SE8505887D0 - indoles - Google Patents
indolesInfo
- Publication number
- SE8505887D0 SE8505887D0 SE8505887A SE8505887A SE8505887D0 SE 8505887 D0 SE8505887 D0 SE 8505887D0 SE 8505887 A SE8505887 A SE 8505887A SE 8505887 A SE8505887 A SE 8505887A SE 8505887 D0 SE8505887 D0 SE 8505887D0
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- represents hydrogen
- phenyl
- group
- r7r8n
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 210000005166 vasculature Anatomy 0.000 abstract 1
- 239000005526 vasoconstrictor agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Novel indoles of the general formula (I): <IMAGE> wherein R1 represents hydrogen, alkyl, cycloalkyl, alkenyl, phenyl or phenyl alkyl in which the phenyl ring may be unsubstituted or substituted by one or two substituents selected from alkoxy, hydroxy, halogen, a group R5R6NCO- where R5 and R6 each represents hydrogen or alkyl, or a group R7R8N-, where R7 and R8 each represents hydrogen or alkyl, or R7R8N- represents a saturated monocyclic 5- to 7- membered ring; R2 represents hydrogen or alkyl; or R1 and R2 together with the nitrogen atom form a saturated monocyclic 5- to 7-membered ring; R3 and R4 each represents hydrogen, alkyl or a 2-propenyl group; and n is an integer from 2 to 5; and physiologically acceptable salts and solvates thereof have selective vasoconstrictor activity and are useful in treating and/or preventing pain resulting from dilatation of the cranial vasculature, in particular migraine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848431426A GB8431426D0 (en) | 1984-12-13 | 1984-12-13 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8505887D0 true SE8505887D0 (en) | 1985-12-12 |
| SE8505887L SE8505887L (en) | 1986-06-14 |
Family
ID=10571103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8505887A SE8505887L (en) | 1984-12-13 | 1985-12-12 | indoles |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS61151172A (en) |
| AU (1) | AU579687B2 (en) |
| BE (1) | BE903846A (en) |
| CH (1) | CH667454A5 (en) |
| DE (1) | DE3543982A1 (en) |
| FR (1) | FR2574793B1 (en) |
| GB (2) | GB8431426D0 (en) |
| IT (1) | IT1182089B (en) |
| NL (1) | NL8503424A (en) |
| SE (1) | SE8505887L (en) |
| ZA (1) | ZA859520B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8530507D0 (en) * | 1985-12-11 | 1986-01-22 | Glaxo Group Plc | Chemical compounds |
| GB8607824D0 (en) * | 1986-03-27 | 1986-04-30 | Glaxo Group Ltd | Chemical compounds |
| GB8614287D0 (en) * | 1986-06-12 | 1986-07-16 | Glaxo Group Ltd | Chemical compounds |
| US4894386A (en) * | 1987-04-15 | 1990-01-16 | Ici Americas Inc. | Aliphatic carboxamides |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| US5225431A (en) * | 1987-10-23 | 1993-07-06 | Burroughs Wellcome Co. | Therapeutic substituted indole compounds and compositions thereof |
| ATE156823T1 (en) * | 1990-06-07 | 1997-08-15 | Zeneca Ltd | THERAPEUTIC HETEROCYCLIC COMPOUNDS |
| GB9209882D0 (en) * | 1992-05-07 | 1992-06-24 | Glaxo Lab Sa | Compositions |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| GB9216009D0 (en) * | 1992-07-28 | 1992-09-09 | Almirall Lab | New indol derivatives |
| ES2056025B1 (en) * | 1992-10-08 | 1995-05-01 | Almirall Lab | NEW DERIVATIVES OF INDOL. |
| FR2707639B1 (en) * | 1993-06-30 | 1995-10-13 | Pf Medicament | New indole compounds derived from arylamines as selective ligands for the 5HT1D and 5HT1B receptors. |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| EP1572647B1 (en) * | 2002-12-20 | 2016-09-21 | Basf Se | Synthesis of amines and intermediates for the synthesis thereof |
| WO2005118551A2 (en) | 2004-05-28 | 2005-12-15 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
| JP4728340B2 (en) * | 2004-10-25 | 2011-07-20 | リガンド・ファーマシューティカルズ・インコーポレイテッド | Compounds that modulate thrombopoietin activity and methods of modulation |
| ES2422284T3 (en) | 2007-03-29 | 2013-09-10 | Daiichi Sankyo Co Ltd | Indole derivative that has cPLA2 inhibitory activity, use thereof and method to produce it |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
| GB2082175B (en) * | 1980-08-12 | 1984-05-02 | Glaxo Group Ltd | Heterocyclic compounds |
| US4785016A (en) * | 1984-12-04 | 1988-11-15 | Glaxo Group Limited | Indole derivatives |
| GB8530507D0 (en) * | 1985-12-11 | 1986-01-22 | Glaxo Group Plc | Chemical compounds |
-
1984
- 1984-12-13 GB GB848431426A patent/GB8431426D0/en active Pending
-
1985
- 1985-12-12 ZA ZA859520A patent/ZA859520B/en unknown
- 1985-12-12 CH CH5301/85A patent/CH667454A5/en not_active IP Right Cessation
- 1985-12-12 GB GB08530591A patent/GB2168347B/en not_active Expired
- 1985-12-12 AU AU51151/85A patent/AU579687B2/en not_active Ceased
- 1985-12-12 DE DE19853543982 patent/DE3543982A1/en not_active Withdrawn
- 1985-12-12 FR FR8518416A patent/FR2574793B1/en not_active Expired
- 1985-12-12 BE BE0/216004A patent/BE903846A/en not_active IP Right Cessation
- 1985-12-12 IT IT48921/85A patent/IT1182089B/en active
- 1985-12-12 SE SE8505887A patent/SE8505887L/en not_active Application Discontinuation
- 1985-12-12 JP JP60278124A patent/JPS61151172A/en active Pending
- 1985-12-12 NL NL8503424A patent/NL8503424A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2168347A (en) | 1986-06-18 |
| GB8530591D0 (en) | 1986-01-22 |
| IT1182089B (en) | 1987-09-30 |
| FR2574793B1 (en) | 1988-10-14 |
| GB8431426D0 (en) | 1985-01-23 |
| AU579687B2 (en) | 1988-12-01 |
| FR2574793A1 (en) | 1986-06-20 |
| JPS61151172A (en) | 1986-07-09 |
| DE3543982A1 (en) | 1986-06-19 |
| CH667454A5 (en) | 1988-10-14 |
| SE8505887L (en) | 1986-06-14 |
| NL8503424A (en) | 1986-07-01 |
| AU5115185A (en) | 1986-06-19 |
| ZA859520B (en) | 1986-08-27 |
| IT8548921A0 (en) | 1985-12-12 |
| GB2168347B (en) | 1988-02-03 |
| BE903846A (en) | 1986-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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