RU2000125889A - SUBSTITUTED BISINDOLYMALEIMIDES INTENDED TO INHIBIT CELL PROLIFERATION - Google Patents
SUBSTITUTED BISINDOLYMALEIMIDES INTENDED TO INHIBIT CELL PROLIFERATIONInfo
- Publication number
- RU2000125889A RU2000125889A RU2000125889/04A RU2000125889A RU2000125889A RU 2000125889 A RU2000125889 A RU 2000125889A RU 2000125889/04 A RU2000125889/04 A RU 2000125889/04A RU 2000125889 A RU2000125889 A RU 2000125889A RU 2000125889 A RU2000125889 A RU 2000125889A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutically acceptable
- compound
- denotes
- formula
- intended
- Prior art date
Links
Claims (8)
где R1 обозначает водород и R2 обозначает метил, или R1 обозначает метил и R2 обозначает водород, или R1 обозначает гидроксиметил и R2 обозначает метил,
а также его фармацевтически приемлемые пролекарства или фармацевтически приемлемые соли.1. The compound of the formula
where R 1 denotes hydrogen and R 2 denotes methyl, or R 1 denotes methyl and R 2 denotes hydrogen, or R 1 denotes hydroxymethyl and R 2 denotes methyl,
as well as its pharmaceutically acceptable prodrugs or pharmaceutically acceptable salts.
и его фармацевтически приемлемые пролекарства или фармацевтически приемлемые соли этого соединения.2. The compound according to claim 1 of formula
and its pharmaceutically acceptable prodrugs or pharmaceutically acceptable salts of this compound.
и его фармацевтически приемлемые пролекарства или фармацевтически приемлемые соли этого соединения.3. The compound of the formula
and its pharmaceutically acceptable prodrugs or pharmaceutically acceptable salts of this compound.
и его фармацевтически приемлемые пролекарства или фармацевтически приемлемые соли этого соединения.4. The compound of the formula
and its pharmaceutically acceptable prodrugs or pharmaceutically acceptable salts of this compound.
где R1 обозначает водород и R2 обозначает метил, или R1 обозначает метил и R2 обозначает водород, или R1 обозначает гидроксиметил и R2 обозначает метил,
или его фармацевтически приемлемую соль или пролекарство этого соединения и фармацевтически приемлемый носитель.5. A pharmaceutical composition comprising a compound of formula
where R 1 denotes hydrogen and R 2 denotes methyl, or R 1 denotes methyl and R 2 denotes hydrogen, or R 1 denotes hydroxymethyl and R 2 denotes methyl,
or its pharmaceutically acceptable salt or prodrug of this compound and a pharmaceutically acceptable carrier.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7833198P | 1998-03-17 | 1998-03-17 | |
| US60/078,331 | 1998-03-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000125889A true RU2000125889A (en) | 2002-09-27 |
| RU2208612C2 RU2208612C2 (en) | 2003-07-20 |
Family
ID=22143350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000125889/04A RU2208612C2 (en) | 1998-03-17 | 1999-03-10 | Substituted bis-indolimaleimides designated for inhibition of cell proliferation |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US6048887A (en) |
| EP (1) | EP1064279B1 (en) |
| JP (2) | JP5026633B2 (en) |
| KR (1) | KR100659411B1 (en) |
| CN (1) | CN1127500C (en) |
| AR (1) | AR018162A1 (en) |
| AT (1) | ATE243693T1 (en) |
| AU (1) | AU755673B2 (en) |
| BR (1) | BR9908882A (en) |
| CA (1) | CA2322689C (en) |
| CO (1) | CO5070675A1 (en) |
| CZ (1) | CZ299068B6 (en) |
| DE (1) | DE69909068T2 (en) |
| DK (1) | DK1064279T3 (en) |
| ES (1) | ES2203111T3 (en) |
| HR (1) | HRP20000585B1 (en) |
| HU (1) | HU228831B1 (en) |
| ID (1) | ID26353A (en) |
| IL (1) | IL138247A (en) |
| MA (1) | MA26613A1 (en) |
| MY (1) | MY121046A (en) |
| NO (1) | NO320306B1 (en) |
| NZ (1) | NZ506476A (en) |
| PE (1) | PE20000340A1 (en) |
| PL (1) | PL195323B1 (en) |
| PT (1) | PT1064279E (en) |
| RS (1) | RS49965B (en) |
| RU (1) | RU2208612C2 (en) |
| SA (1) | SA99191295B1 (en) |
| TR (1) | TR200002580T2 (en) |
| TW (1) | TW539676B (en) |
| WO (1) | WO1999047518A1 (en) |
| ZA (1) | ZA992072B (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL138247A (en) * | 1998-03-17 | 2005-08-31 | Hoffmann La Roche | Substituted bisindolymaleimides for the inhibition of cell proliferation and pharmaceutical compositions comprising them |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| US6559164B1 (en) | 1999-10-12 | 2003-05-06 | Hoffmann-La Roche Inc. | Substituted pyrroles suitable for continuous infusion |
| NZ518038A (en) * | 1999-10-12 | 2004-02-27 | F | Substituted pyrroles as antiproliferative agents for the treatment of cancer |
| US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
| US7129250B2 (en) * | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| US6482847B2 (en) | 2000-10-03 | 2002-11-19 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
| US6469179B1 (en) | 2000-10-03 | 2002-10-22 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
| US6548531B2 (en) | 2001-02-09 | 2003-04-15 | Hoffmann-La Roche Inc. | Method for cancer therapy |
| WO2002102373A1 (en) * | 2001-06-15 | 2002-12-27 | F. Hoffmann-La Roche Ag | Method for administration of cancer therapeutic |
| US20030139373A1 (en) * | 2001-11-20 | 2003-07-24 | Breimer Lars Holger | Method for cancer therapy |
| WO2008117935A1 (en) * | 2007-03-28 | 2008-10-02 | Industry-Academic Cooperation Foundation, Yonsei University | Nk cell activating molecules, nk cells and pharmaceutical compositons comprising the same |
| CN102924437B (en) * | 2012-11-19 | 2014-07-02 | 东华大学 | 3-piperazine-4-indol maleimide compound and preparation and application thereof |
| WO2019000224A1 (en) * | 2017-06-27 | 2019-01-03 | 中国海洋大学 | Bisindolylmaleimide derivative and preparation method and use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ280738B6 (en) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituted pyrroles, their use for preparing medicaments and medicaments based thereon |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| ATE456367T1 (en) * | 1993-12-23 | 2010-02-15 | Lilly Co Eli | PROTEIN KINASE C INHIBITORS |
| PE91698A1 (en) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | SUBSTITUTED PYRROLES |
| PE91598A1 (en) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | SUBSTITUTED PYRROLES |
| PE91498A1 (en) * | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | SUBSTITUTED PYRROLES |
| IL138247A (en) * | 1998-03-17 | 2005-08-31 | Hoffmann La Roche | Substituted bisindolymaleimides for the inhibition of cell proliferation and pharmaceutical compositions comprising them |
-
1999
- 1999-03-10 IL IL13824799A patent/IL138247A/en not_active IP Right Cessation
- 1999-03-10 KR KR1020007010323A patent/KR100659411B1/en not_active Expired - Lifetime
- 1999-03-10 PL PL342964A patent/PL195323B1/en unknown
- 1999-03-10 BR BR9908882-7A patent/BR9908882A/en not_active Application Discontinuation
- 1999-03-10 DE DE69909068T patent/DE69909068T2/en not_active Expired - Lifetime
- 1999-03-10 PT PT99915558T patent/PT1064279E/en unknown
- 1999-03-10 AT AT99915558T patent/ATE243693T1/en active
- 1999-03-10 DK DK99915558T patent/DK1064279T3/en active
- 1999-03-10 AU AU34099/99A patent/AU755673B2/en not_active Expired
- 1999-03-10 TR TR2000/02580T patent/TR200002580T2/en unknown
- 1999-03-10 NZ NZ506476A patent/NZ506476A/en not_active IP Right Cessation
- 1999-03-10 WO PCT/EP1999/001534 patent/WO1999047518A1/en not_active Ceased
- 1999-03-10 ID IDW20001730A patent/ID26353A/en unknown
- 1999-03-10 JP JP2000536713A patent/JP5026633B2/en not_active Expired - Lifetime
- 1999-03-10 HU HU0101258A patent/HU228831B1/en unknown
- 1999-03-10 RU RU2000125889/04A patent/RU2208612C2/en active
- 1999-03-10 EP EP99915558A patent/EP1064279B1/en not_active Expired - Lifetime
- 1999-03-10 ES ES99915558T patent/ES2203111T3/en not_active Expired - Lifetime
- 1999-03-10 CA CA002322689A patent/CA2322689C/en not_active Expired - Lifetime
- 1999-03-10 HR HR20000585A patent/HRP20000585B1/en not_active IP Right Cessation
- 1999-03-10 RS YUP-552/00A patent/RS49965B/en unknown
- 1999-03-10 CZ CZ20003384A patent/CZ299068B6/en not_active IP Right Cessation
- 1999-03-10 CN CN99804045A patent/CN1127500C/en not_active Expired - Lifetime
- 1999-03-12 PE PE1999000199A patent/PE20000340A1/en not_active IP Right Cessation
- 1999-03-12 MA MA25492A patent/MA26613A1/en unknown
- 1999-03-15 ZA ZA9902072A patent/ZA992072B/en unknown
- 1999-03-15 TW TW088103914A patent/TW539676B/en not_active IP Right Cessation
- 1999-03-15 AR ARP990101117A patent/AR018162A1/en active IP Right Grant
- 1999-03-15 MY MYPI99000952A patent/MY121046A/en unknown
- 1999-03-15 CO CO99015752A patent/CO5070675A1/en unknown
- 1999-03-16 US US09/268,887 patent/US6048887A/en not_active Expired - Lifetime
- 1999-04-13 SA SA99191295A patent/SA99191295B1/en unknown
-
2000
- 2000-09-14 NO NO20004579A patent/NO320306B1/en not_active IP Right Cessation
-
2010
- 2010-06-02 JP JP2010126632A patent/JP2010222366A/en active Pending
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