SE0400850D0 - Novel Compounds - Google Patents
Novel CompoundsInfo
- Publication number
- SE0400850D0 SE0400850D0 SE0400850A SE0400850A SE0400850D0 SE 0400850 D0 SE0400850 D0 SE 0400850D0 SE 0400850 A SE0400850 A SE 0400850A SE 0400850 A SE0400850 A SE 0400850A SE 0400850 D0 SE0400850 D0 SE 0400850D0
- Authority
- SE
- Sweden
- Prior art keywords
- novel compounds
- compounds
- metalloproteinase
- mmp
- inhibitors
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0400850A SE0400850D0 (sv) | 2004-03-30 | 2004-03-30 | Novel Compounds |
| US10/593,543 US20070219217A1 (en) | 2004-03-30 | 2005-03-29 | Triazolone Derivatives as Mmp Inhibitors for the Treatment of Asthma and Copd |
| EP05722275A EP1732903B1 (fr) | 2004-03-30 | 2005-03-29 | Derives de la triazolone utilises comme inhibiteurs de la mmp dans le traitement de l'asthme et de la bpco |
| ES05722275T ES2320679T3 (es) | 2004-03-30 | 2005-03-29 | Derivados de triazolona como inhibidores de mmp para el tratamiento del asma y epoc. |
| CNA2005800176722A CN1960979A (zh) | 2004-03-30 | 2005-03-29 | 作为mmp抑制剂用于治疗哮喘和慢性阻塞性肺病的三唑酮衍生物 |
| JP2007506108A JP2007530672A (ja) | 2004-03-30 | 2005-03-29 | 喘息およびｃｏｐｄの処置のためのｍｍｐ阻害剤としてのトリアゾロン誘導体 |
| AT05722275T ATE423105T1 (de) | 2004-03-30 | 2005-03-29 | Triazolonderivate als mmp-inhibitoren zur behandlung von asthma und copd |
| HK07105624.6A HK1099751B (en) | 2004-03-30 | 2005-03-29 | Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd |
| PCT/SE2005/000448 WO2005095362A1 (fr) | 2004-03-30 | 2005-03-29 | Derives de la triazolone utilises comme inhibiteurs de la mmp dans le traitement de l'asthme et de la bpco |
| DE602005012811T DE602005012811D1 (de) | 2004-03-30 | 2005-03-29 | Triazolonderivate als mmp-inhibitoren zur behandlung von asthma und copd |
| US12/538,522 US20090299066A1 (en) | 2004-03-30 | 2009-08-10 | Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0400850A SE0400850D0 (sv) | 2004-03-30 | 2004-03-30 | Novel Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE0400850D0 true SE0400850D0 (sv) | 2004-03-31 |
Family
ID=32105805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE0400850A SE0400850D0 (sv) | 2004-03-30 | 2004-03-30 | Novel Compounds |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20070219217A1 (fr) |
| EP (1) | EP1732903B1 (fr) |
| JP (1) | JP2007530672A (fr) |
| CN (1) | CN1960979A (fr) |
| AT (1) | ATE423105T1 (fr) |
| DE (1) | DE602005012811D1 (fr) |
| ES (1) | ES2320679T3 (fr) |
| SE (1) | SE0400850D0 (fr) |
| WO (1) | WO2005095362A1 (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2331853T3 (es) | 2005-06-28 | 2010-01-18 | Sanofi-Aventis | Derivados de isoquinolina como inhibidores de rho-cinasa. |
| ES2372067T3 (es) | 2005-07-26 | 2012-01-13 | Sanofi | Derivados de ciclohexilamina isoquinolona como inhibidores de la rho-quinasa. |
| NZ565668A (en) | 2005-07-26 | 2010-09-30 | Sanofi Aventis | Piperidinyl-substituted isoquinolone derivatives as RHO-kinase inhibitors |
| KR101517154B1 (ko) | 2006-12-27 | 2015-04-30 | 사노피 | Ｒｈｏ-키나제의 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 |
| ATE502027T1 (de) | 2006-12-27 | 2011-04-15 | Sanofi Aventis | Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren |
| HRP20100705T1 (hr) | 2006-12-27 | 2011-01-31 | Sanofi-Aventis | Cikloalkilaminski supstituirani izokinolinski i izokinolinonski derivati |
| RU2009128693A (ru) | 2006-12-27 | 2011-02-10 | Санофи-Авентис (Fr) | Замещенные производные изохинолина и изохинолинона |
| CN101595094B (zh) | 2006-12-27 | 2013-02-20 | 塞诺菲-安万特股份有限公司 | 环烷基胺取代的异喹诺酮衍生物 |
| CA2673920C (fr) | 2006-12-27 | 2015-03-24 | Sanofi-Aventis | Derives d'isoquinoline substitues par une cycloalkylamine |
| AU2009241365B2 (en) | 2008-04-28 | 2015-01-22 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
| AU2009262517B2 (en) | 2008-06-24 | 2014-01-09 | Sanofi | Substituted isoquinolines and isoquinolinones as Rho kinase inhibitors |
| AU2009262509B2 (en) | 2008-06-24 | 2014-01-30 | Sanofi | Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as Rho kinase inhibitors |
| ES2436531T3 (es) | 2008-06-24 | 2014-01-02 | Sanofi | Isoquinolinas e isoquinolinonas sustituidas en posición 6 |
| GB0813142D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
| GB0813144D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
| CN102858175A (zh) * | 2010-02-22 | 2013-01-02 | 葛兰素史密斯克莱有限责任公司 | 作为脂肪酸合成酶抑制剂的三唑酮 |
| EP2575815A4 (fr) | 2010-06-04 | 2013-12-25 | Albany Molecular Res Inc | Inhibiteurs du transporteur 1 de la glycine, procédés de fabrication associés, et utilisations associées |
| WO2013134562A1 (fr) | 2012-03-09 | 2013-09-12 | Inception 2, Inc. | Composés de triazolone et leurs utilisations |
| MX376108B (es) | 2012-12-20 | 2025-03-07 | Tempest Therapeutics Inc | Compuestos de triazolona y usos de los mismos. |
| KR20160048988A (ko) | 2013-09-06 | 2016-05-04 | 인셉션 2 인코퍼레이티드 | 트라이아졸론 화합물 및 이의 용도 |
| CN104876917B (zh) * | 2015-06-16 | 2017-09-19 | 上海皓元医药股份有限公司 | 用作脂肪酸合成酶抑制剂的三唑酮的合成方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19504627A1 (de) * | 1995-02-13 | 1996-08-14 | Bayer Ag | Verfahren und neue Zwischenprodukte zur Herstellung von Triazolinonen |
| EP1187614A4 (fr) * | 1999-06-04 | 2005-06-22 | Merck & Co Inc | Piperidines substituees en tant qu'agonistes du recepteur de melanocortine-4 |
| AU1196601A (en) * | 1999-10-12 | 2001-04-23 | Board Of Trustees Of The Leland Stanford Junior University | Methods of diagnosing and treating urinary incontinence |
| EP1110958A1 (fr) * | 1999-12-20 | 2001-06-27 | Ucb, S.A. | Derivés de pipérazines-alpha-aryléthyles comme antagonistes de neurokinines |
| WO2001070734A2 (fr) * | 2000-03-17 | 2001-09-27 | Bristol-Myers Squibb Pharma Company | DERIVES DE β-AMINOACIDES EN TANT QU'INHIBITEURS DE METALLOPROTEASES MATRICIELLES ET DE TNF-$g(a) |
| GB0203412D0 (en) * | 2002-02-13 | 2002-04-03 | Pharmagene Lab Ltd | 5-HT 2B receptor antagonists |
| DE60332816D1 (de) * | 2002-03-13 | 2010-07-15 | Schering Corp | Nk1-antagonisten |
| AR039625A1 (es) * | 2002-04-18 | 2005-03-02 | Merck & Co Inc | Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona |
| US20040010010A1 (en) * | 2002-04-30 | 2004-01-15 | Ebetino Frank Hallock | Melanocortin receptor ligands |
| AU2003241903A1 (en) * | 2002-05-31 | 2003-12-19 | Takeda Pharmaceutical Company Limited | Piperidine derivative, process for producing the same, and use |
| SE0202539D0 (sv) * | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| KR20060106106A (ko) * | 2005-04-06 | 2006-10-12 | 삼성전자주식회사 | 고속 레벨 쉬프터 |
-
2004
- 2004-03-30 SE SE0400850A patent/SE0400850D0/xx unknown
-
2005
- 2005-03-29 AT AT05722275T patent/ATE423105T1/de not_active IP Right Cessation
- 2005-03-29 WO PCT/SE2005/000448 patent/WO2005095362A1/fr not_active Ceased
- 2005-03-29 CN CNA2005800176722A patent/CN1960979A/zh active Pending
- 2005-03-29 EP EP05722275A patent/EP1732903B1/fr not_active Expired - Lifetime
- 2005-03-29 ES ES05722275T patent/ES2320679T3/es not_active Expired - Lifetime
- 2005-03-29 US US10/593,543 patent/US20070219217A1/en not_active Abandoned
- 2005-03-29 JP JP2007506108A patent/JP2007530672A/ja active Pending
- 2005-03-29 DE DE602005012811T patent/DE602005012811D1/de not_active Expired - Lifetime
-
2009
- 2009-08-10 US US12/538,522 patent/US20090299066A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE423105T1 (de) | 2009-03-15 |
| HK1099751A1 (en) | 2007-08-24 |
| EP1732903A1 (fr) | 2006-12-20 |
| US20070219217A1 (en) | 2007-09-20 |
| EP1732903B1 (fr) | 2009-02-18 |
| US20090299066A1 (en) | 2009-12-03 |
| WO2005095362A1 (fr) | 2005-10-13 |
| DE602005012811D1 (de) | 2009-04-02 |
| JP2007530672A (ja) | 2007-11-01 |
| CN1960979A (zh) | 2007-05-09 |
| ES2320679T3 (es) | 2009-05-27 |
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