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RU93054537A - DERIVATIVES OF GUANIDINALKYL-1,1-BISPHOSPHONIC ACID, METHOD FOR PRODUCING AND USING THEM - Google Patents

DERIVATIVES OF GUANIDINALKYL-1,1-BISPHOSPHONIC ACID, METHOD FOR PRODUCING AND USING THEM

Info

Publication number
RU93054537A
RU93054537A RU93054537/04A RU93054537A RU93054537A RU 93054537 A RU93054537 A RU 93054537A RU 93054537/04 A RU93054537/04 A RU 93054537/04A RU 93054537 A RU93054537 A RU 93054537A RU 93054537 A RU93054537 A RU 93054537A
Authority
RU
Russia
Prior art keywords
guanidinalkyl
derivatives
producing
bisphosphonic acid
formula
Prior art date
Application number
RU93054537/04A
Other languages
Russian (ru)
Other versions
RU2114855C1 (en
Inventor
Науманн Кристоф
Ланг Ханс-Йохен
Сандов Юрген
Мура Анн-Мари
Original Assignee
Хехст АГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19934316019 external-priority patent/DE4316019A1/en
Application filed by Хехст АГ filed Critical Хехст АГ
Publication of RU93054537A publication Critical patent/RU93054537A/en
Application granted granted Critical
Publication of RU2114855C1 publication Critical patent/RU2114855C1/en

Links

Claims (1)

Соединение таутомерной формулы Iа, Iб или Iс
Figure 00000001

Figure 00000002

Figure 00000003

где R - остаток формулы
Figure 00000004

Figure 00000005

являются эффективными соединениями для лечения и профилактики дегенеративных заболеваний костей. Они находят применение в качестве лекарственных средств.The compound of the tautomeric formula Ia, IB or IC
Figure 00000001

Figure 00000002

Figure 00000003

where R is the remainder of the formula
Figure 00000004

Figure 00000005

are effective compounds for the treatment and prevention of degenerative bone diseases. They find use as medicines.
RU93054537A 1992-12-02 1993-12-01 Guanidinealkyl-1,1-bis- phosphonic acid derivatives, and method of preparing thereof RU2114855C1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DEP4240422.3 1992-12-02
DE4240422 1992-12-02
DEP4316019.0 1993-05-13
DE19934316019 DE4316019A1 (en) 1993-05-13 1993-05-13 Benzoylguanidine alkyl-1,1-bisphosphonic acids, process for their preparation and their use
DE4332362 1993-09-23
DEP4332362.6 1993-09-23

Publications (2)

Publication Number Publication Date
RU93054537A true RU93054537A (en) 1996-12-27
RU2114855C1 RU2114855C1 (en) 1998-07-10

Family

ID=27204511

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93054537A RU2114855C1 (en) 1992-12-02 1993-12-01 Guanidinealkyl-1,1-bis- phosphonic acid derivatives, and method of preparing thereof

Country Status (15)

Country Link
US (3) US5395826A (en)
EP (1) EP0600371B1 (en)
JP (1) JP3499905B2 (en)
KR (1) KR100347423B1 (en)
AT (1) ATE176476T1 (en)
AU (1) AU663983B2 (en)
BR (1) BR9304910A (en)
CA (1) CA2110443C (en)
DE (1) DE59309360D1 (en)
DK (1) DK0600371T3 (en)
ES (1) ES2129485T3 (en)
FI (1) FI108034B (en)
GR (1) GR3030020T3 (en)
NZ (1) NZ250322A (en)
RU (1) RU2114855C1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4223940A1 (en) * 1992-07-21 1994-01-27 Boehringer Mannheim Gmbh New acyclic diphosphonic acid derivatives containing amidine groups, processes for their preparation and medicaments containing these compounds
DE59309360D1 (en) * 1992-12-02 1999-03-18 Hoechst Ag Guanidine alkyl-1, 1-bisphosphonic acid derivatives, process for their preparation and their use
US6169107B1 (en) 1993-04-28 2001-01-02 Sumitomo Pharmaceutical Co., Ltd. Indoloylguanidine derivatives
DE4404183A1 (en) * 1994-02-10 1995-08-17 Merck Patent Gmbh 4-amino-1-piperidylbenzoylguanidine
DE4421495A1 (en) * 1994-06-20 1995-12-21 Merck Patent Gmbh Heterocyclyloxy-benzoylguanidines
CA2160600A1 (en) * 1994-10-18 1996-04-19 Masahumi Kitano Indoloylguanidine derivatives
DE19540995A1 (en) * 1995-11-03 1997-05-07 Hoechst Ag Substituted sulfonimidamides, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
DE19542306A1 (en) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19601303A1 (en) * 1996-01-16 1997-07-17 Boehringer Ingelheim Kg Novel benzoylguanidine derivatives, process for their preparation and their use in the manufacture of medicaments
ATE253073T1 (en) 1997-03-07 2003-11-15 Metabasis Therapeutics Inc NEW BENZIMIDAZOLE INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE
AU6452098A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
AU6691798A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
US6558784B1 (en) 1999-03-02 2003-05-06 Adc Composites, Llc Composite footwear upper and method of manufacturing a composite footwear upper
WO2001049295A1 (en) * 2000-01-04 2001-07-12 The Regents Of The University Of California Use of low dosage bisphosphonates to inhibit cardiac and arterial calcification
ES2268086T3 (en) * 2001-05-02 2007-03-16 Novartis Ag METHOD OF ADMINISTRATION OF BISPHOSPHONATES BY INHALATION IN THE TREATMENT OR PREVENTION OF OSEA RESORTION AND OSTEOPOROSIS.
KR100620672B1 (en) * 2002-12-14 2006-09-13 주식회사 하이닉스반도체 Photoresist composition
WO2005090370A1 (en) * 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
WO2006110655A2 (en) 2005-04-08 2006-10-19 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
EP1865967A4 (en) 2005-04-08 2011-02-09 Chimerix Inc COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS AND OTHER MEDICAL CONDITIONS
US20080132471A1 (en) * 2006-11-21 2008-06-05 Teikoku Pharma Usa, Inc. Bisphosphonate inhalant formulations and methods for using the same
CN101977610B (en) * 2008-01-25 2012-05-16 奇默里克斯公司 Methods of treating viral infections
US20100034752A1 (en) * 2008-08-11 2010-02-11 Toru Hibi Inhalant formulations comprising a bisphosphonate and a pyrazolone derivative and methods for using the same
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
JP2013501056A (en) 2009-08-03 2013-01-10 キメリクス，インコーポレイテッド Compositions and methods for treating viral infections and virus-induced tumors
DK2534150T3 (en) 2010-02-12 2017-06-12 Chimerix Inc METHODS OF TREATING VIRUS INFECTION
WO2011139709A2 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2838437A1 (en) * 1978-09-02 1980-03-20 Benckiser Gmbh Joh A N, N'-DIALKYL-UREIDOMETHANE DIPHOSPHONIC ACID, THEIR PRODUCTION AND USE
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
DE3623397A1 (en) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
KR880011136A (en) * 1987-03-11 1988-10-26 모리오까 시게오 Azole-aminomethylene bisphosphonic acid derivatives
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkyl-phosphinates and pharmaceutical compositions containing them
JPH0248587A (en) * 1988-08-10 1990-02-19 Yamanouchi Pharmaceut Co Ltd Heteroring-substituted bisphosphonic acid derivative and medicine thereof
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
DE3929582A1 (en) * 1989-09-06 1991-03-07 Hoechst Ag BENZOYLGUANIDINE, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICINE AND THE MEDICINE CONTAINING IT
TW222637B (en) * 1991-12-12 1994-04-21 Hoechst Ag
DE59309360D1 (en) * 1992-12-02 1999-03-18 Hoechst Ag Guanidine alkyl-1, 1-bisphosphonic acid derivatives, process for their preparation and their use

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