SE8003277L - Bensimidazolderivat, deras framstellning och anvendning samt kompositioner innehallande dessa derivat - Google Patents
Bensimidazolderivat, deras framstellning och anvendning samt kompositioner innehallande dessa derivatInfo
- Publication number
- SE8003277L SE8003277L SE8003277A SE8003277A SE8003277L SE 8003277 L SE8003277 L SE 8003277L SE 8003277 A SE8003277 A SE 8003277A SE 8003277 A SE8003277 A SE 8003277A SE 8003277 L SE8003277 L SE 8003277L
- Authority
- SE
- Sweden
- Prior art keywords
- linear
- ramified
- radicals
- radical
- derivatives
- Prior art date
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- -1 alkyl radical Chemical class 0.000 abstract 10
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 3
- 229910052794 bromium Inorganic materials 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Substances 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 239000011737 fluorine Substances 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- BQIKRTGTPBOIMK-UHFFFAOYSA-N [O]C[O] Chemical compound [O]C[O] BQIKRTGTPBOIMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000005596 alkyl carboxamido group Chemical group 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical compound O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU81225 | 1979-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8003277L true SE8003277L (sv) | 1980-11-05 |
Family
ID=19729148
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8003278A SE8003278L (sv) | 1979-05-04 | 1980-04-30 | Fenyletylaminderivat |
| SE8003277A SE8003277L (sv) | 1979-05-04 | 1980-04-30 | Bensimidazolderivat, deras framstellning och anvendning samt kompositioner innehallande dessa derivat |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8003278A SE8003278L (sv) | 1979-05-04 | 1980-04-30 | Fenyletylaminderivat |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4338330A (sv) |
| JP (2) | JPS6033424B2 (sv) |
| AT (2) | AT376418B (sv) |
| AU (2) | AU537573B2 (sv) |
| BE (2) | BE883068A (sv) |
| CA (1) | CA1146563A (sv) |
| CH (2) | CH644599A5 (sv) |
| DE (2) | DE3016828A1 (sv) |
| DK (2) | DK187880A (sv) |
| ES (2) | ES8103729A1 (sv) |
| FI (2) | FI801429A7 (sv) |
| FR (2) | FR2455587A1 (sv) |
| GB (2) | GB2055360B (sv) |
| GR (2) | GR68536B (sv) |
| IE (1) | IE50218B1 (sv) |
| IL (2) | IL59974A0 (sv) |
| IT (2) | IT1150018B (sv) |
| NL (2) | NL8002567A (sv) |
| NO (2) | NO150916C (sv) |
| PT (2) | PT71174A (sv) |
| SE (2) | SE8003278L (sv) |
| ZA (2) | ZA802695B (sv) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1156661A (en) * | 1980-02-25 | 1983-11-08 | Hoffmann-La Roche Limited | Phenoxy-aminopropanol derivatives |
| JPS582343A (ja) * | 1981-06-30 | 1983-01-07 | Osaka Soda Co Ltd | 耐窒素酸化物性に優れた加硫性ゴム組成物 |
| GB8310556D0 (en) * | 1983-04-19 | 1983-05-25 | Beecham Group Plc | Compounds |
| US4550119A (en) * | 1983-05-23 | 1985-10-29 | Warner-Lambert Company | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones |
| US5104892A (en) * | 1989-12-11 | 1992-04-14 | American Home Products Corporation | Substituted benzimidazole derivatives possessing Class III antiarrhythmic activity |
| US5541204A (en) * | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
| US7078421B2 (en) | 2002-03-20 | 2006-07-18 | Metabolex, Inc. | Substituted phenylacetic acids |
| US7351719B2 (en) | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
| US7199259B2 (en) * | 2003-06-20 | 2007-04-03 | Metabolex, Inc. | Resolution of α-(phenoxy)phenylacetic acid derivatives |
| US7323480B2 (en) * | 2004-05-25 | 2008-01-29 | Metabolex, Inc. | Substituted triazoles as modulators of PPAR and methods of their preparation |
| JP2008500358A (ja) * | 2004-05-25 | 2008-01-10 | メタボレックス インコーポレーティッド | Ｐｐａｒのモジュレーターとしての、二環式の置換されたトリアゾール、およびこれらの調製方法 |
| US7714131B2 (en) * | 2005-09-23 | 2010-05-11 | Metabolex, Inc. | Process for the stereoselective preparation of (−)-halofenate and derivatives thereof |
| EP2727911B1 (en) * | 2012-10-31 | 2016-12-21 | Medizinische Hochschule Hannover | Novel means and methods for treating malaria and other parasitic disorders |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1157556A (en) * | 1966-06-09 | 1969-07-09 | Egyt Gyogyszervegyeszeti Gyar | Novel Benzazole Derivatives and the Preparation thereof |
| FR1570892A (sv) * | 1968-06-18 | 1969-06-13 | ||
| US3574218A (en) * | 1969-08-11 | 1971-04-06 | Egyt Gyogyszervegyeszeti Gyar | 2-aryl- or aralkyl-substituted benzazole derivatives |
| JPS5231858B1 (sv) * | 1969-12-17 | 1977-08-17 | ||
| CH624395A5 (sv) | 1976-01-08 | 1981-07-31 | Ciba Geigy Ag | |
| DE2609645A1 (de) | 1976-03-09 | 1977-09-15 | Boehringer Sohn Ingelheim | Aminoalkylheterocyclen |
| DE2640730C2 (de) * | 1976-09-10 | 1983-08-25 | Hoechst Ag, 6230 Frankfurt | Benzoxazolyloxy- und Benzothiazolyloxy-phenoxy-Verbindungen und diese enthaltende herbizide Mittel |
| DE2644833A1 (de) * | 1976-10-05 | 1978-04-20 | Boehringer Sohn Ingelheim | Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung |
| DE2737630A1 (de) | 1977-08-20 | 1979-03-01 | Boehringer Mannheim Gmbh | Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE2801953A1 (de) | 1978-01-18 | 1979-07-19 | Boehringer Mannheim Gmbh | 4-hydroxy-2-benzimidazolinon-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| DE2801980A1 (de) | 1978-01-18 | 1979-07-19 | Boehringer Mannheim Gmbh | 4-hydroxy-2-benzimidazolin-thion- derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
| EP0003758A1 (de) | 1978-02-09 | 1979-09-05 | Ciba-Geigy Ag | Verätherte Hydroxy-benzodiheterocyclen und ihre Säureadditionssalze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate |
| DE2905877A1 (de) | 1979-02-16 | 1980-08-28 | Boehringer Mannheim Gmbh | Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE2905876A1 (de) | 1979-02-16 | 1980-08-28 | Boehringer Mannheim Gmbh | Neue piperidinopropylderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1980
- 1980-04-30 US US06/145,144 patent/US4338330A/en not_active Expired - Lifetime
- 1980-04-30 FR FR8009847A patent/FR2455587A1/fr active Granted
- 1980-04-30 BE BE0/200432A patent/BE883068A/fr not_active IP Right Cessation
- 1980-04-30 PT PT71174A patent/PT71174A/pt unknown
- 1980-04-30 FR FR8009846A patent/FR2455572B1/fr not_active Expired
- 1980-04-30 DK DK187880A patent/DK187880A/da not_active Application Discontinuation
- 1980-04-30 SE SE8003278A patent/SE8003278L/sv not_active Application Discontinuation
- 1980-04-30 DK DK187980A patent/DK187980A/da not_active Application Discontinuation
- 1980-04-30 BE BE0/200433A patent/BE883069A/fr not_active IP Right Cessation
- 1980-04-30 PT PT71175A patent/PT71175A/pt unknown
- 1980-04-30 SE SE8003277A patent/SE8003277L/sv not_active Application Discontinuation
- 1980-05-01 IL IL59974A patent/IL59974A0/xx unknown
- 1980-05-01 IL IL59973A patent/IL59973A/xx unknown
- 1980-05-02 FI FI801429A patent/FI801429A7/fi not_active Application Discontinuation
- 1980-05-02 CH CH345380A patent/CH644599A5/fr not_active IP Right Cessation
- 1980-05-02 IT IT8021779A patent/IT1150018B/it active
- 1980-05-02 GB GB8014647A patent/GB2055360B/en not_active Expired
- 1980-05-02 CH CH345280A patent/CH645090A5/fr not_active IP Right Cessation
- 1980-05-02 NO NO801285A patent/NO150916C/no unknown
- 1980-05-02 ES ES491142A patent/ES8103729A1/es not_active Expired
- 1980-05-02 DE DE19803016828 patent/DE3016828A1/de not_active Withdrawn
- 1980-05-02 GR GR61836A patent/GR68536B/el unknown
- 1980-05-02 DE DE19803016827 patent/DE3016827A1/de not_active Withdrawn
- 1980-05-02 ES ES491143A patent/ES8104245A1/es not_active Expired
- 1980-05-02 IT IT8021780A patent/IT1159060B/it active
- 1980-05-02 NO NO801286A patent/NO801286L/no unknown
- 1980-05-02 NL NL8002567A patent/NL8002567A/nl not_active Application Discontinuation
- 1980-05-02 GB GB8014645A patent/GB2055091B/en not_active Expired
- 1980-05-02 NL NL8002568A patent/NL8002568A/nl not_active Application Discontinuation
- 1980-05-02 FI FI801428A patent/FI801428A7/fi not_active Application Discontinuation
- 1980-05-02 CA CA000351169A patent/CA1146563A/en not_active Expired
- 1980-05-02 GR GR61835A patent/GR68535B/el unknown
- 1980-05-05 ZA ZA00802695A patent/ZA802695B/xx unknown
- 1980-05-05 AT AT0238680A patent/AT376418B/de not_active IP Right Cessation
- 1980-05-05 AU AU58095/80A patent/AU537573B2/en not_active Ceased
- 1980-05-05 IE IE918/80A patent/IE50218B1/en unknown
- 1980-05-05 AT AT0238780A patent/AT376210B/de not_active IP Right Cessation
- 1980-05-05 ZA ZA00802694A patent/ZA802694B/xx unknown
- 1980-05-05 AU AU58096/80A patent/AU542596B2/en not_active Ceased
- 1980-05-06 JP JP55059847A patent/JPS6033424B2/ja not_active Expired
- 1980-05-06 JP JP5984680A patent/JPS565465A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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