SE0401300D0 - Novel Galactoside Inhibitors of Galectins - Google Patents
Novel Galactoside Inhibitors of GalectinsInfo
- Publication number
- SE0401300D0 SE0401300D0 SE0401300A SE0401300A SE0401300D0 SE 0401300 D0 SE0401300 D0 SE 0401300D0 SE 0401300 A SE0401300 A SE 0401300A SE 0401300 A SE0401300 A SE 0401300A SE 0401300 D0 SE0401300 D0 SE 0401300D0
- Authority
- SE
- Sweden
- Prior art keywords
- galectins
- novel
- galectin
- inhibitors
- galactoside inhibitors
- Prior art date
Links
- 102000007563 Galectins Human genes 0.000 title abstract 3
- 108010046569 Galectins Proteins 0.000 title abstract 3
- 150000008195 galaktosides Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 102000000802 Galectin 3 Human genes 0.000 abstract 1
- 108010001517 Galectin 3 Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401300A SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Novel Galactoside Inhibitors of Galectins |
| AT05745033T ATE525383T1 (de) | 2004-05-21 | 2005-05-20 | Neue galactosidinhibitoren von galectinen |
| EP05745033A EP1751171B1 (fr) | 2004-05-21 | 2005-05-20 | Nouveaux inhibiteurs galactosides de galectines |
| CA2567694A CA2567694C (fr) | 2004-05-21 | 2005-05-20 | Nouveaux inhibiteurs galactosides de galectines |
| PCT/SE2005/000757 WO2005113568A1 (fr) | 2004-05-21 | 2005-05-20 | Nouveaux inhibiteurs galactosides de galectines |
| US11/561,124 US7638623B2 (en) | 2004-05-21 | 2006-11-17 | Galactoside inhibitors of galectins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401300A SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Novel Galactoside Inhibitors of Galectins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE0401300D0 true SE0401300D0 (sv) | 2004-05-21 |
Family
ID=32589763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE0401300A SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Novel Galactoside Inhibitors of Galectins |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7638623B2 (fr) |
| EP (1) | EP1751171B1 (fr) |
| AT (1) | ATE525383T1 (fr) |
| CA (1) | CA2567694C (fr) |
| SE (1) | SE0401300D0 (fr) |
| WO (1) | WO2005113568A1 (fr) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002362030A1 (en) | 2001-11-27 | 2003-06-10 | Fred Hutchinson Cancer Research Center | Methods for inhibiting deacetylase activity |
| CN103497228B (zh) * | 2008-05-16 | 2016-08-10 | 格莱克特生物技术公司 | 半乳糖苷抑制剂的合成 |
| WO2010126435A1 (fr) * | 2009-04-28 | 2010-11-04 | Forskarpatent I Syd Ab | Nouveaux inhibiteurs galactosides de galectines |
| US9243021B2 (en) | 2012-10-31 | 2016-01-26 | Galecto Biotech Ab | Galactoside inhibitor of galectins |
| WO2014067986A1 (fr) | 2012-10-31 | 2014-05-08 | Galecto Biotech Ab | Galactoside inhibiteur de la galectine-3 et son utilisation pour le traitement de la fibrose pulmonaire |
| AR086543A1 (es) * | 2011-05-25 | 2014-01-08 | Bg Medicine Inc | Inhibidores de galectina-3 y metodos de uso de los mismos, composicion farmaceutica |
| EP2620443A1 (fr) * | 2012-01-25 | 2013-07-31 | Galecto Biotech AB | Nouveaux inhibiteurs de galectines au galactoside |
| ES2773921T3 (es) | 2012-09-17 | 2020-07-15 | Galectin Therapeutics Inc | Método para mejorar las inmunoterapias específicas en el tratamiento del cáncer |
| AU2013329148B2 (en) | 2012-10-10 | 2018-03-29 | Galectin Therapeutics, Inc. | Galactose-pronged carbohydrate compounds for the treatment of diabetic nephropathy and associated disorders |
| JP6366598B2 (ja) * | 2012-11-15 | 2018-08-01 | タフツ ユニバーシティー | ガレクチンタンパク質阻害剤を用いて被験体の眼の血管新生または繊維症を処置し、調節し、または、予防する方法、組成物、およびキット |
| US12390486B2 (en) | 2012-12-20 | 2025-08-19 | Henry Ford Health System | Method for treating diastolic heart failure by inhibiting galectin-3 |
| JP2016507503A (ja) | 2012-12-20 | 2016-03-10 | ヘンリー フォード ヘルス システム | ガレクチン−３を阻害することによる拡張期心不全を治療する方法 |
| CA2949441A1 (fr) | 2014-07-09 | 2016-01-14 | Galecto Biotech Ab | Nouvel inhibiteur galactoside hybride de galectines |
| WO2016113335A1 (fr) | 2015-01-16 | 2016-07-21 | Galecto Biotech Ab | Nouvel inhibiteur galactoside de galectines |
| JP6904906B2 (ja) | 2015-01-30 | 2021-07-21 | ガレクト・バイオテック・エイビイ | ガレクチンの新規なガラクトシド阻害剤 |
| EP3374368B1 (fr) | 2015-11-09 | 2022-06-01 | Galecto Biotech AB | 1,1'-sulfanediyl-di-beta-d-galactopyranosides en tant qu' inhibitors de galectins |
| CA3025867A1 (fr) | 2016-07-12 | 2018-01-18 | Galecto Biotech Ab | Inhibiteurs alpha-d-galactoside de galectines |
| CA3025866A1 (fr) | 2016-07-12 | 2018-01-18 | Galecto Biotech Ab | Inhibiteurs alpha-d-galactoside de galectines |
| WO2018209255A1 (fr) | 2017-05-12 | 2018-11-15 | Galectin Sciences, Llc | Composés pour la prévention et le traitement de maladies et leur utilisation |
| WO2019067702A1 (fr) | 2017-09-27 | 2019-04-04 | Bristol-Myers Squibb Company | Inhibiteurs à petites molécules de galectine-3 |
| US11072626B2 (en) | 2017-10-11 | 2021-07-27 | Bristol-Myers Squibb Company | Small molecule inhibitors of Galectin-3 |
| KR20200104889A (ko) | 2017-12-29 | 2020-09-04 | 글리코미메틱스, 인크. | E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제 |
| BR112020013647A2 (pt) | 2018-01-10 | 2020-12-01 | Galecto Biotech Ab | novo inibidor galactosídeo de galectinas |
| CN112292386B (zh) * | 2018-06-15 | 2024-06-11 | 百时美施贵宝公司 | 作为半乳凝素-3抑制剂的基于四氢吡喃的硫代二糖模拟物 |
| CA3102155A1 (fr) | 2018-06-29 | 2020-01-02 | Glykos Biomedical Oy | Conjugues |
| CA3114055A1 (fr) | 2018-10-15 | 2020-04-23 | Galecto Biotech Ab | Promedicament de galactoside inhibiteur de galectines |
| WO2020078808A1 (fr) | 2018-10-15 | 2020-04-23 | Galecto Biotech Ab | Inhibiteur galactoside de galectines |
| US11447517B2 (en) | 2018-11-21 | 2022-09-20 | Galecto Biotech Ab | Galactoside inhibitor of galectins |
| EP3891144A1 (fr) | 2018-12-06 | 2021-10-13 | Bristol-Myers Squibb Company | Inhibiteurs à petites molécules de la galectine-3 |
| AU2019416330A1 (en) | 2018-12-27 | 2021-07-01 | Glycomimetics, Inc. | Galectin-3 inhibiting c-glycosides |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| US12275719B2 (en) | 2019-03-26 | 2025-04-15 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| CN113631562B (zh) * | 2019-03-29 | 2024-04-19 | 长濑产业株式会社 | 新化合物及其应用 |
| WO2020210308A1 (fr) | 2019-04-10 | 2020-10-15 | Bristol-Myers Squibb Company | Inhibiteurs à petites molécules de galectine -3 |
| CN114340736A (zh) | 2019-04-24 | 2022-04-12 | 糖模拟物有限公司 | E-选择蛋白、半乳凝素-3和/或cxcr4趋化因子受体的半乳糖-连接的多聚体糖模拟物抑制剂 |
| EP3983423A4 (fr) | 2019-06-14 | 2023-07-19 | Université Laval | Synthèse de 3-azido-3-désoxy-d-galactopyranose |
| WO2021001528A1 (fr) | 2019-07-03 | 2021-01-07 | Galecto Biotech Ab | Nouveau galactoside comme inhibiteur de galectines |
| EP3993872A1 (fr) | 2019-07-03 | 2022-05-11 | Galecto Biotech AB | Nouvel inhibiteur de galectines du type galactoside |
| CN114450282A (zh) | 2019-07-05 | 2022-05-06 | 格莱克特生物技术公司 | 半乳糖凝集素的新型半乳糖苷抑制剂 |
| JP7612663B2 (ja) | 2019-08-09 | 2025-01-14 | イドルシア・ファーマシューティカルズ・リミテッド | （２－アセタミジル）チオ－ベータ－ｄ－ガラクトピラノシド誘導体 |
| ES2972509T3 (es) | 2019-08-09 | 2024-06-13 | Idorsia Pharmaceuticals Ltd | Derivados de (hetero)aril-metil-tio-beta-D-galactopiranósidos |
| RS66695B1 (sr) | 2019-08-15 | 2025-05-30 | Idorsia Pharmaceuticals Ltd | 2-hidroksicikloalkan-1-karbamoil derivati |
| HRP20240297T1 (hr) | 2019-08-29 | 2024-05-10 | Idorsia Pharmaceuticals Ltd | Derivati alfa-d-galaktopiranozida |
| WO2021086816A1 (fr) | 2019-10-29 | 2021-05-06 | Glycomimetics, Inc. | C-glycosides inhibiteurs de galectine-3 |
| US20230038373A1 (en) | 2019-12-18 | 2023-02-09 | Glykos Biomedical Oy | Stabile conjugate |
| EP4081519A1 (fr) | 2019-12-24 | 2022-11-02 | GlycoMimetics, Inc. | Cétones, éthers et alcools c-glycosides inhibiteurs de galectine-3 |
| JP7705884B2 (ja) | 2020-05-05 | 2025-07-10 | ブリストル－マイヤーズ スクイブ カンパニー | ガレクチン－３の低分子阻害剤 |
| CN115551850A (zh) | 2020-05-11 | 2022-12-30 | 百时美施贵宝公司 | 半乳凝素-3的小分子抑制剂 |
| US12291522B2 (en) | 2020-05-28 | 2025-05-06 | Bristol-Myers Squibb Company | Galectin-3 inhibitors |
| MX2023004033A (es) | 2020-10-06 | 2023-04-27 | Idorsia Pharmaceuticals Ltd | Espiro derivados de alfa-d-galactopiranosidos. |
| IL302421A (en) | 2020-11-02 | 2023-06-01 | Idorsia Pharmaceuticals Ltd | Galectin-3 inhibiting 2-hydroxycycloalkane-1 -carbamoyl derivatives |
| WO2022171594A1 (fr) | 2021-02-09 | 2022-08-18 | Idorsia Pharmaceuticals Ltd | Dérivés d'hydroxyhétérocycloalcane-carbamoyle |
| CN116888113A (zh) | 2021-03-03 | 2023-10-13 | 爱杜西亚药品有限公司 | 经三唑基-甲基取代的α-D-吡喃半乳糖苷衍生物 |
| JP2024517936A (ja) | 2021-05-14 | 2024-04-23 | グリコミメティクス， インコーポレイテッド | ガレクチン－３阻害性ｃ－グリコシド |
| WO2022250976A1 (fr) | 2021-05-28 | 2022-12-01 | Glycomimetics, Inc. | Oximes de c-glycoside inhibant la galectine 3 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05247078A (ja) * | 1992-03-03 | 1993-09-24 | Japan Tobacco Inc | 糖化合物、シアル酸含有糖鎖類生合成阻害剤、その製造方法、並びに新規な中間体 |
| EP1104307B1 (fr) * | 1998-08-06 | 2006-06-07 | Teijin Limited | Composition pharmaceutique a action inhibitrice de la surproduction de matrice extracellulaire et de son accumulation |
| AU2001243622A1 (en) * | 2000-03-13 | 2001-09-24 | La Jolla Institute For Allergy And Immunology | Monocyte chemoattractant activity of galectin-3 |
| US20060148712A1 (en) * | 2000-03-13 | 2006-07-06 | Fu-Tong Liu | Monocyte chemoattractant activity of galectin-3 |
| SE0100172D0 (sv) * | 2001-01-22 | 2001-01-22 | Ulf Nilsson | New inhibitors against galectins |
-
2004
- 2004-05-21 SE SE0401300A patent/SE0401300D0/xx unknown
-
2005
- 2005-05-20 WO PCT/SE2005/000757 patent/WO2005113568A1/fr not_active Ceased
- 2005-05-20 CA CA2567694A patent/CA2567694C/fr not_active Expired - Fee Related
- 2005-05-20 AT AT05745033T patent/ATE525383T1/de not_active IP Right Cessation
- 2005-05-20 EP EP05745033A patent/EP1751171B1/fr not_active Expired - Lifetime
-
2006
- 2006-11-17 US US11/561,124 patent/US7638623B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005113568A1 (fr) | 2005-12-01 |
| US7638623B2 (en) | 2009-12-29 |
| CA2567694C (fr) | 2013-07-09 |
| ATE525383T1 (de) | 2011-10-15 |
| CA2567694A1 (fr) | 2005-12-01 |
| US20070185039A1 (en) | 2007-08-09 |
| EP1751171B1 (fr) | 2011-09-21 |
| EP1751171A1 (fr) | 2007-02-14 |
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