RU98114080A - Биологически активные этанамины бензотиазолона - Google Patents
Биологически активные этанамины бензотиазолонаInfo
- Publication number
- RU98114080A RU98114080A RU98114080/04A RU98114080A RU98114080A RU 98114080 A RU98114080 A RU 98114080A RU 98114080/04 A RU98114080/04 A RU 98114080/04A RU 98114080 A RU98114080 A RU 98114080A RU 98114080 A RU98114080 A RU 98114080A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- formula
- benzotiazolone
- ethanamines
- biologically active
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000018569 Respiratory Tract disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Claims (7)
1. Соединение формулы I
где X обозначает нафтил; p равно 3; q равно 2; и r равно 2;
и его фармацевтически приемлемые соли.
где X обозначает нафтил; p равно 3; q равно 2; и r равно 2;
и его фармацевтически приемлемые соли.
2. Способ получения соединения формулы I, включающий селективное восстановление соединения формулы II
в которой p, q, r и X определены в п.1.
в которой p, q, r и X определены в п.1.
3. Соединение формулы II
в которой p, q, r и X определены в п.1.
в которой p, q, r и X определены в п.1.
4. Применение соединения по п.1 в терапии.
5. Применение соединения по п.1 для получения лекарственного средства, применяемого для лечения обструктивного заболевания дыхательных путей, в частности, для лечения астмы или хронического бронхита.
6. Способ лечения заболевания дыхательных путей, отличающийся тем, что он включает введение пациенту, страдающему от такого состояния или склонному к нему, терапевтически эффективного количества соединения по п.1.
7. Способ лечения или профилактики глаукомы, отличающийся тем, что он включает введение пациенту, страдающему от такого состояния или склонному к нему, терапевтически эффективного количества соединения по п.1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9526511.2 | 1995-12-23 | ||
| GBGB9526511.2A GB9526511D0 (en) | 1995-12-23 | 1995-12-23 | Pharmaceutically active compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98114080A true RU98114080A (ru) | 2000-06-27 |
| RU2177476C2 RU2177476C2 (ru) | 2001-12-27 |
Family
ID=10786064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98114080/04A RU2177476C2 (ru) | 1995-12-23 | 1996-12-13 | Биологически активные этанамины бензотиазолона |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5929100A (ru) |
| EP (1) | EP0918760B1 (ru) |
| JP (1) | JP2000502681A (ru) |
| KR (1) | KR19990076688A (ru) |
| CN (1) | CN1072214C (ru) |
| AR (1) | AR005008A1 (ru) |
| AT (1) | ATE209638T1 (ru) |
| AU (1) | AU704506B2 (ru) |
| BR (1) | BR9612234A (ru) |
| CA (1) | CA2238877A1 (ru) |
| CZ (1) | CZ288704B6 (ru) |
| DE (1) | DE69617472D1 (ru) |
| EE (1) | EE03440B1 (ru) |
| GB (1) | GB9526511D0 (ru) |
| HU (1) | HUP9900100A3 (ru) |
| IL (2) | IL142502A0 (ru) |
| IS (1) | IS4759A (ru) |
| MX (1) | MX9804828A (ru) |
| NO (1) | NO982927L (ru) |
| NZ (1) | NZ325500A (ru) |
| PL (1) | PL327475A1 (ru) |
| RU (1) | RU2177476C2 (ru) |
| SK (1) | SK82098A3 (ru) |
| TR (1) | TR199801196T2 (ru) |
| TW (1) | TW401411B (ru) |
| WO (1) | WO1997023470A1 (ru) |
| ZA (1) | ZA9610354B (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999009018A1 (en) * | 1997-08-14 | 1999-02-25 | Kirin Beer Kabushiki Kaisha | BENZOTHIAZOLONE DERIVATIVES HAVING SELECTIVE β2 RECEPTOR AGONIST ACTIVITY |
| AR040962A1 (es) * | 2002-08-09 | 2005-04-27 | Novartis Ag | Compuestos derivados de tiazol 1,3-2-ona, composicion farmaceutica y proceso de preparacion del compuesto |
| GB0218629D0 (en) * | 2002-08-09 | 2002-09-18 | Novartis Ag | Organic compounds |
| ES2329586T3 (es) | 2003-11-21 | 2009-11-27 | Theravance, Inc. | Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino. |
| TW200738658A (en) | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200738659A (en) * | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200745067A (en) | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| GB0702458D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| EP2303873A4 (en) | 2008-06-18 | 2012-01-04 | Astrazeneca Ab | BENZOXAZINE DERIVATIVES AS A BETA2 ADRENORE RECEPTOR AGONIST FOR THE TREATMENT OF RESPIRATORY DISEASES |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4314944A (en) * | 1980-08-22 | 1982-02-09 | Smithkline Corporation | 4-Aminoalkyl-7-hydroxy-2(3H)-indolones |
| US4452808A (en) * | 1982-12-07 | 1984-06-05 | Smithkline Beckman Corporation | 4-Aminoalkyl-2(3H)-indolones |
| GB8426200D0 (en) * | 1984-10-17 | 1984-11-21 | Glaxo Holdings Ltd | Chemical compounds |
| US4554287A (en) * | 1984-09-12 | 1985-11-19 | Smithkline Beckman Corporation | Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones |
| US4554284A (en) * | 1984-09-12 | 1985-11-19 | Smithkline Beckman Corporation | 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones |
| ES8606847A1 (es) * | 1984-11-08 | 1986-05-16 | Syntex Inc | Procedimiento para la preparacion de derivados de dialquila-mino-etilanilina antihipertensos |
| DE3728695A1 (de) * | 1987-08-25 | 1989-03-09 | Schering Ag | Neue benzimidazol-derivate |
| IE914003A1 (en) * | 1990-11-20 | 1992-05-20 | Astra Pharma Prod | Biologically Active Amines |
| GB9211172D0 (en) * | 1992-05-27 | 1992-07-08 | Fisons Plc | Compounds |
| GB9210632D0 (en) * | 1992-05-19 | 1992-07-01 | Fisons Plc | Compounds |
| US5648370A (en) * | 1990-11-20 | 1997-07-15 | Astra Pharmaceuticals Limited | 7-(2-aminoethyl) benzothiazolones |
-
1995
- 1995-12-23 GB GBGB9526511.2A patent/GB9526511D0/en active Pending
-
1996
- 1996-12-09 AR ARP960105568A patent/AR005008A1/es unknown
- 1996-12-09 ZA ZA9610354A patent/ZA9610354B/xx unknown
- 1996-12-11 TW TW085115316A patent/TW401411B/zh not_active IP Right Cessation
- 1996-12-13 KR KR1019980704800A patent/KR19990076688A/ko not_active Withdrawn
- 1996-12-13 BR BR9612234A patent/BR9612234A/pt not_active Application Discontinuation
- 1996-12-13 WO PCT/SE1996/001650 patent/WO1997023470A1/en not_active Ceased
- 1996-12-13 AU AU14025/97A patent/AU704506B2/en not_active Ceased
- 1996-12-13 IL IL14250296A patent/IL142502A0/xx unknown
- 1996-12-13 DE DE69617472T patent/DE69617472D1/de not_active Expired - Lifetime
- 1996-12-13 TR TR1998/01196T patent/TR199801196T2/xx unknown
- 1996-12-13 PL PL96327475A patent/PL327475A1/xx unknown
- 1996-12-13 IL IL12499896A patent/IL124998A0/xx unknown
- 1996-12-13 CZ CZ19981684A patent/CZ288704B6/cs not_active IP Right Cessation
- 1996-12-13 SK SK820-98A patent/SK82098A3/sk unknown
- 1996-12-13 CN CN96199237A patent/CN1072214C/zh not_active Expired - Fee Related
- 1996-12-13 NZ NZ325500A patent/NZ325500A/xx unknown
- 1996-12-13 EE EE9800193A patent/EE03440B1/xx not_active IP Right Cessation
- 1996-12-13 JP JP09523560A patent/JP2000502681A/ja active Pending
- 1996-12-13 US US08/793,706 patent/US5929100A/en not_active Expired - Fee Related
- 1996-12-13 CA CA002238877A patent/CA2238877A1/en not_active Abandoned
- 1996-12-13 EP EP96944153A patent/EP0918760B1/en not_active Expired - Lifetime
- 1996-12-13 RU RU98114080/04A patent/RU2177476C2/ru active
- 1996-12-13 HU HU9900100A patent/HUP9900100A3/hu unknown
- 1996-12-13 AT AT96944153T patent/ATE209638T1/de not_active IP Right Cessation
-
1998
- 1998-05-27 IS IS4759A patent/IS4759A/is unknown
- 1998-06-16 MX MX9804828A patent/MX9804828A/es unknown
- 1998-06-23 NO NO982927A patent/NO982927L/no not_active Application Discontinuation
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