RU2771334C1 - Device for modeling chronic neuropathic pain - Google Patents

Abstract

FIELD: medical technology.SUBSTANCE: invention relates to a biomedical engineering and can be used to stimulate the extremity of the test animal in order to aggravate the chronization of neuropathic pain. The device for modeling chronic neuropathic pain contains an electrical stimulator and a camera for the test animal. The camera is made in the form of a rectangular parallelepiped made of transparent plexiglass. The chamber contains a floor and shelves formed by metal rods that are oriented through drilled holes from the front wall to the back wall, protrude from the front wall and end flush in the back wall. The rods of the even row are connected to each other in parallel by an elastic stranded wire connecting the rods of the odd row in parallel with each other and ending with terminals for connection to the electrical stimulator. The upper side of the chamber can be made in the form of a hinged lid, for placing the animal in the chamber.EFFECT: possibility of free placement of the test animal.1 cl, 2 dwg

Description

The invention relates to biomedical technology and can be used to stimulate the limb of the test animal in order to aggravate the chronicity of neuropathic pain.

The technical result of the claimed invention is the possibility of free placement of the test animal.

Free placement of the test animal makes it possible to achieve electrical stimulation parameters that allow experimental maintenance and exacerbation of chronic neuropathic pain.

The claimed invention is illustrated by figures, which schematically depict:

in fig. 1 is a diagram of a chamber of a device for simulating chronic neuropathic pain;

in fig. 2 is a general view of the claimed device.

The claimed invention is a single functional system for stimulating the operated limb of an animal and a partially ligated sciatic nerve, which contains two main blocks - a chamber for an experimental animal and an electrical stimulator. As an electrical stimulator, the laboratory electrical stimulator ESL - 2 can be used.

The chamber for working with an experimental animal is a rectangular parallelepiped made of transparent plexiglass.

The upper side of the chamber is a hinged cover 1 used to place the animal in the chamber.

Holes are drilled horizontally through the front wall of the chamber towards the back wall and through it.

Metal rods 2 and 3 are passed through drilled holes from the front wall to the rear wall. Rods 2 and 3 protrude from the front wall, entering the back wall, and end flush in it.

The rods of the odd row 2 are connected by soldering to each other in parallel with an elastic stranded wire 4. The rods of the even row 3 are connected in the same way.

To the last two rods 2 and 3, i.e. the final even and odd rows are soldered stranded wire 4, ending with terminals for connection to the electrostimulator.

Rods 2 and 3 form shelves onto which the test animal can climb.

At the bottom of the chamber are also rods 2 and 3, representing the floor for placing the test animal. Rods 2 and 3 are connected similarly to a common electrical circuit.

The electrostimulator generates an electrical signal with the following parameters: oscillation frequency, pulse delay time, pulse duration, pulse amplitude (voltage), pulse configuration.

The electrostimulator operates from a 220 V network. The stimulator generates a signal with a voltage (amplitude) from 0.036 to 60.0 V, with an oscillation frequency of 1 * 10 ² Hz, a pulse delay time of 2 ms, a pulse duration of 0.5 * 10 ³ , a configuration - rectangular current.

The operation of the proposed device is as follows:

First, an intact test animal is placed in the chamber and the parameters of the electrical signal are selected empirically, to which it reacts most vividly by pulling back its paws. After determining the threshold value of irritation, an experimental animal is placed in the chamber and stimulated with electrical impulses for 10 minutes.

Before stimulation for the operated animal, electrically irritating signals are empirically selected, which should be lower in their parameters than those selected for intact animals and to which they respond with a motor vegetative or vocal function.

As part of the experiment, the operated animals are placed in the chamber one by one every day, the threshold voltage is set, to which the animal reacts by pulling back its paw.

Claims (2)

1. A device for modeling chronic neuropathic pain, containing an electrical stimulator and a chamber for the test animal in the form of a rectangular parallelepiped, made of transparent plexiglass, and the chamber contains a floor and shelves formed by metal rods, which are oriented through drilled holes from the front wall to the rear wall, protrude from the front wall and end flush in the back wall, while the even row rods are interconnected in parallel by an elastic stranded wire connecting the odd row rods in parallel and ending with terminals for connecting to an electrostimulator. 2. The device according to claim. 1, characterized in that the upper side of the chamber is made in the form of a hinged cover for placing the animal in the chamber.

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