[go: up one dir, main page]

RU93049997A - DERIVATIVES OF METHYLENE-BIS-PHOSPHONIC ACID, METHOD FOR PRODUCING THEM, PHARMACEUTICAL COMPOSITION - Google Patents

DERIVATIVES OF METHYLENE-BIS-PHOSPHONIC ACID, METHOD FOR PRODUCING THEM, PHARMACEUTICAL COMPOSITION

Info

Publication number
RU93049997A
RU93049997A RU93049997/04A RU93049997A RU93049997A RU 93049997 A RU93049997 A RU 93049997A RU 93049997/04 A RU93049997/04 A RU 93049997/04A RU 93049997 A RU93049997 A RU 93049997A RU 93049997 A RU93049997 A RU 93049997A
Authority
RU
Russia
Prior art keywords
methylene
bis
pharmaceutical composition
phosphonic acid
derivatives
Prior art date
Application number
RU93049997/04A
Other languages
Russian (ru)
Other versions
RU2086556C1 (en
Inventor
Похяла Эско
Хейккиля-Хойкка Марьяна
Никандер Ханну
Ханхиярви Ханну
Original Assignee
Лейрас Ой
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI906295A external-priority patent/FI89366C/en
Application filed by Лейрас Ой filed Critical Лейрас Ой
Publication of RU93049997A publication Critical patent/RU93049997A/en
Application granted granted Critical
Publication of RU2086556C1 publication Critical patent/RU2086556C1/en

Links

Claims (1)

Изобретение относится к новым производным метилен-бис-фосфоновой кислоты, способу их получения, а также фармацевтической композиции на их основе.The invention relates to new derivatives of methylene-bis-phosphonic acid, a method for their preparation, as well as a pharmaceutical composition based on them.
RU9193049997A 1990-12-20 1991-12-18 Methylene-bis-phosphonic acid derivatives and a method of their synthesis RU2086556C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI906295 1990-12-20
FI906295A FI89366C (en) 1990-12-20 1990-12-20 PROCEDURE FOR THE FRAMEWORK OF THE PHARMACOLOGICAL PROCEDURE OF METHYLENBISPHOSPHONYRADERIVAT
PCT/FI1991/000395 WO1992011269A1 (en) 1990-12-20 1991-12-18 Novel methylenebisphosphonic acid derivatives

Publications (2)

Publication Number Publication Date
RU93049997A true RU93049997A (en) 1996-09-20
RU2086556C1 RU2086556C1 (en) 1997-08-10

Family

ID=8531620

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9193049997A RU2086556C1 (en) 1990-12-20 1991-12-18 Methylene-bis-phosphonic acid derivatives and a method of their synthesis

Country Status (25)

Country Link
US (1) US5393748A (en)
EP (1) EP0563107B1 (en)
JP (1) JP3224817B2 (en)
KR (1) KR100220157B1 (en)
CN (1) CN1030253C (en)
AT (1) ATE192452T1 (en)
AU (1) AU664541B2 (en)
CA (1) CA2098735C (en)
CZ (1) CZ288084B6 (en)
DE (1) DE69132164T2 (en)
DK (1) DK0563107T3 (en)
EE (1) EE02949B1 (en)
ES (1) ES2147726T3 (en)
FI (1) FI89366C (en)
HU (1) HUT64549A (en)
IE (1) IE914389A1 (en)
IL (1) IL100337A (en)
NO (1) NO302074B1 (en)
NZ (1) NZ241040A (en)
PL (1) PL169796B1 (en)
RU (1) RU2086556C1 (en)
SK (1) SK279601B6 (en)
TW (1) TW201752B (en)
WO (1) WO1992011269A1 (en)
ZA (1) ZA9110008B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI89365C (en) * 1990-12-20 1993-09-27 Leiras Oy PROCEDURE FOR THE FRAMEWORK OF THE PHARMACOLOGICAL PROCEDURE OF METHYLENBISPHOSPHONYRADERIVAT
US5157027A (en) * 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
CZ282760B6 (en) * 1991-11-22 1997-09-17 Procter And Gamble Pharmaceuticals, Inc. Solid pharmaceutical preparation with delayed release for oral administration when treating calcium and phosphate metabolism
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US6444656B1 (en) 1992-12-23 2002-09-03 Biochem Pharma, Inc. Antiviral phosphonate nucleotides
GB9226879D0 (en) * 1992-12-23 1993-02-17 Iaf Biochem Int Anti-viral compounds
US6005107A (en) 1992-12-23 1999-12-21 Biochem Pharma, Inc. Antiviral compounds
TW390813B (en) * 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
US20010007863A1 (en) 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
DE4435496A1 (en) * 1994-10-04 1996-04-11 Hoechst Ag Imidobisphosphoric acids, process for their preparation and use thereof
FI104901B (en) 1997-10-20 2000-04-28 Leiras Oy New methylene bisphosphonic acid derivatives
EP1112275B9 (en) 1998-09-09 2004-03-10 Metabasis Therapeutics, Inc. Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
SE9903345D0 (en) 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
AU2002212378A1 (en) * 2000-10-27 2002-05-06 Schering Oy Method for the preparation of a pharmaceutical composition, and its use
FR2837490B1 (en) * 2002-03-21 2009-04-17 Univ Paris 13 NOVEL DERIVATIVES OF BISPHOSPHONATES, THEIR PREPARATIONS AND USES
US20030036537A1 (en) * 2001-07-16 2003-02-20 Marc Lecouvey Bisphosphonate derivatives, their preparations and uses
ES2336312T3 (en) * 2001-07-16 2010-04-12 Universite Paris 13 PROCEDURE FOR PREPARATION OF BISPHOSPHONATE DERIVATIVES.
US7208481B2 (en) * 2002-02-19 2007-04-24 Ilex Products, Inc. Aminodiphosphonate apolipoprotein E modulators
RU2220588C1 (en) * 2002-08-06 2004-01-10 Научно-производственный центр "БИОЭКОСАН" Feed additive composition and method for producing the same
US7862552B2 (en) * 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
EP2310398A2 (en) * 2008-07-11 2011-04-20 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
JP5850842B2 (en) * 2009-10-26 2016-02-03 ワーナー・チルコット・カンパニー・エルエルシー Bisphosphonate compounds for treating bone metabolic disorders
TWI730039B (en) * 2016-01-29 2021-06-11 日商富士藥品股份有限公司 Novel bisphosphonic acid compound
CN108218918A (en) * 2018-03-01 2018-06-29 四川大学 Aryl is together with diphosphonic acid derivative preparation method and purposes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303139A (en) * 1962-01-27 1967-02-07 Henkel & Cie Gmbh Aminophosphonic acids and their derivatives as complex formers for metal ions
DE1617118C3 (en) * 1966-08-26 1975-04-03 Henkel & Cie Gmbh, 4000 Duesseldorf Methods for cleaning labeled rigid objects
US3962318A (en) 1970-04-13 1976-06-08 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3957858A (en) * 1970-04-13 1976-05-18 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US4447256A (en) * 1977-07-20 1984-05-08 Nissan Chemical Industries, Ltd. N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
GB8530603D0 (en) * 1985-12-12 1986-01-22 Leo Pharm Prod Ltd Chemical compounds
DK126888A (en) * 1987-03-10 1988-09-11 Yamanouchi Pharma Co Ltd BISPHOSPHONIC ACID DERIVATIVES AND THERAPEUTIC PREPARATIONS CONTAINING THESE COMPOUNDS
EP0356866A3 (en) * 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphorus-containing squalene synthetase inhibitors and method

Similar Documents

Publication Publication Date Title
RU93049997A (en) DERIVATIVES OF METHYLENE-BIS-PHOSPHONIC ACID, METHOD FOR PRODUCING THEM, PHARMACEUTICAL COMPOSITION
GB2210879B (en) 4h-1-benzopyran-4-one derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient
RU93005350A (en) NEW SUBSTITUTED PHENYLIMIDAZOLIDINES, METHOD FOR THEIR PRODUCTION, THEIR USE AS MEDICINES AND INCLUDING THEIR PHARMACEUTICAL COMPOUNDS
MA19716A1 (en) PROCESS FOR THE PREPARATION OF NEW DERIVATIVES 3- CETO TO 4.9 19- NORSTEROIDES.
FI906438L (en) Method for preparing novel, therapeutically useful A-nor-steroid-3-carboxylic acid derivatives
DE69104991D1 (en) MOMETASON FUROATE MONOHYDRATE, METHOD FOR THE PRODUCTION THEREOF AND THE CONTAINING PHARMACEUTICAL COMPOSITIONS.
RU93004445A (en) NEW 2-CYANO 3-HYDROXYENAMIDE DERIVATIVES, METHOD FOR THEIR RECEPTION, THEIR APPLICATION AS MEDICATION, CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND NEW OBTAINED INTERMEDIATE
FI931332A0 (en) Novel alkylenediammonium diclavulanate derivatives, process for their preparation as well as their use for the purification of calvulanic acid
FI903752A7 (en) Process for the preparation of 1,2,3,4-tetrahydro-9-acridinamine derivatives
HUT50790A (en) Process for producing new 3,5-dihydroxycarboxylic acids and derivatives thereof, as well as pharmaceutical compositions and intermediates comprising such compounds
FI872831A7 (en) Method for preparing pharmaceutical compositions.
MA21842A1 (en) THIENO - TRIAZOLO - DIAZEPINE DERIVATIVES, AS WELL AS A PROCESS FOR THE PREPARATION OF SAID COMPOUNDS.
FI900145L (en) Process for the preparation of pharmaceutically useful 1,1-dioxo-cephem-4-carbothioic acid derivatives
RU94007342A (en) NEW ERYTHROMYCIN DERIVATIVES, THEIR PRODUCTION METHOD AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS
FI854171A7 (en) 1,4-dihydropyridine-hydroxyamines, a process for their preparation as well as their use as pharmaceuticals.
NO891984D0 (en) PROCEDURE FOR PREPARING 1,4-DICYDRO-4-OXO-QUINOLIN-3-CARBOXYLIC ACID ESTERS.
RU94000724A (en) NEW PREDGHANE 17,20-EPOXIDES, A METHOD FOR THEIR PRODUCTION, OBTAINING CORTISON DERIVATIVES AND INTERMEDIATE CONNECTIONS
FI905930A7 (en) Process for the preparation of novel, pharmacologically useful bispilocarpic acid ester derivatives
RU95109891A (en) 19,11-overbriged 4-estrenes, method for their production, pharmaceutical composition comprising them and intermediate compounds for their production
RU93047049A (en) NEW PHOSPHOLIPIDES DERIVATIVES
FI910159A7 (en) Process for the preparation of novel, therapeutically useful 9α-hydroxy-3-oxo-4,24(25)-stigmastadieno-26-acid derivatives
FI893121L (en) Process for the preparation of pharmacologically active 6,21-dimethyl-19-norprogesterone derivatives
FI93216C (en) Analogous process for the preparation of therapeutically useful 1,3-dioxanoic acid derivatives
IT8202905A0 (en) PROCEDURE FOR THE PRODUCTION OF BODIES OBTAINED BY FORMING FROM POLYLAURIN LACTAM AS WELL AS FORMING BODIES SO OBTAINED.
RU93051079A (en) PHARMACEUTICAL COMPOUNDS, PRODUCTION METHOD, PHARMACEUTICAL COMPOSITION