RU99122597A - NEW THERAPEUTIC COMBINATIONS OF MIRTAZAPINE AND ANTIPSYCHOTIC MEDICINES FOR TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS - Google Patents
NEW THERAPEUTIC COMBINATIONS OF MIRTAZAPINE AND ANTIPSYCHOTIC MEDICINES FOR TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERSInfo
- Publication number
- RU99122597A RU99122597A RU99122597/14A RU99122597A RU99122597A RU 99122597 A RU99122597 A RU 99122597A RU 99122597/14 A RU99122597/14 A RU 99122597/14A RU 99122597 A RU99122597 A RU 99122597A RU 99122597 A RU99122597 A RU 99122597A
- Authority
- RU
- Russia
- Prior art keywords
- mirtazapine
- antipsychotic agent
- combination according
- treatment
- prevention
- Prior art date
Links
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 title claims 7
- 229960001785 mirtazapine Drugs 0.000 title claims 7
- 208000028017 Psychotic disease Diseases 0.000 title claims 5
- 239000003814 drug Substances 0.000 title claims 4
- 230000002265 prevention Effects 0.000 title claims 4
- 230000000561 anti-psychotic effect Effects 0.000 title claims 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 perazina Chemical compound 0.000 claims 8
- 239000000164 antipsychotic agent Substances 0.000 claims 7
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- WSPOMRSOLSGNFJ-AUWJEWJLSA-N (Z)-chlorprothixene Chemical compound C1=C(Cl)C=C2C(=C/CCN(C)C)\C3=CC=CC=C3SC2=C1 WSPOMRSOLSGNFJ-AUWJEWJLSA-N 0.000 claims 2
- DKMFBWQBDIGMHM-UHFFFAOYSA-N 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone Chemical compound C1CC(C)CCN1CCCC(=O)C1=CC=C(F)C=C1 DKMFBWQBDIGMHM-UHFFFAOYSA-N 0.000 claims 2
- MDLAAYDRRZXJIF-UHFFFAOYSA-N 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol Chemical compound C1CC(O)(C=2C=C(C(Cl)=CC=2)C(F)(F)F)CCN1CCCC(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 MDLAAYDRRZXJIF-UHFFFAOYSA-N 0.000 claims 2
- WAOQONBSWFLFPE-VIFPVBQESA-N 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide Chemical compound CCN1CCC[C@H]1CNC(=O)C1=C(O)C(Cl)=CC(Cl)=C1OC WAOQONBSWFLFPE-VIFPVBQESA-N 0.000 claims 2
- FEBOTPHFXYHVPL-UHFFFAOYSA-N 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC(N2C(NC3=CC=CC=C32)=O)CC1 FEBOTPHFXYHVPL-UHFFFAOYSA-N 0.000 claims 2
- GUJRSXAPGDDABA-NSHDSACASA-N 3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide Chemical compound CCN1CCC[C@H]1CNC(=O)C1=C(OC)C=CC(Br)=C1OC GUJRSXAPGDDABA-NSHDSACASA-N 0.000 claims 2
- QOYHHIBFXOOADH-UHFFFAOYSA-N 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 QOYHHIBFXOOADH-UHFFFAOYSA-N 0.000 claims 2
- RKLNONIVDFXQRX-UHFFFAOYSA-N Bromperidol Chemical compound C1CC(O)(C=2C=CC(Br)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 RKLNONIVDFXQRX-UHFFFAOYSA-N 0.000 claims 2
- KLPWJLBORRMFGK-UHFFFAOYSA-N Molindone Chemical compound O=C1C=2C(CC)=C(C)NC=2CCC1CN1CCOCC1 KLPWJLBORRMFGK-UHFFFAOYSA-N 0.000 claims 2
- JTVPZMFULRWINT-UHFFFAOYSA-N N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide Chemical compound CCN(CC)CCNC(=O)C1=CC(S(C)(=O)=O)=CC=C1OC JTVPZMFULRWINT-UHFFFAOYSA-N 0.000 claims 2
- XCWPUUGSGHNIDZ-UHFFFAOYSA-N Oxypertine Chemical compound C1=2C=C(OC)C(OC)=CC=2NC(C)=C1CCN(CC1)CCN1C1=CC=CC=C1 XCWPUUGSGHNIDZ-UHFFFAOYSA-N 0.000 claims 2
- ZGUGWUXLJSTTMA-UHFFFAOYSA-N Promazinum Chemical compound C1=CC=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZGUGWUXLJSTTMA-UHFFFAOYSA-N 0.000 claims 2
- UNRHXEPDKXPRTM-UHFFFAOYSA-N Sultopride Chemical compound CCN1CCCC1CNC(=O)C1=CC(S(=O)(=O)CC)=CC=C1OC UNRHXEPDKXPRTM-UHFFFAOYSA-N 0.000 claims 2
- 229960005054 acepromazine Drugs 0.000 claims 2
- NOSIYYJFMPDDSA-UHFFFAOYSA-N acepromazine Chemical compound C1=C(C(C)=O)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 NOSIYYJFMPDDSA-UHFFFAOYSA-N 0.000 claims 2
- 229960003036 amisulpride Drugs 0.000 claims 2
- NTJOBXMMWNYJFB-UHFFFAOYSA-N amisulpride Chemical compound CCN1CCCC1CNC(=O)C1=CC(S(=O)(=O)CC)=C(N)C=C1OC NTJOBXMMWNYJFB-UHFFFAOYSA-N 0.000 claims 2
- 229960002507 benperidol Drugs 0.000 claims 2
- 229960004037 bromperidol Drugs 0.000 claims 2
- 229960001076 chlorpromazine Drugs 0.000 claims 2
- 229960001552 chlorprothixene Drugs 0.000 claims 2
- NJMYODHXAKYRHW-DVZOWYKESA-N cis-flupenthixol Chemical compound C1CN(CCO)CCN1CC\C=C\1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C2/1 NJMYODHXAKYRHW-DVZOWYKESA-N 0.000 claims 2
- 229960004170 clozapine Drugs 0.000 claims 2
- QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 claims 2
- 229960000394 droperidol Drugs 0.000 claims 2
- RMEDXOLNCUSCGS-UHFFFAOYSA-N droperidol Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CC=C(N2C(NC3=CC=CC=C32)=O)CC1 RMEDXOLNCUSCGS-UHFFFAOYSA-N 0.000 claims 2
- 229960005220 fluanisone Drugs 0.000 claims 2
- IRYFCWPNDIUQOW-UHFFFAOYSA-N fluanisone Chemical compound COC1=CC=CC=C1N1CCN(CCCC(=O)C=2C=CC(F)=CC=2)CC1 IRYFCWPNDIUQOW-UHFFFAOYSA-N 0.000 claims 2
- 229960002419 flupentixol Drugs 0.000 claims 2
- 229960003532 fluspirilene Drugs 0.000 claims 2
- 229960003878 haloperidol Drugs 0.000 claims 2
- 229960000300 mesoridazine Drugs 0.000 claims 2
- SLVMESMUVMCQIY-UHFFFAOYSA-N mesoridazine Chemical compound CN1CCCCC1CCN1C2=CC(S(C)=O)=CC=C2SC2=CC=CC=C21 SLVMESMUVMCQIY-UHFFFAOYSA-N 0.000 claims 2
- 229960004938 molindone Drugs 0.000 claims 2
- 229960005017 olanzapine Drugs 0.000 claims 2
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 claims 2
- 229960002841 oxypertine Drugs 0.000 claims 2
- 229960004505 penfluridol Drugs 0.000 claims 2
- 229960003634 pimozide Drugs 0.000 claims 2
- YVUQSNJEYSNKRX-UHFFFAOYSA-N pimozide Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCCN1CCC(N2C(NC3=CC=CC=C32)=O)CC1 YVUQSNJEYSNKRX-UHFFFAOYSA-N 0.000 claims 2
- 229960002776 pipamperone Drugs 0.000 claims 2
- AXKPFOAXAHJUAG-UHFFFAOYSA-N pipamperone Chemical compound C1CC(C(=O)N)(N2CCCCC2)CCN1CCCC(=O)C1=CC=C(F)C=C1 AXKPFOAXAHJUAG-UHFFFAOYSA-N 0.000 claims 2
- 229950001518 raclopride Drugs 0.000 claims 2
- 229960003448 remoxipride Drugs 0.000 claims 2
- 229960001534 risperidone Drugs 0.000 claims 2
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims 2
- 229950001675 spiperone Drugs 0.000 claims 2
- DKGZKTPJOSAWFA-UHFFFAOYSA-N spiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 DKGZKTPJOSAWFA-UHFFFAOYSA-N 0.000 claims 2
- 229960004724 sultopride Drugs 0.000 claims 2
- 229960004728 thiopropazate Drugs 0.000 claims 2
- AIUHRQHVWSUTGJ-UHFFFAOYSA-N thiopropazate Chemical compound C1CN(CCOC(=O)C)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 AIUHRQHVWSUTGJ-UHFFFAOYSA-N 0.000 claims 2
- 229960003397 thioproperazine Drugs 0.000 claims 2
- VZYCZNZBPPHOFY-UHFFFAOYSA-N thioproperazine Chemical compound C12=CC(S(=O)(=O)N(C)C)=CC=C2SC2=CC=CC=C2N1CCCN1CCN(C)CC1 VZYCZNZBPPHOFY-UHFFFAOYSA-N 0.000 claims 2
- 229960005344 tiapride Drugs 0.000 claims 2
- 229950000809 timiperone Drugs 0.000 claims 2
- YDLQKLWVKKFPII-UHFFFAOYSA-N timiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC(N2C(NC3=CC=CC=C32)=S)CC1 YDLQKLWVKKFPII-UHFFFAOYSA-N 0.000 claims 2
- 229960002324 trifluoperazine Drugs 0.000 claims 2
- ZEWQUBUPAILYHI-UHFFFAOYSA-N trifluoperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 ZEWQUBUPAILYHI-UHFFFAOYSA-N 0.000 claims 2
- 229960002341 trifluperidol Drugs 0.000 claims 2
- GPMXUUPHFNMNDH-UHFFFAOYSA-N trifluperidol Chemical compound C1CC(O)(C=2C=C(C=CC=2)C(F)(F)F)CCN1CCCC(=O)C1=CC=C(F)C=C1 GPMXUUPHFNMNDH-UHFFFAOYSA-N 0.000 claims 2
- WFPIAZLQTJBIFN-DVZOWYKESA-N zuclopenthixol Chemical compound C1CN(CCO)CCN1CC\C=C\1C2=CC(Cl)=CC=C2SC2=CC=CC=C2/1 WFPIAZLQTJBIFN-DVZOWYKESA-N 0.000 claims 2
- BGRJTUBHPOOWDU-NSHDSACASA-N (S)-(-)-sulpiride Chemical compound CCN1CCC[C@H]1CNC(=O)C1=CC(S(N)(=O)=O)=CC=C1OC BGRJTUBHPOOWDU-NSHDSACASA-N 0.000 claims 1
- BTFMCMVEUCGQDX-UHFFFAOYSA-N 1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone Chemical compound C12=CC(C(=O)C)=CC=C2SC2=CC=CC=C2N1CCCN1CCC(CCO)CC1 BTFMCMVEUCGQDX-UHFFFAOYSA-N 0.000 claims 1
- PLDUPXSUYLZYBN-UHFFFAOYSA-N Fluphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 PLDUPXSUYLZYBN-UHFFFAOYSA-N 0.000 claims 1
- RGCVKNLCSQQDEP-UHFFFAOYSA-N Perphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 RGCVKNLCSQQDEP-UHFFFAOYSA-N 0.000 claims 1
- KLBQZWRITKRQQV-UHFFFAOYSA-N Thioridazine Chemical compound C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C KLBQZWRITKRQQV-UHFFFAOYSA-N 0.000 claims 1
- 229960000276 acetophenazine Drugs 0.000 claims 1
- WNTYBHLDCKXEOT-UHFFFAOYSA-N acetophenazine Chemical compound C12=CC(C(=O)C)=CC=C2SC2=CC=CC=C2N1CCCN1CCN(CCO)CC1 WNTYBHLDCKXEOT-UHFFFAOYSA-N 0.000 claims 1
- 239000003693 atypical antipsychotic agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960003030 chlorproethazine Drugs 0.000 claims 1
- DBOUGBAQLIXZLV-UHFFFAOYSA-N chlorproethazine Chemical compound C1=C(Cl)C=C2N(CCCN(CC)CC)C3=CC=CC=C3SC2=C1 DBOUGBAQLIXZLV-UHFFFAOYSA-N 0.000 claims 1
- 229960004278 cyamemazine Drugs 0.000 claims 1
- SLFGIOIONGJGRT-UHFFFAOYSA-N cyamemazine Chemical compound C1=C(C#N)C=C2N(CC(CN(C)C)C)C3=CC=CC=C3SC2=C1 SLFGIOIONGJGRT-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960002690 fluphenazine Drugs 0.000 claims 1
- 229960000423 loxapine Drugs 0.000 claims 1
- XJGVXQDUIWGIRW-UHFFFAOYSA-N loxapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2OC2=CC=C(Cl)C=C12 XJGVXQDUIWGIRW-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229940042053 methotrimeprazine Drugs 0.000 claims 1
- VRQVVMDWGGWHTJ-CQSZACIVSA-N methotrimeprazine Chemical compound C1=CC=C2N(C[C@H](C)CN(C)C)C3=CC(OC)=CC=C3SC2=C1 VRQVVMDWGGWHTJ-CQSZACIVSA-N 0.000 claims 1
- 229960000769 periciazine Drugs 0.000 claims 1
- LUALIOATIOESLM-UHFFFAOYSA-N periciazine Chemical compound C1CC(O)CCN1CCCN1C2=CC(C#N)=CC=C2SC2=CC=CC=C21 LUALIOATIOESLM-UHFFFAOYSA-N 0.000 claims 1
- 229960000762 perphenazine Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960004265 piperacetazine Drugs 0.000 claims 1
- 229960003252 pipotiazine Drugs 0.000 claims 1
- JOMHSQGEWSNUKU-UHFFFAOYSA-N pipotiazine Chemical compound C12=CC(S(=O)(=O)N(C)C)=CC=C2SC2=CC=CC=C2N1CCCN1CCC(CCO)CC1 JOMHSQGEWSNUKU-UHFFFAOYSA-N 0.000 claims 1
- 229960003111 prochlorperazine Drugs 0.000 claims 1
- WIKYUJGCLQQFNW-UHFFFAOYSA-N prochlorperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 WIKYUJGCLQQFNW-UHFFFAOYSA-N 0.000 claims 1
- 229960003598 promazine Drugs 0.000 claims 1
- 229960004431 quetiapine Drugs 0.000 claims 1
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 claims 1
- 229960000652 sertindole Drugs 0.000 claims 1
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 claims 1
- FLGCRGJDQJIJAW-UHFFFAOYSA-N sulforidazine Chemical compound CN1CCCCC1CCN1C2=CC(S(C)(=O)=O)=CC=C2SC2=CC=CC=C21 FLGCRGJDQJIJAW-UHFFFAOYSA-N 0.000 claims 1
- 229960004940 sulpiride Drugs 0.000 claims 1
- 229960002784 thioridazine Drugs 0.000 claims 1
- 229960003904 triflupromazine Drugs 0.000 claims 1
- XSCGXQMFQXDFCW-UHFFFAOYSA-N triflupromazine Chemical compound C1=C(C(F)(F)F)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 XSCGXQMFQXDFCW-UHFFFAOYSA-N 0.000 claims 1
- 229960000607 ziprasidone Drugs 0.000 claims 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 claims 1
Claims (11)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97200881.7 | 1997-03-27 | ||
| EP97200881 | 1997-03-27 | ||
| EP97202785.8 | 1997-09-11 | ||
| EP97202785 | 1997-09-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99122597A true RU99122597A (en) | 2001-09-10 |
| RU2222330C2 RU2222330C2 (en) | 2004-01-27 |
Family
ID=26146283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99122597/14A RU2222330C2 (en) | 1997-03-27 | 1998-03-25 | New therapeutic combinations of mirtazapine and antipsychotic agents for treatment or prophylaxis of psychotic disorders |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0969845B1 (en) |
| JP (2) | JP4377456B2 (en) |
| KR (1) | KR100577865B1 (en) |
| CN (1) | CN1226036C (en) |
| AR (1) | AR012193A1 (en) |
| AT (1) | ATE318604T1 (en) |
| AU (1) | AU726194B2 (en) |
| BR (1) | BR9808077A (en) |
| CA (1) | CA2284551C (en) |
| CZ (1) | CZ298105B6 (en) |
| DE (1) | DE69833645T2 (en) |
| DK (1) | DK0969845T3 (en) |
| ES (1) | ES2259207T3 (en) |
| HU (1) | HUP0002742A3 (en) |
| ID (1) | ID22283A (en) |
| IL (1) | IL123716A (en) |
| NO (1) | NO994673L (en) |
| NZ (1) | NZ337618A (en) |
| PL (1) | PL191449B1 (en) |
| PT (1) | PT969845E (en) |
| RU (1) | RU2222330C2 (en) |
| TR (1) | TR199902334T2 (en) |
| TW (1) | TW587938B (en) |
| WO (1) | WO1998043646A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2232574C2 (en) * | 2002-04-05 | 2004-07-20 | Новосибирский институт органической химии им. Н.Н.Ворожцова СО РАН | "fluoglysine" medicinal preparation for treating different forms of depression |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121076A (en) * | 1996-06-19 | 2000-10-31 | Akzo Nobel Nv | Pharmaceutical combinations comprising mirtazapine and one or more selective serotonin reuptake inhibitors |
| US6280763B1 (en) | 1999-05-10 | 2001-08-28 | Pierce Management, Llc | Apparatus and method for transdermal delivery of bupropion |
| FR2797399B1 (en) * | 1999-08-13 | 2002-10-18 | Aventis Pharma Sa | USE OF CYAMEMAZINE IN THE TREATMENT OF BENZODIAZEPINES WITHDRAWAL |
| US6350773B1 (en) | 1999-12-10 | 2002-02-26 | American Home Products Corporation | Therapeutic combinations of (S)-2-(benzylamino-methyl)-2,3,8,9,-tetrahydro 7H-1,4-dioxino{2,3-e}indol-8-one and neuroleptics for the treatment or prevention of psychotic disorders |
| FR2802101B1 (en) * | 1999-12-10 | 2003-02-28 | Aventis Pharma Sa | COMBINATION OF CYMEMAZINE AND AN ATYPICAL NEUROLEPTIC |
| MXPA02007095A (en) | 2000-01-19 | 2003-04-14 | Akzo Nobel Nv | Drug combination for the treatment of depression and related disorders comprising mirtazapine. |
| US6495154B1 (en) * | 2000-11-21 | 2002-12-17 | Vivus Inc. | On demand administration of clomipramine and salts thereof to treat premature ejaculation |
| EP1795199A3 (en) * | 2001-02-06 | 2007-07-25 | AstraZeneca AB | Quetiapine for the treatment of substance dependence or substance abuse |
| ES2284830T3 (en) * | 2001-02-06 | 2007-11-16 | Astrazeneca Ab | USE OF QUETIAPINE FOR THE TREATMENT OF COCAINA. |
| US20050095292A1 (en) | 2003-10-29 | 2005-05-05 | Wyeth | Sustained release pharmaceutical compositions |
| US7884096B2 (en) | 2003-12-02 | 2011-02-08 | Pharmaneuroboost N.V. | Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| EP1547650A1 (en) * | 2003-12-02 | 2005-06-29 | B & B Beheer NV | Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| EP1541197B8 (en) * | 2003-12-02 | 2009-06-10 | PharmaNeuroBoost N.V. | Use of pipamperone and an SNDRI, SNRI or SSRI for the treatment of mood or anxiety disorders |
| US7855195B2 (en) | 2003-12-02 | 2010-12-21 | Pharmaneuroboost N.V. | Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| CA2547639A1 (en) * | 2003-12-02 | 2005-06-16 | B&B Beheer Nv | Use of d4 and 5-ht2a antagonists, inverse agonists or partial agonists |
| MXPA06014002A (en) | 2004-06-03 | 2007-02-08 | Hoffmann La Roche | Treatment with cisplatin and an egfr-inhibitor. |
| US8354121B2 (en) * | 2006-06-09 | 2013-01-15 | Dainippon Sumitomo Pharma Co., Ltd. | Tape preparation |
| JOP20120083B1 (en) * | 2011-04-05 | 2021-08-17 | Otsuka Pharma Co Ltd | Combinations comprising brexpiprazole or a salt thereof and a second drug for use in the treatment of a cns disorder |
| DE102012011839B4 (en) * | 2012-06-14 | 2018-03-22 | Norbert Müller | Use of interferon-gamma in a method for the treatment of psychiatric disorders |
| RU2509560C1 (en) * | 2013-03-22 | 2014-03-20 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | New therapeutic combinations of mirtazapine applicable in pain conditions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2410821A1 (en) * | 1974-03-07 | 1975-09-18 | Hoechst Ag | PHARMACEUTICAL COMBINATION PREPARATIONS WITH PSYCHOTROPIC EFFECT AND METHOD FOR THEIR PRODUCTION |
| CA1327008C (en) * | 1988-01-15 | 1994-02-15 | Walter Merz | Anti-psychotic imidazobenzodiazepine |
| EP0431663B1 (en) * | 1989-12-06 | 1994-01-12 | Akzo Nobel N.V. | Stabilized solutions of psychotropic agents |
| NZ241481A (en) * | 1991-02-04 | 1994-06-27 | Hoechst Roussel Pharma | Derivatives of 8-aza-bicyclo[3.2.1]octane and pharmaceutical compositions thereof |
| ZA935078B (en) * | 1992-07-15 | 1994-02-07 | Nicolaas Johannes Jaco Loetter | Pharmaceutical composition |
| RU2062114C1 (en) * | 1992-09-30 | 1996-06-20 | Московский научно-исследовательский институт психиатрии МЗ РФ | Method for treating the cases of endogenous psychoses |
| KR100333115B1 (en) * | 1992-11-17 | 2002-12-02 | 미츠비시 파마 코포레이션 | Sustained-release microsphere containing antipsychotic and process for producing the same |
| JPH07242669A (en) * | 1994-03-07 | 1995-09-19 | Akikazu Ogawa | Compound bonding tetracyclic system to butyrophenone derivative |
-
1998
- 1998-03-17 IL IL12371698A patent/IL123716A/en not_active IP Right Cessation
- 1998-03-17 TW TW087103929A patent/TW587938B/en not_active IP Right Cessation
- 1998-03-25 EP EP98919209A patent/EP0969845B1/en not_active Expired - Lifetime
- 1998-03-25 DK DK98919209T patent/DK0969845T3/en active
- 1998-03-25 PL PL335890A patent/PL191449B1/en unknown
- 1998-03-25 TR TR1999/02334T patent/TR199902334T2/en unknown
- 1998-03-25 ID IDW991022A patent/ID22283A/en unknown
- 1998-03-25 CA CA002284551A patent/CA2284551C/en not_active Expired - Fee Related
- 1998-03-25 CZ CZ0343199A patent/CZ298105B6/en not_active IP Right Cessation
- 1998-03-25 NZ NZ337618A patent/NZ337618A/en unknown
- 1998-03-25 ES ES98919209T patent/ES2259207T3/en not_active Expired - Lifetime
- 1998-03-25 CN CNB98803770XA patent/CN1226036C/en not_active Expired - Fee Related
- 1998-03-25 JP JP54116898A patent/JP4377456B2/en not_active Expired - Fee Related
- 1998-03-25 PT PT98919209T patent/PT969845E/en unknown
- 1998-03-25 HU HU0002742A patent/HUP0002742A3/en unknown
- 1998-03-25 AT AT98919209T patent/ATE318604T1/en not_active IP Right Cessation
- 1998-03-25 AU AU72139/98A patent/AU726194B2/en not_active Ceased
- 1998-03-25 WO PCT/EP1998/001920 patent/WO1998043646A1/en not_active Ceased
- 1998-03-25 DE DE69833645T patent/DE69833645T2/en not_active Expired - Lifetime
- 1998-03-25 KR KR1019997008745A patent/KR100577865B1/en not_active Expired - Fee Related
- 1998-03-25 BR BR9808077-6A patent/BR9808077A/en not_active Application Discontinuation
- 1998-03-25 RU RU99122597/14A patent/RU2222330C2/en not_active IP Right Cessation
- 1998-03-27 AR ARP980101406A patent/AR012193A1/en not_active Application Discontinuation
-
1999
- 1999-09-24 NO NO19994673A patent/NO994673L/en not_active Application Discontinuation
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2009
- 2009-07-17 JP JP2009168383A patent/JP5023315B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2232574C2 (en) * | 2002-04-05 | 2004-07-20 | Новосибирский институт органической химии им. Н.Н.Ворожцова СО РАН | "fluoglysine" medicinal preparation for treating different forms of depression |
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