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SE9003652D0 - NEW HETEROCYCLIC COMPOUNDS - Google Patents

NEW HETEROCYCLIC COMPOUNDS

Info

Publication number
SE9003652D0
SE9003652D0 SE9003652A SE9003652A SE9003652D0 SE 9003652 D0 SE9003652 D0 SE 9003652D0 SE 9003652 A SE9003652 A SE 9003652A SE 9003652 A SE9003652 A SE 9003652A SE 9003652 D0 SE9003652 D0 SE 9003652D0
Authority
SE
Sweden
Prior art keywords
group
nitrogen
carbons
ring
heterocyclic compounds
Prior art date
Application number
SE9003652A
Other languages
Swedish (sv)
Inventor
A E A Claesson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9003652A priority Critical patent/SE9003652D0/en
Publication of SE9003652D0 publication Critical patent/SE9003652D0/en
Priority to CN91110925A priority patent/CN1061595A/en
Priority to HU931417A priority patent/HU9301417D0/en
Priority to CA002095224A priority patent/CA2095224A1/en
Priority to CS93809A priority patent/CZ80993A3/en
Priority to EP91920264A priority patent/EP0557375A1/en
Priority to FI932206A priority patent/FI932206A7/en
Priority to AU89391/91A priority patent/AU652399B2/en
Priority to PCT/SE1991/000753 priority patent/WO1992008724A1/en
Priority to SK46993A priority patent/SK46993A3/en
Priority to JP4500566A priority patent/JPH06502421A/en
Priority to MX9101979A priority patent/MX9101979A/en
Priority to IE392291A priority patent/IE913922A1/en
Priority to PT99515A priority patent/PT99515A/en
Priority to IS3782A priority patent/IS3782A7/en
Priority to NO931679A priority patent/NO931679D0/en
Priority to LTIP1718A priority patent/LTIP1718A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)

Abstract

Compounds of formula (I), in which X is an imino, a methylene group, a benzylidine, an 1,1-allylidine, a 1,1-alkylidene group containing from two to seven carbons, or is a group D-E in which D, being part of the ring, is nitrogen and E is a straight or branched lower alkyl or acyl each containing one to seven carbons, an aroyl, a substituted or non-substituted allyl, benzyl or propargyl group; Y is a hydroxyl- or amino-bearing carbon or is a carbonyl group; Z is a group consisting of one to four methylene groups or is a 1,3-allylidene or 1,3-propargylidene group; W is a group P(O)(OR<1>)(OR<2>) wherein R<1> and R<2> is each independently hydrogen, C1-C2 alkyl, acyloxymetyl or -etyl; n, when X does not contain nitrogen in the ring, is 1 or 2, or, when X contains nitrogen, is 2; for use as analgetics, anticonvulsants and antiischemic agents, as well as methods for their preparation, their pharmaceutical preparations and their use.
SE9003652A 1990-11-15 1990-11-15 NEW HETEROCYCLIC COMPOUNDS SE9003652D0 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
SE9003652A SE9003652D0 (en) 1990-11-15 1990-11-15 NEW HETEROCYCLIC COMPOUNDS
CN91110925A CN1061595A (en) 1990-11-15 1991-11-05 Novel heterocyclic compound used as excitatory amino acid receptor antagonist and its preparation method and use
JP4500566A JPH06502421A (en) 1990-11-15 1991-11-07 Novel heterocyclic compounds, methods of their preparation and their use as antagonists of excitatory amino acid receptors
FI932206A FI932206A7 (en) 1990-11-15 1991-11-07 Novel heterocyclic compounds as antagonists of excitatory amino acid receptors, method for their preparation and use
SK46993A SK46993A3 (en) 1990-11-15 1991-11-07 New heterocyclic compounds as antagonists of excitatory amino acid receptors, process for their preparation and their use
CS93809A CZ80993A3 (en) 1990-11-15 1991-11-07 Novel heterocyclic compounds as antagonists of amino acid receptors excitation, processes of their preparation and their use
EP91920264A EP0557375A1 (en) 1990-11-15 1991-11-07 New heterocyclic compounds as antagonists of excitatory amino acid receptors, processes for their preparation and their use
HU931417A HU9301417D0 (en) 1990-11-15 1991-11-07 Methods for producing new heterocyclic compounds and pharmaceutical preparatives containing them
AU89391/91A AU652399B2 (en) 1990-11-15 1991-11-07 New heterocyclic compounds as antagonists of excitatory amino acid receptors, processes for their preparation and their use
PCT/SE1991/000753 WO1992008724A1 (en) 1990-11-15 1991-11-07 New heterocyclic compounds as antagonists of excitatory amino acid receptors, processes for their preparation and their use
CA002095224A CA2095224A1 (en) 1990-11-15 1991-11-07 Heterocyclic compounds as antagonists of excitatory amino acid receptors, processes for their preparation and their use
MX9101979A MX9101979A (en) 1990-11-15 1991-11-08 NEW HETERO-CYCLE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
IE392291A IE913922A1 (en) 1990-11-15 1991-11-12 New heterocyclic compounds as antagonists of excitatory¹amino acid receptors, processes for their preparation and¹their use
PT99515A PT99515A (en) 1990-11-15 1991-11-14 METHOD FOR PREPARING NEW PIPERIDINIC AND PYRROLIDINIC PIPERAZINIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IS3782A IS3782A7 (en) 1990-11-15 1991-11-14 Method of Preparation of New Heterocyclic Compounds, Antagonists of Stimulating Amino Acids
NO931679A NO931679D0 (en) 1990-11-15 1993-05-07 NEW Heterocyclic Compounds as Antagonists for Excitatory Amino Acid Receptors, Procedures for their Preparation and Their Use
LTIP1718A LTIP1718A (en) 1990-11-15 1993-12-30 New heterocyclic compounds as antagonists of exitatory amino acids receptors, process for their preparation and their use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9003652A SE9003652D0 (en) 1990-11-15 1990-11-15 NEW HETEROCYCLIC COMPOUNDS

Publications (1)

Publication Number Publication Date
SE9003652D0 true SE9003652D0 (en) 1990-11-15

Family

ID=20380925

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9003652A SE9003652D0 (en) 1990-11-15 1990-11-15 NEW HETEROCYCLIC COMPOUNDS

Country Status (17)

Country Link
EP (1) EP0557375A1 (en)
JP (1) JPH06502421A (en)
CN (1) CN1061595A (en)
AU (1) AU652399B2 (en)
CA (1) CA2095224A1 (en)
CZ (1) CZ80993A3 (en)
FI (1) FI932206A7 (en)
HU (1) HU9301417D0 (en)
IE (1) IE913922A1 (en)
IS (1) IS3782A7 (en)
LT (1) LTIP1718A (en)
MX (1) MX9101979A (en)
NO (1) NO931679D0 (en)
PT (1) PT99515A (en)
SE (1) SE9003652D0 (en)
SK (1) SK46993A3 (en)
WO (1) WO1992008724A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194430A (en) * 1990-05-17 1993-03-16 Merrell Dow Pharmaceuticals Inc. Heterocyclic-nmda antagonists
TW281670B (en) * 1993-09-02 1996-07-21 Hoffmann La Roche
US5491241A (en) * 1993-10-18 1996-02-13 Eli Lilly And Company Bicyclic intermediates for excitatory amino acid receptor antagonists
HRP20220127T1 (en) 2016-02-04 2022-04-15 Takeda Pharmaceutical Company Limited SUBSTITUTED COMPOUND OF PIPERIDINE AND ITS USE

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
JPS612519A (en) * 1984-04-24 1986-01-08 Aron Kasei Co Ltd Method of injection molding
US4906621A (en) * 1985-05-24 1990-03-06 Ciba-Geigy Corporation Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
US4740346A (en) * 1986-02-26 1988-04-26 The Budd Company Perimeter resin feeding of composite structures
JPS63112129A (en) * 1986-10-30 1988-05-17 Toyoda Gosei Co Ltd Multi-color resin molding die
DE3768000D1 (en) * 1986-11-21 1991-03-14 Ciba Geigy Ag UNSATURATED PHOSPHONIC ACID AND DERIVATIVES.

Also Published As

Publication number Publication date
HU9301417D0 (en) 1993-09-28
EP0557375A1 (en) 1993-09-01
FI932206A0 (en) 1993-05-14
IE913922A1 (en) 1992-05-20
IS3782A7 (en) 1992-05-16
CN1061595A (en) 1992-06-03
WO1992008724A1 (en) 1992-05-29
AU652399B2 (en) 1994-08-25
NO931679L (en) 1993-05-07
SK46993A3 (en) 1993-10-06
CA2095224A1 (en) 1992-05-16
AU8939191A (en) 1992-06-11
CZ80993A3 (en) 1994-02-16
NO931679D0 (en) 1993-05-07
MX9101979A (en) 1992-07-08
PT99515A (en) 1992-09-30
FI932206L (en) 1993-05-14
FI932206A7 (en) 1993-05-14
LTIP1718A (en) 1995-07-25
JPH06502421A (en) 1994-03-17

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