RU93057572A - 6,9-BIS (AMINO-SUBSTITUTED) -BENZO (D) IZOHINOLIN-5,10-DIONA, METHODS OF THEIR RECEIVING, PHARMOCOMPOSITION, METHOD OF TUMOR TREATMENT - Google Patents
6,9-BIS (AMINO-SUBSTITUTED) -BENZO (D) IZOHINOLIN-5,10-DIONA, METHODS OF THEIR RECEIVING, PHARMOCOMPOSITION, METHOD OF TUMOR TREATMENTInfo
- Publication number
- RU93057572A RU93057572A RU93057572/04A RU93057572A RU93057572A RU 93057572 A RU93057572 A RU 93057572A RU 93057572/04 A RU93057572/04 A RU 93057572/04A RU 93057572 A RU93057572 A RU 93057572A RU 93057572 A RU93057572 A RU 93057572A
- Authority
- RU
- Russia
- Prior art keywords
- pharmocomposition
- izohinolin
- diona
- benzo
- bis
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Claims (1)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66595491A | 1991-03-08 | 1991-03-08 | |
| US665,954 | 1991-03-08 | ||
| US82730292A | 1992-01-29 | 1992-01-29 | |
| US827,302 | 1992-01-29 | ||
| US827.302 | 1992-01-29 | ||
| PCT/US1992/001606 WO1992015300A1 (en) | 1991-03-08 | 1992-03-09 | 6,9 BIS(SUBSTITUTED-AMINO)BENZO[g]ISOQUINOLINE-5,10-DIONES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93057572A true RU93057572A (en) | 1996-07-20 |
| RU2129546C1 RU2129546C1 (en) | 1999-04-27 |
Family
ID=27099336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93057572A RU2129546C1 (en) | 1991-03-08 | 1992-03-09 | 6,9-bis-(aminosubstituted)-benzo[g]isoquinoline-5,10-diones, method of their synthesis, pharmaceutical composition on their basis, a method of tumor suppression in mammals |
Country Status (22)
| Country | Link |
|---|---|
| EP (2) | EP0503537B1 (en) |
| JP (1) | JP3009465B2 (en) |
| KR (1) | KR100193593B1 (en) |
| AT (1) | ATE153018T1 (en) |
| AU (1) | AU663494B2 (en) |
| BR (1) | BR9205740A (en) |
| CA (1) | CA2104582A1 (en) |
| CZ (1) | CZ286180B6 (en) |
| DE (1) | DE69219646T2 (en) |
| DK (1) | DK0503537T3 (en) |
| ES (1) | ES2104753T3 (en) |
| FI (1) | FI103575B (en) |
| GR (1) | GR3024436T3 (en) |
| HU (1) | HU215967B (en) |
| IE (1) | IE920754A1 (en) |
| IL (1) | IL102087A (en) |
| MX (1) | MX9201020A (en) |
| NZ (1) | NZ241868A (en) |
| RU (1) | RU2129546C1 (en) |
| SG (1) | SG66252A1 (en) |
| TW (1) | TW201735B (en) |
| WO (1) | WO1992015300A1 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA936396B (en) * | 1992-09-08 | 1994-06-13 | Univ Vermont | 4-Substituted 6,9-bis(substituted-amino)benzo[g] isoquinoline-5,10,diones |
| US5519029A (en) * | 1992-09-08 | 1996-05-21 | Boehringer Mannheim Italia, S.P.A. | 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones |
| US5587382A (en) * | 1994-03-28 | 1996-12-24 | Boehringer Mannheim Italia, Spa | 6,9-bis[(2-aminoethyl) amino]benzo [g]isoquinoline-5,10- dione dimaleate; an aza-anthracenedione with reduced cardiotoxicity |
| US5506232A (en) * | 1994-03-28 | 1996-04-09 | Boehringer Mannheim Italia S.P.A. | 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt |
| US6747039B2 (en) | 2002-03-12 | 2004-06-08 | Albany Molecular Research, Inc. | Aza-benzothiopyranoindazoles with antitumor activity |
| ITMI20021040A1 (en) | 2002-05-16 | 2003-11-17 | Novuspharma Spa | INJECTABLE PHARMACEUTICAL COMPOSITIONS OF AN ANTHROCENEDIONAL DERIVATIVE WITH ANTI-TUMOR ACTIVITY |
| WO2005097128A1 (en) * | 2004-03-30 | 2005-10-20 | Novacea, Inc. | 1,4-bis-n-oxide azaanthracenediones and the use thereof |
| WO2008103320A1 (en) * | 2007-02-16 | 2008-08-28 | Novacea, Inc. | Methods of treating ophthalmic disorders with anthraquinones |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| CL2009002207A1 (en) | 2008-12-23 | 2011-02-18 | Gilead Pharmasset Llc | Compounds derived from 3-hydroxy-5- (9h-purin-9-yl) tetrahydrofuran-2-yl, an inhibitor of the replication of arn-dependent viral arn; pharmaceutical composition; use for the treatment of hepatitis c. |
| KR20110104074A (en) | 2008-12-23 | 2011-09-21 | 파마셋 인코포레이티드 | Synthesis of Purine Nucleosides |
| CL2009002208A1 (en) | 2008-12-23 | 2010-10-29 | Gilead Pharmasset Llc | A compound (2s) -2 - ((((2r, 3r, 4r, 5r) -5- (2-amino-6-ethoxy-9h-purin-9-yl) -4-fluoro-3-hydroxy-4 -methyltetrahydrofuran-2-yl) methoxy) (hydroxy) phosphorylamino) propanoic acid, viral arn replication inhibitors; pharmaceutical composition; and its use in the treatment of infection with hepatitis c, West Nile virus, among others. |
| MX2012011171A (en) | 2010-03-31 | 2013-02-01 | Gilead Pharmasset Llc | Nucleoside phosphoramidates. |
| CN104513201B (en) * | 2013-09-28 | 2017-12-26 | 正大天晴药业集团股份有限公司 | Crystal of pixantrone maleate |
| CN104557704B (en) * | 2013-10-28 | 2017-05-10 | 北京凯莱天成医药科技有限公司 | Preparation method of pixantrone maleate |
| CN103787970A (en) * | 2014-01-14 | 2014-05-14 | 北京万全德众医药生物技术有限公司 | Technology for preparing 6,9-difluoro benzisothiazol-5,10-diketone employing one-pot method |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2051005A (en) * | 1933-09-19 | 1936-08-11 | Gen Aniline Works Inc | Process of producing n-substitution products of 1, 4-diaminoanthraquinones |
| US2552263A (en) * | 1947-09-27 | 1951-05-08 | Eastman Kodak Co | alpha-anthrapyridinequinone compounds |
| ZA774443B (en) * | 1977-07-22 | 1978-06-28 | Allied Chem | Anthrquinone compounds as anti-cancer agents |
| US4197249A (en) * | 1977-08-15 | 1980-04-08 | American Cyanamid Company | 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof |
| EP0270306B1 (en) * | 1986-12-01 | 1991-03-27 | Sumitomo Chemical Company, Limited | Anthrapyridone compounds, their production process and their use |
-
1992
- 1992-03-06 NZ NZ241868A patent/NZ241868A/en not_active IP Right Cessation
- 1992-03-06 IE IE075492A patent/IE920754A1/en not_active IP Right Cessation
- 1992-03-07 TW TW081101743A patent/TW201735B/zh not_active IP Right Cessation
- 1992-03-09 EP EP92104004A patent/EP0503537B1/en not_active Expired - Lifetime
- 1992-03-09 BR BR9205740A patent/BR9205740A/en not_active Application Discontinuation
- 1992-03-09 AU AU15803/92A patent/AU663494B2/en not_active Expired
- 1992-03-09 CA CA002104582A patent/CA2104582A1/en not_active Abandoned
- 1992-03-09 EP EP92908816A patent/EP0575526A1/en active Pending
- 1992-03-09 HU HU9302540A patent/HU215967B/en unknown
- 1992-03-09 AT AT92104004T patent/ATE153018T1/en active
- 1992-03-09 KR KR1019930702688A patent/KR100193593B1/en not_active Expired - Lifetime
- 1992-03-09 MX MX9201020A patent/MX9201020A/en unknown
- 1992-03-09 CZ CZ19931847A patent/CZ286180B6/en not_active IP Right Cessation
- 1992-03-09 DE DE69219646T patent/DE69219646T2/en not_active Expired - Lifetime
- 1992-03-09 WO PCT/US1992/001606 patent/WO1992015300A1/en not_active Ceased
- 1992-03-09 JP JP04508231A patent/JP3009465B2/en not_active Expired - Lifetime
- 1992-03-09 RU RU93057572A patent/RU2129546C1/en active
- 1992-03-09 DK DK92104004.4T patent/DK0503537T3/en active
- 1992-03-09 ES ES92104004T patent/ES2104753T3/en not_active Expired - Lifetime
- 1992-03-09 SG SG1996004917A patent/SG66252A1/en unknown
- 1992-06-03 IL IL10208792A patent/IL102087A/en not_active IP Right Cessation
-
1993
- 1993-09-07 FI FI933895A patent/FI103575B/en not_active IP Right Cessation
-
1997
- 1997-08-13 GR GR970402079T patent/GR3024436T3/en unknown
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