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WO2001012214A3 - MYCOPHENOLATE MOFETIL IN ASSOCIATION WITH PEG-IFN-$g(a) - Google Patents

MYCOPHENOLATE MOFETIL IN ASSOCIATION WITH PEG-IFN-$g(a) Download PDF

Info

Publication number
WO2001012214A3
WO2001012214A3 PCT/EP2000/007666 EP0007666W WO0112214A3 WO 2001012214 A3 WO2001012214 A3 WO 2001012214A3 EP 0007666 W EP0007666 W EP 0007666W WO 0112214 A3 WO0112214 A3 WO 0112214A3
Authority
WO
WIPO (PCT)
Prior art keywords
ifn
peg
association
mycophenolate mofetil
therapeutically effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/007666
Other languages
French (fr)
Other versions
WO2001012214A2 (en
Inventor
Mary Catherine Graves
Stephen Christopher Pappas
Friederike Zahm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HK03101248.5A priority Critical patent/HK1048951A1/en
Priority to PL00357367A priority patent/PL357367A1/en
Priority to AU74082/00A priority patent/AU7408200A/en
Priority to KR1020027001782A priority patent/KR20020020809A/en
Priority to MXPA02001296A priority patent/MXPA02001296A/en
Priority to CA002380653A priority patent/CA2380653A1/en
Priority to EP00962297A priority patent/EP1220683A2/en
Priority to IL14761200A priority patent/IL147612A0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to BR0013252-7A priority patent/BR0013252A/en
Priority to JP2001516559A priority patent/JP2003507339A/en
Publication of WO2001012214A2 publication Critical patent/WO2001012214A2/en
Publication of WO2001012214A3 publication Critical patent/WO2001012214A3/en
Priority to NO20020704A priority patent/NO20020704L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The use of therapeutically effective amount of IFN- α or PEG-IFN-α in association with a therapeutically effective amount of a pharmaceutically acceptable salt or prodrug of mycophenolic acid for the manufacture of medicaments for treating liver diseases patients. The components are administered over a period of time at least sufficient to reduce the amount of HCV-RNA present in the peripheral blood of said patient to less than 100 copies/ml at 24 weeks after the end of treatment.
PCT/EP2000/007666 1999-08-13 2000-08-08 MYCOPHENOLATE MOFETIL IN ASSOCIATION WITH PEG-IFN-$g(a) Ceased WO2001012214A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP00962297A EP1220683A2 (en) 1999-08-13 2000-08-08 Mycophenolate mofetil in association with peg-ifn-alpha
AU74082/00A AU7408200A (en) 1999-08-13 2000-08-08 Mycophenolate mofetil in association with peg-ifn-alpha
KR1020027001782A KR20020020809A (en) 1999-08-13 2000-08-08 Mycophenolate mofetil in association with peg-ifn-alpha
MXPA02001296A MXPA02001296A (en) 1999-08-13 2000-08-08 MYCOPHENOLATE MOFETIL IN ASSOCIATION WITH PEG-IFN-alpha.
CA002380653A CA2380653A1 (en) 1999-08-13 2000-08-08 Mycophenolate mofetil in association with peg-ifn-.alpha.
IL14761200A IL147612A0 (en) 1999-08-13 2000-08-08 MYCOPHENOLATE MOFETIL IN ASSOCIATION WITH PREG-IFN-α
BR0013252-7A BR0013252A (en) 1999-08-13 2000-08-08 Mycophenolate mofetil in combination with peg-ifn-alfa
HK03101248.5A HK1048951A1 (en) 1999-08-13 2000-08-08 MYCOPHENOLATE MOFETIL IN ASSOCIATION WITH PEG-IFN-α
PL00357367A PL357367A1 (en) 1999-08-13 2000-08-08 Mycophenolate mofetil in association with peg-ifn-alpha
JP2001516559A JP2003507339A (en) 1999-08-13 2000-08-08 Mycophenolate mofetil in combination with PEG-IFN-α
NO20020704A NO20020704L (en) 1999-08-13 2002-02-12 Mycophenolate mofetil associated with PEG-IFN- <alfa>

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP99115950 1999-08-13
EP99115950.0 1999-08-13
US18790700P 2000-03-08 2000-03-08
US60/187,907 2000-03-08

Publications (2)

Publication Number Publication Date
WO2001012214A2 WO2001012214A2 (en) 2001-02-22
WO2001012214A3 true WO2001012214A3 (en) 2001-10-04

Family

ID=29762814

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/007666 Ceased WO2001012214A2 (en) 1999-08-13 2000-08-08 MYCOPHENOLATE MOFETIL IN ASSOCIATION WITH PEG-IFN-$g(a)

Country Status (14)

Country Link
EP (1) EP1220683A2 (en)
JP (1) JP2003507339A (en)
CN (1) CN1368887A (en)
AU (1) AU7408200A (en)
BR (1) BR0013252A (en)
CA (1) CA2380653A1 (en)
HU (1) HUP0202525A3 (en)
MX (1) MXPA02001296A (en)
PE (1) PE20010490A1 (en)
PL (1) PL357367A1 (en)
RU (1) RU2002105485A (en)
TR (1) TR200200401T2 (en)
WO (1) WO2001012214A2 (en)
ZA (1) ZA200200280B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
ATE428714T1 (en) 2004-02-24 2009-05-15 Japan Tobacco Inc CONDENSED HETEROTETRACYCLIC COMPOUNDS AND THEIR USE AS HCV POLYMERASE INHIBITORS
DE602005022895D1 (en) * 2004-08-12 2010-09-23 Schering Corp STABLE PEGYLATED INTERFERON FORMULATION
US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor
US8017612B2 (en) 2006-04-18 2011-09-13 Japan Tobacco Inc. Piperazine compound and use thereof as a HCV polymerase inhibitor
US8623348B2 (en) * 2009-03-27 2014-01-07 Jw Pharmaceutical Corporation Interferon-α (IFN-α) fused proteins comprising IFN-α and a cytoplasmic transduction peptide (CTP)
CH707030B1 (en) 2011-10-21 2015-03-13 Abbvie Inc Combination treatment of DAAs for use in the treatment of HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
ES2529143B1 (en) 2011-10-21 2015-10-26 Abbvie Inc. COMBINATION OF AT LEAST TWO DIRECT ACTION ANTIVIRAL AGENTS, RIBAVIRINE BUT NOT INTERFERONED FOR THE USE OF HCV TREATMENT
ES2966888T3 (en) * 2014-11-06 2024-04-24 Pharmaessentia Corp Dosing Regimen for Pegylated Interferon
EP3448392A4 (en) 2016-04-28 2020-01-15 Emory University ALCYNE-CONTAINING NUCLEOTIDES AND NUCLEOSIDES THERAPEUTIC COMPOSITIONS AND USES THEREOF

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998048840A1 (en) * 1997-04-29 1998-11-05 Schering Corporation Polyethylene glycol-interferon alpha conjugates for therapy of infection
WO2000050064A2 (en) * 1999-02-26 2000-08-31 Institute Of Molecular And Cell Biology Synergistic combination for treatment of viral-mediated diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998048840A1 (en) * 1997-04-29 1998-11-05 Schering Corporation Polyethylene glycol-interferon alpha conjugates for therapy of infection
WO2000050064A2 (en) * 1999-02-26 2000-08-31 Institute Of Molecular And Cell Biology Synergistic combination for treatment of viral-mediated diseases

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KWO P Y ET AL: "Combination therapy with ribavirin plus alpha-interferon is beneficial for the treatment of chronic hepatitis C in patients who have failed treatment with alpha-interferon.", GASTROENTEROLOGY, vol. 116, no. 4 PART 2, April 1999 (1999-04-01), Digestive Disease Week and the 100th Annual Meeting of the American Gastroenterological Association;Orlando, Florida, USA; May 16-19, 1999, pages A1235, XP000990387, ISSN: 0016-5085 *
PLATZ K P ET AL: "INDICATIONS FOR MYCOPHENOLATE MOFETIL THERAPY IN HEPATITIS C-PATIENTS UNDERGOING LIVER TRANSPLANTATION", TRANSPLANTATION PROCEEDINGS,US,ORLANDO, FL, vol. 30, no. 4, June 1998 (1998-06-01), pages 1468 - 1469, XP000889647, ISSN: 0041-1345 *
POL S ET AL: "Ribavirin + Inerferon-alfa 2B combination shows increased efficiency compared to high doses alfa INF, alone in naive patients infected by genotype 1B", HEPATOLOGY,US,WILLIAMS AND WILKINS, BALTIMORE, MD, vol. 28, no. 4, PART 02, October 1998 (1998-10-01), pages 507A, XP002110250, ISSN: 0270-9139 *

Also Published As

Publication number Publication date
AU7408200A (en) 2001-03-13
JP2003507339A (en) 2003-02-25
RU2002105485A (en) 2004-01-27
ZA200200280B (en) 2003-04-11
EP1220683A2 (en) 2002-07-10
HUP0202525A2 (en) 2002-11-28
HUP0202525A3 (en) 2003-11-28
BR0013252A (en) 2002-04-16
PL357367A1 (en) 2004-07-26
MXPA02001296A (en) 2002-07-22
WO2001012214A2 (en) 2001-02-22
CN1368887A (en) 2002-09-11
CA2380653A1 (en) 2001-02-22
PE20010490A1 (en) 2001-04-27
TR200200401T2 (en) 2002-06-21

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