RU96101801A - 2-Phenylindole derivatives, a mixture of their isomers or separate isomers and their salts, a pharmaceutical composition with anti-arteriosclerotic and anti-restenotic activity - Google Patents
2-Phenylindole derivatives, a mixture of their isomers or separate isomers and their salts, a pharmaceutical composition with anti-arteriosclerotic and anti-restenotic activityInfo
- Publication number
- RU96101801A RU96101801A RU96101801/04A RU96101801A RU96101801A RU 96101801 A RU96101801 A RU 96101801A RU 96101801/04 A RU96101801/04 A RU 96101801/04A RU 96101801 A RU96101801 A RU 96101801A RU 96101801 A RU96101801 A RU 96101801A
- Authority
- RU
- Russia
- Prior art keywords
- isomers
- carbon atoms
- mixture
- branched alkyl
- salts
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 5
- 150000003839 salts Chemical class 0.000 title claims 5
- KLLLJCACIRKBDT-UHFFFAOYSA-N 2-phenyl-1H-indole Chemical class N1C2=CC=CC=C2C=C1C1=CC=CC=C1 KLLLJCACIRKBDT-UHFFFAOYSA-N 0.000 title claims 4
- 230000002769 anti-restenotic effect Effects 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
Claims (4)
где R1 - фенил, циклоалкил с 3 - 6 атомами углерода, неразветвленный или разветвленный алкил с 1 - 5 атомами углерода;
R2 - неразветвленный или разветвленный алкил с 1 - 8 атомами углерода или водород;
R3 - остаток формулы -СО-NН2 или -СН2-ОН;
смесь их изомеров или отдельные изомеры и их соли.1. Derivatives of 2-phenylindole of the general formula I
where R 1 is phenyl, cycloalkyl with 3 to 6 carbon atoms, unbranched or branched alkyl with 1 to 5 carbon atoms;
R 2 is unbranched or branched alkyl with 1 to 8 carbon atoms or hydrogen;
R 3 is a residue of the formula —CO — NH 2 or —CH 2 —OH;
a mixture of their isomers or individual isomers and their salts.
где R1 - фенил, циклопропил, циклопентил, циклогексил, неразветвленный или разветственный алкил с 1 - 4 атомами углерода;
R2 - неразветственный или разветвленный алкил с 1 - 6 атомами углерода или водород;
R3 - остаток формулы -СО-NН2 или -СН2-ОН, смесь их изомеров или отдельные изомеры и их соли.2. Derivatives of 2-phenylindole of the general formula I according to claim 1,
where R 1 is phenyl, cyclopropyl, cyclopentyl, cyclohexyl, unbranched or branched alkyl with 1 to 4 carbon atoms;
R 2 is a straight or branched alkyl with 1 to 6 carbon atoms or hydrogen;
R 3 is a residue of the formula —CO — NH 2 or —CH 2 —OH, a mixture of their isomers or individual isomers and their salts.
где R1 - фенил, циклопропил, этил, изо-пропил или н-бутил;
R2 - неразветвленный или разветвленный алкил с 1 - 5 атомами углерода или водород;
R3 - остаток формулы -СО-NН2 или -CH2-OH,
смесь их изомеров или отдельные изомеры и их соли.3. Derivatives of 2-phenylindole of the general formula I according to claim 1,
where R 1 is phenyl, cyclopropyl, ethyl, iso-propyl or n-butyl;
R 2 is unbranched or branched alkyl with 1 to 5 carbon atoms or hydrogen;
R 3 is a residue of the formula —CO — NH 2 or —CH 2 —OH,
a mixture of their isomers or individual isomers and their salts.
где R1 - фенил, циклоалкил с 3 - 6 атомами углерода, неразветвленный или разветвленный алкил с 1 - 5 атомами углерода;
R2 - неразветвленный или разветвленный алкил с 1 - 8 атомами углерода или водород;
R3 - остаток формулы -СО-NН2 или -СН2-ОН,
смесь его изомеров или отдельный изомер или его соль в эффективном количестве.4. A pharmaceutical composition with anti-arteriosclerotic and anti-restenotic activity, comprising at least one inert non-toxic, pharmaceutically acceptable target additive and at least one active principle, characterized in that it contains a compound of the above general formula I as an active principle
where R 1 is phenyl, cycloalkyl with 3 to 6 carbon atoms, unbranched or branched alkyl with 1 to 5 carbon atoms;
R 2 is unbranched or branched alkyl with 1 to 8 carbon atoms or hydrogen;
R 3 is a residue of the formula —CO — NH 2 or —CH 2 —OH,
a mixture of its isomers or a single isomer or its salt in an effective amount.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19503159 | 1995-02-01 | ||
| DE19503159.8 | 1995-04-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU96101801A true RU96101801A (en) | 1998-03-27 |
| RU2162842C2 RU2162842C2 (en) | 2001-02-10 |
Family
ID=7752848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU96101801/04A RU2162842C2 (en) | 1995-02-01 | 1996-01-31 | Derivatives of 2-phenylindole, mixture of their isomers or separate isomers or their physiologically acceptable salts, pharmaceutical composition showing antiproliferative activity |
Country Status (10)
| Country | Link |
|---|---|
| KR (1) | KR960031439A (en) |
| DE (2) | DE19513716A1 (en) |
| MY (1) | MY132270A (en) |
| RU (1) | RU2162842C2 (en) |
| SG (1) | SG38925A1 (en) |
| SV (1) | SV1996000009A (en) |
| TN (1) | TNSN96021A1 (en) |
| TW (1) | TW349092B (en) |
| YU (1) | YU5796A (en) |
| ZA (1) | ZA96726B (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2517659A1 (en) * | 1975-04-22 | 1976-11-11 | Merck Patent Gmbh | INDOLDER DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION |
| WO1984002131A1 (en) * | 1982-11-22 | 1984-06-07 | Sandoz Ag | Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
| DE3739882A1 (en) * | 1987-11-25 | 1989-06-08 | Bayer Ag | SUBSTITUTED HYDROXYLAMINE |
| US5122534A (en) * | 1991-02-08 | 1992-06-16 | Pfizer Inc. | Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides |
-
1995
- 1995-04-11 DE DE19513716A patent/DE19513716A1/en not_active Withdrawn
-
1996
- 1996-01-19 DE DE59605373T patent/DE59605373D1/en not_active Expired - Fee Related
- 1996-01-22 TW TW085100681A patent/TW349092B/en active
- 1996-01-29 MY MYPI96000315A patent/MY132270A/en unknown
- 1996-01-30 YU YU5796A patent/YU5796A/en unknown
- 1996-01-31 RU RU96101801/04A patent/RU2162842C2/en active
- 1996-01-31 KR KR1019960002343A patent/KR960031439A/en not_active Ceased
- 1996-01-31 ZA ZA96726A patent/ZA96726B/en unknown
- 1996-02-01 TN TNTNSN96021A patent/TNSN96021A1/en unknown
- 1996-02-01 SV SV1996000009A patent/SV1996000009A/en unknown
- 1996-02-01 SG SG1996000770A patent/SG38925A1/en unknown
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