RU2768126C1 - Pharmaceutical composition promoting removal of radionuclides from body and eliminating effects of radiation - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: present invention relates to the field of medicine, namely to radiation medicine, and discloses a pharmaceutical composition promoting the removal of radionuclides from the body and levelling the damaging effect of radionuclides on organs and functional systems of the body in accidents characteristic of emissions of nuclear power plants such as Chernobyl or Fukushima, containing mainly iodine isotopes (¹³¹J+¹³²J), caesium (¹³⁴Cs+¹³⁶Cs+¹³⁷Cs) and technetium (¹³²Tc), including thymosin, organic iodine, glycyrrhizin, silymarin and a complex of eleutherosides, as well as the amino acid carnitine, organic compounds of calcium, magnesium and selenium, provitamin beta-carotene, pectin as a carrier of the composition.

EFFECT: excretion of radionuclides and recovery of parenchymal organs, the functions of which are disturbed by the effect of radionuclides; at the same time, it turned out that the critical organs damaged by radionuclides are muscles and a thyroid gland.

1 cl, 1 tbl, 1 ex

Description

The invention relates to the field of radiomedicine and can be used in the treatment of radioactive lesions in humans. Recently, the situation with the technogenic danger of radiation exposure of the population has seriously aggravated: radionuclides generated at nuclear power plants, during the production of nuclear fuel and testing of nuclear weapons, began to enter the natural environment. More than 20 such radionuclides are known. The most dangerous of them are short lived J ¹³¹ and long lived Sr ⁹⁰ and Cs ¹³⁷ . Radiation is harmful in several ways at once. First, it negatively affects the protective functions of the immune system. Secondly, it negatively affects the cells of the body, including stem cells. Thirdly, radiation changes the structure of epithelial cells. Negative effects are also associated with a slowdown in the body's metabolism. In addition, radiation can cause a change in the structure of red cells in the blood. In addition, the effects of radiation on the body can lead to more serious diseases - infertility, cancer, metabolic disorders [What removes radiation from the body, what products? Internet resource. Access mode: https://www.syl.ru/article/364134/chto-vyivodit-iz-organizma-radiatsiyu-kakie-produktyi].

During prolonged work in places with a high radioactive background, the destructive effect of high radiation occurs gradually. If the radiation dose is up to 100 Rad, the clinical picture of radiation sickness may be blurred. At a dose of more than 100 Rad, a bone marrow form of radiation sickness develops. Months or years after receiving a serious dose of radiation, physical illnesses such as insomnia and depression may develop. The inevitable consequences of radiation sickness are stochastic effects. These include cancer, infertility, mental disorder. - [SYL.ru: https://www.syl.ru/article/364134/chto-vyivodit-iz-organizma-radiatsiyu-kakie-produktyi].

General state of the art

There are 4 ways of exposure of radionuclides to the body: remote from radionuclides located or distributed outside the body of a person or animal, contact, inhalation and oral (alimentary). Most radionuclides are characterized by pronounced uneven (organotropic) distribution in organs and tissues. This circumstance largely determines the features of the biological action of incorporated radionuclides. For example, when large amounts of evenly distributed radionuclides enter the body, a typical acute radiation syndrome develops, and when organotropic radionuclides enter the body, radiation pathology with a primary lesion of the depositing organ develops. There are hepatotropic radionuclides (for example, plutonium ²³⁹ Pu), renal (for example, uranium ²³⁹ U), uniform or mitotropic (for example, cesium ¹³⁷ Cs), osteotropic (for example, strontium ⁹⁰ Sr) and thyrotropic (iodine ¹³¹ J). In the case of prolonged exposure or when relatively small amounts of radionuclides enter the body, chronic non-specific inflammation occurs in the organs of preferential deposition, resulting in sclerotic processes (pneumosclerosis, liver cirrhosis, nephrosclerosis, or malignant tumors).

There are five groups of means for removing radionuclides from the body:

- mechanical removal of radionuclides (taking emetics, washing the stomach and intestines, drinking plenty of water, taking adsorbents);

- the use of adsorbents (substances that absorb radionuclides);

- accelerated removal of radionuclides by the method of substitution or complex formation (displacement of a radioisotope by similar or those that are naturally present in the body);

- the use of radioprotectors (a radioprotector is administered before the intended exposure);

- support for the protective and regenerative forces of the body.

Analogues

Known drugs designed to prevent resorption (absorption) of radionuclides into the blood. Enterosorbents are known as such agents: for example, adsorbar, polysurmin, ferrocin, bentonite. Known complexone pentacin, trisodium-calcium salt of diethylenetriaminepentaacetic acid, used to stimulate the excretion of already deposited radionuclides from the body for cases of acute and chronic poisoning by these radionuclides. However, the drug is toxic: in high doses it causes dystrophic changes in the kidneys.

It is known the use of synthetic zeolite (mordenite) to reduce the absorption and accelerate the excretion of radioactive cesium by the body of goats and lambs that consumed hay contaminated with Chernobyl radioactive fallout. The addition of zeolite to the feed at a dose of 10 g per day unexpectedly led to the excretion of ¹³⁴ Cs and ¹³⁷ Cs with urine and feces in an amount 2 times greater than that currently absorbed with hay. The use of synthetic zeolite (mordenite) to reduce the absorption and accelerate the excretion of radioactive cesium by the body of goats and lambs that consumed hay contaminated with Chernobyl radioactive fallout. The addition of zeolite to the feed at a dose of 10 g per day unexpectedly led to the excretion of ¹³⁴ Cs and ¹³⁷ Cs with urine and feces in an amount 2 times greater than that currently absorbed with hay. Obviously, mordenite contributed not only to the binding of cesium supplied with feed, but also to the excretion of cesium isotopes deposited in the body. Enterosorbents are known as such agents: for example, adsorbar, polysurmin, ferrocin, bentonite. It has been established that under the influence of natural zeolite-containing tuff, the excretion of the incorporated radionuclide with faeces is significantly accelerated, and the incorporated and deposited radioactive cesium is mainly excreted in the urine [Harmful chemicals. radioactive substances. L. Chemistry, 1990, p. 64]. Accelerated excretion of cesium with faeces with a multiplicity of excretion of 5-8.5 leads to a redistribution of the excretory load from the kidneys to the gastrointestinal tract [Toxicological and hygienic studies of zeolites of the Shivyrtuiskoye deposit: Research Report / Rostov-on-Don Medical Institute, 1990]. When determining chronic specific activity, no mutagenic, embryotoxic, immunotoxic, allergenic, carcinogenic effects were detected [Research reports of the Institute of Biochemistry of the Siberian Branch of the Russian Academy of Medical Sciences, 2nd Moscow Medical Institute, 1990-1992].

Also known complexone pentacin, trisodium-calcium salt of diethylenetriaminepentaacetic acid, used to stimulate the excretion of already deposited radionuclides from the body for cases of acute and chronic poisoning by these radionuclides. For the same purpose, clinoptilolite varieties of zeolite-containing rocks were used to remove deposited radionuclides from the body, and Shivyrtuin or Khongurin is used as a clinoptilolite variety of zeolite-containing rocks [RF Patent No. 2063229. Means for removal of the radionuclides deposited in an organism. Authors: Panin L.E., Tretyakova T.A., Gaidash A.A. Internet resource: https://new.fips.ru/registers-doc-view/fips_servletl.

The disadvantages of zeolite-containing preparations include their selectivity: they are all used as antidotes for emergency treatment of acute oral poisoning with radionuclides or as food additives for chronic alimentary intake of radionuclides into the body. That is, in all cases, the means are intended for their direct contact with radionuclides in the gastrointestinal tract.

Special means - enterosorbents that help the body cope with the effects of radiation. This is the drug ASD-2. It can be used as a biologically active food supplement. This drug successfully removes radiation from the body and stops the negative effects of radionuclides. To protect the DNA structure, you can use the drug "Dimethyl sulfide". It has an excellent antioxidant effect: [Internet resource. Access mode: https://www. syl.ru/article/364134/chto-vyivodit-iz-organizma-radiatsiyu-kakie-produktyi to remove radiation from the body].

Pills from radiation - "Polifepan". This tool helps to effectively deal with the negative effects of x-ray exposure. For adults, the daily dose of this drug is approximately 16 tablets. Children are recommended to give no more than 10 pieces. The drug is completely harmless. It can be taken even by young children and pregnant women [Internet resource. Access mode: https://www. syl. ru/article/364134/chto-vyivodit-iz-organizma-radiatsiyu-kakie-produktyi].

Organic preparations, substances and products that promote the removal of already deposited radionuclides from the body have become very widespread. These include polysaccharides (pectin, dextrin), phenyl and phytic compounds, gallates, serotonin, ethyl alcohol, certain fatty acids, trace elements, vitamins, B and P vitamins (vitamin C enhances their effect, although it does not have a protective effect on its own). ); enzymes, hormones, and flavonoids; calcium and potassium - prevent the absorption and accumulation of radioisotopes and accelerate their excretion [Internet resource: //studwood.ru>veschestva produkty sposobstvuyuschie vyvedeniyu organiz].

Calcium contributes to the excretion of strontium from the body. As a result of 10 years of research, the Hungarian doctor Krompher, with a group of physicians and biologists, established that eggshell is an excellent excretory agent for radionuclides, prevents the accumulation of strontium-90 nuclei in the bone marrow [Internet resource. Access mode: studwood.ru>…vyvedeniyu_organizma_radionuklidov].

Calcium promotes the excretion of strontium from the body. Radioactive substances are quickly excreted from the body, concentrating in soft tissues and internal organs (cesium, molybdenum, ruthenium, iodine, tellurium), slowly - firmly fixed in the bones (strontium, plutonium, barium, yttrium, zirconium, niobium, lanthanides). Of the large number of radionuclides, strontium-90 and cesium-137 are the most important as a source of public exposure [Strontium-90. Products that remove radionuclides. TopTraining.ru>articles/543/].

Reference

1. Calcium salts, like CaCl ₂ chloride, CaBr ₂ bromide, CaI ₂ iodide and Ca(N0 ₃ ) ₂ nitrate, are highly soluble in water. CaF ₂ fluoride, CaCO ₃ carbonate, CaSO ₄ sulfate, Ca ₃ orthophosphate (PO ₄ ) ₂ , CaC ₂ O ₄ oxalate and some others are insoluble in water [Calcium salts - Wikipedia. Internet resource. Access mode: ru.wikipedia.org>Calcium salts];

2. Norms of physiological needs for energy and nutrients for various groups of the population of the Russian Federation according to MP 2.3.1.2432-08: for persons aged 25-50 years, the consumption rate is 1000.0 mg / day.

3. Calcium citrate (1200 mg/day) in combination with vitamin D (800 mg/day) reduces the risk of all types of fractures by 13%, and the absorption of calcium from calcium citrate was significantly higher than from calcium carbonate: by 20% in the average for the sample, by 24% in category "A", by 22-27%. The citrate anion itself contributes to the normalization of bone metabolism. A randomized trial of elderly patients without osteoporosis (n=201 people aged 65 years and older) showed that long-term intake of potassium citrate (4.5 g/day for 2 years) contributed to the increase in bone mineral density (by an average of 1.7±1, 5%, P=95%) [Source of information. Internet resource: A differentiated approach to the choice of soluble calcium preparations of the second generation. https://www.lvrach.ru/2014/11/154360971.

4. Plasma magnesium levels below 0.76 mmol/l are considered as a significant risk factor for myocardial infarction and stroke: the European epidemiological study on cardiovascular disease identified hypomagnesemia as an important risk factor for mortality from stroke and cardiovascular disease [Schimatschek HF, Rempis R. Prevalence of Hypomagnesemia in an unselected German population of 16,000 individuals//Magnes Res. 2001; 14 (4): 283-290]. With a decrease in the level of Mg ²⁺ , the tone of the coronary vessels increases, which leads to ischemic damage. The introduction of the necessary and sufficient amount of magnesium, calcium and potassium, unsaturated fats, as well as the norm (but not an excess!) of antioxidants is considered as an important reserve for reducing mortality from cardiovascular diseases. A low concentration of extracellular magnesium leads to vasospasm, increasing their sensitivity to vasopressor agents [Vascular diseases. Internet resource. Access mode: https://medi.ru/info/5209].

The participation of magnesium as a central substrate of the Krebs cycle of interaction with dicarboxylate transporter proteins and the physicochemical features of the citrate molecule itself. It should be emphasized that all citrate metabolites are essential endogenous molecules. The almost complete utilization of citrate (transformation into carbon dioxide and water) makes it an ideal carrier of magnesium; citrate is an ideal, fully biodegradable, "environmentally friendly container" for the transport of magnesium into cells, which also serves as an effective fuel. Magnesium citrate promotes the activation of magnesium transport into the cell.

Magnesium citrate leads to an increase in the content of potassium, sodium and magnesium in the blood plasma, but also causes a significant increase in the activity of Na, K-pumps in erythrocytes [Sriboonlue P., Jaipakdee S., Jirakulsomchok D., Mairiang E., To-sukhowong P. , Prasongwatana V., Savok S. Changes in erythrocyte contents of potassium, sodium and magnesium and Na, K-pump activity after the administration of potassium and magnesium salts // J Med Assoc Thai. 2004; 87 (12): 1506-1512].

To remove heavy metals from the body, including cesium-134, use products with a high content of oxalic acid (sorrel, spinach, lettuce, etc.). Garlic, onions, cottage cheese, viburnum and gooseberries have the greatest ability to absorb radioactive elements. Anti-radiation effect is provided by vegetable oil, cottage cheese, calcium preparations, alcohol [Cleansing the body from radionuclides and heavy ... Internet resource. Access mode: medbe.ru>For health Purification of the body>…-ot-radionuklidov-i…].

Proponents of dairy products for radiation claim that the calcium they contain reduces the accumulation of radioactive strontium. It is also indicated that cottage cheese cleanses the body of dangerous substances better than milk. Dairy products also contain methionine, an amino acid indispensable for the removal of radionuclides. Methionine: Responsible for cell repair. This substance is rich in fish, quail eggs, asparagus.

β-Carotene is a substance that detects pathogenic cells and restores them. Penetrating through cellular structures, carotene eliminates infected atoms. Then, it reacts to create a new cellular element. Carotene is called one of the most effective components against the complications of radiation. In addition to apples, it is useful to eat citrus fruits: grapefruits; oranges; tangerines; lemons. In addition to fruit pectins, citrus fruits contain potassium and calcium. Potassium recreates something like a barrier in the way of radionuclides. The component inhibits the absorption of radioactive ingredients into the bloodstream. A sufficient amount of potassium in the body helps to increase immune forces and increases protection against infections and viruses.

2. Vegetables are widely used to remove radiation. Preference is given to radish, which contains pectin and selenium - an element that removes radionuclides from the tissues and cells of the body. Selenium is able to penetrate deeply into infected cells, delaying their development. In addition to vegetables, this substance is also found in nuts and cereals.

It is recommended to consume pepper with pectin, carotene and fiber - resistant elements that can prevent the effects of radiation. Fiber can react with radionuclides, which are then excreted from the human body with amino acids.

Cabbage is rich in caffeic acid, which breaks down infected particles into simple compounds. Subsequent to such splitting, other elements present in the body can act on them and eliminate them. Fiber, caffeic acid, is also found in greens and fruits. Onions and garlic also get rid of radionuclides.

Grape and pomegranate juices have an antioxidant effect, which help the body fight the effects of radiation.

For the preparation of decoctions, preference should be given to such plants: linden; chamomile; tea mushroom; burdock; buckwheat; linen; prunes; nettle; echinacea; calendula; St. John's wort. To prevent the effects of radiation, it is proposed to choose a green tea drink. Natural green tea contains catechins - flavonoids, the strongest antioxidants [Products that remove radiation from the human body. Internet resource: https://medicina.top/produktv-vwodvashhie-radiaciyu-iz-organizma-cheloveka].

The absorption of cesium-137 is prevented by the use of foods containing a large amount of potassium (beets, dried apricots, nuts, unpeeled potatoes); the absorption of other radionuclides is weakened by pomegranates, raisins, blackcurrants, cranberries, nuts, garlic, onions, beets, parsley, as well as squid and seaweed.

The most effective domestic drug that removes heavy metals from the body is Zosterin. It was derived from the sea grass zostera. The tool actively attracts, retains, and then removes heavy metal ions and other industrial toxins even from bone systems. The drug "Befungin" has a similar effect. Chaga is considered an effective cleanser. Methionine, contained in dairy products, meat and fish, is also necessary for the removal of radionuclides [How to remove radioactive elements (radionuclides) from the body [Internet resource. Access mode: https://ongreenway.org/2011/03/radionuklidy/].

3. Iodine - as the most famous remedy for radiation. Inside it was prescribed as potassium iodide. Iodine is effective when applied before irradiation. If it accumulates in the thyroid gland before radiation, then radioactive isotopes will cause less harm to the body. Iodine can be found in seafood, squid, seaweed. This microelement prevents cesium and strontium from accumulating [Internet resource. Access mode: medicina.top/produkty-vyvodyashhie-radiaciyu-iz-organizma-cheloveka]. When irradiated, it is also useful to take preparations based on iodine and seaweed. The accumulation of radioactive trace elements leads to dysfunction of the thyroid gland. The iodine-containing products include: cod liver; pork; beef; cheeses; persimmon; spinach; fish fat. Iodine is taken orally in the form of potassium iodide. The drug should be taken at a dosage of 100-200 mg per day. Tablets are washed down with water or milk. Such an additive is an excellent prevention of radiation accumulation and thyroid problems - [Read more on SYL.ru: https://www.svl.m/article/364134/chto-vyivodit-iz-organizma-radiatsivu-kakie-produktyi].

Traditional medicine for thyroid diseases recommends organic iodine, for example, as part of feijoa berries. There is a lot of iodine in fruits: up to 4 mg per 1 kg, which is in them in a water-soluble state, which allows a high degree of absorption in the human body [source: PRO Wellness blog. Feijoa berry - how to eat and what is useful: Internet resource. Access mode: https://m.siberianhealth.com/m/blogs/pitanie/yagoda-fey]dioa-kak-edyat-i-chem-poleznal. According to the Great Soviet Encyclopedia, the iodine content in feijoa fruits is 2.06-3.9 mg per 1 kg of fruit (the daily iodine requirement for a middle-aged person of normal build is 0.15 mg).

The disadvantages of iodine-containing drugs include the fact that they must be taken before irradiation. As a result, the substance accumulates in the thyroid gland, and helps the body resist the effects of harmful isotopes.

Thus, from the analysis of the general level of technology, it follows that there are various methods and various preparations, mainly of plant origin, capable of removing radionuclides from the body, and each of the basic plants in its composition has one or more ingredients that bind or neutralize certain groups of radionuclides. , which subsequently the human body can naturally excrete with urine or feces.

The list of medicinal plants that have been tested as "removing radionuclides from the body" is small:

1. Herb horsetail. 2. Birch mushroom chaga. 3. Flower baskets of black elderberry. 4. Lingonberry leaf.5. Orthosiphon sheet. 6. Herb sweet clover. 7. Grass knotweed or knotweed. 8. Sea grass "Zostera" [How to remove radionuclides from the body? Traditional medicine recipes (http://www.biochaga.ru/kak-vvvesti-radionuklidvl. A number of herbs with active ingredients are presented in the form of teas, others in the form of tablets, but mainly as traditional medicine.

Special opinion as a means of removing radionuclides belongs to licorice. Licorice root is a real pantry of useful and healing substances, such as asparagine, ascorbic, free glycyrrhetin, glycyrrhizic acid and glycyrrhizin. It also contains flavonoids, essential oils and resins. The first component promotes wound healing and relieves inflammation. [Healing properties of licorice root. Internet resource. Access mode: http://polzavred-edi.ru>solodka-lechebnye-svojstva-i…]

The presence of glycyrrhizic acid allows you to take licorice for poisoning, infectious diseases, manifestations of intoxication. It is an excellent detoxifying agent that neutralizes the toxic effect of chemical drugs [The use of licorice. Internet resource. Access mode: https://www.ayzdorov.ru/tvtravnik_solodka.php].

As it turned out, it was the presence of flavonoids [flavonoid glycosides (liquiritin, liquiritigenin, liquirithoside), isoflavonoids (formononetin, glabren, glabridin, glabrol, 3-hydroxyglabrol, glycyrrhizoflavone] that licorice owes to the properties of protection against radiation, namely, they are antagonists of radionuclides.

In folk medicine, licorice is considered an unsurpassed way to protect against radiation. An American rocket soldier won't get to work until he's drunk a glass of licorice. Her herb contains glycyrrhizin. It protects against radiation and is able to remove nuclides from the body. Decoction: one or two teaspoons of the root of the grass is poured into a cup of water and boiled for ten minutes [Folk remedies for radiation 22/09/20157200. Internet resource. Access mode: http://griskomed.ru/narodnyie-sredstva-ot-radiatsiipechat.htmll.

The technical task set before the invention is not only the development of a means of removing radionuclides from the body, but also the elimination of the consequences of the harmful effects of their stay in the body. However, there are no means for removing from the body and neutralizing the consequences of the penetration and deposition of radionuclides "in general": it is known about the organ-specificity of their effect on the body and the selectivity of accumulation in organs. For illustration, we took the consequences of accidents with the release of radionuclides at the Fukushima NPP and the Chernobyl NPP. Emissions were quantitatively commensurate and represented by isotopes: iodine ( ¹³¹ J+ ₁₃₂ J), cesium ( ¹³⁴ Cs+ ¹³⁶ Cs+ ¹³⁷ Cs) and technetium ( ¹³² Tc). [Organotropy of radionuclides. Comparison of the activity ratios of radionuclides in the mixture released from the emergency reactors of the Fukushima-1 nuclear power plant and the Chernobyl release in relation to cesium 137, taken as a unit. Internet resource. Access mode: http:yandex.ru/images/search].

Cesium refers to a uniform distribution (muscle type) in the body and accumulates 79% in the muscles, 8% in the bones (bone marrow syndrome), liver - 9% and less than 1% in the kidneys. Radioactive iodine in critical organs is distributed as follows: 20% in the thyroid gland, 13% in the bones, 2% in the kidneys and 6% in the liver. Technetium (Tc99) accumulates mainly in the thyroid gland. [Organotropism of radionuclides. Shares of accumulation of nuclides in critical organs. Internet resource. Access mode: http:yandex.ru/images/search].

Thus, with such data on the organotropism of NPP emissions, the “critical organs” that need preferential protection turned out to be muscles (even distribution) and the thyroid gland.

A technical solution is known that helps to increase the body's resistance, increase efficiency and counteract extreme influences, based on the healing properties of milk thistle, eleutherococcus and licorice root [RF patent No. 2475257 "Tool for increasing the body's adaptability to extreme conditions". Tretyak L.N., Gerasimov E.M.]. The product contains brewer's yeast plasmolysate, enriched with extracts of eleutherococcus, milk thistle and licorice root. The originality of the action of the proposed remedy consists in the organization of complex protection of organs and body systems from the damaging effects of excess stress hormones, including:

- activation of phosphorus metabolism in brain cells, which ensures a rapid restoration of the functions of the central nervous system,

- contributes to the expansion of the entire capillary bed of the myocardium, preventing the development of angina pectoris;

- protects hepatocytes from excess catecholamines and free radicals, providing long-term endogenous energy supply to working muscles without exogenous carbohydrate supplementation by stimulating gluconeogenesis and glycogen neogenesis;

- the presence of glyceram not only leads to an increase in the drainage function of the broncho-pulmonary system, but also has a powerful detoxifying effect.

Also known is an anti-stress drink created on the basis of agents that increase efficiency, tolerance to extreme loads, adaptability to extreme conditions and containing a 50% aqueous solution of plasmolysate obtained from brewer's yeast, equipped with the active principles of eleutherococcus, milk thistle and malt root, and the drink contains the amino acids glycine and L-carnitine, as well as organic compounds of magnesium and selenium [Anti-stress drink, Application for invention No. 2020132527 dated 10/02/2020. Authors Tretyak L.N., Gerasimov E.M.].

However, the drink does not sufficiently activate the immune system and requires special storage conditions.

A direct prototype of a comprehensive solution for neutralizing radionuclides and compensating for their damaging effect on organs and systems of the human body has not been identified.

However, it was found that the main natural agents for the removal of radionuclides from the body are the polysaccharide pectin or glycyrrhizin-containing compositions.

A known method for producing pectin from watermelon peels, which involves washing the raw material with water, grinding the raw material, after which hydrodynamic cavitation is carried out, sonication at a frequency of 300-400 Hz, and then acid hydrolysis, at a pH of 5.0-6.0, a temperature of 68-72 °C for 50-70 min, the obtained extract is separated, ultrafiltration purification of the pectin-containing extract is carried out, pectin substances are precipitated with calcium chloride [Method of obtaining pectin from watermelon peels, RF patent 2333669, published 20.09.2008].

The closest technical solution is a pharmaceutical composition with a stress-protective effect, and a method for the prevention and treatment of functional or stress-induced disorders, characterized in that it contains a thymus hormone, for example, thymosin, which has an immunostimulating effect at the amino acid sequence: Ac-Ser- Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala- Glu-Asn-OH; moreover, organic compounds of deficient bioelements, such as iodine, lithium, selenium and organic compounds of zinc and magnesium, are added to the composition. At the same time, in the composition, organic compounds of metals and iodine are mixed with eleutherosides, silymarin and glyceram, and contain the amino acids glycine and L-carnitine. A feature of the pharmaceutical composition is that the carrier of the composition is pectin, and all elements of the composition are in a form adapted for administration through the oral cavity, for example, in the form of marshmallow or marmalade. At the same time, the product with the maximum allowable single daily dose for an adult is given to the patient once a day for the period necessary to achieve a therapeutic effect determined by medical indications [Application for invention No. and treatment of functional or stress-induced disorders. Authors: Gerasimov E.M., Tretyak L.N., Kichenko E.E.]. At the same time, the technical task set before the invention was the creation of a pharmaceutical composition with a stress-protective effect, for use as a method for the prevention and treatment of functional or stress-induced disorders in regions with pronounced geochemical deviations in the content of, for example, iodine, lithium, fluorine and Selene; however, it was required to provide oral administration of the peptide, disguised as the use of a flavored dessert delicacy. For this, organic compounds of deficient bioelements are added to the composition, such as iodine, which ensures the functioning of the thyroid gland and is responsible for regulating the basic metabolism in the body; lithium, which ensures the normal functioning of the brain; selenium as an antioxidant and stimulator of immune processes in the body; as well as organic zinc compounds, which stimulate the action of thymus hormones and metal-dependent enzymes; as well as magnesium, which enhances the contractility of the heart muscle and its blood supply; mixed with extracts of Eleutherococcus, which stimulates metabolic processes in the cerebral cortex, while at the same time weakening the effects of stress and supporting the immune system, eleutherosides significantly increase overall performance and are used as a tonic for fatigue; silymarin, which enhances the antitoxic function of the liver, glyceram, in addition to enhancing the drainage function of the lungs, which has anticoagulant and detoxifying properties; the composition contains the amino acid glycine, which improves metabolic processes in the brain and has a sedative effect, and L-carnitine, a factor in providing myocardium with energy; moreover, in the method for the prevention and treatment of stress-dependent conditions, all components of the composition are taken in the amount of daily doses acceptable for adults in mg/kg of the body weight of the consumer, while the composition is introduced into the marshmallow from watermelon-melon juice, and pectin from watermelon is used as a binder crust.

The technical problem set before the present invention is not only in the removal of radionuclides, but also in the direct restoration of parenchymal organs, the functions of which are impaired by exposure to radionuclides; it turned out that the critical organs damaged by radionuclides are the muscles and the thyroid gland.

The technical problem was solved by the fact that a pharmaceutical composition was created that promotes the removal of radionuclides from the body, and leveling the damaging effect of radionuclides on the organs and functional systems of the body, which contains the polysaccharide pectin and organic calcium salts, which contribute to the removal of isotopes from the body; thymus hormone and organic selenium compound as immunogenesis stimulants; organic iodine to protect the thyroid gland; licorice root extract as a drug with antioxidant, anticoagulant and detoxifying properties; silymarin, which increases the antitoxic function of the liver; the amino acid carnitine and organic magnesium compounds to protect muscles and improve myocardial blood supply, as well as a complex of eleutherosides that protect the brain; moreover, the composition is given the form of a delicacy in the form of watermelon-melon candy.

Application example

The claimed pharmaceutical composition differs from other compositions in an advantageous combination of organic and mineral substances that have the ability to adsorb radionuclides, as well as the properties of removing already deposited radionuclides from the body, while the complex of drugs used in the composition stops or prevents the negative effects of the action of radionuclides on vulnerable organs and body systems. The dosage is calculated for the consumption of no more than one kilogram of marshmallow per day (in equal portions three times a day). At the same time, the maximum allowable dose of daily consumption of any of the components of the composition permitted by the Ministry of Health of the Russian Federation (Upper allowable consumption level according to MP 2.3.1.1915-04.) will not be exceeded. The duration of use is determined by the medical indicators of the course of drug remission.

All this allows us to conclude that the claimed technical solution is patentable.

The government of the Orenburg region, knowing the consequences of nuclear weapons tests in the Totsk region of the region, decided to allocate one of the lines of the projected pectin plant for the production of marshmallow with the composition of the declared technical solution.

This allows us to talk about the technical feasibility of implementing the claimed technical solution.

Thus, the financing of the construction of a watermelon-melon pectin plant and the implementation of the proposed invention are underway.

Claims (1)

Pharmaceutical composition that promotes the excretion of radionuclides from the body and levels the damaging effect of radionuclides on organs and functional systems of the body during accidents typical for emissions from nuclear power plants such as "Chernobyl" or "Fukushima", containing mainly isotopes of iodine ( ¹³¹ J + ¹³² J), cesium ( ¹³⁴ Cs+ ¹³⁶ Cs+ ¹³⁷ Cs) and technetium ( ¹³² Tc), including thymosin, organic iodine, glycyrrhizin, silymarin and a complex of eleutherosides, as well as the amino acid carnitine, organic compounds of calcium, magnesium and selenium, provitamin beta-carotene included in the pectin polysaccharide as composition carrier.