RU93017260A - N-METHYL-N- / ALPHA, D-Glucopyranosyl / AMMONIA-2- / ACRIDONE-9-OH-10-IL / ACETATE (CYCLOPHERON), POSSESSING INTERFERONOGENOUS, ANTIVIRTOMA, ANTI-ANTROTHROMITIS, ANTROTHROMITIS, AND ANTROTHROMITIS ACTIVITY - Google Patents
N-METHYL-N- / ALPHA, D-Glucopyranosyl / AMMONIA-2- / ACRIDONE-9-OH-10-IL / ACETATE (CYCLOPHERON), POSSESSING INTERFERONOGENOUS, ANTIVIRTOMA, ANTI-ANTROTHROMITIS, ANTROTHROMITIS, AND ANTROTHROMITIS ACTIVITYInfo
- Publication number
- RU93017260A RU93017260A RU93017260/04A RU93017260A RU93017260A RU 93017260 A RU93017260 A RU 93017260A RU 93017260/04 A RU93017260/04 A RU 93017260/04A RU 93017260 A RU93017260 A RU 93017260A RU 93017260 A RU93017260 A RU 93017260A
- Authority
- RU
- Russia
- Prior art keywords
- antrothromitis
- alpha
- methyl
- acridone
- glucopyranosyl
- Prior art date
Links
- 125000003535 D-glucopyranosyl group Chemical group [H]OC([H])([H])[C@@]1([H])OC([H])(*)[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] 0.000 title claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 title 1
- UOMKBIIXHQIERR-UHFFFAOYSA-N cridanimod Chemical compound C1=CC=C2N(CC(=O)O)C3=CC=CC=C3C(=O)C2=C1 UOMKBIIXHQIERR-UHFFFAOYSA-N 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- WCWOEQFAYSXBRK-GASJEMHNSA-N (3r,4s,5s,6r)-2-amino-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound NC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O WCWOEQFAYSXBRK-GASJEMHNSA-N 0.000 claims 1
- 230000036436 anti-hiv Effects 0.000 claims 1
- 230000002141 anti-parasite Effects 0.000 claims 1
- 230000002732 anti-promotor Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000286 interferogenic effect Effects 0.000 claims 1
- 239000000718 radiation-protective agent Substances 0.000 claims 1
Claims (1)
Usage: in medicine, in particular as an interferonogenic, antiviral (including anti-HIV), antiparasitic, antipromotor and radioprotective agents. The inventive product is N-methyl-N- (alpha, D-glucopyranosyl) ammonium-2- (acridone-9-one-10-yl) acetate, BF C22 H26 N2 08, T. pl. 129-132 o C, yield 100%. Reagent 1: N-methyl-N- (alpha, D-glucopyranosylamine). Reagent 2: 2- (acridon-9-one-10-yl) acetic acid. Reaction conditions: in ethanol at room temperature. Product structure
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU93017260/04A RU2036198C1 (en) | 1993-04-01 | 1993-04-01 | N-METHYL- N- (α-D- GLUCOPYRANOSYL) -AMMONIUM -2-(ACRIDONE -9-ONE -10-YL) -ACETATE (CYCLOFERON) SHOWING INTERFEROGENIC, ANTIVIRAL AMONG THEM ANTI-HIV, ANTIPARASITIC, ANTIPROMOTER AND RADIOPROTECTIVE ACTIVITIES |
| US08/351,385 US5658886A (en) | 1993-04-01 | 1994-02-23 | Acridinone derivative, compositions containing same and a method for using same to treat Chlamydia trachomatis |
| AU62650/94A AU6265094A (en) | 1993-04-01 | 1994-02-23 | N-methyl-n-/alpha,delta-glucopyranozil/ammonia-2-/acridon-9- on-10-yl/acetate/cyclopherone, with interferon producing, anti-viral (including anti-hiv), anti-parasitic, anti-promoter and radioprotective properties |
| EP94910067A EP0692475A4 (en) | 1993-04-01 | 1994-02-23 | N-METHYL-N-/-g(a),-g(D)-GLUCOPYRANOZIL/AMMONIA-2-/ACRIDON-9-ON-10-YL/ACETATE/CYCLOPHERONE, WITH INTERFERON PRODUCING, ANTI-VIRAL (INCLUDING ANTI-HIV), ANTI-PARASITIC, ANTI-PROMOTER AND RADIOPROTECTIVE PROPERTIES |
| PCT/RU1994/000032 WO1994022837A1 (en) | 1993-04-01 | 1994-02-23 | N-METHYL-N-/α,Δ-GLUCOPYRANOZIL/AMMONIA-2-/ACRIDON-9-ON-10-YL/ACETATE/CYCLOPHERONE, WITH INTERFERON PRODUCING, ANTI-VIRAL (INCLUDING ANTI-HIV), ANTI-PARASITIC, ANTI-PROMOTER AND RADIOPROTECTIVE PROPERTIES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU93017260/04A RU2036198C1 (en) | 1993-04-01 | 1993-04-01 | N-METHYL- N- (α-D- GLUCOPYRANOSYL) -AMMONIUM -2-(ACRIDONE -9-ONE -10-YL) -ACETATE (CYCLOFERON) SHOWING INTERFEROGENIC, ANTIVIRAL AMONG THEM ANTI-HIV, ANTIPARASITIC, ANTIPROMOTER AND RADIOPROTECTIVE ACTIVITIES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2036198C1 RU2036198C1 (en) | 1995-05-27 |
| RU93017260A true RU93017260A (en) | 1997-01-10 |
Family
ID=20139670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93017260/04A RU2036198C1 (en) | 1993-04-01 | 1993-04-01 | N-METHYL- N- (α-D- GLUCOPYRANOSYL) -AMMONIUM -2-(ACRIDONE -9-ONE -10-YL) -ACETATE (CYCLOFERON) SHOWING INTERFEROGENIC, ANTIVIRAL AMONG THEM ANTI-HIV, ANTIPARASITIC, ANTIPROMOTER AND RADIOPROTECTIVE ACTIVITIES |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5658886A (en) |
| EP (1) | EP0692475A4 (en) |
| AU (1) | AU6265094A (en) |
| RU (1) | RU2036198C1 (en) |
| WO (1) | WO1994022837A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2118532C1 (en) * | 1996-04-10 | 1998-09-10 | Олег Викторович Травкин | Antiinfectious, antiinflammatory and antitumor drug |
| RU2093510C1 (en) * | 1996-09-26 | 1997-10-20 | Олег Викторович Травкин | 2-deoxy-2-amino (or 2-methylamino)-d-glucose salts with n-acrydonacetic acid having antimicrobial activity |
| RU2162843C2 (en) * | 1998-05-19 | 2001-02-10 | Закрытое Акционерное Общество "Асгл - Исследовательские Лаборатории" | Method of preparing sodium 10-methylene carboxylate-9-acridone or 10- methylenecarboxy-9-acridone from acridone |
| US6310073B1 (en) * | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
| RU2135474C1 (en) * | 1998-08-19 | 1999-08-27 | Травкин Олег Викторович | Salts of 1-deoxy-1-n-methylaminohexaalcohols with n-acridone acetic acid showing immunomodulating activity and drugs on their base |
| RU2197248C2 (en) * | 2001-03-20 | 2003-01-27 | Травкин Олег Викторович | Medicinal preparation eliciting immunomodulating, immunocorrecting, antiparasitic, antisclerotic, antiviral, antibacterial, antifungal, anti-inflammatory and antitumor effect and method of its preparing |
| RU2232593C2 (en) * | 2002-08-12 | 2004-07-20 | НИИ онкологии им. проф. Н.Н.Петрова | Method for treating cancer of uterine cervix of ib-ii stages |
| US7833339B2 (en) | 2006-04-18 | 2010-11-16 | Franklin Industrial Minerals | Mineral filler composition |
| US7651559B2 (en) | 2005-11-04 | 2010-01-26 | Franklin Industrial Minerals | Mineral composition |
| RU2326115C2 (en) | 2005-11-21 | 2008-06-10 | Ефаг АО | Salts of 1-alkylamino-1-desoxypolyols with 9-oxoacridine-10-acetic acid, medicinal preparations on their base, their use, preventive measures and treatment |
| GB2450088A (en) * | 2007-06-11 | 2008-12-17 | Diosamine Dev Corp | Optionally modified monosaccharides with imine/iminium or glycosidic amine/ammonium group for use in modifying the level of cytokines & in therapy |
| RU2449792C1 (en) * | 2010-08-27 | 2012-05-10 | Открытое акционерное общество "Московское производственное химико-фармацевтическое объединение им. Н.А. Семашко" | Pelletised drug showing antiviral and interferonogenic action, and method for preparing it |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3681360A (en) * | 1971-04-09 | 1972-08-01 | Hoffmann La Roche | Antiviral substituted acridanones |
| US4362720A (en) * | 1977-04-14 | 1982-12-07 | Chembiomed Ltd. | Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals |
| DE2759468A1 (en) * | 1977-08-29 | 1979-06-07 | Sterling Drug Inc | Aminoalkoxy-acridone derivs. - useful as antiviral agents |
| US4244954A (en) * | 1978-10-02 | 1981-01-13 | Sterling Drug Inc. | Acridine compounds and methods of combatting viruses with them |
| US4399283A (en) * | 1980-03-11 | 1983-08-16 | Warner Lambert Company | Pharmaceutical salts of 4'-(9-acridinylamino)-methanesulfon-m-anisidide |
| JPS5724365A (en) * | 1980-04-28 | 1982-02-08 | Dev Finance | Antitumoral compound, manufacture and medicinal composition containing same |
| NZ201084A (en) * | 1982-06-25 | 1985-10-11 | New Zealand Dev Finance | 4-carboxamidoacridine derivatives and pharmaceutical compositions containing such |
| CA1258854A (en) * | 1982-11-26 | 1989-08-29 | Urs Brombacher | Acridanone derivatives |
| US4711889A (en) * | 1983-11-15 | 1987-12-08 | Hoffman-La Roche Inc. | Schistosomicidal acridanone hydrazones |
| JPS63310826A (en) * | 1987-06-09 | 1988-12-19 | Santen Pharmaceut Co Ltd | Antiviral agent |
| FR2640508B1 (en) * | 1988-12-19 | 1994-07-01 | Dietlin Francois | NOVEL COMPOSITIONS AND NEW PHARMACEUTICAL PRODUCTS ENSURING THE REGENERATION OF LEUKOCYTES AND THEIR USE FOR THE TREATMENT OF IMMUNE DEFICIT SYNDROME |
| US5175172A (en) * | 1988-12-19 | 1992-12-29 | Francois Dietlin | Method of alleviating AIDS symptoms and compositions therefor |
| FR2651230B1 (en) * | 1989-08-25 | 1992-03-13 | Synthese Rech | DERIVATIVES OF 5-AMINO-1,2,3,4 TETRAHYDRO-ACRIDINE AND APPLICATIONS AS DRUGS. |
| GEP20002210B (en) * | 1991-01-11 | 2000-08-25 | Laboratoires Glaxo S A | Acridine Derivatives |
| US5296602A (en) * | 1991-03-18 | 1994-03-22 | Sloan-Kettering Institute For Cancer Research | Multisubstituted 1-hydroxy-9-acridones with anticancer activity |
-
1993
- 1993-04-01 RU RU93017260/04A patent/RU2036198C1/en active
-
1994
- 1994-02-23 EP EP94910067A patent/EP0692475A4/en not_active Withdrawn
- 1994-02-23 AU AU62650/94A patent/AU6265094A/en not_active Abandoned
- 1994-02-23 WO PCT/RU1994/000032 patent/WO1994022837A1/en not_active Ceased
- 1994-02-23 US US08/351,385 patent/US5658886A/en not_active Expired - Fee Related
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