RU2799937C1 - Composition for the care of facial prostheses - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to the means of hygienic treatment of facial prostheses, that is epitheses. The proposed composition for the care of facial prostheses is characterized by containing, wt.%: 10.0 of an aqueous extract from the wood of the trunk of Scotch pine, subspecies Pinus sylvestris var. Mongolica (Pinus Sylvestris Trunk Water), 2.0 of lactobacillus lysate (Lactobacillus Ferment Lysate), 1.0 of fermented licorice extract (Glycyrrhiza glabra Fermented Filtrate), 3.0 of 1,2-pentanediol (pentylene glycol), 3.0 of sorbitol, 1.0 of sodium cocoamphoacetate, 0.7 of hydroxyacetophenone, up to 100.0 of deionized water.

EFFECT: effective cleaning of facial prostheses from physical and biological contaminants, the composition of a soft, non-irritating effect on the mucous membranes and skin of patients with combined defects of the face and jaws.

1 cl, 1 ex

Description

The invention relates to the field of hygiene medicine, and in particular for the hygienic treatment of facial prostheses - epitheses.

The prior art composition for disinfection of removable dentures containing cetrimide, silver ions, water, characterized in that it additionally contains chitosan succinate, a stabilizer and a fragrance, and silver ions obtained by electrolytic diffusion from a silver electrode, and cetrimide are taken at the following content of components, wt.%: cetrimide - 0.45-2.2; silver ions - 0.0008-0.002; chitosan succinate - 0.008-1.7; fragrance "Cranberry" - 0.009-2.2; stabilizer - 0.9-3.2; water - the rest (RF Patent No. 2 476 199 dated February 27, 2015).

There are special means for cleaning removable dentures, mainly imported in the form of antiseptic soluble tablets, for preparing solutions, for example, Protefix and others, which have a high cleaning ability and a short exposure time of 10-15 minutes (Hygiene in dental prosthetics: Textbook / Ulitovsky S.B., - 2nd ed. - M .: MEDpress-inform, 2009. - 112 p.). The composition of the special means "Protefix" includes: sodium bicarbonate - 41.77%; potassium caroate - 35.18%; sodium perborate - 16.63%; citric acid - 5.65%; sodium lauryl sulfate - 0.47%; peppermint (peppermint oil + mint oil) - 0.3%; indigo dye Cl 73015 - 0.07%.

A known method of hygienic treatment and disinfection of removable dentures, maxillofacial prostheses and splints using mechanical cleaning and disinfection with antibacterial drugs, characterized in that an aqueous solution based on a low molecular weight cationic peptide warnerin with a concentration of 60 mg/ml is used as a disinfectant, in which removable dentures or splints are immersed for 20-30 minutes, followed by rinsing under running water; the frequency of treatment in a solution of varnerin peptide is 2-3 times a week (RF Patent No. 2739029 dated 12/21/2020).

Known disinfectant for disinfection of removable dentures containing in its composition, wt.%: sodium hypochlorite 0.3-0.6; sodium lauryl sulfate - 0.3-0.5; polyvinylpyrrolidone - 2.0-3.0; sodium silicate - 0.2-2.0; water - the rest up to 100, characterized in that the specified disinfectant is applied with a toothbrush on the denture for 15-20 minutes, followed by placing the denture in a container with water, in which 3% hydrogen peroxide is poured from a dropper to carry out a chemical reaction with the release of highly bactericidal active singlet oxygen, solutions of sodium hypochlorite and hydrogen peroxide are taken in a ratio of 8:1 by volume (Patent RU No. 24818 18, dated 11/16/2019).

Known tablets for cleaning dentures Corega Corega Bio Formula, consisting of: Sodium Bicarbonate, Citric Acid, Potassium Caroate (Potassium Monopersulfate), Sodium Carbonate, Sodium Carbonate Peroxide, TAED, Sodium Benzoate, PEG-180, Sodium Lauryl Sulfate, VP / VA Copolymer, Aroma, Cellulose Gum, CI 42090, CI 73015 .

The disadvantages of these funds is their aggressiveness in relation to structural materials (silicone) used in the technology of production of facial prostheses.

From the prior art, a therapeutic and prophylactic composition for caring for teeth and oral cavity is known, containing sodium fluoride, sodium lauryl sulfate, polyvinylpyrrolidone, panthenol, saccharin, fragrance and water, characterized in that it additionally contains lauryl, glucoside, cocamidopropyl betaine, phytopain, propolis extract in the following ratio, wt.%: sodium fluoride 0.05-0.15; sodium lauryl sulfate 3.0-10.0; lauryl glucoside 1.0-6.0; cocamidopropyl betaine 1.0-6.0; polyvinylpyrrolidone 0.05-1.0; panthenol 0.05-0.5; phytopain 0.05-1.0; propolis extract 0.1-1.0; saccharin 0.2-1.5; fragrance 0.1-1.0; water up to 100 (RF Patent No. 2423100 dated 07/10/2011).

The problem to which the invention is directed is the development of a hygienic product for the care of facial prostheses, in particular those made by 3D printing.

The technical result of the invention is the effective cleaning of facial prostheses from physical and biological contaminants, the composition of a soft, non-irritating effect on the mucous membranes and skin of patients with combined defects of the face and jaws.

The technical result is achieved by the fact that the composition for the care of facial prostheses, contains in its composition, wt.%: an aqueous extract from the wood of the trunk of Scotch pine, subspecies Pinus sylvestris var. Mongolica (Pinus Sylvestris Trunk Water) - 10.0; Lysate of lactobacilli (Lactobacillus Ferment Lysate) - 2.0; Fermented licorice extract (Glycyrrhiza glabra Fermented Filtrate) - 1.0; 1,2-pentanediol (pentylene glycol) - 3.0; Sorbitol - 3.0; Sodium cocoamphoacetate - 1.0; Hydroxyacetophenone - 0.7; Deionized water - up to 100.0.

Deionized water (Deionized Water / Aqua) - water purified from ion impurities in the process of reverse osmosis. Such water has a high resistivity. Promotes the dissolution of active ingredients in the composition, is the carrier of the composition.

Water extract from the wood of the Scots pine trunk (Pinus Sylvestris Trunk Water - subspecies of Pinus sylvestris var. Mongolica). It has cleansing, tonic properties, is able to reduce transepidermal water loss. Contains more than 50 individual components characteristic of the wood of plants of the Pine family (Pinaceae), exhibiting antimicrobial and antiviral activity, antifungal effect. Promotes antimicrobial, antiviral and antifungal protection in the composition. Creates a light aromatization of the product.

Pentylene glycol (Pentylene Glycol) - 1,2-pentadiol, synthetic low molecular weight solvent, moisturizing ingredient, enhancer with antimicrobial action. It contributes to preservation in the composition (together with other ingredients of the composition), enhances antimicrobial protection during the processing of prostheses.

Sorbitol is a six-hydric aliphatic alcohol with a sweet taste. Moisturizing, softening component. In the composition, it is an auxiliary moisturizing component that improves the sensory characteristics of the product.

Lactobacillus Ferment Lysate - a moisturizing component, stimulates the natural synthesis of collagen and elastin, prevents swelling and effectively restores cell immunity, effectively normalizes the microflora, enhances the skin's ability to regenerate. It affects the composition of the skin microbiome, and also activates the activity of dermal structures. In the composition, it contributes to the normalization of microflora, restoration of the skin microbiome.

Fermented licorice extract (Glycyrrhiza glabra Fermented Filtrate) - a bioavailable licorice root extract is used to promote wound healing. Licorice root extracts protect the skin from oxidative stress, accelerate wound epithelization, improve remodeling at the wound site, and effectively reduce the symptoms of atopic dermatitis. Shows antimicrobial, anti-inflammatory, antioxidant properties. Contains a wide range of bioactive compounds: glycyrrhizin, glabridin, licochalcone, isoliquiritigenin. In the composition, it contributes to the normalization of the skin microbiome, prevents the adhesion of microbiological biofilms on the surface of the prosthesis, destroying their integrity.

Sodium Cocoamphoacetate (Sodium Cocoamphoacetate) is an ultra-soft amphoteric surfactant, foaming agent, cleaning and conditioning agent. An aqueous solution of an amphoteric surfactant derived from coconut oil fatty acids. It has good foaming ability, solubilizes and stabilizes fat-soluble/aromatic ingredients, promotes the dissolution and stabilization of active ingredients in the composition.

Hydroxyacetophenone (Hydroxyacetophenone) is a patented multifunctional component identical to the natural one found in cloudberries growing in the Alpine region.

Increases the effectiveness of preservatives in various cosmetic formulations, antioxidant, has a calming and anti-inflammatory effect. It contributes to the antibacterial and antioxidant protection of the product in the composition.

Composition for care of facial prostheses is produced as follows:

The proposed composition is prepared by mixing its ingredients in proportions corresponding to the invention. First, deionized water at 25°C is poured into the mixing vessel (reactor), then sorbitol, 1,2-pentanediol, hydroxyacetophenone, previously diluted in a separate vessel in deionized water at a temperature of 50°C and at a mass ratio of acetophenone: water of 1:10, are introduced sequentially with stirring. Stir until a homogeneous solution. Next, sodium cocoamphoacetate, an aqueous extract from the wood of a pine trunk, a lysate of lactobacilli, and a fermented licorice extract are sequentially introduced into the reactor with stirring. The solution is stirred until homogeneous.

The entire process of preparing the composition takes 30 minutes. The mass is allowed to settle, if necessary, filtration is carried out. Then, after performing the physicochemical and organoleptic analysis of the sample, the mass of the composition is transferred to the collection, from where it is distributed into small containers made of plastic that is compatible with the contents in terms of physicochemical properties (for example, polyfluoroethylene, polyvinyl chloride). The container is a bottle of individual use (usually 50 ml of the composition) easily held in the hand, equipped with a device for spraying the refilled mass.

Clinical example

A patient came to the clinic with the absence of the auricle, traumatic genesis. The epithesis of the auricle was made for the patient by the method of three-dimensional printing from photopolymerization silicone material. The patient used the prosthesis for a week fixing it once a day with a medical grade silicone adhesive. Every day before going to bed, the prosthesis was treated with the developed hygienic composition by spraying on the surface of the prosthesis adjacent to the patient's skin with an exposure of 2 minutes, after which the prosthesis was washed under warm running water. When wearing prostheses with regular use of the composition for their cleaning, the irritating effect of the skin was not revealed, on the contrary, a positive effect on the skin was observed, in particular, the removal of previously existing irritations. After a week of use, microscopic examination of the prostheses showed no traces of adhesive glue. Also, facial prostheses after use were studied for adhesion of oral microorganisms, the control group consisted of samples of structural material that were not treated with a hygienic composition. According to the obtained results, the index of adhesion of the studied microorganisms to the starting material is determined as low and was not more than 0.281 ( St. aureus ATCC 6538). Treatment of prostheses with the proposed composition reduced the adhesion index to zero results.

Claims (2)

Composition for the care of facial prostheses, characterized in that it contains, wt.%: Water extract from the wood of the trunk of Scotch pine, subspecies Pinus sylvestris var. Mongolica (Pinus Sylvestris Trunk Water) 10.0 Lactobacillus lysate (Lactobacillus Ferment Lysate) 2.0 Fermented Licorice Extract (Glycyrrhiza glabra Fermented Filtrate) 1.0 1,2-pentanediol (pentylene glycol) 3.0 Sorbitol 3.0 Sodium cocoamphoacetate 1.0 Hydroxyacetophenone 0.7 Water deionized Up to 100.0