RU2817886C1 - Dry beverage concentrate for bone tissue recovery - Google Patents

Abstract

FIELD: food industry.

SUBSTANCE: invention relates to the food industry, which produces products in the form of preventive and/or functional nutrition, or biologically active food additives, and can be used as a food product, a product of dietary and dietary preventive nutrition, including enteral nutrition, for recovery and regeneration of bone and cartilage tissue, in case of injuries, fractures, operations and diseases of locomotor apparatus, including osteoporosis. Disclosed is a dry beverage concentrate for bone tissue recovery, containing milk proteins, collagen hydrolyzate, vitamins A, B2, B6, C, D, citric acid, mineral substances calcium, magnesium, potassium, zinc, which additionally contains common horsetail extract, burdock root extract, propolis extract, flower pollen, succinic acid, mineral substance fluorine, rutin, pectin, guar gum, buckwheat flour, vegetable oil and auxiliary substances – potato starch, a flavouring agent, sucrose, in the following ratio of components, wt.%: milk proteins 1.0–30.0; collagen hydrolyzate 0.5–15.0; vitamin A 0.00008–0.0016; vitamin B2 0.00016–0.0032; vitamin B6 0.0002–0.004; vitamin C 0.006–0.1200; vitamin D 0.0000005–0.00001; rutin 0.003–0.060; calcium 0.1–2.0; magnesium 0.040–0.8; potassium 0.350–7.0; zinc 0.0015–0.03; fluorine 0.0004–0.008; citric acid 0.001–0.05; succinic acid 0.005–0.1; common horsetail extract 0.1–10.0; burdock root extract 0.1–8.0; propolis extract 0.005–0.2; flower pollen 0.01–0.1; pectin 1.0–10.0; guar gum 1.0–10.0; vegetable oil 1.0–10.0; buckwheat flour 0.1–5.0; potato starch 3.0–15.0; flavoring agent 0.01–0.45; sucrose is the rest.

EFFECT: invention extends the range of food products for bone tissue in the form of a beverage with high efficiency, the action of which is aimed at strengthening and maintaining the function of the musculoskeletal system.

1 cl, 4 ex

Description

FIELD OF TECHNOLOGY TO WHICH THE INVENTION RELATES

The invention relates to the field of the food industry producing products in the form of preventive and/or functional nutrition, or biologically active food additives, and can be used as a food product, a product of dietary and dietary preventive nutrition, including enteral nutrition, for restoration (regeneration) of bone and cartilage tissue, for injuries, fractures, cracks, operations and diseases of the musculoskeletal system, including osteoporosis.

BACKGROUND OF THE ART

In recent years, diseases of the musculoskeletal system and connective tissue have consistently occupied one of the leading places in the structure of the general morbidity of the population. According to the Federal State Statistics Service (Rosstat), the annual prevalence of such diseases for the period 2018 – 2020. averages 11–12 thousand per 100 thousand population, including 3–4 thousand people diagnosed for the first time in their lives [Healthcare in Russia. 2021: Stat. Sat. / Rosstat. - M., 2021. - 171 p., https://rosstat.gov.ru/folder/210/document/13218, accessed 08/28/2023].

Diseases of the musculoskeletal system are caused not only by injuries as a result of external causes, but also by various systemic diseases of the bone skeleton, the most common of which is osteoporosis, which leads to a high risk of bone fractures. According to the International Osteoporosis Foundation and several studies, about 200 million women worldwide suffer from osteoporosis, which causes more than 8.9 million bone fractures annually. In Russia, approximately 14 million people (10% of the population) suffer from osteoporosis, about 20 million Russians have osteopenia, which amounts to 34 million people at high risk of fractures. A hip fracture in people over 65 years of age is a high risk factor for death (20% per year after a fracture), more than half of patients never return to their original functional state [Osteoporosis. Clinical guidelines of the Russian Federation, 2021 https://diseases.medelement.com/disease/%D0%BE%D1%81%D1%82%D0%B5%D0%BE%D0%BF%D0%BE%D1%80% D0%BE%D0%B7-%D0%BA%D0%BF-%D1%80%D1%84-2021/16662, accessed 08/28/2023].

When severe injuries to bone tissue occur in the human body, catabolism increases, along with which the need for basic nutrients, primarily proteins, increases. This condition is often accompanied and complicated by serious metabolic changes. Severe injury to bone tissue is accompanied by pronounced metabolic changes, which are partly an adaptation of the body to a new state for it, but they also often cause significant losses of protein, which often leads to disruption of the vital functions of the human body.

Traumatic disease contributes to disruption of the gastrointestinal tract. It is caused by acute stress, post-traumatic ischemia and hypoxia, and metabolic changes. Victims experience reflux, pyloric insufficiency, acute erosions and hemorrhages in the body and antrum of the stomach. Developing post-traumatic disorders of the intestinal mucosa are accompanied by a decrease in the production of mucus and mucopolysaccharides, as well as an increase in the permeability of cell membranes, which leads to the release of proteolytic enzymes and toxins formed in the intestinal wall (including cardiotoxins). In addition to them, toxic substances contained in the intestinal cavity (amines, long-chain fatty acids, hydrolases, bacterial and viral toxins) enter the bloodstream.

With a traumatic disease, a significant decrease in the excretory function of the pancreas is observed. Due to impaired glucose oxidation, post-traumatic diabetes occurs, accompanied by an increase in glucose levels in the blood and urine. In addition to catabolic processes, difficulties with eating food often lead to the appearance of protein-energy deficiency. Patients either significantly reduce its volume or stop eating altogether. Therefore, if natural nutrition is impossible or limited, patients need adequate artificial nutrition, including enteral nutrition.

According to G.S. Doig et al. an earlier start of enteral nutrition (18-24 hours after injury) reduces the risk of developing sepsis and pneumonia, as it promotes greater blood flow to the digestive organs, stimulates systemic and local immunity (the production of immunoglobulin A, vasoactian and trophic substances increases, the composition of the intestinal tract is stabilized) microflora) [Doig, G.S. Enteral nutrition within 24 h of ICU admission significantly reduces mortality: a meta-analysis of RCTs. Care Med./G.S. Doig, P.T. Heighes, F. Simpson et al.//2009/ - V. 35 – P. 2018-2027].

Enteral nutrition is administered through a nasogastric or nasoduodenal tube using the gravity-drip method or using enteral pumps. If the patient is conscious and able to swallow independently, then he takes enteral nutrition orally.

In connection with the above, the use of food and biologically active substances in the organization of nutritious nutrition in the treatment or prevention of diseases of the musculoskeletal system and connective tissue is of extreme relevance.

A known therapeutic and prophylactic composition for improving the functional state of the musculoskeletal system [RF patent No. 2220737, publ. 01/10/2004], including glycamine (protein-glycoside complex from sea cucumbers), glucosamine hydrochloride, dry extract of burdock root, dry extract of aspen bark and cryopowder of chicken eggshells in the following ratio of components, wt. %: glycamine (protein-glycoside complex from holothurians) 10±0.5; glucosamine hydrochloride 20±1; dry burdock root extract 5±0.25; dry aspen bark extract 5±0.25; chicken egg shell cryopowder - the rest.

A specialized food product is known that promotes the regeneration and maintenance of the integrity of connective tissue and, in particular, the skeletal system, in relation to which there is a steady increase in the number of dystrophic diseases [RF patent 2674590, publ. 12/11/2018]. Contains by weight. %: chondroitin sulfate – 19.3, glucosamine sulfate – 19.3, dry red wine extract – 9.7, “L-Ornithine” – 9.7, para-aminobenzoic acid – 9.7, calcium ascorbate – 5.8, green tea extract dry – 4.8, food grade zinc citrate – 4.67, aloe vera dry extract – 2.9, grape seed extract – 2.9, rutin – 2.9, quercetin – 2.9, nicotinamide – 1.93, lipoic acid acid – 1.45, copper aspartate – 0.85, bamboo extract – 0.71, pyridoxine hydrochloride – 0.19, thiamine mononitrate – 0.1496, retinol acetate – 0.09, sodium selenite – 0.02, biotin – 0.04, cholecalciferol – 0.0004.

A known food additive [RF patent 2664838, publ. 08/23/2018], which can be used to strengthen bone tissue and prevent osteoporosis. Made in the form of dragees, it contains calcium citrate, drone jelly, vitamin D, plant extracts, including spirulina, immortelle, mint, dandelion, chamomile, licorice, clover, rose hips, dry honey, isomalt, while the components included in its composition are relative to the total mass food additives are made at the following ratio, wt.%: calcium citrate – 13.00-20.60; drone jelly – 0.48-0.68; vitamin D – 0.04-0.10; plant extracts – 1.42-1.70; dry honey – 11.97-19.97, isomalt – 60.02-65.69.

A known composition helps to increase bone density, joint mobility and reduce joint pain [RF patent 2723584, publ. 06/16/2020], which is a dispersed collagen powder from the connective tissue of the Yakut horse and calcium gluconate in a mass ratio of 1:9. At the same time, collagen from the connective tissue of the Yakut horse contains increased amounts of the amino acids glycine, proline and alanine.

A well-known food additive [patent for invention GB 2585619A, publ. 01/20/2021], used to improve metabolism, musculoskeletal system, connective tissue (prototype). Contains vitamins D, E, C, B2, B6, B12, folic acid, L-methylfolate, calcium, magnesium, zinc, copper, selenium, chromium, iodine and black pepper extract. The supplement may additionally include iron, potassium, molybdenum, manganese, biotin, boron, glucosamine, chondroitin, hydrolyzed collagen, hyaluronic acid, methylsulfonylmethane, pantothenic acid, coenzyme Q10, caffeine, fish oil, vitamins A, B1, B3 (niacin) and K , xanthophyll, milk proteins and lactase enzyme, and/or an antioxidant such as grape seed extract. The supplement can be in the form of tablets, capsules or powder.

The above-mentioned known compositions, which are analogues in relation to the claimed technical solution, have disadvantages associated, first of all, with the low efficiency of their use, since they do not take into account that bone tissue is a depot of toxic substances, the accumulation of which becomes a factor preventing its recovery. Therefore, the known compositions do not contribute to the removal of toxic substances and high-quality restoration of bone tissue.

Thus, there is a need for products that, unlike the prior art, are characterized by improved properties that help strengthen and improve the musculoskeletal system.

DISCLOSURE OF THE INVENTION

The objective of the present invention was to create a new food product for bone tissue in the form of a drink that provides an increased content of proteins and other biologically active substances that promote bone tissue repair, as well as containing substances that help accelerate the recovery of bone tissue.

The technical result is the expansion of the arsenal of food products for bone tissue in the form of a drink with higher efficiency, the action of which is aimed at strengthening and maintaining the function of the musculoskeletal system.

The technical result is achieved in that the dry concentrate of the drink for restoring bone tissue contains milk proteins, collagen hydrolysate, vitamins A, B2, B6, C, D, citric acid, minerals calcium, magnesium, potassium, zinc, characterized in that it additionally contains horsetail extract, burdock root extract, propolis extract, pollen, succinic acid, mineral fluorine, rutin, pectin, guar gum, buckwheat flour, vegetable oil and excipients potato starch, flavoring, sucrose, in the following ratio of components, wt. %:

milk proteins 1.0 – 30.0 collagen hydrolyzate 0.5 – 15.0 vitamin A 0.00008 – 0.0016 vitamin B2 0.00016 – 0.0032 vitamin B6 0.0002 – 0.004 vitamin C 0.006 – 0.1200 vitamin D 0.0000005 – 0.00001 routine 0.003 – 0.06 calcium 0.1 – 2.0 magnesium 0.040 – 0.8 potassium 0.350 – 7.0 zinc 0.0015 – 0.03 fluorine 0.0004 – 0.008 lemon acid 0.001 – 0.05 succinic acid 0.005 – 0.1 horsetail extract 0.1 – 10.0 burdock root extract 0.1 – 8.0 propolis extract 0.005 – 0.2 pollen 0.01 – 0.1 pectin 1.0 – 10.0 guar gum 1.0 – 10.0 vegetable oil 1.0 – 10.0 buckwheat flour 0.1– 5.0 potato starch 3.0 – 15.0 flavoring 0.01 – 0.45 sucrose rest

The specified content and ratio of components of the dry drink concentrate for bone tissue restoration is optimal for achieving the technical result. Reducing the quantitative content of components in the composition below or above the specified values will change the balance of the composition and will not provide sufficiently high stimulation of bone tissue repair and acceleration of bone tissue recovery.

The drink for bone tissue has good technological and consumer properties due to the use of only natural ingredients, without synthetic preservatives, thickeners, stabilizers, dyes, while maintaining high organoleptic properties.

Here is a description of the ingredients used.

Milk proteins (milk protein) are a mixture of whey protein and casein. Whey protein is a complete, highly digestible protein that contains all the essential and nonessential amino acids. Whey protein contains essential sulfur-containing amino acids and branched-chain amino acids, which provide whey protein with an optimal protein efficiency ratio. Whey protein is characterized by a high content of the most deficient amino acids - lycine and tryptophan, which are carriers of special protective factors - immunoglobulins. Whey protein lactoferrin prevents the growth of staphylococci, Candida albicans in the body. Products containing whey protein improve the functional state of the main detoxification organs and improve the spectrum of immunoglobulins, increasing the content of IgG, IgA and IgM. It has been proven that the introduction of whey protein into the diet increases glutathione content, promoting a pronounced antioxidant effect. Casein breaks down 2 times slower than whey protein, ensuring a uniform supply of the amino acids it contains to the body. The slow digestibility of casein stops the catabolism of muscle protein. Physiologically active peptides are formed from caseins during digestion. Milk protein provides protection and supports the functions of detoxification organs, participates in phases I and II of the detoxification process. Proteins play a significant role in the detoxification process. A toxicant that enters the bloodstream can interact with proteins and blood cells, thereby changing its toxicokinetic characteristics. The physiological function of albumin is to bind free fatty acids and bilirubin circulating in the blood. These substances can influence the process of interaction of proteins with xenobiotics. Milk proteins contain L-cystine, a sulfur-containing amino acid that ensures the conjugation of intermediate metabolites of toxic substances (phase II of detoxification) necessary for the formation of glutathione. L-cystine is involved in ensuring the elasticity, firmness and texture of the skin, in the detoxification reaction of poisons, due to the content of methyl groups, it ensures liver function, reduces the likelihood of its fatty degeneration as a result of diseases or chemical influences, and exhibits antioxidant properties. High-protein products such as whole milk powder and/or whey protein concentrate, which are characterized by high bioavailability, consisting in the ability to absorb nutrients by the body, a high level of absorption in the intestinal tract and assimilation by cells, are actively used as milk proteins in food products and dietary supplements. .

Collagen is one of the most common proteins in the human body, containing a balanced amino acid complex. Collagen is synthesized by the body independently and is present in almost all its tissues, especially in connective tissues that perform mechanical functions: bones, cartilage, ligaments. Taking exogenous collagen for preventive purposes has a positive effect on the metabolism of cartilage tissue and the regeneration of collagen in bone tissue. Collagen hydrolyzate contains 18 basic amino acids and is identical in amino acid composition to type I collagen of human bones. Collagen hydrolyzate is used as part of nutritional-metabolic therapy for protein-energy deficiency, including injuries, fractures and wounds, reduces pain and inflammation in osteoarthritis and osteoporosis, strengthens joints and ligaments, and accelerates recovery. Collagen hydrolyzate has a higher saturating capacity compared to other proteins (30-50%).

Vitamin A affects lipid metabolism, the processes of their peroxidation, plays an important role in the metabolism of glycoproteins and glycosaminoglycans, affects the state of cell membranes, tissue respiration and energy metabolism, affects the metabolism of amino acids, carbohydrates, the formation of proteins in tissues and adrenal hormones , on the functions of the reproductive and thyroid glands, promotes healing. It is a strong antioxidant and plays a direct biochemical role in the processes of biotransformation of xenobiotics.

Vitamin B2 substrate activates the synthesis of flavin coenzymes, interacts with ATP, forms flavin mononucleotide and flavin adenine dinucleotide, which are involved in proton transfer and regulation of redox processes. Supports the process of phagocytosis, affects the morphology and function of the central and autonomic nervous system. Helps improve glycogen-fixing, antitoxic liver function, increases the sensitivity of liver cells to the action of insulin, promotes insulin incretion. Normalizes the level of bilirubin in the blood (hepatitis A).

Vitamin B6 plays an important role in the metabolism of proteins and fats, promotes the metabolism of tryptophan, methionine, cysteine, glutamic and other amino acids, plays an important role in the metabolism of histamine, is involved in energy production, helps strengthen the immune system and eliminate toxins.

Vitamin C is a powerful antioxidant that can increase the body’s resistance to various adverse factors and influence the processes of biotransformation of poisons. Participates in redox reactions of cells, protects against free radicals, blocks free radical oxidation reactions and restores oxidized compounds, protects cell membranes and, in particular, lymphocytes from the damaging effects of peroxidation, promotes the synthesis of serotonin from tryptophan, increases immunity, stimulates activity endocrine system, central nervous system, promotes iron absorption and normal hematopoiesis, improves the functional state of the liver.

Vitamin D is involved in regulating the differentiation and proliferation of epithelial and hematopoietic cells, suppressing the activation of certain oncogenes and lipid peroxidation processes, as well as reducing angiogenesis (the formation of new blood vessels). Affects the state of the musculoskeletal system - the metabolism of calcium and phosphates, the synthesis of parathyroid hormone, the function of osteoblasts and osteoclasts. Necessary for the prevention of the development of osteoporosis and rickets, rapid regeneration and strengthening of bone tissue.

Rutin is a bioflavonoid with P-vitamin activity, an antioxidant, and an antihypoxant. It has anti-inflammatory, immunomodulatory, bactericidal, antiviral, antispasmodic effects. Strengthens the vascular wall (promote the formation of intercellular substance and reduces the activity of hyaluronidase), reduces the permeability and fragility of capillaries.

Calcium performs plastic and structural functions in the body, is part of the main mineral component of bone tissue - oxyapatite, microcrystals of which form a rigid structure of bone tissue, gives stability to cell membranes, forming bonds between negatively charged groups of phospholipids, structural proteins and glycoproteins, takes part in the implementation intercellular connections that ensure cell adhesion during tissue formation (adhesion process). Calcium is necessary for normal excitability of nervous tissue and contractility of muscle fibers, is an activator of a number of enzymes and hormones, and an essential component of the blood coagulation system. Calcium is also involved in the regulation of the permeability of cell membranes, has an effect opposite to sodium, promotes the removal of heavy metal salts and radionuclides from the body, and exhibits an antioxidant effect.

Magnesium is important for bone tissue, is involved in the activation of amino acids, the synthesis of protein and fatty acids, the phosphorylation of glucose and its derivatives along the glycolytic pathway, and the oxidative decarboxylation of citrate.

Potassium is the main intracellular ion that takes part in the regulation of water, acid and electrolyte balance, and is involved in the processes of conducting nerve impulses. Important for a variety of cellular functions, including growth, muscle contraction, nervous activity and glucose metabolism, peripheral nervous system functions, maintenance of vascular endothelial function, normal blood pressure, acid-base balance in the body, and influence on hormone release.

Zinc is found in all organs and tissues, where its amount varies widely. Skeletal muscles are the richest in zinc, accounting for 62.6% of the total amount of this element. Zinc plays an important role in the synthesis of nucleic acids and proteins, including collagen. Zinc is necessary for bone formation, protects the liver from chemical damage, increases the activity of bone and intestinal phosphatase, participates in the process of preventing the formation of free radicals, and is a strong antioxidant with reparative and regenerative effects. Zinc is involved in the formation of immunity and increases resistance to stress.

Fluorine is known for its ability to effectively replace hydroxyl ion not only in apatite of enamel, dentin of teeth and bone tissue, but also in non-mineralized tissues. The element plays a significant role not only in the initial stages of mineralization of hard tissues, but is also able to prevent their demineralization.

Citric acid belongs to a group of compounds widespread in the plant world - organic acids, characterized by active participation in metabolism. It is an antioxidant, increases the body’s energy potential, and participates in the Krebs cycle along with succinic acid.

Succinic acid is an energy corrector, an antioxidant, participates as a coenzyme in the Krebs cycle, supports reduced glutathione, and enhances the reparative regeneration of hepatocytes.

Horsetail extract saturates the body with biologically active substances: organic acids, tannins, flavonoids, carotene, ascorbic acid, sitosterol, potassium, calcium, magnesium, iron, manganese, copper, zinc, molybdenum, aluminum, selenium, nickel, strontium, iridium. It has anti-inflammatory, hemostatic, disinfectant, epithelializing effects, promotes bone growth after fractures, increases the rate of bone regeneration, and inhibits the activity of osteoclasts.

Burdock root extract saturates the body with biologically active substances: fatty and organic acids, proteins, sterols, dietary fiber, vitamins C and group B. Improves mineral metabolism and has an anti-inflammatory effect.

Propolis extract saturates the body with biologically active substances: tannins, organic acids, flavonoids, vitamins A, C, E, macro- and microelements (manganese, zinc, barium, titanium, copper, tin, nickel, phosphorus, sulfur, molybdenum, chromium, iron, fluorine), amino acids. Propolis has regenerative, anesthetic, antibacterial, antiviral, antifungal, anti-inflammatory, immunostimulating, antioxidant activity. Stimulates metabolism, tissue regeneration, including bone, and the body's defenses.

Flower pollen stimulates the growth and regeneration of damaged tissues, hematopoiesis, enhancing the formation of erythrocytes and leukocytes, normalizes the activity of the nervous and endocrine systems, strengthens capillaries, reduces cholesterol in the blood, regulates and stimulates important internal processes, and has a general strengthening effect.

Pectins are a group of high-molecular polysaccharides that are part of the cell walls and intercellular formations of plants along with cellulose, hemicellulose, and lignin. They are also found in plant cell sap. Pectins are the most important representative of dietary fiber, a natural enterosorbent, which have a pronounced detoxifying effect on the body. They are not digested or absorbed by the body, but are excreted from it along with harmful substances such as heavy metals, radionuclides and other xenobiotics, endotoxins, microbial cells of pathogenic strains and their toxins.

Guar gum, along with pectins, is a representative of dietary fiber, a natural enterosorbent. Dietary fiber improves intestinal microflora, absorption of vitamins and minerals, strengthens local immunity, improves digestion, and promotes the elimination of toxins. Due to its high emulsifying and enveloping ability, guar gum protects the gastrointestinal tract from the damaging effects of toxins and accelerates the elimination of toxic substances.

Vegetable oil is a source of polyunsaturated fatty acids, which normalize the structure and function of cell membranes, improve the capabilities of cellular regulation, help reduce cholesterol in membranes, help maintain immunity, have antioxidant activity, and inhibit lipid peroxidation. Polyunsaturated fatty acids are essential nutritional factors, since they are not synthesized in the body and therefore must be supplied with food.

Buckwheat is a valuable dietary product; it does not contain gluten. Buckwheat fruits are rich in protein and amino acids, in particular tryptophan and lysine, which are essential. Buckwheat proteins are close in value to animal proteins. The biological value of buckwheat is determined by its complex composition. The grain contains protein, starch, fiber, fat, mineral salts of calcium, iron, phosphorus, copper, zinc, boron, iodine, nickel, cobalt, etc. Buckwheat contains organic acids (malic, citric), vitamins A, E, C, PP, P, groups B, K, folic acid, large amounts of fiber. Buckwheat has antioxidant, antimicrobial, anti-inflammatory effects, promotes normal functioning of the gastrointestinal tract, and has a beneficial effect on the immune system and metabolism.

Carbohydrates (sucrose, starch) provide energy and quickly saturate the body. Carbohydrates play an important role in detoxification processes, being a source of energy necessary for the metabolism of xenobiotics.

The balanced and verified composition of the components included in the dry concentrate of the drink for restoring bone tissue in the stated quantitative range ensures the achievement of the above technical result. The choice of balanced ratios of components and quantitative intervals is scientifically justified, taking into account the optimal limits of physiological fluctuations of any pathogenetically justified nutritional and biologically active substance, since both its deficiency and excess are harmful to the human body.

IMPLEMENTATION OF THE INVENTION

The dry concentrate of the drink for restoring bone tissue is obtained in the form of a dry powder mixture, when using which the end consumer can independently prepare the finished dish (without cooking) by adding water and, after restoration, use it as a drink.

In addition, the dry concentrate of the bone tissue restoration drink, obtained in the form of a dry powder mixture, can be prepared and packaged in liquid form directly in the factory - during the production process (adding water to the dry powder mixture).

The raw materials used to obtain the dry drink concentrate for restoring bone tissue are used in the form of standardized dry powders, including dry vegetable oil powder. Raw materials are accompanied by documents confirming their compliance with the current Technical Regulations of the Customs Union TR CU 029/2012. Safety requirements for food additives, flavorings and technological aids (adopted by Decision of the Council of the Eurasian Economic Commission of July 20, 2012 N 58).

The vitamins are included in the bone drink in the following forms, which should not be considered by one skilled in the art to limit the claims of the applicant. Vitamin A is used in the form of retinol, or retinol acetate, or retinol palmitate, or beta-carotene. Vitamin B2 is used in the form of riboflavin, or sodium riboflavin-5-phosphate. Vitamin B6 is used in the form of pyridoxine hydrochloride, or pyridoxine-5-phosphate, or pyridoxine dipalmitate. Vitamin C is used in the form of ascorbic acid, or L-ascorbic acid, or sodium L-ascorbate, or calcium L-ascorbate, or 6-palmityl-L-ascorbic acid (ascorbyl palmitate), or potassium ascorbate. Vitamin D is used in the form of D3 cholecalciferol or D2 ergocalciferol. These vitamins may be included in the bone tissue drink in other forms known to those skilled in the art.

Minerals are included in the dry bone regenerative beverage concentrate in the following forms, which should not be considered by a person skilled in the art to limit the claims of the applicant. Calcium is used in the form of calcium carbonate, or calcium citrate, or calcium gluconate, or calcium glycerophosphate, or calcium lactate, or calcium stearate, or calcium phosphate, or calcium salts of orthophosphoric acid, or calcium chloride, or calcium hydroxide. Magnesium is used in the form of magnesium sulfate, or magnesium stearate, or magnesium carbonate, or magnesium citrate, or magnesium chloride, or magnesium gluconate, or magnesium salts of orthophosphoric acid, or magnesium sulfate, or magnesium lactate, or magnesium hydroxide, or magnesium oxide. Potassium is used in the form of potassium citrate, potassium lactate, potassium salt of orthophosphoric acid, potassium bicarbonate, potassium carbonate, potassium chloride, potassium gluconate, potassium hydroxide. Zinc is used in the form of zinc sulfate 7-hydrate, or zinc sulfate, or zinc chloride, or zinc lactate, or zinc citrate, or zinc gluconate, or zinc oxide. Fluorine is used in the form of potassium fluoride, or calcium fluoride, or sodium fluoride, or sodium monofluorophosphate. These minerals may be included in the bone tissue drink in other forms known to those skilled in the art.

Milk proteins are introduced into the composition of the dry drink concentrate to restore bone tissue in the form of a mixture of whey protein concentrate and whole milk powder, preferably in a proportion of 5:95 to 95:5 parts by weight based on a specific amount of milk proteins, taken within the stated limits quantitative range (wt.%) for milk proteins in the present invention.

The method for producing a dry drink concentrate for bone tissue restoration consists of the following sequential technological steps:

- preparation of raw materials, during which the raw materials are inspected, possible impurities are removed, crushed (if necessary), sifted, weighed;

- mixing components;

- packaging, packaging, labeling, storage and transportation.

The following examples, which are illustrative and not intended to limit the scope of the applicant's claims, describe a method for producing a dry concentrate of a bone tissue restoration drink.

EXAMPLE 1. In the technology for preparing a dry drink concentrate for restoring bone tissue, the raw materials are milk proteins, collagen hydrolyzate, vitamins A, B2, B6, C, D3, rutin, calcium gluconate, magnesium citrate, potassium citrate, zinc sulfate 7-aqueous, sodium fluoride, citric acid, succinic acid, extracts of horsetail, burdock root and propolis, pollen, pectin, guar gum, vegetable oil, buckwheat flour, potato starch, flavoring, sucrose - inspect, remove possible impurities, sifting on vibrating sifters with a built-in magnetic catcher through a mesh with a vibrating sieve hole diameter of 1.0 - 1.5 mm, weighed. Quantitative content of components – per 100 kg of raw materials.

A weighed amount of the prepared components is mixed at room temperature in the order described below.

First, the following mixtures of components are prepared separately using mixers, subjecting the ingredients to mixing until smooth:

- mixture of vitamins: A (retinol palmitate) – 0.00008 kg, B2 (riboflavin) – 0.00016 kg, B6 (pyridoxine hydrochloride) – 0.0002 kg, C (ascorbic acid) – 0.006 kg, D (D3 cholecalciferol) – 0.0000005 kg, rutin – 0.003 kg;

- a mixture of minerals: calcium gluconate (0.1 kg), magnesium citrate (0.040 kg), potassium citrate (0.350 kg), zinc sulfate 7-water (0.0015 kg), sodium fluoride (0.0004 kg);

- the resulting mixture of vitamins and a mixture of minerals are combined, starch (15.0 kg) is added and mixed again until smooth;

- protein mixture: milk proteins (1.0 kg) are obtained by mixing whey protein concentrate (0.05 kg) and whole milk powder (0.95 kg), taken in a proportion of 5:95 parts by weight, to which collagen hydrolyzate is then added (0.5 kg), all ingredients are mixed;

- a mixture of enterosorbents: pectin (10.0 kg) and guar gum (1.0 kg);

- a mixture of the following substances: citric acid (0.001 kg), succinic acid (0.005 kg), horsetail extract (0.1 kg), burdock root extract (8.0 kg), propolis extract (0.005 kg), pollen (0 .01 kg), vegetable oil (10.0 kg), buckwheat flour (5.0 kg).

Then the separately obtained mixtures are combined and their general mixing is performed. To do this, they are loaded into a mixer, sucrose (48.8676595 kg) and flavoring (0.01 kg) are added, and mixed for 25 minutes until the ingredients are evenly distributed throughout the entire volume of products.

The finished product is obtained - a dry concentrate of a drink for restoring bone tissue. Depending on the specified specific conditions for using the product, the dry concentrate of the drink for bone tissue is sent to:

- for packaging and packaging of 20 g in a sealed bag, which requires the end consumer to add 180 - 200 ml of warm water (temperature no higher than 50 ° C) to the contents of the bag, mix thoroughly and consume in liquid form;

- to the technological production site, where in the factory, water is added to the dry concentrate and a drink for bone tissue is prepared in liquid form, which is to be packaged and packaged in an airtight container.

EXAMPLE 2. Dry drink concentrate for bone tissue restoration contains raw materials in the following quantitative values (per 100 kg of raw materials): milk proteins (15.0 kg: whey protein concentrate (7.5 kg) and whole milk powder (7. 5 kg), taken in a proportion of 50:50 parts by weight), collagen hydrolyzate (15.0 kg), vitamin A (beta-carotene) - 0.0011 kg, vitamin B2 (sodium riboflavin-5-phosphate) - 0.008 kg, vitamin B6 (pyridoxine-5-phosphate) – 0.0008 kg, vitamin C (sodium L-ascorbate) – 0.6 kg, vitamin D (D2 ergocalciferol) – 0.000005 kg, rutin (0.03 kg), calcium stearate (1.0 kg), magnesium sulfate (0.4 kg), potassium bicarbonate (2.5 kg), zinc chloride (0.01 kg), potassium fluoride (0.001 kg), citric acid (0.023095 kg) , succinic acid (0.05 kg), horsetail extract (5.0 kg), burdock root extract (4.0 kg), propolis extract (0.01 kg), pollen (0.05 kg), pectin ( 5.0 kg), guar gum (5.0 kg), vegetable oil (5.0 kg), buckwheat flour (2.5 kg), potato starch (7.5 kg), flavoring (0.2 kg), sucrose (31.116 kg). The preparation of raw materials, the order of their mixing, packaging and packing are carried out as in example 1.

EXAMPLE 3. Dry drink concentrate for bone tissue restoration contains raw materials in the following quantitative values (per 100 kg of raw materials): milk proteins (26.0 kg: whey protein concentrate (9.1 kg) and whole milk powder (16.0 kg) 9 kg), taken in a ratio of 35:65 parts by weight), collagen hydrolyzate (3.846 kg), vitamin A (retinol) - 0.001 kg, vitamin B2 (riboflavin) - 0.007 kg, vitamin B6 (pyridoxine dipalmitate) - 0.003 kg, vitamin C (L-calcium ascorbate) – 0.02 kg, vitamin D (D3 cholecalciferol) – 0.000008 kg, rutin (0.009 kg), calcium citrate (0.9 kg), magnesium gluconate (0.6 kg), potassium hydroxide (3.0 kg), zinc citrate (0.025 kg), calcium fluoride (0.0009 kg), citric acid (0.01 kg), succinic acid (0.023092 kg), horsetail extract (0.26 kg ), burdock root extract (2.0 kg), propolis extract (0.009 kg), pollen (0.025 kg), pectin (2.25 kg), guar gum (3.5 kg), vegetable oil (7.5 kg ), buckwheat flour (0.19 kg), potato starch (10.0 kg), flavoring (0.09 kg), sucrose (39.731 kg). The preparation of raw materials, the order of their mixing, packaging and packing are carried out as in example 1.

EXAMPLE 4. Dry drink concentrate for bone tissue restoration contains raw materials in the following quantitative values (per 100 kg of raw materials): milk proteins (30.0 kg: whey protein concentrate (28.5 kg) and whole milk powder (1. 5 kg), taken in a ratio of 95:5 parts by weight), collagen hydrolyzate (7.5 kg), vitamin A (retinol acetate) - 0.0016 kg, vitamin B2 (sodium riboflavin-5-phosphate) - 0.0032 kg , vitamin B6 (pyridoxine hydrochloride) - 0.004 kg, vitamin C (ascorbyl palmitate) - 0.12 kg, vitamin D (D2 ergocalciferol) - 0.00001 kg, rutin (0.06 kg), calcium chloride (2.0 kg) , magnesium hydroxide (0.80 kg), potassium chloride (7.0 kg), zinc gluconate (0.03 kg), sodium monofluorophosphate (0.008 kg), citric acid (0.05 kg), succinic acid (0.1 kg), horsetail extract (10.0 kg), burdock root extract (0.1 kg), propolis extract (0.2 kg), pollen (0.1 kg), pectin (1.0 kg), guar gum (10.0 kg), vegetable oil (1.0 kg), buckwheat flour (0.1 kg), potato starch (3.0 kg), flavor (0.45 kg), sucrose (26.37319 kg). The preparation of raw materials, the order of their mixing, packaging and packing are carried out as in example 1.

The invention allows us to expand the arsenal of food products for restoring bone tissue in the form of a drink that has higher efficiency:

- is a balanced, easily digestible nutrition, including enteral, for restoration (regeneration) of bone and cartilage tissue in case of injuries, fractures, cracks, operations involving bone tissue and diseases of the musculoskeletal system, including osteoporosis;

- improves the functional state of bone tissue, increases the mechanical strength of bone tissue, provides nutritional and metabolic support and improves metabolic processes in the body, helps prevent protein-energy deficiency;

- has a general strengthening effect, reduces inflammation, improves overall well-being, reduces the frequency of complications, accelerates bone tissue regeneration, reduces the formation of callus, reduces intoxication, has an antioxidant effect, relieves destructive oxidative stress, and ensures the functioning of the Krebs cycle.

The drink for bone tissue can be used in complex therapy for bone injuries (fractures) and diseases of bone tissue, including osteoporosis.

Claims (2)

Dry drink concentrate for bone tissue restoration, containing milk proteins, collagen hydrolyzate, vitamins A, B2, B6, C, D, citric acid, minerals calcium, magnesium, potassium, zinc, characterized in that it additionally contains horsetail extract, extract burdock root, propolis extract, pollen, succinic acid, mineral fluorine, rutin, pectin, guar gum, buckwheat flour, vegetable oil and excipients potato starch, flavoring, sucrose, in the following ratio of components, wt.%: milk proteins 1.0 – 30.0 collagen hydrolyzate 0.5 – 15.0 vitamin A 0.00008 – 0.0016 vitamin B2 0.00016 – 0.0032 vitamin B6 0.0002 – 0.004 vitamin C 0.006 – 0.1200 vitamin D 0.0000005 – 0.00001 routine 0.003 – 0.060 calcium 0.1 – 2.0 magnesium 0.040 – 0.8 potassium 0.350 – 7.0 zinc 0.0015 – 0.03 fluorine 0.0004 – 0.008 lemon acid 0.001 – 0.05 succinic acid 0.005 – 0.1 horsetail extract 0.1 – 10.0 burdock root extract 0.1 – 8.0 propolis extract 0.005 – 0.2 pollen 0.01 – 0.1 pectin 1.0 – 10.0 guar gum 1.0 – 10.0 vegetable oil 1.0 – 10.0 buckwheat flour 0.1– 5.0 potato starch 3.0 – 15.0 flavoring 0.01 – 0.45 sucrose rest