[go: up one dir, main page]

RU94017851A - Ингибиторы протеолитических ферментов на основе производных сахарина, фармацевтическая композиция для лечения дегеративных заболеваний - Google Patents

Ингибиторы протеолитических ферментов на основе производных сахарина, фармацевтическая композиция для лечения дегеративных заболеваний

Info

Publication number
RU94017851A
RU94017851A RU94017851/04A RU94017851A RU94017851A RU 94017851 A RU94017851 A RU 94017851A RU 94017851/04 A RU94017851/04 A RU 94017851/04A RU 94017851 A RU94017851 A RU 94017851A RU 94017851 A RU94017851 A RU 94017851A
Authority
RU
Russia
Prior art keywords
pharmaceutical composition
diseases
sucharine
degerative
inhibitors
Prior art date
Application number
RU94017851/04A
Other languages
English (en)
Other versions
RU2126798C1 (ru
Inventor
Джон Ласта Деннис
Говард Акерман Джеймс
Джозеф Мура Альберт
Чиманлал Десай Ранджит
Original Assignee
Стерлинг Уинтроп Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/066,805 external-priority patent/US5378720A/en
Application filed by Стерлинг Уинтроп Инк. filed Critical Стерлинг Уинтроп Инк.
Publication of RU94017851A publication Critical patent/RU94017851A/ru
Application granted granted Critical
Publication of RU2126798C1 publication Critical patent/RU2126798C1/ru

Links

Claims (1)

  1. Описывается соединение, имеющее структурную формулу
    Figure 00000001

    которое ингибирует ферментативную активность протеолитических ферментов, способы его получения, способ его использования для лечения дегенеративных заболеваний и содержащая его фармацевтическая композиция.
RU94017851/04A 1993-05-25 1994-05-24 Производное сахарина или его фармацевтически приемлемая соль, фармацевтическая композиция для ингибирования протеолитических ферментов при лечении дегенеративных заболеваний RU2126798C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US066805 1993-05-25
US08/066,805 US5378720A (en) 1991-12-19 1993-05-25 Saccharin derivative proteolytic enzyme inhibitors

Publications (2)

Publication Number Publication Date
RU94017851A true RU94017851A (ru) 1996-01-10
RU2126798C1 RU2126798C1 (ru) 1999-02-27

Family

ID=22071832

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94017851/04A RU2126798C1 (ru) 1993-05-25 1994-05-24 Производное сахарина или его фармацевтически приемлемая соль, фармацевтическая композиция для ингибирования протеолитических ферментов при лечении дегенеративных заболеваний

Country Status (21)

Country Link
US (2) US5378720A (ru)
EP (1) EP0626378B1 (ru)
JP (1) JPH0770094A (ru)
KR (1) KR100334345B1 (ru)
AT (1) ATE231496T1 (ru)
AU (1) AU685785B2 (ru)
CA (1) CA2122886A1 (ru)
CZ (1) CZ289573B6 (ru)
DE (1) DE69432035D1 (ru)
FI (1) FI942423A7 (ru)
HU (1) HUT70760A (ru)
IL (1) IL109780A (ru)
MY (1) MY129998A (ru)
NO (1) NO302474B1 (ru)
NZ (1) NZ260585A (ru)
PH (1) PH31435A (ru)
RU (1) RU2126798C1 (ru)
SG (1) SG55137A1 (ru)
SK (1) SK281020B6 (ru)
TW (1) TW420679B (ru)
UA (1) UA44682C2 (ru)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
AU1090795A (en) * 1993-11-12 1995-05-29 Cell Therapeutics, Inc. Method for preventing tissue injury from hypoxia
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5512576A (en) * 1994-12-02 1996-04-30 Sterling Winthrop Inc. 2-substituted 1,2,5,-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5494925A (en) * 1994-12-02 1996-02-27 Sterling Winthrop Inc. 2-heterocyclyloxymethyl and 2-heterocyclylthiomethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5556909A (en) * 1994-12-02 1996-09-17 Sanofi Winthrop Inc. Substituted 2-arylcarbonyloxymethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives and compositions and method of use thereof
US5541168A (en) * 1994-12-02 1996-07-30 Sterling Winthrop Inc. Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5750550A (en) * 1995-09-15 1998-05-12 Sanofi 2-(pyrazol-5-yl-oxymethyl)-1,2-benzisothiazol-3 (2H)-One 1, 1-dioxides and compositions and method of use thereof
HUP9904624A2 (hu) * 1999-12-17 2002-01-28 Sanofi-Synthelabo Szacharinszármazékok, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és intermedierjeik
AU2002351412B2 (en) * 2001-12-21 2010-05-20 Exelixis Patent Company Llc Modulators of LXR
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
AP1822A (en) * 2002-02-14 2008-01-30 Pharmacia Corp Substituted pyridinones as modulators of P38 MAP kinase.
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
NZ584152A (en) 2007-09-14 2011-11-25 Ortho Mcneil Janssen Pharm 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
US8722894B2 (en) * 2007-09-14 2014-05-13 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
SI2203439T1 (sl) 2007-09-14 2011-05-31 Ortho Mcneil Janssen Pharm 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
RU2492170C9 (ru) * 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
US8324405B2 (en) 2008-02-05 2012-12-04 Fibrogen, Inc. Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
US8697689B2 (en) 2008-10-16 2014-04-15 Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
CN105037323A (zh) 2008-11-14 2015-11-11 菲布罗根有限公司 作为hif羟化酶抑制剂的苯并噻喃衍生物
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
CN102439008B (zh) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
JP5852665B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
PT2649069E (pt) 2010-11-08 2015-11-20 Janssen Pharmaceuticals Inc Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2
WO2012062759A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
ES2860298T3 (es) 2014-01-21 2021-10-04 Janssen Pharmaceutica Nv Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso
AU2015208233B2 (en) 2014-01-21 2019-08-29 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
US12378229B2 (en) 2021-02-02 2025-08-05 Liminal Biosciences Limited GPR84 antagonists and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2855401A (en) * 1954-04-30 1958-10-07 May & Baker Ltd Certain n-(aminophenoxy pentyl) sulfonamide or saccharine compounds and higher homologues
US3220940A (en) * 1962-02-07 1965-11-30 Udylite Res Corp Electrodeposition of nickel
US4195023A (en) * 1975-08-20 1980-03-25 Merck & Co., Inc. 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin
US4276298A (en) * 1978-03-24 1981-06-30 Merck & Co., Inc. 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
DE3617976A1 (de) * 1986-05-28 1988-01-14 Alter Sa 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
US5128339A (en) * 1990-11-01 1992-07-07 Sterling Winthrop Inc. Proteolytic enzyme inhibition method
WO1990013549A1 (en) * 1989-05-04 1990-11-15 Sterling Winthrop Inc. Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof
US5236917A (en) * 1989-05-04 1993-08-17 Sterling Winthrop Inc. Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU642537B2 (en) * 1990-11-01 1993-10-21 Sanofi 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU656027B2 (en) * 1991-11-15 1995-01-19 Sanofi Saccharin derivative proteolytic enzime inhibitors
AU668694B2 (en) * 1991-12-19 1996-05-16 Sanofi-Synthelabo Saccharin derivative proteolytic enzyme inhibitors

Similar Documents

Publication Publication Date Title
RU94017851A (ru) Ингибиторы протеолитических ферментов на основе производных сахарина, фармацевтическая композиция для лечения дегеративных заболеваний
RU92016244A (ru) Производные сахарина-ингибиторы протеолитических ферментов
NO941937D0 (no) Sakarinderivater som inhiberer proteolytiske enzymer
TW225532B (ru)
RU93048636A (ru) 7-/замещенные/-8-/замещенные/-9-/замещенные амино/-6-диметил-6-дезокситетрациклины, промежуточные соединения, способы получения соединений, способ профилактики и лечения и фармацевтическая композиция
EA199800943A1 (ru) Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы
MX9704030A (es) 1,1-dioxidos de 2-heterocicliloxi y tiometil-1,2,5-tiadiazolidin-3-ona y composiciones y metodo de uso de los mismos.
SG48298A1 (en) Saccharin deriatives useful as proteolytic enzymeinhibitors and preparation of
RU93054537A (ru) Производные гуанидиналкил-1,1-бисфосфоновой кислоты, способ их получения и их применение
ATE225171T1 (de) Aminosäurederivate zur behandlung von schlaganfall
PL336897A1 (en) Novel salts of bpc peptides, pharmaceutic compositions conatining them and method of obtaining such salts
WO1999050671A3 (en) Toso as a target for drug screening
EP0331105A3 (en) 1,2-hydroxy phosphonates and derivatives thereof
ES2185154T3 (es) Metodo de uso de inhibidores de la ciclooxigenasa-2 en el tratamiento y prevencion de la demencia.
RU94013445A (ru) Новое соединение, лейстродуксин н, способ его получения и терапевтическая композиция
RU93055681A (ru) Ингибиторы вич-протеазы, способ их получения, их использование в фармкомпозициях
DE59003806D1 (de) Zubereitung eines salzes von oxypurinol in oraler form zur behandlung von hyperuricämie.
RU93055683A (ru) Ингибиторы вич-протеазы, способ их получения, их использование, композиция
RU93055680A (ru) Ингибиторы вич-протеазы, способ получения, их использование, композиция
DE69822628D1 (de) Zur vorbeugung oder behandlung von östrogenabhängigen krankheiten nützliche pyrrolo[2.1.5-cd]indolizin-derivate
IT8919204A0 (it) Composizione per la prevenzione e la cura di parodontopatte.
RU93056617A (ru) Ингибиторы ретровирусной протеазы, способ их получения, промежуточные продукты, способ лечения и фармацевтическая композиция
ZA200104651B (en) Use of substituted 4-biarylbutyric 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases.