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RU93036185A - DOUBLE ACTION INHIBITORS - Google Patents

DOUBLE ACTION INHIBITORS

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Publication number
RU93036185A
RU93036185A RU93036185/04A RU93036185A RU93036185A RU 93036185 A RU93036185 A RU 93036185A RU 93036185/04 A RU93036185/04 A RU 93036185/04A RU 93036185 A RU93036185 A RU 93036185A RU 93036185 A RU93036185 A RU 93036185A
Authority
RU
Russia
Prior art keywords
double action
action inhibitors
formula
proposed
inhibitors
Prior art date
Application number
RU93036185/04A
Other languages
Russian (ru)
Other versions
RU2124503C1 (en
Inventor
Сю Караневский Дональд
С.Бэрриш Джоел
В.Патрилло Эдвард
И.Рионо Джефри
Original Assignee
И.Р. Сквибб энд санз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by И.Р. Сквибб энд санз, Инк. filed Critical И.Р. Сквибб энд санз, Инк.
Publication of RU93036185A publication Critical patent/RU93036185A/en
Application granted granted Critical
Publication of RU2124503C1 publication Critical patent/RU2124503C1/en

Links

Claims (1)

Предложены соединения формулы
Figure 00000001

в которой радикалы имеют значения, приведенные в описании, обладающие двойной активностью, а именно - способностью ингибировать ангиотензин - конвертирующий фермент и нейтральную эндопептидазу и их фармацевтически приемлемые соли. Предложена также фармацевтическая композиция на их основе, способ получения и промежуточные соединения для получения соединения формулы.The proposed compounds of the formula
Figure 00000001

in which the radicals have the meanings given in the description with dual activity, namely, the ability to inhibit angiotensin - a converting enzyme and neutral endopeptidase and their pharmaceutically acceptable salts. A pharmaceutical composition based on them, a method of production and intermediate compounds for the preparation of a compound of the formula are also proposed.
RU93036185/04A 1992-05-18 1993-05-17 Heterocyclic nitrogen-containing derivatives of carboxylic acid, method of their synthesis, pharmaceutical composition RU2124503C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88466492A 1992-05-18 1992-05-18
US884,664 1992-05-18
US884664 1992-05-18

Publications (2)

Publication Number Publication Date
RU93036185A true RU93036185A (en) 1996-02-27
RU2124503C1 RU2124503C1 (en) 1999-01-10

Family

ID=25385092

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93036185/04A RU2124503C1 (en) 1992-05-18 1993-05-17 Heterocyclic nitrogen-containing derivatives of carboxylic acid, method of their synthesis, pharmaceutical composition

Country Status (28)

Country Link
EP (2) EP0599444B1 (en)
JP (1) JP3487611B2 (en)
KR (2) KR100288722B1 (en)
CN (1) CN1039008C (en)
AT (1) ATE162800T1 (en)
AU (2) AU659550B2 (en)
BR (1) BR1101081A (en)
CA (1) CA2096460C (en)
CY (1) CY2093B1 (en)
CZ (1) CZ289824B6 (en)
DE (1) DE69316717T2 (en)
DK (1) DK0599444T3 (en)
ES (1) ES2111712T3 (en)
FI (1) FI103337B1 (en)
GR (1) GR3026665T3 (en)
HK (1) HK1003597A1 (en)
HU (1) HU217078B (en)
IL (1) IL105729A (en)
MX (1) MX9302876A (en)
MY (1) MY111370A (en)
NO (1) NO304372B1 (en)
NZ (1) NZ247642A (en)
PL (1) PL173036B1 (en)
RU (1) RU2124503C1 (en)
SG (1) SG54138A1 (en)
SK (1) SK283556B6 (en)
TW (1) TW290544B (en)
ZA (1) ZA933461B (en)

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