11-25 2016-06-02 Kempharm, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
CA3007587C (en) 2015-12-09 2023-12-05 Phosphagenics Limited Pharmaceutical formulation
ES2983921T3 (es) 2016-12-21 2024-10-28 Avecho Biotechnology Ltd Proceso para fosforilar un alcohol complejo

Family Cites Families (8)

* Cited by examiner, † Cited by third party
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US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4673679A (en) * 1986-05-14 1987-06-16 E. I. Du Pont De Nemours And Company Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
US4940586A (en) * 1987-02-26 1990-07-10 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4879297A (en) * 1987-06-01 1989-11-07 Warner-Lambert Company Fatty acids and their small chain esters as penetration enhancers in aqueous systems
US4891377A (en) * 1988-12-02 1990-01-02 Board Of Regents Acting For And On Behalf Of University Of Michigan Transdermal delivery of the narcotic analgesics etorphine and analogs
EP0480054B1 (en) * 1990-03-30 1996-10-02 Morimoto, Yasunori Percutaneously absorbable composition of morphine hydrochloride
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine

Also Published As

Publication number Publication date
JP3493434B2 (ja) 2004-02-03
ATE168560T1 (de) 1998-08-15
EP0557385B1 (en) 1998-07-22
IE913682A1 (en) 1992-05-20
US5908846A (en) 1999-06-01
ES2121793T3 (es) 1998-12-16
FI932212A0 (fi) 1993-05-14
DE69129861D1 (de) 1998-08-27
IL99905A (en) 1995-06-29
FI932212L (fi) 1993-05-14
ZA918512B (en) 1992-08-26
NO931766L (no) 1993-05-14
AU655612B2 (en) 1995-01-05
NZ240349A (en) 1993-07-27
EP0557385A1 (en) 1993-09-01
IL99905A0 (en) 1992-08-18
CA2095223C (en) 2002-12-17
CA2095223A1 (en) 1992-05-17
FI932212A7 (sv) 1993-05-14
DE69129861T2 (de) 1999-04-01
PT99513B (pt) 1999-04-30
DK0557385T3 (da) 1999-04-26
AU8938191A (en) 1992-06-11
JPH06502422A (ja) 1994-03-17
PT99513A (pt) 1992-09-30
NO931766D0 (no) 1993-05-14
WO1992008459A1 (en) 1992-05-29

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