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RU95113717A - Способ получения производных таксана и промежуточные продукты для их получения - Google Patents

Способ получения производных таксана и промежуточные продукты для их получения

Info

Publication number
RU95113717A
RU95113717A RU95113717/04A RU95113717A RU95113717A RU 95113717 A RU95113717 A RU 95113717A RU 95113717/04 A RU95113717/04 A RU 95113717/04A RU 95113717 A RU95113717 A RU 95113717A RU 95113717 A RU95113717 A RU 95113717A
Authority
RU
Russia
Prior art keywords
ris
alkyl
alkenyl
aryl
hydrogen
Prior art date
Application number
RU95113717/04A
Other languages
English (en)
Other versions
RU2116303C1 (ru
Inventor
Мас Жан-Манюель
Fr]
Массоно Вивьян
Original Assignee
Рон-Пуленк Роре С.А. (FR)
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк Роре С.А. (FR), Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А. (FR)
Publication of RU95113717A publication Critical patent/RU95113717A/ru
Application granted granted Critical
Publication of RU2116303C1 publication Critical patent/RU2116303C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Предложен способ получения производных таксана общей формулы I путем этерификации баккатина-III или защищенного 10-дезацетил-баккатина III с помощью кислоты общей формулы VII, удаления защищающих группировок из полученного сложного эфира с последующим ацилированием аминной функции боковой цепи. Указанные формулы приведены в описании изобретения.

Claims (1)

  1. Предложен способ получения производных таксана общей формулы I путем этерификации баккатина-III или защищенного 10-дезацетил-баккатина III с помощью кислоты общей формулы VII, удаления защищающих группировок из полученного сложного эфира с последующим ацилированием аминной функции боковой цепи. Указанные формулы приведены в описании изобретения.
RU95113717A 1992-10-05 1993-10-04 Способ получения таксана и промежуточные продукты для их получения RU2116303C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9211741A FR2696458B1 (fr) 1992-10-05 1992-10-05 Procédé de préparation de dérivés du taxane.
FR9211741 1992-10-05

Publications (2)

Publication Number Publication Date
RU95113717A true RU95113717A (ru) 1996-12-27
RU2116303C1 RU2116303C1 (ru) 1998-07-27

Family

ID=9434119

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95113717A RU2116303C1 (ru) 1992-10-05 1993-10-04 Способ получения таксана и промежуточные продукты для их получения

Country Status (24)

Country Link
US (3) US5616739A (ru)
EP (1) EP0663906B1 (ru)
JP (1) JP3014760B2 (ru)
KR (1) KR100311198B1 (ru)
AT (1) ATE146174T1 (ru)
AU (1) AU689080B2 (ru)
CA (1) CA2146250C (ru)
CZ (1) CZ283261B6 (ru)
DE (1) DE69306591T2 (ru)
DK (1) DK0663906T3 (ru)
ES (1) ES2095081T3 (ru)
FI (1) FI109793B (ru)
FR (1) FR2696458B1 (ru)
GR (1) GR3021997T3 (ru)
HU (1) HU226412B1 (ru)
MX (1) MX9305766A (ru)
NO (1) NO309089B1 (ru)
NZ (1) NZ256445A (ru)
PL (1) PL182284B1 (ru)
RU (1) RU2116303C1 (ru)
SK (1) SK280627B6 (ru)
TW (1) TW419472B (ru)
WO (1) WO1994007877A1 (ru)
ZA (1) ZA937318B (ru)

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Also Published As

Publication number Publication date
DK0663906T3 (da) 1996-12-30
ZA937318B (en) 1994-04-25
PL308241A1 (en) 1995-07-24
FI109793B (fi) 2002-10-15
JPH08501788A (ja) 1996-02-27
GR3021997T3 (en) 1997-03-31
NO951201L (no) 1995-03-29
AU689080B2 (en) 1998-03-26
SK43695A3 (en) 1995-08-09
HUT72679A (en) 1996-05-28
US5616739A (en) 1997-04-01
NO309089B1 (no) 2000-12-11
CA2146250C (fr) 2003-03-11
SK280627B6 (sk) 2000-05-16
FI951595A0 (fi) 1995-04-04
CZ84195A3 (en) 1995-09-13
RU2116303C1 (ru) 1998-07-27
FR2696458A1 (fr) 1994-04-08
PL182284B1 (pl) 2001-12-31
KR950703546A (ko) 1995-09-20
DE69306591T2 (de) 1997-04-17
NZ256445A (en) 1997-01-29
HU226412B1 (en) 2008-11-28
FR2696458B1 (fr) 1994-11-10
ATE146174T1 (de) 1996-12-15
DE69306591D1 (de) 1997-01-23
JP3014760B2 (ja) 2000-02-28
US5677462A (en) 1997-10-14
EP0663906B1 (fr) 1996-12-11
US5869680A (en) 1999-02-09
FI951595L (fi) 1995-04-04
EP0663906A1 (fr) 1995-07-26
KR100311198B1 (ko) 2002-04-24
NO951201D0 (no) 1995-03-29
AU5115093A (en) 1994-04-26
ES2095081T3 (es) 1997-02-01
MX9305766A (es) 1995-01-31
TW419472B (en) 2001-01-21
WO1994007877A1 (fr) 1994-04-14
HU9500971D0 (en) 1995-06-28
CA2146250A1 (fr) 1994-04-14
CZ283261B6 (cs) 1998-02-18

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