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SE8301785D0 - PROCEDED PREPARATION DE DERIVES DE L'ACIDE 2-THIOPHENE ACETIQUE ET PRODUCTS INTERMEDIAIRES NECESSAIRES POUR LEUR PREPARATION - Google Patents

PROCEDED PREPARATION DE DERIVES DE L'ACIDE 2-THIOPHENE ACETIQUE ET PRODUCTS INTERMEDIAIRES NECESSAIRES POUR LEUR PREPARATION

Info

Publication number
SE8301785D0
SE8301785D0 SE8301785A SE8301785A SE8301785D0 SE 8301785 D0 SE8301785 D0 SE 8301785D0 SE 8301785 A SE8301785 A SE 8301785A SE 8301785 A SE8301785 A SE 8301785A SE 8301785 D0 SE8301785 D0 SE 8301785D0
Authority
SE
Sweden
Prior art keywords
preparation
thiophene
necessaires
acetique
intermediaires
Prior art date
Application number
SE8301785A
Other languages
Swedish (sv)
Other versions
SE8301785L (en
SE453992B (en
Inventor
R Nabet
S Andres
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of SE8301785D0 publication Critical patent/SE8301785D0/en
Publication of SE8301785L publication Critical patent/SE8301785L/en
Publication of SE453992B publication Critical patent/SE453992B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A 2-thiophene acetic acid compound of formula (I): <IMAGE> in which: R represents an alkyl radical of 1 to 4 carbon atoms; and R1, R2 and R3 are the same or different and each represents a hydrogen atom, an alkyl radical of 1 to 4 carbon atoms or a halogen atom; is prepared by decarbalkoxylating an alkylmalonate of formula (IV): <IMAGE> in which R, R1, R2 and R3 are as defined above and Alk1 and Alk2 are the same or different and each represents an alkyl radical of 1 to 4 carbon atoms. The 2-thiophene acetic acid compound is an intermediate in the production of pharmaceuticals. The alkylmalonate used is itself claimed per se.
SE8301785A 1982-12-03 1983-03-30 SET TO PREPARE 2-THIOPHENIC ACETIC ACID DERIVATIVES SE453992B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8220271A FR2537137B1 (en) 1982-12-03 1982-12-03 PROCESS FOR THE PREPARATION OF ACETIC 2-THIOPHENE ACID DERIVATIVES AND INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION

Publications (3)

Publication Number Publication Date
SE8301785D0 true SE8301785D0 (en) 1983-03-30
SE8301785L SE8301785L (en) 1984-06-04
SE453992B SE453992B (en) 1988-03-21

Family

ID=9279757

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8301785A SE453992B (en) 1982-12-03 1983-03-30 SET TO PREPARE 2-THIOPHENIC ACETIC ACID DERIVATIVES
SE8703494A SE457724B (en) 1982-12-03 1987-09-09 2-TIENYL MALONE DERIVATIVES FOR USE IN THE PREPARATION OF 2-THIOPHENETIC ACID DERIVATIVES

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8703494A SE457724B (en) 1982-12-03 1987-09-09 2-TIENYL MALONE DERIVATIVES FOR USE IN THE PREPARATION OF 2-THIOPHENETIC ACID DERIVATIVES

Country Status (22)

Country Link
JP (1) JPS59106482A (en)
KR (1) KR900005681B1 (en)
AT (1) AT392784B (en)
AU (1) AU556803B2 (en)
BE (1) BE896439A (en)
CA (1) CA1201441A (en)
CH (2) CH659817A5 (en)
DE (1) DE3314029A1 (en)
DK (2) DK160427C (en)
ES (1) ES8401957A1 (en)
FI (1) FI83646C (en)
FR (1) FR2537137B1 (en)
GB (1) GB2132607B (en)
HU (1) HU192136B (en)
IE (1) IE55075B1 (en)
IT (1) IT1174757B (en)
LU (1) LU84748A1 (en)
NL (1) NL8301692A (en)
NZ (1) NZ204509A (en)
PT (1) PT76534B (en)
SE (2) SE453992B (en)
ZA (1) ZA832698B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338494B1 (en) * 1988-04-22 1996-01-10 Byk Gulden Lomberg Chemische Fabrik GmbH 3-Anilino-2-hydroxycarbonyl-4-thiophen-acetic acids
IT1276738B1 (en) * 1995-06-16 1997-11-03 Erregierre Spa PROCESS FOR THE PREPARATION OF DERIVATIVES OF -METHYL-2- THIOPHENEACETIC ACID
DE102004008807A1 (en) 2004-02-20 2005-09-08 Bayer Cropscience Ag pyrazolopyrimidine
CN113896709B (en) * 2021-11-22 2023-02-28 南京一苇医药科技有限公司 Synthetic method of benzothiophene-3-acetic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB683337A (en) * 1949-10-01 1952-11-26 Warner Hudnut Inc Improvements in or relating to the preparation of antispasmodic compounds
IE33054B1 (en) * 1968-04-16 1974-03-06 Ici Ltd Heterocyclic compounds
FR2260575A1 (en) * 1974-02-11 1975-09-05 Innothera Lab Sa Cyclohexyl 3-thienyl acetic acid prodn - from methyl 3-thienylacetate through diethyl cyclohexyl 3-thienyl malonate as starting material for basic esters as drugs
GB2003570B (en) * 1977-06-08 1982-01-20 Imi Opella Ltd Stop valve
FR2421897A1 (en) * 1978-04-04 1979-11-02 Labaz Alpha substd. 3-thienyl:acetamide derivs. - useful as hypnotic, anticonvulsant and tranquillising agents

Also Published As

Publication number Publication date
CA1201441A (en) 1986-03-04
ZA832698B (en) 1984-05-30
CH655722A5 (en) 1986-05-15
SE8301785L (en) 1984-06-04
HU192136B (en) 1987-05-28
KR900005681B1 (en) 1990-08-06
DK138490D0 (en) 1990-06-06
IT8348215A0 (en) 1983-05-04
PT76534A (en) 1983-05-01
NZ204509A (en) 1986-02-21
SE8703494D0 (en) 1987-09-09
FI83646C (en) 1991-08-12
DK164550B (en) 1992-07-13
IT1174757B (en) 1987-07-01
DK164550C (en) 1992-11-30
DK139983D0 (en) 1983-03-28
ES521230A0 (en) 1984-01-01
ATA286683A (en) 1990-11-15
IE55075B1 (en) 1990-05-23
DE3314029C2 (en) 1993-03-04
FI831115L (en) 1984-06-04
SE457724B (en) 1989-01-23
GB2132607A (en) 1984-07-11
FI831115A0 (en) 1983-03-31
AU1357483A (en) 1984-06-07
FR2537137B1 (en) 1985-07-19
SE453992B (en) 1988-03-21
NL8301692A (en) 1984-07-02
ES8401957A1 (en) 1984-01-01
KR840006986A (en) 1984-12-04
DK138490A (en) 1990-06-06
GB2132607B (en) 1986-05-08
DK160427B (en) 1991-03-11
DK160427C (en) 1991-08-19
IE831075L (en) 1984-06-03
LU84748A1 (en) 1983-12-05
JPH0480910B2 (en) 1992-12-21
CH659817A5 (en) 1987-02-27
GB8312701D0 (en) 1983-06-15
FI83646B (en) 1991-04-30
BE896439A (en) 1983-10-12
SE8703494L (en) 1987-09-09
AU556803B2 (en) 1986-11-20
DE3314029A1 (en) 1984-06-07
AT392784B (en) 1991-06-10
DK139983A (en) 1984-06-04
FR2537137A1 (en) 1984-06-08
JPS59106482A (en) 1984-06-20
PT76534B (en) 1986-03-12

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