RU2800282C1 - Cleansing foam for surface treatment of facial prostheses - Google Patents

Abstract

FIELD: hygiene and medicine.

SUBSTANCE: invention relates to the hygienic treatment of facial prostheses. Foam cleansing for surface treatment of facial prostheses is proposed, the said foam cleansing contains the following components in its composition, wt.%: 10.0 of sodium cocoamphoacetate (Sodium Cocoamphoacetate); 5.0 of Isopentyldiol (Isopentyldiol); 5.0 of sodium laureth-5 carboxylate; 3.0 of 1,2-pentadiol (Pentylene Glycol); 0.9 of phenoxyethanol with glyceryl laurate (Phenoxyethanol, Glyceryl Laurate); and up to 100.0 of deionized water (Deionized Water/Aqua).

EFFECT: invention provides effective cleaning of dental and facial prostheses from physical and biological contaminants. The proposed composition does not irritate the mucous membranes of the mouth and skin of patients with combined defects of the face and jaws. The treatment of prostheses with the proposed foam reduces the adhesion index of oral microorganisms to the material of prostheses.

1 cl, 2 ex

Description

The invention relates to the field of medical hygiene, and in particular to dentistry, and can be used to remove surface contaminants and microbiological biofilms from the surface of a facial prosthesis after its use.

The prior art composition for disinfection of removable dentures containing cetrimide, silver ions, water, characterized in that it additionally contains chitosan succinate, a stabilizer and a fragrance, and silver ions obtained by electrolytic diffusion from a silver electrode, and cetrimide are taken at the following content of components, wt.%: cetrimide - 0.45-2.2; silver ions - 0.0008-0.002; chitosan succinate - 0.008-1.7; fragrance "Cranberry" - 0.009-2.2; stabilizer - 0.9-3.2; water - the rest (RF Patent No. 2476199 dated February 27, 2015).

There are special means for cleaning removable dentures, mainly imported in the form of antiseptic soluble tablets, for preparing solutions, for example, Protefix, etc., which have a high cleaning ability and a short exposure time of 10-15 minutes. (Hygiene in dental prosthetics: Textbook / Ulitovsky S.B., - 2nd ed. - M.: MEDpress-inform, 2009. - 112 p.). The composition of the special means "Protefix" includes: sodium bicarbonate - 41.77%; potassium caroate - 35.18%; sodium perborate - 16.63%; citric acid - 5.65%; sodium lauryl sulfate - 0.47%; peppermint (peppermint oil + mint oil) - 0.3%; indigo dye Cl 73015 - 0.07%.

A known method of hygienic treatment and disinfection of removable dentures, maxillofacial prostheses and splints using mechanical cleaning and disinfection with antibacterial drugs, characterized in that an aqueous solution based on a low molecular weight cationic peptide warnerin with a concentration of 60 mg/ml is used as a disinfectant, in which removable dentures or splints are immersed for 20-30 minutes, followed by rinsing under running water; the frequency of treatment in a solution of varnerin peptide is 2-3 times a week (RF Patent No. 2739029 dated 12/21/2020).

Known disinfectant for disinfection of removable dentures containing in its composition, wt.%: sodium hypochlorite 0.3-0.6; sodium lauryl sulfate - 0.3-0.5; polyvinylpyrrolidone - 2.0-3.0; sodium silicate - 0.2-2.0; water - the rest up to 100, characterized in that the specified disinfectant is applied with a toothbrush on the denture for 15-20 minutes, followed by placing the denture in a container with water, in which 3% hydrogen peroxide is poured from a dropper to carry out a chemical reaction with the release of highly bactericidal active singlet oxygen, solutions of sodium hypochlorite and hydrogen peroxide are taken in a ratio of 8:1 by volume (Patent RU No. 248181 8, dated 11/16/2019).

Known tablets for cleaning dentures Corega Corega Bio Formula, consisting of: Sodium Bicarbonate, Citric Acid, Potassium Caroate (Potassium Monopersulfate), Sodium Carbonate, Sodium Carbonate Peroxide, TAED, Sodium Benzoate, PEG-180, Sodium Lauryl Sulfate, VP / VA Copolymer, Aroma, Cellulose Gum, CI 42090, CI 73015 .

The disadvantages of these funds is their aggressiveness in relation to structural materials (silicone) used in the technology of production of facial prostheses.

From the prior art, a therapeutic and prophylactic composition for caring for teeth and oral cavity is known, containing sodium fluoride, sodium lauryl sulfate, polyvinylpyrrolidone, panthenol, saccharin, fragrance and water, characterized in that it additionally contains lauryl, glucoside, cocamidopropyl betaine, phytopain, propolis extract in the following ratio, wt.%: sodium fluoride 0.05-0.15; sodium lauryl sulfate 3.0-10.0; lauryl glucoside 1.0-6.0; cocamidopropyl betaine 1.0-6.0; polyvinylpyrrolidone 0.05-1.0; panthenol 0.05-0.5; phytopain 0.05-1.0; propolis extract 0.1-1.0; saccharin 0.2-1.5; fragrance 0.1-1.0; water up to 100 (RF Patent No. 2423100 dated 07/10/2011).

The problem to be solved by the invention is the selection of the ratio of components and the development of a hygienic product for the care of facial prostheses, in particular those made by 3D printing.

The technical result of the invention is the effective cleaning of dental and facial prostheses from physical and biological contaminants, the composition of the proposed composition, non-irritating action on the mucous membranes of the mouth and skin of patients with combined defects of the face and jaws.

The technical result is achieved by the fact that the cleansing foam for surface treatment of facial prostheses contains, wt. %: sodium cocoamphoacetate (Sodium Cocoamphoacetate) - 10.0; Isopentyldiol (Isopentyldiol) - 5.0; Laureth-5 sodium carboxylate (Sodium Laureth-5 Carboxylate) - 5.0; 1,2-pentadiol (Pentylene Glycol) - 3.0; phenoxyethanol with glyceryl laurate (Phenoxyethanol, Glyceryl Laurate) - 0.9; deionized water (Deionized Water / Aqua) - up to 100.0.

Deionized water (Deionized Water / Aqua) - water purified from ion impurities in the reverse osmosis process. Such water has a high resistivity. Promotes the dissolution of active ingredients in the composition, is the carrier of the composition.

Sodium Cocoamphoacetate (Sodium Cocoamphoacetate) is an ultra-soft amphoteric surfactant, foaming agent, cleaning and conditioning agent. An aqueous solution of an amphoteric surfactant derived from coconut oil fatty acids. It has good foaming ability, solubilizes and stabilizes fat soluble/aromatic ingredients. It contributes to the effective cleaning of the surface of the facial prosthesis in the composition, without affecting its structure, works in combination with sodium laureth-5 carboxylate, isopentyldiol.

Isopentyldiol (Isopentyldiol) - brings a number of advantages for formulas: provides easier addition of hydrophilic active substances in anhydrous formulas and lipophilic additives in aqueous systems; has good solvent power, is a foam stabilizer and a carrier for fragrance formulations in oral care products; promotes transparency and dispersion aid for polymers in aqueous gels; creates unique sensory sensations on the skin from the use of hygiene products, skin care products and decorative cosmetics; provides effective skin hydration and foaming and thickening properties in surfactant systems with SLES. It contributes to the effective cleaning of the surface of the facial prosthesis in the composition, without affecting its structure, works in combination with sodium laureth-5 carboxylate, sodium cocoamphoacetate.

Sodium Laureth-5 Carboxylate is an alkyl ethoxycarboxylate, a high-foaming cryptoanionic surfactant, compatible with various surfactants, improves the dermatological softness of the finished product, enhances foaming, increases density and stabilizes the foam, has a thickening effect, the scope is mild cleansers. It contributes to the effective cleaning of the surface of the facial prosthesis in the composition, without affecting its structure, works in combination with sodium cocoamphoacetate, isopentyldiol.

1,2-Pentadiol (Pentylene Glycol) is a multifunctional product with a proven safety profile, enhancing the action of the active ingredients of the formulation, improving the aesthetics and sensory profile of finished products. Provides antimicrobial protection, has a moisturizing effect, suitable for patients with sensitive skin. The composition uses pentylene glycol of green origin.

Phenoxyethanol with glyceryl laurate (Phenoxyethanol, Glyceryl Laurate) is a mixture of a preservative (phenoxyethanol (80.5%) with a naturally occurring emollient (glyceryl laurate). It is used as a preservative for rinse-off and leave-in cosmetic products, for example, systems with surfactants, hair conditioners, creams, lotions, etc. Suitable for most formulations, compatible with most ingredients, including cationic, Anionic and ionic surfactants Soluble in polar organic solvents and slightly soluble in water Allows formulating with lower concentrations of preservative agents while providing optimal protection to the finished product and minimizing possible unwanted side effects such as skin irritation or sensitization Promotes preservation in the composition (together with other formulation ingredients) and enhances antimicrobial protection during surface treatment of facial prostheses

Cleansing foam for the care of facial prostheses is made as follows:

The proposed foam is prepared by mixing its ingredients in proportions corresponding to the invention. First, deionized water at 25°C is poured into the mixing vessel (reactor), then 1,2-pentadiol and isopentyldiol are added sequentially with stirring, and stirred until a homogeneous solution is obtained. Next, sodium cocoamphoacetate (with a deduction of % for solubilization of the preservative mixture), sodium laureth-5 carboxylate are sequentially introduced into the reactor with stirring and stirred until homogeneous, then a mixture of phenoxyethanol with glyceryl laurate pre-mixed 1:5 with sodium cocoamphoacetate. The whole process of preparing the foam takes 30 minutes. The mass is allowed to settle. Then, after performing the physicochemical and organoleptic analysis of the sample, the mass of the foam is transferred to the collection, from where it is distributed into small containers made of plastic that is compatible with the contents in terms of physicochemical properties (for example, polyfluoroethylene, polyvinyl chloride). The container is a bottle of individual use (usually for 50 ml of the composition) easily held in the hand, equipped with a device for supplying the filled mass of foam through the dispensing nozzle.

Clinical example 1

A patient came to the clinic with the absence of the auricle, traumatic genesis. The epithesis of the auricle was made for the patient by the method of three-dimensional printing from photopolymerization silicone material. The patient used the prosthesis for a week, fixing it once a day with a medical grade silicone adhesive. Every day before going to bed, the prosthesis was treated with the developed hygienic composition by applying foam to the surface of the prosthesis adjacent to the patient's skin with an exposure of 2 minutes, after which the prosthesis was washed under warm running water. When wearing prostheses with regular use of the composition for their cleaning, the irritating effect of the skin was not revealed, on the contrary, a positive effect on the skin was observed, in particular, the removal of previously existing irritations. After a week of use, microscopic examination of the prostheses showed no traces of adhesive glue. Also, facial prostheses after use were studied for adhesion of oral microorganisms, the control group consisted of samples of structural material that were not treated with a hygienic composition. According to the obtained results, the index of adhesion of the studied microorganisms to the starting material is determined as low and was not more than 0.281 ( St. aureus ATCC 6538). The treatment of prostheses with the proposed foam reduced the adhesion index to zero results.

Clinical example 2

A patient came to the clinic with a complete absence of teeth, previously prosthetic with removable dentures. When examining the oral cavity, foci of aphthous stomatitis were revealed under the prostheses of the upper and lower jaws. When assessing the hygienic state of prostheses according to the index of dental plaque of a removable denture - the Index of Jeganathan et al. (1996) found more than 75% of the painted surface, which corresponds to a severe form of pollution. Every day before going to bed, the prosthesis was treated with the developed hygienic composition by applying foam to the surface of the prosthesis adjacent to the mucous membranes of the patient's mouth with an exposure of 3 minutes, after which the prosthesis was washed under warm running water. When wearing prostheses with regular use of the composition for their cleaning, the irritating effect of the oral mucosa was not revealed, on the contrary, the disappearance of foci of aphthous stomatitis was observed. After a week of use, the presence of plaque on the prosthesis was not observed, when assessing the hygienic state of the prostheses according to the plaque index, no staining was detected.

Claims (2)

Cleansing foam for surface treatment of facial prostheses, containing in its composition, wt.%: Sodium Cocoamphoacetate (Sodium Cocoamphoacetate) 10.0 Isopentyldiol (Isopentyldiol) 5.0 Laureth-5 sodium carboxylate (Sodium Laureth-5 Carboxylate) 5.0 1,2-pentadiol (Pentylene Glycol) 3.0 Phenoxyethanol with glyceryl laurate (Phenoxyethanol, Glyceryl Laurate) 0.9 Deionized water (Deionized Water/Aqua) Up to 100.0