RU2707193C1 - Method for treating postpartum paresis in cows - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: invention relates to veterinary medicine and represents a method for treating postpartum paresis in cows, comprising administering into an animal's body a complex preparation consisting of a fraction of ASD-2 and additives, characterized in that the preparation contains additives represented by calcium boron gluconate and 70 % ethyl alcohol, and the filler used is mixture of 40 % glucose solution and 2 % novocaine taken in ratio of 1:1, with following ratio of components, wt%: ASD-2 fraction – 5 %, calcium boron gluconate – 15 %, 70 % ethyl alcohol – 10 %, filler – rest, which is introduced intraperitoneally once in a dose of not more than 200 ml per one animal's head heated to temperature of 35–38 °C.

EFFECT: use of the declared invention provides higher clinical effectiveness in postpartum paresis of cows with no negative effect on tissues.

1 cl, 3 tbl, 3 ex

Description

The invention relates to the field of veterinary medicine, in particular to veterinary obstetrics, namely the treatment of postpartum paresis in cows.

A known method of treating cows with postpartum paresis is to pump air into the mammary gland through the mammary canal and cistern. To blow air into the mammary gland, they use the Evers apparatus, consisting of discharge balls. The dosage of air is determined by practice. The disadvantage of this method of treating postpartum paresis in cows is that when pumping an insufficient amount of therapeutic effect may not be. If the udder is inflated quickly and quickly, the alveoli rupture and subcutaneous emphysema occurs, which leads to damage to the parenchyma and inflammation of the mammary gland, often before and after raising the cow to its legs, it has a general muscular tremor that lasts several hours, the symptoms of the disease subside gradually, the animal’s condition is restored 3-5 days (Veterinary obstetrics, gynecology and biotechnology of reproduction / A.P. Studentsov, VS Shipilov, V.Ya. Nikitin, etc. / Edited by V.Ya. Nikitin and M.G. Mirolyubov, - M: Kolos , 1999 - S. 319 - 322).

Known methods of treating postpartum paresis in cows by introducing through the nipple channel fresh milk or milk heated to 48 ° C, potassium iodide, potassium bromide solution, lysol, saline and others. In some cases, positive results were also obtained (Nerve diseases of animals. A.N. Golikov / Ed. By A.N. Golikov, - M .: Kolos, 1972 - S. 109-120.).

The disadvantages of these methods of treating postpartum paresis in cows are that the injected air, warm milk, bactericidal preparations, irritate breast tissue, inhibit local resistance, disrupt the natural biocenosis of the mammary gland, which leads to the development of dysfunction of the mammary gland, frequent recurrence of the pathological process . For a long time, the components of the drugs (antibiotics, sulfonamides) are excreted in milk, which poses a threat to human health.

To treat a postpartum cut in cows, Kamagsol-G is used, which includes: calcium chloride, magnesium chloride, aqueous magnesium and nipagin. Cows are introduced heated to a temperature of 35-37 ° C intravenously at a dose of 0.5-1 ml per 1 kg of body weight. In animals, Kamagsol-G stabilizes the levels of calcium and magnesium, stimulates metabolism, enhances cardiac activity, neutralizes toxic substances, and promotes desensitization of the body and eliminates inflammatory processes. When the drug gets under the skin at the injection site, necrosis of surrounding tissues is observed, which sometimes leads to culling of animals (N.I. Miron // Veterinary Medicine - 1978.- No. 2.- C - 76.)

Also known is a method for treating cattle comprising administering a preparation containing an ASD-2 fraction, wherein a treatment solution of an ASD-2 preparation is prepared in a 0.9% isotonic sodium chloride solution. As an additive, use the liquid form of the drug "Vivaton". (RF patent No. 2316 329, class A61K 35/00, 2007 prototype).

A disadvantage of the known prototype is the lack of treatment for postpartum paresis in cows.

The technical result is to expand the functionality and increase the effectiveness of the method of treatment of cows with postpartum paresis.

The technical result is achieved by the fact that in the method of treating postpartum paresis in cows, comprising administering to the animal’s body a complex preparation consisting of the ASD-2 fraction and additives, according to the invention, calcium borglu-conate and 70% ethyl alcohol are used as additives in the preparation and as a filler is a mixture of a 40% glucose solution and a 2% solution of novocaine taken in a ratio of 1: 1 in the following ratio of components, wt. %:

ASD-2 fraction - 5%

calcium borgluconate - 15%

70% ethyl alcohol - 10%

filler - the rest,

which is administered once intraperitoneally in a dose of not more than 200 ml per head of an animal heated to a temperature of 35-38 ° C.

The novelty of the proposed technical solution lies in the fact that the treatment of postpartum paresis in lactating cows is carried out by intraperitoneal administration to the animal of a complex preparation (Dorogov's Antiseptic Stimulator (ASD-2) in combination with glucose, novocaine, calcium borgluconate and ethyl alcohol), which is used once in a dose 0.3 - 0.5 ml per 1 kg of mass. The peritoneum has a resorption ability, especially in the diaphragm; in a short time, the peritoneum can absorb an amount of fluid equal to 1/10 of the animal’s body weight. Therefore, the introduction of drugs into its cavity can replace intravenous injection. The drugs included in the composition are recommended for the treatment of postpartum paresis, due to which the neurotropic cholinomimetic effect on the central and autonomic nervous systems is rapidly stimulated (15–20 minutes after administration). The drug stimulates the motor activity of the gastrointestinal tract, the secretion of digestive glands and the activity of digestive enzymes, improves digestion and absorption of nutrients, increases the activity of tissue enzymes.

The drug does not adversely affect the body of the animal, milk is used without restriction during its use.

A method of treating postpartum paresis in cows is as follows. Previously, to prepare one dose of the drug, a mixture of a 40% glucose solution and a 2% solution of novocaine taken in a ratio of 1: 1 is taken, namely 70 ml of a 40% glucose solution and 70 ml of a 2% solution of novocaine, 30 ml calcium borgluconate, 10 ml of ASD-2 and 20 ml of 70% ethyl alcohol, mixed and filtered. After preparing the surgical field in the region of the right hungry fossa using the Napalkov method, a sterile preparation in a dose of not more than 200 ml is heated to a temperature of 35-37 ° C and using the sterile syringe Janet, the prepared solution is injected through the abdominal wall into the abdominal cavity.

The working name of the used drug is Polyvel.

To prove the effectiveness of the proposed technical solution, studies were carried out, presented in the following examples:

Example 1. To determine the optimal therapeutic dose of Polyvel, 30 lactating cows with postpartum paresis were selected. Of these, 3 groups were formed according to the principle of pair-analogues (n = 10 goals). The cows of the same age, productivity, lactation period with the same clinical signs of postpartum paresis were included in the groups. According to aseptic rules, the animals of the experimental groups were administered Polyvel intraperitoneally, once in the following doses: the first group - 170 ml, the second - 200 ml, the third - 225 ml. Before administration, the drug was heated to a temperature of 35-37 ° C.

The treatment results were taken into account to improve the clinical signs of the disease, the time of rising of the animal and the intake of feed. The results obtained are summarized in table 1.

From the materials of table 1 it follows that the greatest therapeutic effect was obtained after a single intraperitoneal administration of Polyvel at a dose of 200 ml.

A decrease in the dose of the administered drug to 170 ml led to a 10.0% decrease in the number of recovered animals. Increasing the dose of Polyvel to 225 ml did not lead to an increase in the number of cured animals.

Example 2. To study the action of Polyvel on tissues, organs of the abdominal cavity and biochemical parameters of blood serum of healthy and sick animals when using 200 ml of the tested drug, warm, subject to aseptic rules, was administered once intraperitoneally to healthy (1 experimental), patients (2 experimental) postpartum paresis and healthy animals which were not administered drugs (3 control). The effect of Polyvel on tissues and organs of the abdominal cavity was judged by the presence (absence) of general oppression of the animal, appetite, general tremor, body temperature, especially limbs and horns, palpebral reflex, loss of tongue due to its paralysis, detection of dry stool in direct gut, tympanum, when lying characteristic S-curvature of the neck is observed biochemical parameters of blood serum. The control was symmetrical healthy animals to which the drug was not administered (see table. 2).

As a result of the studies, it was found that the intraperitoneal administration of the test drug to healthy animals in no case did not cause a negative reaction and changes in the clinical condition of animals, an increase in milk by an average of 1.3 liters was observed. Throughout the experiment, the clinical condition of the control (healthy) animals remained within the physiological norm. Intraperitoneal administration of the drug to patients with postpartum paresis of animals, (2 experimental), led to their recovery in the first three days. In the following days, their condition stabilized and did not differ from those of healthy ones (Table 2). Before treatment, a sharp decrease in glucose, calcium and phosphorus was observed in the blood serum of cows. After the injection of the drug, all signs of the disease quickly disappear.

Example 3. To study the comparative therapeutic efficacy of Polyvel, 20 cows with postpartum paresis were selected, of which two groups of 10 animals each were formed according to the principle of par-analogs. The cows of the same age, productivity, lactation period with the same clinical signs of the disease were included in the groups.

As the basic therapy, the drug “Kamagsol-G” was chosen, which includes: calcium chloride, magnesium chloride, aqueous magnesium and nipagin, which is most widely used in veterinary practice for the treatment of cows with this pathology.

Postpartum paresis in the cows of the first group was treated using the recommended drug, which was administered intravenously 2 or more times. In animals of the second group, postpartum paresis was treated by single-dose intravenous administration of Polyvel on the right side to the center of the hungry fossa in a dose of 200 ml, having previously prepared the surgical field at the injection site.

The treatment results were taken into account after 15, 30, 45, 60, 90, 120, 180, 240, 1440 minutes and 3 days after the last intravenous and intraperitoneal administration of drugs. They judged by the presence (absence) of general oppression of the animal, its rising, weakening of the signs of the disease, appetite, general tremor, body temperature, especially limbs and horns, palpebral reflex, loss of tongue due to its paralysis, detection of dry feces in the rectum, tympanum, when lying, is there a characteristic S-curvature of the neck, biochemical parameters of blood serum (Table 3).

According to the data shown in table 3, the intraperitoneal use of Polyvel allowed to cure 10.0% more cows compared to the basic treatment, the frequency of administration of the drug was reduced to 1 time, it is simple and accessible in any environment

The use of the Polyvela complex preparation in cows, along with an increase in the effectiveness of therapeutic measures, does not adversely affect the tissues and organs of the abdominal cavity, is accompanied by a decrease in labor costs of veterinarians, allows to obtain environmentally friendly products, increase productivity, and prevent complications after the introduction and relapse of the pathological process.

Claims (6)

A method of treating postpartum paresis in cows, comprising administering to the animal’s body a complex preparation consisting of an ASD-2 fraction and additives, characterized in that calcium borgluconate and 70% ethyl alcohol are used as additives and the mixture is a filler 40% glucose solution and 2% novocaine solution, taken in a ratio of 1: 1, in the following ratio of components, wt. %: fraction ASD-2 - 5; calcium borgluconate - 15; 70% ethyl alcohol - 10; filler - the rest, which is administered once intraperitoneally in a dose of not more than 200 ml per animal head heated to a temperature of 35-38 ° C.