RU2726465C1 - Method of treating withdrawal syndrome in alcoholism - Google Patents

Abstract

FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to addictology. To treat manifestations of withdrawal syndrome in alcoholism, biologically active points of acupuncture are exposed to high-frequency electromagnetic radiation in range of 59–61 GHz. Exposure is performed for 15–20 minutes sequentially on each of three-four points selected according to prevailing symptoms. It involves 4–8 procedures per therapeutic course.EFFECT: method provides higher clinical effectiveness ensured by overall systemic and more accurate effects on withdrawal symptoms.1 cl, 3 tbl, 3 ex

Description

The invention relates to medicine, namely to narcology, and can be used to treat withdrawal symptoms in alcoholism.

Mental and behavioral disorders due to alcohol use are the most common mental illness. In recent years, there has been a significant aggravation of the somatic state of alcohol-dependent patients at the time of seeking help, both as a result of massive alcohol consumption and as a result of an increase in concomitant therapeutic and neurological pathology [1], which leads to an increase in the intensity and duration of treatment and an increase in the risk complications during therapy [2, 3, 4]. In this regard, one of the priority directions in modern narcology is the development of new technologies that increase the effectiveness of therapy for patients with alcoholism [5].

The modern multi-axis multidisciplinary model of alcohol dependence is a methodological basis for using the latest achievements in biophysics and new technological advances in therapeutic programs for alcohol dependence with the development of physiotherapeutic direction [6, 7].

Physiotherapy in recent years has occupied a limited niche among other methods of treating alcoholism and is used in complex treatment for stopping AAS and restorative therapy of a narrow list of alcohol-related somatoneurological organopathology [8, 9, 10].

There are several areas of physiotherapy used in the treatment of alcohol dependence: controlled cerebral hypothermia, electro- and laser puncture, transcranial electrical stimulation with direct and pulsed current. All of these methods have significant limitations in application due to the need for highly qualified personnel, the bulkiness of the equipment, the complexity of the procedures, the presence of a large number of contraindications, the instability of the therapeutic effect, all this leads to an increase in treatment costs [11, 12].

The limited use of electrophysical factors in the treatment of alcohol dependence is due to at least two main reasons - the complexity of the choice of physical and technical parameters of the effect with the specified therapeutic effects (Shvets M.V. 2008;) and the low activity of researchers in this area, associated with the prevailing attitude to physiotherapy as to an auxiliary method of treating alcoholism [14, 15, 16, 17, 18].

Among the general contingent of alcoholic patients, a significant proportion are alcoholic patients with associated vertebro-basilar pathology, the choice of therapeutic programs for which presents significant difficulties, since cerebrovascular manifestations of toxico-ischemic encephalopathy limit the arsenal of "active" treatment methods. Treatment of concomitant cerebral pathology is not very specific in this case [19, 20].

Modern reflexotherapy shows itself to be very promising in this direction, allowing one to target both individual symptoms and general manifestations of the disease [21]. Various types of effects on groups of biologically active points allow regulating blood circulation, metabolic processes, convincingly showing their effectiveness and low resource consumption and a small percentage of complications, however, a search is underway for a universal non-invasive method of influencing biologically active points, which guarantees an accurate hit and a predictable effect [22].

At the same time, there is a large number of studies showing changes in central and cerebral hemodynamics under the influence of EHF therapy [23, 24, 25, 26, 27. 28]. The normalization of immunological reactivity and oxidative status after the course of EHF therapy was revealed [29, 30, 31, 32].

Non-thermal intensity millimeter wave therapy is actively used in the treatment of post-traumatic neurocirculatory brain lesions [33, 34]. Thus, the conducted studies show that EHF-therapy has a systemic, pathogenetic effect on the main mechanisms of comorbid toxico-ischemic disorders, through which neuroregulatory and metabolic disorders are realized. The rapidity of the onset of the therapeutic effect, mild regulatory effect and minor side effects make it possible to use it already in the stage of extensive abstinence.

All of the above was a prerequisite for the development of a new method of using extremely high-frequency therapy with millimeter waves of non-thermal intensity (EHF) for relief of withdrawal syndrome in patients with alcoholism.

There is a known method of treating smelly withdrawal syndrome with the removal of craving for alcohol, including drug therapy and exposure to needles on corporal and auricular acupuncture points, characterized in that after preliminary abstinence from alcohol intake for 5-9 hours, an autoheterosuggestative effect is performed that provokes the desire to drink, then they act with a multi-needle metal applicator on the paravertebral zones of the back for 10-25 minutes, after which the needles are inserted into the auricular acupuncture points AT-84, AT-55, AT-82, AT-34, AT-87 for 10-20 minutes, followed by impact on corporal acupuncture points from the GI10,11 series; F2.3; E36.38; RP6; R6.7; MC6.7; C3.7; P7; VB14.20; VG20; VC10,12; yin-tang for 30-40 minutes using medium, strong and weak irritations, after which the Ipplator and needles are removed and the liver is massaged with 10-15 massage movements [35].

The described method has several disadvantages:

1. Does not take into account the individual syndromic characteristics of the patient.

2. It is invasive, which is currently a weakness due to the widespread prevalence of blood-borne infections (HIV and Hepatitis).

A known method of relief of complicated alcohol withdrawal syndrome by extremely high-frequency electromagnetic radiation using the auricular point AT55 using a variable frequency of EHF radiation [36].

The method is carried out as follows. A patient with alcoholism in the acute period, starting in the first 24-36 hours after the last drinking of alcohol, is exposed to extremely high-frequency electromagnetic radiation of non-thermal intensity (the flux density of the incident power is 3 mW / cm ² ) with circularly repeating self-modulation of the frequency (at a slew rate of 40 MHz / s ) in the range from 59 to 61 GHz (gigahertz) to the auricular biological active point AT55 through a dielectric waveguide (cross-section of the working contact 0.64 mm ² on one side for 20-30 minutes every 10-12 hours in an amount of three to four procedures per a course of treatment.

This method is the closest to the claimed one in terms of technical essence and the achieved result, and is chosen as a prototype.

The described method has several disadvantages:

1. Exposure to one biologically active point does not allow achieving equally effective correction in various patients who have different physical conditions (gender, height, weight, constitution), physiological parameters (metabolism, hormonal background) and clinical characteristics of use and concomitant pathology.

2. The method can be used only when combined with traditional detoxification drug therapy.

3. The method is effective mainly in relation to affective and dyssomnic manifestations of pathological craving for alcohol in the structure of withdrawal symptoms and does not affect the somato-vegetative component of the craving.

The objective of this invention is to increase the effectiveness and reduce the number of adverse reactions in the treatment of withdrawal symptoms in alcoholism.

The task is solved as follows: an alcoholic patient with alcohol deprivation syndrome, starting in the first 6-24 hours after the last drinking of alcohol, is exposed to extremely high-frequency electromagnetic radiation of non-thermal intensity (the flux density of the incident power in the aperture <10 mW / cm ² with frequency self-modulation in the range 59 to 61 GHz to the next hotspots according to the prevailing syndromes and symptoms.

New in the proposed method is the use of several biologically active points for the individualization of therapy.

To implement the proposed method, a set of several individually selected acupuncture biologically active points is used in accordance with the symptoms.

In deprivation syndrome with a predominance of astheno-vegetative disorders, influence on several points is used in accordance with the identified symptoms: tremor - VB20 (Feng-chi), GI4 (He-Gu), IG3 (Hou-Xi); sweating -R3 (Tai-si) K7 (Fu-liu); dizziness VB20 (Feng-chi), E2 (Sy-Bai), V10 (Tien-chu), TR22 (He-Liao), TR23 (Si-Chu-Kun), VG16 (Feng-Fu); anorexia E42 (Chu-Yang), RP4 (Gun-sun); insomnia MC6 (Nei-Guan), C7 (Shen-Men), E36 (Tsu-San-Li), VB20 (Feng-Chi), VG14 (Da-Zhui) V62 (Shen-Mai). In case of prevalence of somato-neurological disorders, the following biologically active points are used in accordance with the identified disorders: weakness - GI4 (He-Gu), RP4 (Gun-sun) VG14 (Da-Chzhui); heart pains - C7 (Shen-Men), MC6 (Nei-Guan), MC8 (Lao-Gong), P4 (Xia-Bai), P5 (Chi-Tse) P7 (Le-Qué); high blood pressure MC6 (Nei-Guan); headache: frontal part - TR23 (Si-Chu-Kun), V1 (Mei-Chun), VG20 (Bai-Hui); migraine - GI4 (He-Gu), TR18 (Chi-Mai), VB20 (Feng-Chi); neck pain - VB20 (Feng Chi), IG3 (Hou Xi), E2 (Sy-Bai), V11 (Da-Zhu); for disorders of the gastrointestinal tract: nausea, vomiting RP4 (Gun-sun) VG20 (Bai-Hui); cramps, abdominal pain - E25 (Tien-Shu), V23 (Shen-Shu); diarrhea - VB25 (Ching Men); constipation - VC12 (Zhong-Wan), R18 (Shi-Guan); the severity of pain in the liver GI4 (He-Gu). F3 (Tai Chun); vascular disorders: pallor, cold extremities, pain, numbness in the fingers - MC6 (Nei-Guan), P9 (Tai-Yuan). The impact is carried out for 10 minutes sequentially on each of the 3 - 4 points selected in accordance with the prevailing symptoms, 4-8 procedures per course.

The technical result of the method proposed as the invention is to increase the effectiveness of treatment due to targeted targeted action on points in accordance with specific symptoms of the patient.

The essential features of the invention have shown in the claimed set of new properties explicitly, not arising from the prior art and not obvious to a specialist.

An identical set of properties was not found in the patent and medical scientific literature.

The proposed method can be used in practical health care to improve the quality of treatment, reduce the recovery time and reduce the number of complications.

Based on the foregoing, the proposed method should be considered as corresponding to the conditions of patentability "Novelty", "Inventive level", "Industrial applicability".

The invention will be clear from the following description and the tables attached thereto. The method is carried out as follows: A patient with alcohol withdrawal syndrome, starting in the first 6-24 hours after the last drinking of alcohol, is exposed to extremely high-frequency electromagnetic radiation of non-thermal intensity (the flux density of the incident power in the aperture is <10 mW / cm ² with frequency self-modulation in the range from 59 to 61 GHz. A preliminary physical examination is carried out, anamnesis and complaints of the patient are collected. When autonomic disorders are detected, exposure to several points is used in accordance with the identified symptoms: tremor - VB20 (Feng Chi), GI4 (He-Gu), IG3 (Hou -Si); sweating - R3 (Tai-si) R7 (Fu-lu); dizziness VB20 (Feng-chi), E2 (Si-Bai), V10 (Tien-chu), TR22 (He-Liao), TR23 ( Sy-Chu-Kun), VG16 (Feng-Fu); anorexia E42 (Chu-Yai), RP4 (Gun-sun); insomnia MC6 (Nei-Guan), C7 (Shen-Men), E36 (Tszu-San- Li), VB20 (Feng-Chi), VG14 (Da-Zhui), V62 (Shen-Mai).

In case of prevalence of somato-neurological disorders, the following biologically active points are used in accordance with the identified disorders: weakness - GI4 (He-Gu), RP4 (Gun-sun) VG14 (Da-Chzhui); pain in the heart - C7 (Shen-Men), MC6 (Nei-Guan), MC8 (Lao-Gong), P4 (Xia-Bai), P5 (Chi-Tse), P7 (Le-Quie); high blood pressure MC6 (Nei-Guan), VG20 (Bai-Hui); headache: frontal part - TR23 (Sy-Chu-Kun), V1 (Mei-Chun), migraine - G14 (He-Gu), TR18 (Chi-Mai), VB20 (Feng-Chi); neck pain - VB20 (Feng Chi), IG3 (Hou Xi), E2 (Sy-Bai), V11 (Da-Zhu); for disorders of the gastrointestinal tract: nausea, vomiting RP4 (Gun-sun) VG20 (Bai-Hui); cramps, abdominal pain - E25 (Tien-Shu), V23 (Shen-Shu); diarrhea -VB25 (Ching-Men); constipation - VC12 (Zhong-Wan), R18 (Shi-Guan); severity of pain in the liver area GI4 (He-Gu), F3 (Tai-Chun); vascular disorders: pallor, cold extremities, pain, numbness in the fingers - MC6 (Nei-Guan), P9 (Tai-Yuan). The impact is carried out for 10 minutes sequentially on each of the 3 - 4 points selected in accordance with the prevailing symptoms.

The correctness of the choice of the point is assessed by a change in the state of health (a decrease in the severity of the symptom), the appearance of a feeling of "creepy", "warm wave", "relaxation" in the patient after 2-3 minutes, if the effect does not occur, the emitter is transferred to another point from the above list causing when exposed the described effect. At each subsequent session, the choice of points is carried out in accordance with the identified (prevailing) symptoms at the time of the conduct. In total, the impact is made in the amount of 4-8 procedures per course.

The proposed method, in the conditions of the department of addictive states of the Research Institute of Mental Health, treated 30 patients aged 25 to 55 years (average age 38.5 ± 2.7 years) with an average duration of the 2nd stage of 9.8 ± 0.6 years. with mental and behavioral disorders as a result of alcohol consumption (F10.3x), withdrawal state, with concomitant somatoneurological diseases, which constituted the main therapeutic (group - "A"). At the time of the beginning of EHF-therapy, all patients had a detailed clinical picture of AAS, which included symptoms of a pathological craving for alcohol and varying degrees of severity of somatoneurological manifestations of the toxic effect of ethanol.

As a comparison group, this group (group - "B") to assess the effectiveness of the proposed method for the relief of deprivation syndrome in relation to the prototype method, relief of alcohol withdrawal syndrome by exposure to the AT55 point was carried out in 32 patients with stage 2 alcoholism aged 25 to 55 years (mean age 39.8 ± 3.4 years) with an average duration of stage 2 of 10.7 ± 0.6 years. All patients had an extensive clinic of deprivation syndrome, which included symptoms of a pathological craving for alcohol and somatoneurological manifestations of the toxic effect of ethanol of moderate severity.

Patients in the control group were statistically standardized with the main therapeutic "A" group by gender, age, duration of the second stage of alcoholism, alcohol tolerance and the severity of AAS. Assessment of the severity of pathological craving for alcohol before using therapy according to the "Pennsylvania Alcohol Craving Scale" (PAAS); assessment of withdrawal syndrome according to the clinical scale CIWA-Ar in points; assessment of depression using the Hospital Anxiety and Depression Scale; assessment of anxiety using the Hospital Anxiety and Depression Scale.

The procedures performed by all patients were tolerated painlessly and comfortably. After the first procedure, the patients willingly accepted all subsequent procedures due to the rapid improvement in their condition, which they had not previously observed with traditional methods.

In addition, against the background of this method of treatment, a rapid reduction in pathological drive was observed (Table 2).

To assess the severity of affective disorders, the hospital anxiety and depression scale (HADS) was used.

Thus, after the course of treatment of deprivation syndrome in alcohol dependence according to the proposed method in the main therapeutic "A" - group was observed reliably (at p <0.05) more rapid relief of withdrawal symptoms during the first 2 days up to 27 ± 2.1 points in group "A"; (31 ±, 5 in group "B"); pathological craving for alcohol up to 18 ± 2.2 points in group "A"; (23 ± 1 points in group "B") and accelerated reduction of anxiety up to 11 ± 2.5 points in group "A"; (13 ± 2.6 points in group "B") and depressive disorders up to 13 ± 1.5 points in group "A"; (15 ± 2.1 points in group "B").

Clinical example No. 1.

Patient S. 49 years old. He was admitted for treatment at the 4th clinical narcological department of the Research Institute of Mental Health of the TNIMTs RAS.

Diagnosis: Mental and behavioral disorders due to alcohol use. Advanced withdrawal syndrome of moderate severity with somatoneurological and mental (subdepressive and dyssomnic) disorders (F10.3).

Complaints upon admission to severe general weakness, fatigue throughout the body, sweating, headache and dizziness, hand tremors and chills of the whole body, palpitations, feeling of constriction, pain in the heart, shortness of breath during physical exertion, dry mouth, nausea, dreary depressed mood, restless superficial sleep with frequent awakenings.

Anamnestic information: First tried alcohol at the age of 17. He has been abusing alcohol for about 25 years, previously underwent inpatient treatment in a drug dispensary and in a private clinic. Alcohol is drunk for 3-7 days with a daily tolerance of up to 1.2 liters of vodka. Withdrawal symptoms clinically developed for about 30 years. Without medical assistance, it can last two to three weeks. Since the patient feels very bad at this time, he physically cannot work. In this regard, he is forced to often change jobs. For the same reason, he was divorced, as in a state of intoxication he became embittered and aggressive.

He entered the department after a five-day binge, during which he consumed up to 1.5 liters of vodka per day, and in the last days before admission, due to a lack of funds, he was forced to use various alcohol substitutes (pharmacy tinctures, paint thinner, industrial alcohol).

Objective state upon admission: The muscular system is poorly developed, the physique is asthenic. In the lungs, vesicular breathing, no wheezing. Heart sounds are loud and sonorous, the rhythm is unstable. HELL 170/135 mm Hg. pulse 110 beats per minute, extrasystoles 1-2 per minute. The abdomen is of the usual shape, slightly painful on palpation in the right hypochondrium. The liver is enlarged, the lower border is +1 cm below the costal arch. Stool, urine output are normal.

Consciousness is clear, orientation is preserved, mood is reduced, tense, anxious, restless. The face is symmetrical, the nasolabial fold is normal, no pathology has been identified on the side of the cranial nerves, there is a tendency to deviate the tongue to the left. Muscle strength and tone are preserved. Reflexes from the limbs are revived, symmetrical D = S. No pathological reflexes of meningeal signs were revealed. Sensitivity is preserved, pain is observed on palpation of the trapezius and calf muscles. In the Romberg position, it is unstable, there is a tremor of the fingers, pronounced inteational tremors when performing coordination tests. The face is hyperemic, there are large drops of sweat on the face, the sclera of the eyes are injected, peripheral hyperhidrosis is observed, the skin is wet.

Mental condition:

Looks older than his age. Unkempt, disheveled hair, not washed, a strong smell of alcohol from the mouth. The face is hyperemic, edematous, the eyelids hang over the eyes, the sclera are injected, the mucous membranes of the oral cavity are dry, the lips are cracked. The patient's hands are shaking, wet sticky, periodically there is a pronounced tremor of the whole body, sweat spots on the clothes.

He enters into conversation willingly. He says that he drinks a little to "relieve stress". Recently, I began to use vodka and alcohol substitutes. He says that he can drink a liter of vodka and a liter of beer or wine to achieve pronounced intoxication. She notes that in recent years it has been difficult to recover from the use: it "shakes" strongly, the head and heart hurt. Facial expressions and gestures correspond to the theme of the statement. Self-esteem is somewhat reduced, the feeling of guilt is not expressed. She blames circumstances for her drunkenness. The criticism of the disease is formal. Anosognosia is expressed, he believes that in favorable conditions he will be able to refuse alcohol and only needs to withdraw abstinence. The attitudes towards sobriety are formal. The patient has no idea what he will do to stay sober.

The patient was exposed to electromagnetic radiation of the parameters described above on the following biologically active points according to the identified leading symptoms: VG20 (Bai-Hui); VB20 (Feng-chi), GI4 (He-Gu) through the horn of the emitter for 10 minutes at each point. During the procedure, the patient dozed off. During the procedure (during the operation of the apparatus), the patient experienced a "feeling of pressure and warmth" at the site of exposure. By the end of the procedure, the patient had practically no headache, decreased tremor, and decreased sweating. Notes a decrease in anxiety and tension ("the soul has become easier"), became much less pronounced weakness and pain in the heart. The patient expressed sincere surprise at the rapid improvement in his condition. Over the next 2 hours, blood pressure dropped to 140/105 mm Hg, pulse to 92 beats. per minute, single extrasystoles were noted. The improvement in the condition persisted for about 6-8 hours, and then there was a slight increase in these symptoms, but to a much lesser degree of severity. 10 hours after the first session before going to bed, a similar procedure for EHF-therapy VG20 (Bai-Hui), GI4 (He-Gu), MC6 (Nei-Guan), C7 (Shen-Men) was carried out. The headache completely stopped, the body tremor, dizziness and nausea decreased. She notes a significant decrease in the desire to drink alcohol. The feeling of compression and discomfort in the region of the heart and mild thirst persisted. In the evening I fell asleep rather quickly, sleep is light, superficial, in the morning I have a feeling of palpitations, severity of compression in the region of the heart, early awakening. In the morning I was looking forward to the repeated EHF-therapy procedure, associating it with the rapid onset of the effect and the comfort of the procedure itself, as compared to the intravenous and intramuscular injections that were used earlier during hospitalizations. EHF-impact on MC6 (Nei-Guan) GI4 (He-Gu), F3 (Tai-Chun) was carried out; 10 minutes each. After the procedure, the sensations in the area of the heart became minimal. Complaints of discomfort and palpitations persisted when walking or moving up stairs from floor to floor. BP 130/90 mm Hg, pulse 92 beats. in min. single extrasystoles. Slight hand tremor persists. Stable in the Romberg position. Hyperhidrosis was practically stopped (light moisture of the palms remained). In the evening, another (fourth in a row) procedure was carried out to points C7 (Shen-Men), MC6 (Nei-Guan), E36 (Tszu-San-Li) according to the above scheme. After the procedure, he himself did not present any complaints. BP 130/75 mm Hg, pulse 86 beats. in min. rhythmic. The night sleep is satisfactory. No complaints in the morning. There remains some tension and anxious concerns about the return of withdrawal symptoms. At the request of the patient, the last procedure of EHF-therapy with MC6 (Nei-Guan), F3 (Tai-Chun), E36 (Tszu-San-Li) was carried out. After the procedure, the patient feels good, blood pressure 130/80 mm Hg, pulse 84 beats. in min. rhythmic. The patient is directed to undergo psychotherapeutic rehabilitation. There were no side effects and complications in the patient.

Clinical example No. 2.

Patient A. 37 years old. She was admitted for treatment at the 4th clinical narcological department of the Research Institute of Mental Health, TNIMTs RAS. Diagnosis:

Mental and behavioral disorders due to alcohol use. Advanced withdrawal syndrome of moderate severity with somatoneurological and mental (anxiety-depressive) disorders (F10.3). ()

Complaints upon admission to tremors of the arms and the whole body, weakness, sweating, dizziness, feeling of "heaviness" in the head, palpitations, discomfort in the region of the heart, feeling of thirst, dry mouth, heaviness, discomfort in the stomach, heartburn, bloating, nausea, vomiting of food and bile, loose unstable stool, feeling of internal tension, dull irritable mood, difficulty falling asleep, anxious, superficial sleep with frightening dreams.

Anamnesis of the underlying disease: Heredity aggravated by alcoholism, the patient's uncle suffers from alcohol dependence, his brother, born in 1974, abused alcohol, repeatedly underwent treatment for this, currently in remission. The patient was born the second child in the family. Pregnancy and childbirth without pathology. By nature, she grew mobile, lively, attended preschool institutions, loved outdoor games, often acted as their organizer. I went to school on time. She studied well, exactly in all subjects. In her free time she studied in circles. I first tried alcohol at the age of 13. In the village, my grandmother and her friends tried diluted alcohol. In a state of alcoholic intoxication, nausea and repeated vomiting appeared. This condition worried for three days. Subsequent alcoholization at the high school graduation party. In a state of alcoholic intoxication, the mood rose, communicated, had fun. She continued her studies at the TPU Lyceum, in the first year in a state of alcoholic intoxication "behaved badly", for which she was expelled. She was transferred to Academlitsa, which she successfully completed. During his studies, he denies alcoholism, explaining this by those. which was a shame for the exception. After graduation, she entered the Polytechnic University. She graduated from the university as an external student. During this period, she was in dire need of money. I got a job as an accountant. Alcoholization during this period was episodic, in small quantities. In case of overdose, the protective gag reflex persisted. She married at 23, gave birth to a daughter at 24. At the age of 30, she divorced her husband. After the divorce, she was in constant psycho-emotional stress. To relax, she began to regularly consume alcoholic beverages, preferred wine, drinking up to 1.5 liters a day. In this regard, there were conflicts at work and with loved ones. Two years later, drunkenness acquired a pseudo-drunken character. An abstinence syndrome with vegetative-asthenic manifestations was formed. Ashamed of her appearance and behavior, she disappeared from home for 2-3 days, leaving her daughter to her parents. After returning, complete abstinence from alcoholism lasted 2-3 weeks. During these periods, she was happy to be engaged in housekeeping, raising her daughter. The last binge for 5 days, consumed up to 1.5-2.0 liters of fortified wine and 0.5 liters of vodka per day. She could not cope with the craving for alcohol on her own, against this background she developed severe nausea and repeated vomiting, weakness, strong tremors of the hands and the whole body, a feeling of intense anxiety. in this regard, she decided to undergo a course of treatment. I went to the clinic of the Research Institute of Mental Health.

Objective condition upon admission: The constitution is correct, the muscular system is developed normally. The skin is clean, the sclera of the eyes are hyperemic, injected, distal hyperhidrosis is expressed.

In the lungs, vesicular breathing, no wheezing. Heart sounds are loud, sonorous, the rhythm is unstable, BP is 140/100 mm Hg, the pulse is 92 beats per minute, tense, rhythmic. The abdomen is distended, painful on palpation in the epigastric region; along the colon, swelling is revealed, rumbling on palpation. The liver is enlarged, the lower border is +3 cm below the costal arch, painful on palpation. The stool is unstable, liquid. Diuresis is normal. Body temperature 36.8.

Consciousness is clear, orientation in the place of time of one's own personality is not disturbed, tense, restless. The face is symmetrical, the nasolabial fold is normal, no pathology has been identified on the side of the cranial nerves, there is a tendency to deviate the tongue to the left. Muscle strength and tone are preserved. Reflexes from the limbs are animated, symmetrical D = S. No pathological reflexes of meningeal signs were revealed. The sensitivity is preserved. In the Romberg position, pronounced swaying, pronounced tremor of outstretched fingers, performs coordination tests confidently.

Mental condition.

Looks age appropriate. The face is puffy, the injection of the sclera of the eyes remains. Hair is carelessly pulled back. She uses bright decorative cosmetics. The clothes are wrinkled and stale. The patient's hands are shaking, wet sticky, tremor of the whole body is expressed. He enters into conversation willingly. She blames her husband for her drunkenness. Says: “I drank wine, relieved stress, thought it was all harmless. Recently, I also began to use vodka. I can drink a liter of vodka and a liter of wine. I try to drink when my daughter goes to school to recover by her arrival. " Pays special attention to abdominal disorders: nausea, vomiting, abdominal pain, stool disorder. Associates these disorders with poor quality alcoholic beverages. Facial expressions and gestures correspond to the theme of the statement. Self-esteem is situationally somewhat reduced with a pronounced sense of guilt, and is generally unstable. The criticism of the disease is declared. The phenomena of anosognosia are revealed. The motives of sobriety are voiced. However, they are not sufficiently structured and require correction.

Taking into account the symptomatology at admission, the patient was exposed to electromagnetic radiation of the parameters described above on the following biologically active points according to the identified leading symptoms: RP4 (Gun-sun), E36 (Tszu-San-Li). IG3 (Hou-Xi), F3 (Tai-Chun), E25 (Tien-Shu), through the horn of the emitter for 10 minutes at each point. After the procedure (during the procedure at the site of exposure, the patient experienced a slight feeling of "goose bumps", "pressure" with a slight irradiation around the points), the patient largely stopped dizziness, headache, decreased tremor of the hands and body, sweating, and nausea. Has a decrease in heart rate, heart discomfort and weakness. The patient notes a decrease in nausea and disappearance of vomiting, the appearance of a more calm, relaxed state. Blood pressure dropped to 130/90 mm Hg, pulse to 84 beats. per minute. The improvement lasted for about 6-7 hours, vomiting did not occur. 8 hours before bedtime, a similar procedure for EHF-therapy for sharpening GI4 (He-Gu), F3 (Tai-Chun), C7 (Shen-Men), MC6 (Nei-Guan) E25 (Tien-Shu) was carried out for 10 minutes point .. Decreased headache, dizziness and nausea, body tremor, decreased anxiety. Notes a significant decrease in craving for alcohol, a calmer mood. Periodic spastic stomach pains and mild thirst persisted. She fell asleep on her own, anxious superficial sleep, could not complain of an increased reaction to ambient sounds, worried about stomach pains, heartburn, a state of internal tension, early awakening. In the morning, I willingly went to a repeated session of EHF-therapy, noting a significant subjective effect after the procedures. EHF-impact on MC6 points (Nei-Guan) was carried out. E36 (Tzu-San-Li), GI4 (He-Gu), F3 (Tai-Chun), 10 minutes each. After the procedure, pain in the epigastric region was minimal. Complaints persisted for discomfort in the abdomen, but the feeling of heaviness, soreness in the right hypochondrium significantly decreased, there was no loose stool. BP 130/80 mm Hg, pulse 82 beats. in min. In the Romberg position, slight non-systemic swaying; during coordination tests, a slight tremor of the hands remains. In the evening, the following procedure was carried out at points MC6 (Nei-Guan), E36 (Tszu-San-Li), GI4 (He-Gu), F3 (Tai-Chun) according to the above scheme. After the procedure, the patient had no complaints. BP 120/75 mm Hg, pulse 78 beats. in min. rhythmic. Falling asleep quickly, sleep at night without awakening. No complaints in the morning. On palpation, slight pain in the right hypochondrium. The last procedure of EHF-therapy with MC6 (Nei-Guan), E36 (Tsu-San-Li), RP4 (Gun-sun), F3 (Tai-Chun) was carried out. After the procedure, the patient feels satisfactory, blood pressure 130/80 mm Hg, pulse 84 beats. in min. rhythmic. Pain in the region of the heart, no feeling of compression was observed. Slight pain persists in the right hypochondrium, the lower edge of the liver will stand from under the edge of the costal arch by +2 cm. The chair is normal. The patient is directed to undergo psychological and social rehabilitation. There were no side effects and complications in the patient.

Clinical example No. 3.

Patient R. 52 years old.

Diagnosis: Mental and behavioral disorders due to alcohol use. Moderate withdrawal symptoms with somatoneurological and mental (astheno-subdepressive) disorders (F10.3).

Complaints upon admission to weakness, rapid fatigue, severe headaches, dizziness, impaired speech articulation, impaired coordination of movements, instability when walking, severe nausea, loss of apatite, periodic discomfort, heaviness in the right hypochondrium, bitterness in the mouth, irritability, sadness - spiteful mood with pronounced anxiety and a sense of inner tension, insomnia.

Anamnesis of the underlying disease: Heredity is not psychopathologically burdened. Was born the second child in the family, earlier development was unremarkable. I went to school on time. He finished 8 classes, studied mediocre. After school he entered the technical school as an electrician. At the age of 18 he was drafted into the ranks of the Soviet army, served in the Airborne Forces. In 1990 he was discharged after 9 months for injury and concussion. Received the second group of disability. After demobilization he got married and has a daughter and a son. I got a job in a private security company as a security guard, did not work in my specialty, changed jobs several times due to changes in working conditions, a decrease in wages or the liquidation of an enterprise. She has been working at her current location for 6 years. In 2002, at the age of 30, under general anesthesia, he underwent surgery for a dislocation of the clavicle.

First drinking at age 19 after demobilization, in the company of comrades at the place of residence. They drank vodka, in a state of alcoholic intoxication experienced an elated mood, which was quickly replaced by drowsiness and relaxation. Regular use since 20 years old, drank on holidays, in companies, with his family, not a large amount of light alcoholic beverages. In a state of alcoholic intoxication, he was cheerful, more sociable, active. Control over the amount of alcohol was maintained. In the morning I felt fatigue, headache, dizziness, aversion to alcohol. By the age of 30, tolerance to alcohol has increased, and today it is about 1.5 liters of vodka. In a state of intoxication, he quickly loses control over himself, becomes irritable, aggressive, quickly gets drunk until he loses consciousness, at the end he does not remember what happened in the intoxication and how the alcoholization ended. Formed withdrawal syndrome: after the withdrawal of alcohol notes severe headaches, dizziness, impaired coordination, insomnia, anxiety and anxiety, a desire to "get drunk" nausea, lack of appetite. It recovers after alcoholization for a long time, withdrawal disorders lasts about 4-6 days, accompanied by a strong craving for alcohol, a melancholy spiteful mood, a shaky gait, impaired sensitivity in the hands and feet. The duration of alcoholism can be up to 1-2 weeks with a break of up to 2 weeks. The patient indicates that the reasons for the onset of alcoholization are situational: in the company of friends or family, on vacation, on holidays, but do not stop when the situation changes. In the "light intervals" can refrain from drinking alcohol.

The last binge for 6 days, consumed up to 1.5 liters of vodka and 2.0 beer per day. He could not stop drinking alcohol on his own, due to a deterioration in health and, at the insistence of his relatives, turned to the clinic for help.

Objective condition upon admission: The constitution is correct; the constitution of the hypersteic muscular system is well developed. Height 182 cm.Weight 130 kg. The skin is hyperemic, moist, the sclera are injected, the face is swollen. The tongue is coated with a dirty gray coating. In the lungs, breathing is vesicular with a hard shade, no wheezing. NPV 18 per min. Heart tones are clear, rhythmic. BP 158/113 mm Hg, heart rate 113 per minute. The abdomen is soft on palpation, painless in all parts. The liver protrudes from under the costal margin by +1 cm, the spleen is not palpable. The tapping symptom is negative on both sides. Physiological functions are normal. Body temperature 36.6.

Consciousness is clear, orientation is preserved, mood is lowered, tense, irritable, quick-tempered, restless. The face is generally symmetrical, there is a slight flattening of the nasolabial fold, a tendency to deviate the tongue to the right. Pupils of the correct shape D <S. The reaction to light is saved. With extreme abductions, small-sweeping horizontal nystagmus. No pathology was revealed on the part of other cranial nerves. Muscle strength and tone are reduced. Reflexes from the limbs are animated, symmetrical D = S. No pathological reflexes of meningeal signs were revealed. Sensitivity is preserved, pain is observed on palpation of the trapezius and calf muscles. In the Romberg position, it is unstable, there is a tremor of the fingers, pronounced inteational tremor when performing coordination tests, a symptom of a miss, manifestations of adiadochokinesis are expressed. There is a violation of the sensitivity of the type of socks and gloves. There is a pronounced distal hyperhidrosis.

Mental condition:

Looks older than his age. Strong smell of alcoholic fumes from the mouth. The face is hyperemic. puffy, injected sclera, edematous eyelids, dry mucous membranes of the mouth, cracked lips. The patient has a pronounced tremor of the hands, periodically there is a chill-like trembling of the whole body, dirty clothes with the smell of sweat on the clothes.

He enters into a conversation reluctantly, in a conversation he periodically raises his voice. He says that he drinks to "improve the mood", at first a little, but then quickly loses control and often does not remember how the alcohol abuse ended. He claims that he can drink a liter of vodka to achieve a pronounced intoxication. In the latter, he prefers to use vodka and other strong alcoholic drinks. At the same time, he notes that in recent years it has been difficult to recover after use: the head hurts badly, gait is disturbed, and hands are shaking so that it becomes difficult to pour water into a glass and drink, besides this draws on a feeling of compression in the chest in the region of the heart ... Facial expressions and gestures correspond to the theme of the statement. She does not feel guilty, she believes that she "drinks like everyone else." She blames others and circumstances for her drunkenness. The criticism of the disease is formal, he believes that he can independently refuse to take alcohol and only needs to withdraw abstinence. Attitudes towards sobriety are formal, He believes that if he can keep himself sober for a year, then in the future he will be able to return to controlled drinking.

According to the identified leading symptomatology, the patient was exposed to electromagnetic radiation of the parameters described above on the following biologically active points: VG20 (Bai-Hui); VB20 (Feng-chi), GI4 (He-Gu) MC6 (Nei-Guan), through the horn of the emitter for 10 minutes at each point. During the procedure, the patient noted a feeling of relaxation. During the procedure (during the operation of the apparatus) at the site of exposure, the patient experienced “senestopathic sensations in the head and face”. By the end of the procedure, the patient's headache decreased and acquired the character of "heaviness in the head", tremor of the body and hands was noticeably reduced. She notes a decrease in internal tension ("it became calmer inside"), weakness and a feeling of pressure in the heart became much less pronounced. The patient became calmer, more relaxed. Over the next hour, blood pressure dropped to 145/100 mm Hg, pulse to 96 beats. per minute. 10 hours after the first session, before going to bed, a similar procedure for EHF-therapy VG20 (Bai-Hui), MC6 (Nei-Guan), GI4 (He-Gu), F3 (Tai-Chun) was carried out. The headache completely stopped, the body tremor, dizziness and nausea decreased. The urge to drink alcohol remained, but transformed into obsessive thoughts without a behavioral component. The feeling of compression and discomfort in the region of the heart and mild thirst persisted. In the evening the patient fell asleep quickly, superficial sleep with awakenings. In the morning, I independently came to the EHF-therapy procedure, noting a pronounced positive effect. EHF-impact on MC6 (Nei-Guan), GI4 (He-Gu), F3 (Tai-Chun); 10 minutes each. After the procedure, I again felt the disappearance of internal tension, the tremor of the hands was unstable. Complaints about decreased sensitivity, feeling of "cold" in the hands and feet persisted. BP 135/90 mm Hg, pulse 92 beats. in min. Slight hand tremor persists. Stable in the Romberg position. Peripheral hyperhidrosis persists (light moisture in the palms). In the evening, another (fourth in a row) procedure was carried out at points C7 (Shen-Men), MC6 (Nei-Guan) E36 (Tszu-San-Li), P7 (Le-Quie), 10 minutes each. After the procedure, the patient had no complaints. BP 130/75 mm Hg, pulse 86 beats. in min. rhythmic. The night sleep is satisfactory. No complaints in the morning. Some tension persists, a decrease in dysphoric mood is noted. The next morning, the last EHF-therapy procedure was carried out with VG20 (Bai-Hui), VG16 (Feng-Fu), F3 (Tai-Chun), E36 (Tszu-San-Li). After the procedure, the patient feels good, blood pressure 125/70 mm Hg, pulse 82 beats. in min. rhythmic. The patient was sent for further psychological rehabilitation. There were no side effects and complications in the patient.

Based on the foregoing, it can be concluded that the effectiveness of the relief of the withdrawal syndrome by the proposed method significantly exceeds the effectiveness of the prototype method (p <0.05). At the same time, the proposed method for relieving deprivation syndrome in alcohol dependence differs in that, along with the systemic (vegetative stabilizing, hypotensive, thymoleptic, relaxation, sedative, analgesic,) targeted effect due to the information and energy impact of electromagnetic radiation in the range from 59 to 61 GHz on receptors with optimal physiological parameters. The proposed method for the relief of deprivation syndrome in alcohol dependence is non-invasive, drug-free and does not require large expenditures on equipment and training.

Thus, the proposed method for the treatment of alcohol withdrawal syndrome allows:

1. To stop the main clinical manifestations of the withdrawal syndrome in alcoholism in patients with alcoholism.

2. To reliably increase the efficiency of relief of alcoholism withdrawal syndrome due to simultaneous systemic exposure and targeted exposure to existing key clinical manifestations in comparison with the prototype method.

3. To avoid complications and side effects associated with the use of the prototype method and analog methods.

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Claims (1)

A method of treating withdrawal syndrome in alcoholism, which consists in the fact that a sequential effect on acupuncture points with extremely high-frequency electromagnetic radiation of non-thermal intensity, the flux density of the incident power in the aperture <10 mW / cm ² with automatic frequency modulation in the range from 59 to 61 GHz, differing the fact that they affect the following biologically active points in accordance with the prevailing syndromes and symptoms: in deprivation syndrome with a predominance of asthenic-vegetative disorders, points are used in accordance with the identified symptoms: tremor - AT 55; sweating - TR17 (I-Fen); dizziness - E1 (Chen-Qi), 2E (Sy-Bai), TR10 (Tien-Jing), TR22 (He-Liao), TR23 (Si-Chu-Kun), VG16 (Feng-Fu) (Lin-Tai) ; anorexia - GI1 (Shang-Yang), AT 87; insomnia - MC6 (Nei-Guan), C7 (Shen-Men), E36 (Tsu-San-Li), VB20 (Feng-Chi), VG14 (Da-Zhui), AT 35, AT 66, AT 95, and in in the case of predominance of somatoneurological disorders, the following biologically active points are affected in accordance with the identified disorders: weakness - AT 13; pain in the heart - C7 (Shen-Men), MC6 (Nei-Guan), MC8 (Lao-Gong), P4 (Xia-Bai), P5 (Chi-Tse), P8 (Ching-Qu), AT 100; headache: a) frontal part - TR18 (Chi-Mai), TR23 (Sy-Chu-Kun), GI1 (Shang-Yang), VG20 (Bai-Hui); b) migraine - GI14 (Bi-Nao), VB20 (Feng-Chi), P9 (Tai-Yuan); pain in the back of the head - VB20 (Feng-Chi), P7 (Le-Quie), IG5 (Yang-Xi), V2 (Tsuan-chu), V11 (Da-Chu). AT25; pain in the eyes - VB1 (Tong-Tzu-Liao), V18, AT 35; for disorders of the gastrointestinal tract: a) spasms, tenesmus - V1 (Ching-Ming), C1 (Ching-Chuan); b) diarrhea - VB25 (Ching-Men); c) constipation - VC5 (Shi-Men), AT51, AT92; severity, pain in the liver - GI4 (He-Gu), F3 (Tai-Chun), AT97, AT127, AT128; vascular disorders: pallor, cold extremities, pain, numbness in the fingers - C7 (Shen-Men), VC6 (Qi-Hai), AT34, the exposure is carried out for 15-20 minutes sequentially on each of 3-4 points selected in according to the prevailing symptoms, 4-8 procedures per course.