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SE8104783L - Heterocyclic Associations - Google Patents

Heterocyclic Associations

Info

Publication number
SE8104783L
SE8104783L SE8104783A SE8104783A SE8104783L SE 8104783 L SE8104783 L SE 8104783L SE 8104783 A SE8104783 A SE 8104783A SE 8104783 A SE8104783 A SE 8104783A SE 8104783 L SE8104783 L SE 8104783L
Authority
SE
Sweden
Prior art keywords
group
alkyl
hydrogen atom
cycloalkyl
represent
Prior art date
Application number
SE8104783A
Other languages
Swedish (sv)
Other versions
SE454777B (en
Inventor
I H Coates
K Mills
C F Webb
M D Dowle
D E Bays
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SE8104783L publication Critical patent/SE8104783L/en
Publication of SE454777B publication Critical patent/SE454777B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Compounds are disclosed of general formula (I> <IMAGE> wherein R1 represents a group CHO, COR8, CO2R8, CONR9R10, CSNR9R10 or SO2NR9R10, where R8 represents an alkyl, cycloalkyl, aryl or aralkyl group, R9 represents a hydrogen atom or an alkyl group, and R10 represents a hydrogen atom or an alkyl, cycloalkyl, aryl or aralkyl group; R2, R3, R4, R6 and R7, which may be the same or different, each represents a hydrogen atom or a C1-3 alkyl group; R5 represents a hydrogen atom or an alkyl, cycloalkyl, alkenyl or an aralkyl group or R4 and R5 together form an aralkylidene group or R4 and R5 together with the nitrogen atom to which they are attached form a saturated monocyclic 5- to 7-membered ring; n is zero or 1; and Alk represents an alkylene chain containing two or three carbon atoms which may be unsubstituted or substituted by not more than two C1-3 alkyl groups; with the provisos that, when n is zero and (i) R4 and R5, both represent alkyl groups, R1 does not represent the group CHO or COR8; and (ii) R1 does not represent the group SO2NH2; and physiologically acceptable salts, solvates and bioprecursors thereof. The compounds are described as potentially useful for the treatment of migraine.
SE8104783A 1980-08-12 1981-08-11 5-SUBSTITUTED 3-AMINOALKYL-1H INDOLES, PROCEDURES FOR THE PREPARATION OF THESE AND A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MIGREN SE454777B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8026288 1980-08-12
GB8026287 1980-08-12

Publications (2)

Publication Number Publication Date
SE8104783L true SE8104783L (en) 1982-02-13
SE454777B SE454777B (en) 1988-05-30

Family

ID=26276534

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8104783A SE454777B (en) 1980-08-12 1981-08-11 5-SUBSTITUTED 3-AMINOALKYL-1H INDOLES, PROCEDURES FOR THE PREPARATION OF THESE AND A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MIGREN

Country Status (12)

Country Link
AU (1) AU550010B2 (en)
CH (1) CH652394A5 (en)
DE (1) DE3131752A1 (en)
DK (1) DK157995C (en)
ES (2) ES504694A0 (en)
FR (1) FR2488606A1 (en)
GB (1) GB2083463B (en)
IE (1) IE51493B1 (en)
IT (1) IT1171450B (en)
NL (1) NL8103764A (en)
NZ (1) NZ197998A (en)
SE (1) SE454777B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170387B (en) * 1982-06-07 1987-06-03 Glaxo Group Ltd HETEROCYCLIC COMPOUNDS, PROCEDURE TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PT78358B (en) * 1983-04-07 1986-05-30 Smith Kline French Lab Chemical process
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
SK278998B6 (en) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Imidazole, triazole and tetrazole derivatives, method of producing same, their use and pharmaceutical compositons on their base
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
RU2110516C1 (en) * 1992-04-10 1998-05-10 Пфайзер Инк. Derivatives of acylaminoindole and aminoindole
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme 4-substituted 1, 2, 4-triazole derivatives, their preparation and pharmaceutical compositions containing them
ES2070772B1 (en) * 1993-08-09 1996-02-16 Pfizer DERIVATIVES OF ACILAMINOINDOL
WO1996017842A1 (en) * 1994-12-06 1996-06-13 Merck Sharp & Dohme Limited Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
FR2731224B1 (en) * 1995-03-02 1997-05-30 Pf Medicament NOVEL BI-TRYPTAMINIC SULFONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2870162A (en) * 1954-04-28 1959-01-20 Upjohn Co Production of certain tryptamines and compounds produced in the process
FR1203195A (en) * 1958-07-25 1960-01-15 Chimiotherapie Lab Franc Process for the preparation of a new derivative of tryptamine
NL7316677A (en) * 1972-12-21 1974-06-25
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
IT8149085A1 (en) 1983-02-11
ES8405371A1 (en) 1984-06-01
DK157995C (en) 1990-08-06
DK157995B (en) 1990-03-12
DE3131752C2 (en) 1992-04-23
SE454777B (en) 1988-05-30
GB2083463A (en) 1982-03-24
ES513934A0 (en) 1984-06-01
IE811832L (en) 1982-02-12
FR2488606B1 (en) 1984-10-26
ES8300699A1 (en) 1982-11-01
AU550010B2 (en) 1986-02-27
ES504694A0 (en) 1982-11-01
DK357281A (en) 1982-02-13
NL8103764A (en) 1982-03-01
IT1171450B (en) 1987-06-10
IE51493B1 (en) 1987-01-07
FR2488606A1 (en) 1982-02-19
CH652394A5 (en) 1985-11-15
IT8149085A0 (en) 1981-08-11
AU7399581A (en) 1982-02-18
NZ197998A (en) 1985-08-16
DE3131752A1 (en) 1982-06-16
GB2083463B (en) 1984-05-10

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