RU2719728C9 - Specialized food product for improving memorizing and reproduction processes and a method for production thereof - Google Patents

Abstract

FIELD: food industry.SUBSTANCE: invention relates to food industry and concerns a specialized functional purpose food product for improvement of memorizing and reproduction processes. Product contains the following ratio of the initial components, wt%: tryptophan – 16.2; hesperidin – 2.16; ascorbic acid – 1.34, superoxide dismutase – 1.34; dry hibiscus extract – 1.24; vitamin E (tocopherol acetate) – 0.53; dihydroquercetin – 0.53; beta-carotene – 0.2; coenzyme Q10– 0.2; 5-hydroxytryptophan – 8.1; glycine – 8.1; gamma-aminobutyric acid – 8.1; pantothenic acid – 8.1; inositol 8.1; ginkgo biloba extract – 3.23; ginger extract – 5.93; ginseng extract – 4.85; Valeriana extract – 2.15; pyridoxine hydrochloride (vitamin B6) – 0.1; potato starch – 5.37; Instantgum AB – 1.1; magnesium – 1.1; microcrystalline cellulose – 6.47, talc – 3.78; kafos – 0.22; selenium – 1.1; cobalamin (vitamin B12) – 0.26; riboflavin (vitamin B2) – 0.1. Invention also relates to a method of producing a specialized food product for improving memorizing processes, which involves preparation of a granulation mixture by dosing tryptophan, glycine, inositol, gamma-aminobutyric acid, pantothenic acid, microcrystalline cellulose. Granulate is obtained by adding to the mixture for granulation of the starch paste moisturizer in concentration of humidifier of 40 %. Wet granulate is dried at 67 °C to residual moisture content of 3 %. Dry granulation process is carried out to obtain regranulate. One prepares powdering mixtures: the first dusting mixture – by way of combined dosing of extracts of ginger, valeriana, ginkgo biloba, ginseng, Instantgum AB, magnesium, vitamin B6, riboflavin, the second one – by combined dosing and mixing of Hesperidin, ascorbic acid, superoxide dismutase, hibiscus extract, vitamin E, dihydroquercetin, beta-carotene, coenzyme Q10, cobalamin, potato starch, kafos, talc. Method comprises preparation of tableting mixture by mixing first powdering mixture, second dusting mixture and regranulate for 1 hour, obtained mixture is tableted.EFFECT: invention is aimed at expansion of the range of specialized food products of functional orientation, to obtain a safe and useful product of high quality, consumption of which promotes health improvement due to a wide range of composition, which plays a significant role in systemic maintenance of metabolic processes of brain, mindfulness of behavior, processes of memorizing and reproduction in conditions of psychophysiological loads.2 cl, 3 tbl, 1 ex

Description

The invention relates to the field of the food industry and relates to a specialized food product of a functional orientation (prophylactic purpose) with a balanced vitamin-mineral composition of the complex, in particular to a method for producing a specialized product suitable for human consumption, incl. improving the processes of memorization and reproduction and the quality of life under conditions of psycho-physiological stress, from a mixture of plant materials and biologically active substances.

The long historical period of modern medicine convincingly testifies to the preventive role of the nutritional factor in the prevention and treatment of the disease. This is strongly manifested against the background of an unbalanced diet, deficient in essential nutrients.

One of the promising vectors in solving this problem is the use of medications and natural specialized complexes of functional orientation, as the most affordable and effective way to correct nutrition and health.

Known biologically active food supplement, which includes the following components: retinol acetate (A) - 0.7 mg; α-tocopherol acetate (E) - 13.6 mg; ascorbic acid - 94.5 mg; beta-carotene - 3.4 mg; cholecalciferol (D ₃ ) - 14.5 mcg; phylloquinone (K ₁ ) - 174.0 μg, thiamine hydrochloride (B ₁ ) - 1.7 mg; riboflavin (B ₂₎ - 2.0 mg; pantothenic acid (B ₅ ) - 6.2 mg; pyridoxine hydrochloride (B ₆ ) - 2.2 mg; folic acid (B ₉ ) - 500.1 μg; cyanocobalamin (B ₁₂ ) - 3.9 μg; nicotinamide (PP) - 21.0 mg; biotin (H) - 54.9 μg; magnesium (in the form of magnesium oxide) - 100.0 mg; iron (in the form of iron fumarate) - 10.0 mg, zinc (in the form of zinc oxide) - 7.0 mg; manganese (in the form of manganese sulfate) - 1.4 mg; copper (in the form of copper sulfate) - 0.9 mg; iodine (in the form of potassium iodide) - 129.9 mcg; chromium (as chromium picolinate) - 24.9 mcg; Selenium (as sodium selenite) 35.1 mcg zeolite - 195.0 mg and sterilized dried culture liquid containing metabolites of bacteria Bacillus subtilis VKPM No. B-2335 - 5.0 mg [RF 2552006 A23L 1/30, A23L 1/302 from 10.06.2015, Bul. No. 16].

The disadvantages of the analogue are the limited vitamin-mineral composition, which does not have a synergistic effect on the metabolic processes of the brain, does not relieve excitement, does not provide a calming effect, as well as the inability to use it as a source of energy and vitamins in the brain's consumption under conditions of psycho-physiological stress.

Optimization of the diet of a modern person at the expense of specialized products of various functional orientation is the most acceptable way to preserve the health and working capacity of the population. There are many ways to obtain specialized products for various purposes.

The closest technical solution was chosen as a prototype to obtain a biologically active food supplement "Sophia", which includes the following components: extract of schisandra chinensis, ginkgo biloba leaves, motherwort extract, valerian root extract, hibiscus extract, cyfrol-5 (antioxidant complex), tyrosine , hesperidin, ascorbic acid, vitamin E, dihydroquercetin, beta-carotene, coenzyme Q10, 5-hydroxytryptophan, glycine, glutamic acid, para-aminobenzoic acid, inositol, vitamins B3, B5, B6, B1, lactose, E460, E553b, potato E464, croscarmellose sodium, instantgam AB, E1521, E551, E171, E141i. [Biologically active food supplement "Sophia", reg. N RU.77.99.32.003.E.001060.01.15, date of issue 27.01.2015].

However, the disadvantages of the closest prototype are a narrow range of useful components for human health, the absence in its composition of extracts of ginger, ginseng in combination with vitamins B2, 12, magnesium and tryptophan, which are characterized by synergistic systemic action and unidirectional functional properties in relation to the correction of metabolic processes in the head. the brain to maintain a state of awareness of behavior, the processes of remembering and reproducing under conditions of psycho-physiological stress, as well as the closest prototype does not significantly affect the activity of the brain (does not have a synergistic systemic effect), which does not cause relaxation and a feeling of emotional well-being associated with seasonal effective disorders.

The invention is aimed at expanding the range of specialized food products of a functional orientation, at obtaining a safe and healthy product of high quality, the consumption of which contributes to the improvement of health due to a wide range of composition, which plays a significant role in the systemic maintenance of metabolic processes in the brain, awareness of behavior, processes of memorization and reproduction ...

This is achieved by the fact that a specialized food product for strengthening the processes of memorization and reproduction, containing ascorbic acid, dry hibiscus extract, vitamin E (tocopherol acetate), hesperidin, dihydroquercetin, beta-carotene, coenzyme Q10, 5-hydroxytryptophan, glycine, ginkgo biloba extract , valerian extract, pyridoxine hydrochloride (vitamin B ₆ ), inositol, potato starch, instantgam AB, microcrystalline cellulose, talc, and it additionally contains tryptophan, selenium, superoxide dismutase, gamma aminobutyric acid, pantothenic acid, magnesium extract cobalamin (vitamin B ₁₂ ), riboflavin (vitamin B ₂ ), kaphos, with the following ratio of starting components, wt. %:

Tryptophan 16.2 Hesperidin 2.16 Ascorbic acid 1.34 Superoxide dismutase 1.34 Hibiscus extract 1.24 Vitamin E (tocopherol acetate) 0.53 Dihydroquercetin 0.53 Beta carotene 0.2 Coenzyme Q ₁₀ 0.2 5-hydroxytryptophan 8.1 Glycine 8.1 Gamma Aminobutyric Acid 8.1 Pantothenic acid 8.1 Inositol 8.1 Ginger extract 5.93 Ginseng extract 4.85 Ginkgo biloba extract 3.23 Valerian extract 2.15 Magnesium 1.1 Selenium 1.1 Cobalamin (vitamin B12) 0.26 Pyridoxine Hydrochloride (Vitamin B6) 0.1 Riboflavin (vitamin B2) 0.1 Microcrystalline cellulose 6.47 Potato starch 5.37 Talc 3.78 Instantgam AB 1.1 Kaphos 0.22

A method of obtaining a specialized food product to improve the processes of memorization and reproduction, which consists in preparing a mixture for granulation by dosing tryptophan, glycine, inositol, gamma-aminobutyric acid, pantothenic acid, microcrystalline cellulose, then a granulate is obtained by adding to the mixture for granulation a starch paste humidifier at a humidifier concentration of 40%, the wet granulate is dried at a temperature of 67 ° C to a residual moisture content of 3%, a dry granulation process is carried out to obtain a regranulate, then powdering mixtures are prepared: the first powdering mixture is by joint dosing of extracts of ginger, valerian, ginkgo biloba , ginseng and instantgam AB, magnesium, vitamin B6, riboflavin, and the second by joint dosing and mixing of hesperidin, ascorbic acid, superoxide dismutase, hibiscus extract, vitamin E, dihydroquercetin, beta-carotene, coenzyme Q10, cobalamin, starch leg, kaphos, talc, then a mixture for tableting is obtained by mixing the first dusting mixture, the second dusting mixture and regranulate for 1 hour, the resulting mixture is tableted.

Example

To obtain a specialized food product to improve the processes of memorization and reproduction, suitable for eating, tryptophan is taken as the main and auxiliary raw materials - 16.2 wt. %, hesperidin - 2.16 wt. %, ascorbic acid - 1.34 wt. %, superoxide dismutase - 1.34 wt. %, hibiscus extract - 1.24 wt. %, vitamin E (tocopherol acetate) - 0.53 wt. %, dihydroquercetin - 0.53 wt. %, beta-carotene - 0.2 wt. %, coenzyme Q10 - 0.2 wt. %, 5-hydroxytryptophan - 8.1 wt. %, glycine - 8.1 wt. %, gamma-aminobutyric acid - 8.1 wt. %, pantothenic acid - 8.1 wt. %, inositol - 8.1 wt. %, ginger extract - 5.93 wt. %, ginseng extract - 4.85 wt. %, ginkgo biloba extract - 3.23 wt. %, valerian extract - 2.15 wt. %, magnesium - 1.1 wt. %, selenium - 1.1 wt. %, cobalamin (vitamin B12) - 0.26 wt. %, pyridoxine hydrochloride (vitamin B6) - 0.1 wt. %, riboflavin (vitamin B2) - 0.1 wt. %, microcrystalline cellulose - 6.47 wt. %, potato starch - 5.37 wt. %, talc - 3.78 wt. %, instantgam AB - 1.1 wt. %, kaphos - 0.22 wt. %.

To obtain a specialized food product to improve the processes of memorization and reproduction, the preparation and dosage of the main and auxiliary raw materials is carried out in the following order:

- joint dosing for semi-finished product No. 1 (extracts of ginger, valerian, ginkgo biloba, ginseng and instantgam AB);

- joint dosing for semi-finished product No. 2 (magnesium, pyridoxine, riboflavin).

Preparation of raw materials. Recipe ingredients - substances and plant extracts are weighed and sieved through a sieve with a mesh size of 1 mm. Screenings are subjected to grinding on a hammer mill MM-10 and re-screening.

Cooking semi-finished product No. 1. The required amount of water is dosed into the homogenizer reactor. The weighed amount of extracts of ginger, valerian, ginkgo biloba, ginseng and instantgam AB are slowly, in small portions, with the stirrer running, poured into the homogenizer reactor and stirred for 12 minutes. Then homogenized for 8 minutes with the mixer turned on. A weighed amount of pellets is loaded into the granulator. Connect the homogenizer reactor to the Huttlin fluid bed granulator and begin the process of applying the suspension to the pellets. After the end of the application process, the finished granules are discharged. The homogeneity of the suspension and the appearance of the granules are monitored.

Cooking semi-finished product No. 2. The required amount of water is dosed into the homogenizer reactor. The weighed amount of magnesium, pyridoxine, riboflavin is slowly, in small portions, with the stirrer running, poured into the homogenizer reactor and stirred for 12 minutes. Then homogenized for 8 minutes with the mixer turned on. A weighed amount of pellets is loaded into the granulator. Connect the reactor-homogenizer to the granulator and begin the process of applying the suspension to the pellets. After the end of the application process, the finished granules are discharged. Check the homogeneity of the suspension and the appearance of the granules.

Preparation of a mixture for granulation. Prescription components are dosed into the V-shaped mixer S-300: tryptophan, glycine, inositol, gamma-aminobutyric acid, pantothenic acid, microcrystalline cellulose. The control of the name, quantity and series of raw materials on the technological map is carried out.

Screening. The mixture for granulation is sieved through a vibrating sieve with a hole diameter of 1 mm. The screenings are subjected to grinding in a hammer mill and re-screening. There should be no lumps and foreign inclusions.

Mixing. The components will interfere with the V-shaped mixer, mix for 1 hour per 100 kg of the mixture. Check the homogeneity of the mixture by pressing with a pestle on the surface - there should be no lumps and foreign inclusions.

Preparation of granules (wet granulation-extrusion). It is carried out in an extruder press machine (FATA or MAKIZ). A moisturizer is added to the granulation mixture - starch paste in an amount of 40%. Check the uniformity of the color of the granulate.

Drying of granules. The wet granulate is dried at 67 ° C in an oven to a residual moisture of 3%. The moisture content and uniformity of drying are controlled by sampling from the upper, middle and lower parts of the drying oven in an amount of 10 g.

Dry granulation. It is carried out in a Fitz Mill granulator with a mesh No. 3, 5. There should be no foreign inclusions in the presence of a fractional composition of the regranulate.

Preparation of a powdering mixture. In the V-shaped mixer S-300, semi-finished products 1 and 2 are dosed together to obtain a powdering mixture No. 1, which does not require sifting, then a powdering mixture No. 2 is obtained by joint dosing and mixing of the components: hesperidin, ascorbic acid, superoxide dismutase, hibiscus extract, vitamin E (tocopherol acetate), dihydroquercetin, beta-carotene, coenzyme Q10, cobalamin, potato starch, kaphos, talc.

Check the compliance of the name, quantity and batch of raw materials with the technological map.

Powder mixture No. 2 is sieved through a vibrating sieve with a diameter of 1 mm. The screenings are subjected to grinding in a hammer mill and re-screening. There should be no lumps and foreign inclusions;

Preparation of a mixture for tableting. Mixing of the components is carried out in a V-shaped mixer in the following sequence: powdering mixture No. 1, No. 2, then regranulate for 1 hour based on 100 kg of the mixture.

The finished mixture is transferred to the quality control department for analysis for compliance with the requirements of technological documentation;

Tabletting and dedusting. The mixture is tableted on a Cadmach rotary tablet machine. Every 30 minutes check the average weight of the tablets by weighing 20 tablets and the weight of the individual tablets by weighing 20 tablets in turn. Deviations of the average weight and weight of individual tablets should not exceed ± 3% from that indicated in the itinerary and accompanying sheet.

Every 60 minutes, check the appearance of the tablets by inspecting 10 tablets on both sides. There should be no chips, flaking, bumps, pits or sticking (the tablet should be smooth and strong). The finished tablets are transferred to a dedusting device and to a film-coating stage. Tablets are poured into the working chamber of the installation (installation of the Manesty-150, 350 type). Connect the homogenizer to the installation, start the process of spraying the film coating. After the end of the process, the tablets are unloaded, the compliance of the specified quality indicators with the requirements of technical documentation is checked.

Currently, from the patent and scientific and technical literature, there is no specialized food product for improving the processes of memorization and reproduction under conditions of psychophysiological stress and a method for its production in the claimed set of features.

Organoleptic and physicochemical indicators and nutritional value characterizing the functional orientation of a specialized food product to improve the processes of memorization and reproduction under conditions of psychophysiological stress are given in Tables 1, 2, the contents of toxic elements, pesticides, radionuclides are given in Table 3.

Currently, the creation of new specialized food products of a functional orientation is one of the promising areas of the food industry.

The use of the proposed specialized food product to improve the processes of memorization and reproduction and the method of its production provide the following advantages in comparison with existing specialized food products:

1. Expands the range of specialized products of a functional orientation, improves health due to a wide range of composition, which plays a significant role in the systemic maintenance of metabolic processes in the brain and energy consumption by the brain under conditions of psychophysiological stress;

2. Balanced vitamin and mineral composition of the complex in combination with extracts of ginger, ginseng, with vitamins B 1, 5, 6, 12, magnesium and tryptophan, which are characterized by systemic action and unidirectional functional properties in relation to the correction of brain metabolism, maintaining a state of mindfulness of behavior , initiative, the processes of memorization and reproduction, and also normalizes blood pressure and muscle tone in conditions of psychophysiological stress;

3. Promotes stabilization of cell membranes, reducing LPO processes (lipid peroxidation), has a powerful antioxidant effect (due to the content of selenium), also improves psycho-emotional state, being an effective treatment for moderate vegetative-vascular dystonia.

4. The scientifically substantiated formulation of a specialized product provides a targeted, systemic and prolonged action; the pelleted form of the ingredients allows for the programmed, in a certain order, release of active substances from the frame tablet;

5. A single reception of the complex makes the application convenient and affordable;

6. Physiological dosage of active substances ensures the absence of addiction and other undesirable effects.

Sources of information

1. Austrievskikh A.N. Healthy food products: new technologies, quality assurance, efficiency of application / A.N. Austrievskikh, A.A. Vekovtsev, V.M. Poznyakovsky. - Novosibirsk: Sib. univ. publishing house, 2005 .-- 416 p.

2. Poznyakovsky, V.M. Food ingredients and biologically active additives / V.M. Poznyakovsky, O. V. Chugunova, M.Yu. Tamova. - M .: INFRA-M, 2017 .-- 143 p.

3. RU 2552006 A23L 1/30 dated 06/10/2015 (analogue).

4. Biologically active food supplement "Sophia", reg. No. RU.77.99.32.003.E.001060.01.15, date of issue 27.01.2015 (prototype).

Claims (3)

1. A specialized food product for improving the processes of memorization and reproduction, containing ascorbic acid, dry hibiscus extract, vitamin E (tocopherol acetate), hesperidin, dihydroquercetin, beta-carotene, coenzyme Q ₁₀ , 5-hydroxytryptophan, glycine, ginkgo biloba extract, extract valerian, pyridoxine hydrochloride (vitamin B ₆ ), inositol, potato starch, instantgam AB, microcrystalline cellulose, talc, characterized in that it additionally contains tryptophan, selenium, superoxide dismutase, gamma aminobutyric acid, pantothenic acid, extract of gum magnesium, cobalamin (vitamin B ₁₂ ), riboflavin (vitamin B ₂ ), kaphos, with the following ratio of the starting components, wt%: Tryptophan 16.2 Hesperidin 2.16 Ascorbic acid 1.34 Superoxide dismutase 1.34 Hibiscus extract 1.24 Vitamin E (tocopherol acetate) 0.53 Dihydroquercetin 0.53 Beta carotene 0.2 Coenzyme Q ₁₀ 0.2 5-hydroxytryptophan 8.1 Glycine 8.1 Gamma Aminobutyric Acid 8.1 Pantothenic acid 8.1 Inositol 8.1 Ginger extract 5.93 Ginseng extract 4.85 Ginkgo biloba extract 3.23 Valerian extract 2.15 Magnesium 1.1 Selenium 1.1 Cobalamin (vitamin B ₁₂ ) 0.26 Pyridoxine Hydrochloride (Vitamin B ₆ ) 0.1 Riboflavin (vitamin B ₂ ) 0.1 Microcrystalline cellulose 6.47 Potato starch 5.37 Talc 3.78 Instantgam AB 1.1 Kaphos 0.22 2. A method of obtaining a specialized food product for improving the processes of memorization and reproduction according to claim 1, characterized in that a mixture is prepared for granulation by dosing tryptophan, glycine, inositol, gamma-aminobutyric acid, pantothenic acid, microcrystalline cellulose, then a granulate is obtained by adding into a mixture for granulation of a starch paste humidifier at a humidifier concentration of 40%, the wet granulate is dried at a temperature of 67 ° C to a residual moisture content of 3%, a dry granulation process is carried out to obtain a regranulate, then powdering mixtures are prepared: the first powdering mixture - by joint dosing of ginger extracts, valerian, ginkgo biloba, ginseng, instantgam AB, magnesium, vitamin B ₆ , riboflavin, and the second by joint dosing and mixing of hesperidin, ascorbic acid, superoxide dismutase, hibiscus extract, vitamin E, dihydroquercetin, beta-carotene ₁₀ , coenzyme Q , cr ahmal potato, kaphos, talc, then a mixture for tableting is obtained by mixing the first dusting mixture, the second dusting mixture and regranulate for 1 hour, the resulting mixture is tableted.