RU2803777C1 - Voscosap wax ointment - Google Patents

Abstract

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to compositions for external use for flaccid granulating wounds, purulent wounds, frostbite, burns, trophic ulcers. The antiseptic agent in the form of an ointment contains beeswax, refined olive oil and powdered sugar in the following ratio of components, wt.%: 50 of wax, 40 of refined olive oil and 10 of powdered sugar.

EFFECT: proposed ointment promotes the maturation of granulation tissue, epithelial proliferation and reduces wound healing time.

1 cl, 2 ex

Description

The invention relates to medicine, namely to compositions for external use for flaccid granulating wounds, purulent wounds, frostbite, burns, trophic ulcers. According to the All-Russian Surgical Forum (2018), patients with purulent-inflammatory diseases of the skin and subcutaneous tissue account for more than 40% of surgical departments; about 30% of the bed capacity of surgical hospitals in Russia. According to a number of authors (Bubnova N.A. et al., 2008), erysipelas of the lower extremities ranks second in the structure of all surgical infections. Frequent relapses and an increase in severe (hemorrhagic and bullous) forms of erysipelas up to 70-80% make the study of this pathology relevant. https://cyberleninka.ru/article/n/sovremennyy-vzglyad-na-problemu-pathogeneza-i-lecheniya-rozhistogo-vospaleniya/viewer

Wax ointment contains a composition of pure wax, olive vegetable oil and powdered sugar in a certain mass. proportions. The use of this ointment does not cause an allergic reaction, quickly relieves tissue swelling, and promotes rapid maturation of granulation tissue to close the wound defect; is plastic; has increased penetrating ability. As a prototype, we have chosen an antiseptic in the form of an ointment containing wax, vegetable oil and sterile glycerin in the ratio of components, wt.%: wax 14 - 15; sterile glycerin 3 - 4; vegetable oil - the rest. https://yandex.ru/patents/doc/RU95110153A1_19970620

The proposed composition for external use has the following disadvantages: it has less bioimmunological activity, the complexity of the technological process in the manufacture of this composition (boiling for 5-6 minutes), which also reduces the bioimmunological activity; contains a significantly smaller amount of oleic acid and vitamin K, necessary for the synthesis of proteins that ensure normal levels of blood coagulation and tissue repair.

Propolis ointment is known, containing fat-soluble propolis with the addition of boiled water. However, fat-based ointment is not acceptable in the early stages of wound healing. https://findpatent.ru/patent/215/2155597.html

There is an ointment with propolis and a base containing polyethylene oxide with a mol. m. 400 and 1500 and preservatives: nipagin and nipazole. The product is intended for the treatment of wounds. This ointment contains chemicals in its composition, and the contact of propolis with the affected area in ointment forms is less long than in the proposed dosage form. https://www.freepatent.ru/patents/2135159

“Benin” ointment is known for the treatment of purulent and infected wounds of various etiologies, consisting of fir oil, propolis, resin, spermaceti and penguin fat (RU, patent No. 2058776, class A 61 K 9/06, 1995). This ointment can be used to treat purulent and infected wounds of various etiologies, but is not intended for the treatment of burns; in addition, it includes penguin fat, the availability and raw material base of which is limited.

The objective of the present invention is to create an antiseptic composition with increased bioimmunological activity in the case of an allergic history to antiseptics of non-natural origin obtained by chemical means.

The antiseptic agent we offer in the form of an ointment according to the technical solution contains the following components: beeswax, refined olive oil and powdered sugar in the following ratio of components, wt.%: wax 40-50; refined olive oil - 30-40 and powdered sugar - 5-10. The ability of powdered sugar to absorb excess moisture and dry the wound as part of the composition makes it possible to quickly stop signs of inflammation, because microorganisms die from dehydration. Thus, granulation tissue matures faster, the wound defect heals, and complete epithelization of wounds occurs. Refined olive oil contains significant amounts of oleic acid (a monounsaturated omega-9 fatty acid) and vitamins that have a powerful antioxidant effect, suppressing the activity of pro-inflammatory cytokines and the inflammatory focus itself. Wax, of all production products, has the least ability to respond to its use and is a source of obtaining a large number of biologically active compounds necessary for reparative regeneration and wound healing.

The proposed antiseptic is prepared as follows. The beeswax is melted in a water bath until completely dissolved, refined olive oil and powdered sugar are added. Mix until a homogeneous mass is obtained and boil for 2 minutes. There is no need to strain the hot mixture. It is poured hot into forms of the required configuration and volume (jars, tubes, etc.) for subsequent cooling naturally. The result is a packaged ointment.

The ointment is stored in a dark, cool place for up to 5 years, without loss of initial activity. The ointment at room temperature is a homogeneous composition of a solid consistency of dark yellow color. When in contact with the body or heated above 25°C, the ointment softens and becomes plastic. Insoluble in water and alcohol. Non-toxic. Contraindication for use is individual intolerance to the components of the ointment (allergy).

Apply a thin layer of cooled ointment to the wound surface using a medical spatula. This remedy for the treatment of wounds has a pronounced regenerating effect, has an anti-inflammatory, anti-edematous, trophic effect and stimulates the processes of reparative regeneration of integumentary tissues. Examples of practical use of the proposed wax ointment “Voskosap”:

Example 1.

Patient A., 49 years old. She was admitted as an emergency to the surgical department on May 20, 2022 with a diagnosis of erysipelas of the left leg. Mixed form (Erythematous-bullous). Recurrent course. Obesity 2 degrees.

Locally upon admission: on the anterior surface of the left leg there was hyperemia, swelling, weeping, a wound with a diameter of 14 cm from opened blisters (bullas), pain on palpation. In the surgical department, dressings were performed with this wax ointment “Voskosap” every day, 2 times a day. A thin layer of cooled ointment was applied to the wound surface using a medical spatula. After 4 days, swelling, hyperemia, and pain decreased significantly, and the wound defect was reduced by 2 times. On 05/27/22 the patient was discharged in satisfactory condition, the wound defect was completely closed.

Example 2.

Patient N., 58 years old, was admitted urgently on September 10, 2022 with a trophic ulcer in the lower third of the right leg, pain, swelling of the tissues surrounding the ulcer. Diagnosis: Chronic venous disease of the lower extremities C2,3,4,6S,Ep,As,Pr;09/22/2022;LI. CVI degree II. Diabetes mellitus type 2, compensation.

Locally upon admission: on the anterior surface in the lower third of the right leg there was a trophic ulcer 10 cm in diameter, with undermined edges, with a coating of fibrin. Around the ulcer there is hyperemia, tissue swelling, pain on palpation. In the surgical department, dressings were performed with this wax ointment “Voskosap” every day, 2 times a day. A thin layer of cooled ointment was applied to the wound surface using a medical spatula. After 7 days, swelling, hyperemia, and tissue tenderness disappeared, the trophic ulcer significantly decreased in diameter, amounting to 4 cm. On September 24, 2022, the trophic ulcer completely closed and epithelialized; the patient was discharged in satisfactory condition,

The proposed wax ointment “Voskosap” for local treatment of wounds was introduced at the base: “Private healthcare institution “Clinical Hospital” Russian Railways-Medicine”, Tyumen.” This remedy was used in 7 patients with trophic ulcers, 5 patients with a mixed form of erysipelas (erythematous-bullous), and 3 patients with bedsores. It should be noted that tissue regeneration in patients who used the new agent was more pronounced, complete wound healing was noted on average 5-7 days faster than in patients who did not use the proposed agent for local treatment of wounds.

Thus, the proposed Voskosap ointment accelerates the development of young granulation tissue, epithelial proliferation, promotes the rejection of necrotic tissue, and reduces wound healing time.

From the patent and scientific and technical literature, we do not know of medicinal ointments containing the combination of the above ingredients in the proposed quantitative ratio, which allows us to draw a conclusion about the novelty of the proposed technical solution.

Claims (1)

Antiseptic agent in the form of an ointment containing beeswax, refined olive oil and powdered sugar in the following ratio of components, wt.%: beeswax - 50, refined olive oil - 40 and powdered sugar - 10.