SE8700250D0 - 8ALFA-ACYLAMINOERGOLINES, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
8ALFA-ACYLAMINOERGOLINES, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- SE8700250D0 SE8700250D0 SE8700250A SE8700250A SE8700250D0 SE 8700250 D0 SE8700250 D0 SE 8700250D0 SE 8700250 A SE8700250 A SE 8700250A SE 8700250 A SE8700250 A SE 8700250A SE 8700250 D0 SE8700250 D0 SE 8700250D0
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- phenyl
- 8alfa
- acylaminoergolines
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Novel compounds of the formula I <IMAGE> wherein R1 is hydrogen or (C1-4)alkyl, R2 is CN, COOH, COOR5, CONH2, CONHR5, CON(R5)R6, SR5, SOR5, SO2R5, CHO, CH2OH, COR7, CH2R7', CH(OH)R5, CH2CF3, iodine, C IDENTICAL CR8, CH=CHR8, (C2-12)alkyl, NO2, NH2 or NHCOR9,wherein R5 and R6 are independently (C1-4)alkyl, R7 is (C1-4)alkyl, CF3, phenyl or phenyl(C1-5)alkyl, R7' is phenyl or phenyl(C1-5)alkyl, R8 is hydrogen, (C1-10)alkyl or phenyl and R9 is (C1-6)alkyl, R3 is (C1-5)alkyl or (C3-5)alkenyl, in which the double bond is not at the carbon atom adjacent to the nitrogen atom, and R4 is (C1-12)alkyl, (C3-7)cycloalkyl or adamantyl, or acid addition salts thereof, are useful as neuroleptic and antidepressant agents. Some of the compounds possess prolactin secretion inhibiting activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3602058 | 1986-01-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8700250D0 true SE8700250D0 (en) | 1987-01-22 |
| SE8700250L SE8700250L (en) | 1987-07-25 |
Family
ID=6292510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8700250A SE8700250L (en) | 1986-01-24 | 1987-01-22 | 8ALFA-ACYLAMINOERGOLINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS62190184A (en) |
| KR (1) | KR870007175A (en) |
| AU (1) | AU6791487A (en) |
| BE (1) | BE1000039A4 (en) |
| DK (1) | DK35787A (en) |
| ES (1) | ES2003774A6 (en) |
| FI (1) | FI870293A7 (en) |
| FR (1) | FR2595699A1 (en) |
| GB (1) | GB2185743A (en) |
| GR (1) | GR870093B (en) |
| HU (1) | HUT45248A (en) |
| IL (1) | IL81355A0 (en) |
| IT (1) | IT1216783B (en) |
| LU (1) | LU86743A1 (en) |
| NL (1) | NL8700046A (en) |
| PT (1) | PT84184A (en) |
| SE (1) | SE8700250L (en) |
| ZA (1) | ZA87520B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8714767D0 (en) * | 1987-06-24 | 1987-07-29 | Erba Farmitalia | Egoline derivatives |
| EP0160842B1 (en) * | 1984-04-09 | 1994-06-22 | Schering Aktiengesellschaft | 2-Substituted ergoline derivatives, processes for their preparation, and their use as medicaments |
| DK338789A (en) * | 1988-07-15 | 1990-01-16 | Schering Ag | 2-SUBSTITUTED ERGOLINYLURINE DERIVATIVES AND PROCEDURES FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINES AND INTERMEDIATES FOR THE PRODUCTION THEREOF |
| DE3915950A1 (en) * | 1989-05-12 | 1990-11-15 | Schering Ag | 8 (ALPHA) ACYLAMINO ERGOLINE, THEIR PRODUCTION AND USE AS A MEDICINAL PRODUCT |
| RU2013158449A (en) * | 2011-06-23 | 2015-07-27 | Мэп Фармасьютикалс, Инк. | NEW FLUOROGOLINE ANALOGUES |
| EP2793580A4 (en) * | 2011-12-19 | 2015-05-20 | Map Pharmaceuticals Inc | Novel iso-ergoline derivatives |
| BR112017015487A2 (en) | 2015-01-20 | 2018-01-30 | Xoc Pharmaceuticals Inc | COMPOUND; COMPOSITION; METHOD OF TREATMENT AND / OR PREVENTION OF MIGRAINE, ALS, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, EXTRAPYRIMIDAL DISORDERS, DEPRESSION, NAUSEA, AEMESIS, SYNDROME OF THE WASTE LEGS, INSOMENESS, HYGERNESS, AGING , ANXIETY, DRUG DEPENDENCIES, DYSTONIA, PARASSONIA OR HYPERLACTINEMIA IN AN INDIVIDUAL; AGONIZATION METHODS OF D2, 5-HT1D, 5-HT1A AND 5-HT2C RECEPTORS, IN AN INDIVIDUAL; ANTAGONIZATION METHOD OF THE D3 RECEPTOR IN AN INDIVIDUAL; METHODS OF SELECTIVE AGONIZATION OF RECEPTORS 5 -HT1D, AND 5-HT2C, METHOD OF PROVIDING FUNCTIONAL ANTAGONIST ACTIVITY IN RECEPTOR 5 -HT2B OR IN RECEIVER 5-HT7, OR IN BOTH, IN AN INDIVIDUAL; METHOD OF PROVIDING FUNCTIONAL ANTAGONIST ACTIVITY IN ADRENERGIC RECEPTORS IN AN INDIVIDUAL |
| CN107405346A (en) * | 2015-01-20 | 2017-11-28 | Xoc制药股份有限公司 | Isergoline compounds and uses thereof |
| CA3064274A1 (en) | 2017-06-01 | 2018-12-06 | Xoc Pharmaceuticals, Inc. | Ergoline derivatives for use in medicine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1517971A (en) * | 1974-07-19 | 1978-07-19 | Sandoz Ltd | 8alpha-substituted ergoline i derivatives |
| CH615929A5 (en) * | 1975-06-02 | 1980-02-29 | Sandoz Ag | Process for the preparation of novel ergoline compounds |
| HU197569B (en) * | 1984-01-12 | 1989-04-28 | Sandoz Ag | Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds |
-
1987
- 1987-01-12 HU HU8792A patent/HUT45248A/en unknown
- 1987-01-12 NL NL8700046A patent/NL8700046A/en not_active Application Discontinuation
- 1987-01-21 GB GB08701274A patent/GB2185743A/en not_active Withdrawn
- 1987-01-22 FR FR8700834A patent/FR2595699A1/en active Pending
- 1987-01-22 AU AU67914/87A patent/AU6791487A/en not_active Abandoned
- 1987-01-22 KR KR870000556A patent/KR870007175A/en not_active Ceased
- 1987-01-22 DK DK035787A patent/DK35787A/en not_active Application Discontinuation
- 1987-01-22 IT IT8747551A patent/IT1216783B/en active
- 1987-01-22 ES ES8700163A patent/ES2003774A6/en not_active Expired
- 1987-01-22 PT PT84184A patent/PT84184A/en unknown
- 1987-01-22 IL IL81355A patent/IL81355A0/en unknown
- 1987-01-22 LU LU86743A patent/LU86743A1/en unknown
- 1987-01-22 SE SE8700250A patent/SE8700250L/en not_active Application Discontinuation
- 1987-01-22 GR GR870093A patent/GR870093B/en unknown
- 1987-01-23 ZA ZA87520A patent/ZA87520B/en unknown
- 1987-01-23 BE BE8700046A patent/BE1000039A4/en not_active IP Right Cessation
- 1987-01-23 JP JP62015028A patent/JPS62190184A/en active Pending
- 1987-01-23 FI FI870293A patent/FI870293A7/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK35787A (en) | 1987-07-25 |
| IT1216783B (en) | 1990-03-14 |
| ES2003774A6 (en) | 1988-11-16 |
| IL81355A0 (en) | 1987-08-31 |
| DK35787D0 (en) | 1987-01-22 |
| FI870293A7 (en) | 1987-07-25 |
| IT8747551A0 (en) | 1987-01-22 |
| ZA87520B (en) | 1988-09-28 |
| PT84184A (en) | 1987-02-01 |
| KR870007175A (en) | 1987-08-17 |
| GB2185743A (en) | 1987-07-29 |
| LU86743A1 (en) | 1987-09-03 |
| AU6791487A (en) | 1987-07-30 |
| JPS62190184A (en) | 1987-08-20 |
| GR870093B (en) | 1987-05-25 |
| HUT45248A (en) | 1988-06-28 |
| BE1000039A4 (en) | 1987-12-15 |
| SE8700250L (en) | 1987-07-25 |
| GB8701274D0 (en) | 1987-02-25 |
| FI870293A0 (en) | 1987-01-23 |
| NL8700046A (en) | 1987-08-17 |
| FR2595699A1 (en) | 1987-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 8700250-7 Effective date: 19900623 |