RU2626678C1 - Diet composition with treatment and preventive properties - Google Patents

Abstract

FIELD: pharmacology.

SUBSTANCE: diet composition for intestinal microflora normalization is proposed, based on a mixture of prebiotics, including citric acid as monomeric substances, disaccharides as dimeric substances, inulin as polymer substances, natural gum; pectin, plant extracts and flavor. The composition contains stevia leaves extract, aqueous extracts of callisia fragrans shoots and white willow bark as plant extracts, the composition further contains glucosamine, and isomalt as disaccharide, with a certain ratio of components.

EFFECT: composition described above increases the bioavailability of components, has a prebiotic, antioxidant, anti-inflammatory, immunomodulatory and restorative effect, effectively normalizes the intestinal microflora.

1 tbl, 2 ex

Description

The invention relates to the food and pharmaceutical industries and can be used to obtain a biologically active additive (BAA), used for direct consumption as a prophylactic, or to create functional food products, namely, a composition containing prebiotics, callisia extracts and willow extracts , glucosamine, a natural sweetener designed to regulate intestinal microbiocenosis, normalize the composition and functions of the natural human microflora, improve metabolism on the substance, the functional state of the immune status of the musculoskeletal system, connective tissue, skin, nails, hair and epithelium.

Various organs and cavities of the human body, together with their natural microflora, represent a single ecological system - microbiocenosis. Normal microflora is a complex association of bacteria, fungi, viruses and other microorganisms. Normoflora microorganisms carry out vital functions for humans: protective, digestive, trophic, energetic, cleansing (detoxification), antimutagenic, immune, etc.

Currently, interest in biologically active substances of plant origin has increased due to the transformation of the nature of a number of diseases, increased reaction of the body to synthetic drugs, and also because when using decoctions of medicinal herbs, it is not always possible to achieve the required results, in particular, pronounced favorable pharmacologically effects combined with high consumer properties.

One of the active ingredients in creating dietary supplements is prebiotics.

Prebiotics are substances that have a selective stimulating effect on the reproduction, growth and functional activity of microorganisms of the natural (normal) microflora of the person, primarily the normoflora of the digestive tract. Prebiotics perform the functions of selective stimulation and restoration of the abundance and activity of the normal natural bacterial microflora of the digestive tract. Indirectly due to this, such effects are realized - improving digestion, normalizing the regularity and lightness of stools, improving the condition of the liver, spleen, pancreas, small and large intestines, eliminating chronic inflammation, dysbiosis, improving the absorption of calcium and other macro- and microelements, as a result, maintaining the structure and density of bones, teeth, healthy nails, hair, joints, epithelium, improving metabolism, for example, cholesterol, increasing immunity, lowering blood sugar in diabetes e reduction of overweight and others.

The main types of such prebiotic compounds: monosaccharides (xylitol, raffinose, sorbitol, etc.), oligosaccharides (lactulose, isomalt, lacitol, etc.), polysaccharides (pectins, dextrin, inulin, chitosan, gums, etc.), enzymes (beta microbial galactosidases, proteases, etc.), amino acids (valine, arginine, glutamic acid, etc.), unsaturated fatty acids (eicosopentaenoic, etc.), organic acids (propionic, acetic, citric, etc.), plant and microbial extracts (carrot, potato, garlic, yeast, etc.) and others (lecithin, glitch ononic acid, starch syrup, etc.).

The most studied group of prebiotics is the group of carbohydrate prebiotics, which are carbohydrates consisting of one, two or more molecules connected by beta-glycosidic bonds. The absence of betaglycosidases in the enzyme system of the human digestive system, that is, enzymes that break down such bonds, makes prebiotics indigestible (digestive enzymes) carbohydrates. Prebiotics, not being digested and not absorbed in the upper digestive tract, are split (hydrolyzed and absorbed) exclusively by the normal flora of the digestive tract and thus act for it as a selective nutritional growth factor.

The selection of prebiotic substances in a balanced composition is carried out in accordance with their systematization along the chain length (the number of monomer units in the prebiotic molecule) to obtain an effect on a specific section of the digestive tract. So, monomeric prebiotics (number of units 1) begin to show an effect from the oral cavity and esophagus (monomeric carbohydrates, citric acid). Oligomeric prebiotics (with the number of links from 2 to 10) - show an effect in the small intestine and upper parts of the large intestine. These include isomalt oligosaccharide. Polymeric prebiotics (with a number of units of more than 10) exhibit an effect from the upper sections to the lower sections of the large intestine. The combination of different types of prebiotics allows you to create balanced prebiotic complexes for direct use, as well as target products based on them to obtain accented effects in relation to certain organs and systems (for the heart, immunity, liver, etc.). These include pectin, for example, apple pectin (a polymer prebiotic such as methylgalacturonate), guar gum (a polymer prebiotic such as galactomannan), xanthan gum (a polymer prebiotic such as galactomannan), and inulin (a polymer prebiotic fructan).

It is known to use prebiotics to improve, supplement, expand the consumer characteristics of known products - milk drink, chocolate, ice cream, cheese, nutritious mixture / sweetener / sweetener composition, including to reduce side effects of the main active substances or as a filler (US Pat. RF No. No. 2268069, 2428051). In these products, prebiotics are used in concentrations insufficient to meet the recommended daily requirements for prebiotic substances, i.e. They are not used for targeted action on the normoflora of the digestive tract, but for a concomitant effect on the effect exerted by the main active substance. Therefore, in these products, their prebiotic properties are not fully realized in full and in the required volume, through which a versatile healing effect on the human body is carried out.

A known composition for normalizing microflora and cleansing the body of toxins (US Pat. RF No. 2433751), containing at least one insoluble enterosorbent, at least one prebiotic and at least one lauric type edible fat with a melting point not higher than 39 ° C, and the enterosorbent and prebiotic are introduced in the form of a powder with a particle size of not more than 65 microns, with the following components: enterosorbent (for example, highly esterified insoluble pectin), prebiotic in the form of an oligosaccharide (for example, isomalt) or polys Harida (e.g., inulin), edible fat of lauric type. The composition may further comprise at least one flavoring, preferably a food flavoring, or a flavor corrector.

A known composition (US Pat. RF No. 2473347) to normalize the microflora of the body, containing at least 3 prebiotic substances with different lengths of the molecular chain: monomeric prebiotics with the number of units 1; dimeric prebiotics with a number of units of 2; oligomeric prebiotics with a number of units from 3 to 10; polymer prebiotics with more than 10 units; moreover, the components in the composition are in a certain ratio. An example is the prebiotic complex for sports nutrition, consisting of palatinose (isomaltulose), resistant starch, oligofructose, inulin, lactitol (lactitol), ground flax and sesame seeds, guar gum (polymer prebiotic such as galactomannan maloic acid), pectin Stevia extract (sweetener). This invention provides the restoration, maintenance of qualitatively-quantitative composition and the activation of bacteria of various kinds of normoflora of the digestive tract for the full realization of the function of microbiocenosis throughout the digestive tract, starting from the oral cavity and esophagus to the lower parts of the large intestine, as well as the restoration of microbiocenosis of other parts of the body. To obtain problem-oriented prebiotic complexes, it is effective to use extracts and other extracts from plants.

Known combination drug with a specific composition and ratio of components (US Pat. RF No. 2303453), namely, a composition containing glucosamine and having increased anti-inflammatory activity, the Composition relates to the pharmaceutical industry. The composition contains the following ingredients in g: glucosamine 0.5; willow extract 0.1; citric acid 0.02; pectin 0.25; sucrose 0.25.

Known dietary supplement for food (US Pat. RF 2251934), which contains pectin, liquid paraffin, flavoring, preservative, polysaccharide and distilled water. In this case, the polysaccharide is selected from the group: agaragar, agaroid, agaropectin, starch, xanthan gum. The components are contained in the additive in a specific ratio. The invention allows to obtain an additive with an increased shelf life and having a tonic, antioxidant, immunomodulatory effect.

Known tool (US Pat. RF №2217191) for the treatment and prevention of diarrhea and gastric ulcers in animals and humans, consisting of a mixture of pectin plant fiber material with a phospholipid.

Known composition for instant tea drinks (US Pat. RF No. 2553565), containing isomalt as a sweetener. The invention allows to obtain non-cariogenic, low-calorie foods with exceptional organoleptic properties, having optimal sweetness, high mechanical stability during storage, improved solubility and flowability, improved ability to absorb or absorb flavor or aromatic components.

Known biologically active food supplement - tea "Night Dreams", which includes chamomile flowers, leaves and blueberries, chicory root, stevia leaves, green mint leaves, passionflower, hawthorn berries, valerian root, hop flowers (cones), scutellaria . It is recommended for use as a general strengthening and mild sedative with high psycho-emotional stress.

Known multicomponent concentrate for diabetic and dietary products (US Pat. RF No. 2157643) containing maltose syrup, extract of stevia leaves, natural honey and water. The resulting multicomponent concentrate forms the taste of products for patients with diabetes, enriches them with natural biologically active substances, micro and macro elements, reduces the calorie content of the finished product containing it, and reduces the consumption of the product, which forms the harmony of taste.

Known collection with antidiabetic action, stevia herb, noble laurel, eugenolus basil, medicinal hemorrhage (US Pat. RF No. 2000793).

It is known to use dry stevia leaves (powder) containing essential and non-essential amino acids for dry diet foods (US Pat. RF No. 2428054).

Various formulations are known based on an extract from stevia leaves, for example, having a positive effect on the gastrointestinal tract, liver, respiratory, endocrine and urogenital systems and the thyroid gland and exhibits antitoxic, antioxidant and antistress properties on the human body, which also contribute to cleansing the body of toxins and toxins, and therefore can be used in the diet of the general population, including in geriatric practice (US Pat. RF No. 2279837); a composition that allows you to increase the body's resistance to colds, normalize blood pressure and activate the process of splitting sugar in the blood, so it can be used in diet and diabetic nutrition (US Pat. RF No. 2160309); a composition that exhibits antihypoxic, antistress and antioxidant properties that positively affect the general condition of vital systems of the body (US Pat. RF No. 2279836); a composition that allows you to normalize carbohydrate metabolism, as well as increase the antioxidant activity of the body and reduce blood cholesterol (US Pat. RF No. 2391850); a composition that is a powerful source of bioflavonoids, silicon, catechins, steviosides and tannins, which has a directed effect on improving the condition of the liver and lymphatic system, preventing edema, optimizing metabolic processes (US Pat. RF No. 2403812).

A number of developments based on the herb of callisia aromatic are known from the prior art. A propylene glycolic callisia extract has been proposed as a serum with a regenerating effect used in medical cosmetology (US Pat. RF No. 2469704). Tincture of fragrant callisia herb is used as a separate step in the treatment of precancerous and early stages of gastric cancer (US Pat. RF No. 2467758). Supplements based on fragrant callisia are not developed and are not described in the literature.

A common drawback of the above compositions and dietary supplements is the lack of useful properties inherent in juice and aqueous extract obtained from fresh shoots of fragrant callisia, in particular, immunomodulating, pronounced antioxidant, biostimulating, detoxifying, actoprotective, etc.

Closest to the claimed technical solution is a composition (US Pat. RF No. 2473347) with therapeutic and prophylactic properties based on a mixture of prebiotics, including citric acid as monomer substances, disaccharides as dimeric substances, inulin, plant gum, pectin as polymeric substances, plant extracts and flavoring. The disadvantage of the prototype is the lack of components that have therapeutic properties in chronic diseases of the musculoskeletal system.

The technical result of the proposed composition is the selection of the optimal ratio of components in the composition, in a synergistic effect with the combined use of already known ingredients. The composition allows to increase the bioavailability of the components, expand the range of dietary supplements and compositions for functional nutrition with prebiotic, antioxidant, anti-inflammatory, immunomodulatory and restorative properties.

The technical result is achieved through the use of a dietary composition to normalize the intestinal microflora based on a mixture of prebiotics, including citric acid as monomer substances, disaccharides as dimeric substances, inulin, natural gum, pectin as polymeric substances; plant extracts and flavoring. At the same time, the composition contains extracts of the fragrant callisia shoots, extracts of stevia leaves and extracts of white willow bark obtained by water extraction as plant extracts, the composition additionally contains glucosamine, and isomalt as disaccharide, in the following ratio of components, mass. %:

Stevia leaf extract 19.0-21.0 Fragrant Callisia Shoot Extract 10.0-14.0 White Willow Bark Extract 0.5-5.5 Glucosamine 5.0-17.0 Isomalt 20.0-22.0 Pectin 18.0-20.0 Inulin 0.5-5.0 Citric Acid 0.5-1.9 Flavoring 0.1-0.3 Gum the rest is up to 100%

Dry extract of shoots of callisia fragrant (golden mustache) - the sum of extractives from fresh leafy shoots of a perennial herbaceous plant Callisia fragrant (Callisia fragrans Wood., Syn. Fragrant rektanthera - Rectanthera fragrans, family Commeline - Commelinaceae), obtained by sequential separation of juice, extract water, combining juice and extracts, filtering, evaporating to a thick consistency and drying the product to a residual moisture content of not more than 5%. The extract is a powder from light brown to brown color without a pronounced odor, soluble in water with the formation of a clear or colloidal solution.

Studies on fragrant callisia (in folk medicine known as the "golden mustache") have shown that the main biologically

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the active substances in its composition are polysaccharides, in the hydrolyzate of which galacturonic acid, galactose, arabinose, ramnose, glucose and xylose were found in a ratio of 16.8: 18.6: 16.1: 1.6: 4.9: 1.0 [ one]. In addition to polysaccharides, shoots of callisia contain free carbohydrates, flavonoids (quercetin, kempferol), proteins, amino acids, organic acids, coumarins (umbelliferone, scopoletin), anthracene derivatives (aloe-emodin), phenolic acids (gallic, coffee, chicorye, β-feru sitosterol, carotenoids, ascorbic acid, nitrous bases, etc. [2], as well as some B vitamins, microelements, ecdysteroids (kalekdisterola A, B, C) [3]. Callisia juice also has antihypoxic activity [4], actoprotective [5], stress-protective and immunomodulating [6]. Experimental studies of the biological activity of callisia juice revealed antioxidant (antiradical) activity [1].

The experience of the practical application of fragrant callisia in folk medicine allows us to conclude that it has adaptogenic and anti-inflammatory activity, joint diseases. The tincture on the callisia extract is used in the treatment of atherosclerosis, with cardiovascular diseases, with osteochondrosis, fractures and bruises, with thrombophlebitis, atherosclerosis, lung diseases and blood diseases, to strengthen immunity.

Glucosamine (Glucosaminum) is one of the most common monosaccharides, the aminosaccharide, which is part of polysaccharides such as chitosan and chitin. In nature, glucosamine is found in mollusk shells, as well as animal bones, bone marrow, and some types of mushrooms. Glucosamine - a substance produced by the cartilage tissue of the joints, is a component of chondroitin, is part of the synovial fluid, can be produced in the body, serves as an important element in the biochemical synthesis of glycosylated proteins and lipids. This substance is one of the main building elements of connective tissues - cartilage and ligamentous apparatus, stimulates the production of hyaluronic acid, which is a universal precursor of the so-called. “Joint lubricants” and “shock absorbing tissues”. Since glucosamine is a precursor to glycosaminoglycans, which are the main component of articular cartilage, it has been suggested that its use can help restore cartilage tissue and treat arthrosis. According to the pharmacological classification, glucosamine belongs to the correctors of bone and cartilage tissue metabolism and to the group of non-steroidal anti-inflammatory and anti-rheumatoid drugs.

Glucosamine (in the form of sulfate or hydrochloride) has an anti-arthritic effect [7]. Glucosamine is part of numerous biologically active food supplements (BAA), therapeutic agents for topical use, as well as complex medicines designed to stop pathological processes in the most common chronic joint disease - osteoarthritis [8].

Dry extract of white willow bark - the sum of extractives from the dried white willow bark (Salix alba L. sem. Willow - Salicaceae). Obtained by exhaustive extraction of dried bark with water, followed by drying by spray drying to a residual moisture content of not more than 5%. Contains at least 5.5% salicin (salicylic alcohol glycoside), tannins (at least 5% in terms of tannin), flavones, vitamin C, tarry and other substances. In addition to salicin, other phenological glycosides were discovered in the willow bark - frailin, triandrin, vimalin, salidroside, salicortin, saliperoside.

White willow extract contains phenologic glycoside-salicin, which, under the action of the enzyme salicase, is hydrolytically cleaved into aglycon-saleginin and glucose. Saleginin is further oxidized to salicylic acid, which inhibits prostaglandin synthesis and platelet aggregation. In addition, willow extract contains tannins and flavonoids [9]. Willow bark extract has a pronounced anti-inflammatory effect, is a natural natural remedy that helps reduce inflammation and pain, also has a hemostatic, diuretic, disinfectant, astringent, antipyretic and antiseptic effect, and prevents platelet aggregation. The anti-inflammatory effect of willow bark is caused by the content of salicin in it, which in the body, under the action of the enzyme salicase, is hydrolytically cleaved into saligenin and glucose aglycone, and saligenin is further oxidized to salicylic acid [10].

Willow extract is part of many dietary supplements for food and dietary compositions, including Arthrocin (manufactured by VIS, Russia), Honda (manufactured by Evalar, Russia), Gerbasprin (manufactured by in "Vitamer", Russia), "Ivapirin plant phytocomplex" (pr-in "Golfstream Company", Russia), "Sustavit-Aktiv" (pr-in "NPP" Demiurg ", Russia), etc.

Isomalt (syn: isomalt, palatinite) - O-α-D-glucopyranosyl-D-mannitol, is two isomeric glucopyranosyl aldites - maltitol and isomalt. It is a colorless, sweet-tasting crystals soluble in water. Isomalt is found in nature in sugarcane, sugar beets and honey. In the food industry, E953 is widely used as a food additive.

Isomalt belongs to the class of prebiotics, has the properties of plant fiber and works as a ballast substance, creating a feeling of satiety and filling the stomach. Due to its specific properties, isomalt, like other polyols, is absorbed in the gastrointestinal tract in small quantities, and not the digested part is metabolized by intestinal bacteria. Isomalt has a wide range of applications in the food industry.

By sweetness, isomalt is close to sucrose (0.5 sweetness of sucrose), but is poorly absorbed in the intestinal tract, is used as a sweetener and sweetener in the manufacture of products for diabetics (glycemic index - 2). Low-calorie and dietary product (1 g of isomalt contains only 2.4 kcal = 10 kJ). Numerous studies have shown that taking isomalt slightly affects glucose and insulin levels in healthy people and patients with type 1 and type 2 diabetes [11].

It acts on the digestive system like dietary fiber, stimulating the active work of the intestine, with an excess it has a laxative effect [12].

Stevia honey - Stevia rebaudiana (syn.: Honey grass) - a shrub, representative of the Asteraceae family. It is found in the wild in semi-arid territories from plains to mountainous regions in South and Central America, north to Mexico. It is cultivated and widely used in food products in East Asia, including China, Korea, Taiwan, Thailand and Malaysia, as well as in Israel. Stevia is the sum of glycosides (steviosides), extracted from the leaves of honey stevia and having a pronounced sweet taste, which is many times higher than that of sucrose, which determined their use as a natural sweetener.

Diterpenic glycosides (steviosides, rebuadiosides, etc.), which have a stable sweet taste, were found in the leaves of stevia. Steviosides are found in all parts of the plant, but mainly in the leaves, with a total stevioside content of (3-10)%, calculated on dry raw materials. The bitter aromatic resin, which is part of stevia, has a tonic effect on the digestive organs, is a heat-resistant acidifier. Natural glycoside from stevia leaves is safe for health, is a good preservative. Stevia leaves as a herbal supplement enrich the product with natural biologically active substances, micro and macro elements, irreplaceable sulfur-containing amino acids, minerals. Dry stevia leaves are recommended for use as dietary supplements for dietary nutrition (TU 9729-003-00668620-06).

Stevia is recommended to be used as a sweetener not only for patients with diabetes mellitus, but also for people suffering from overweight and obesity, for the treatment of disorders of the gastrointestinal tract, including ulcers, gastritis, while reducing the level of enzyme production; for the treatment of viral and infectious diseases; with high cholesterol in the blood; to activate the body's immune forces; with allergic reactions, dermatitis and other skin diseases; with diseases of the kidneys and pancreas. The inclusion in the diet of stevia and products based on it has a positive effect on the human body in diseases of the thyroid gland, they have a calming effect on the nervous system, remove radionuclides from the body, and inhibit the growth of tumors. With the use of stevia decoctions, an anti-inflammatory effect is observed, the growth and reproduction of pathogenic bacteria and pathogenic microorganisms, including those causing intestinal diseases, is restrained and also reduces the risk of caries and periodontal disease. The bactericidal properties of stevia are manifested in the healing of wounds and trophic ulcers. Stevia is an excellent weight corrector, because does not contain calories and helps fight hunger, optimizes metabolic processes [15]. Stevia can be used, inter alia, in the treatment of joint diseases, in which it is necessary to exclude the use of sugar [13].

Inulin is a polysaccharide, a polymer of D-fructose (polyfructosan) with the general formula (C ₆ H ₁₀ O ₅ ) _n,. The molecular weight is 5000-6000, the inulin molecule is a chain of 30-35 residues of fructose in furanose form. Inulin is obtained in the form of an amorphous powder, readily soluble in hot water and difficult in cold. It has a sweet taste. During hydrolysis under the action of acids and the enzyme, inulase forms D-fructose and a small amount of glucose. Inulin, as well as intermediate products of its enzymatic cleavage - inulides, does not have reducing properties. Like starch, inulin serves as a reserve carbohydrate and is found in many plants, mainly the Asteraceae family - tubers and roots of tuberose, dandelion, chicory and earth pear (Jerusalem artichoke), etc.

Inulin is not digested by the digestive enzymes of the human body, belongs to the group of dietary fiber and is used as a substitute for starch and sugar in diabetes mellitus. It belongs to the group of prebiotics, as it promotes the growth of favorable intestinal microflora and normalization of digestion, provides the normal intestinal microflora with substances that promote its reproduction and, thus, helps maintain the normal composition of the microbiota. In the course of studies, it was shown that inulin, in addition to stimulating the growth and activity of bifidobacteria and lactobacilli, increases the absorption of calcium in the colon, that is, reduces the risk of osteoporosis, affects the metabolism of lipids, reducing the risk of atherosclerotic changes in the cardiovascular system and, possibly, preventing the development type II diabetes mellitus, it is used to prevent intestinal dysbiosis in various functional disorders of the biliary tract, there are preliminary data on its anticarcinogenic effect.

Pectin is a polysaccharide formed by the remains of mainly galacturonic acid and obtained by acid extraction of raw materials. Depending on the source, apple, beet, citrus, and other pectins are distinguished. The technological scheme for producing pectin provides for its extraction from feedstock, purification, precipitation with organic solvents, drying, grinding and standardization, which is a process of modifying the properties of pectin achieved by physical and / or chemical methods, in order to bring them into line with technological and prescription requirements for the production of various groups of food and non-food products. Pectin is a gelling agent, stabilizer, thickener, water-retaining agent, brightener, filter aid and encapsulation agent. Pectin is not absorbed by the human digestive system, therefore, it serves as a natural enterosorbent, removes toxins and heavy metals, and has a pronounced detoxifying effect on the body. Apple pectin is approved for use in the Russian Federation as a food additive (E440A).

The choice of pectin as one of the components of dietary supplements is due to its characteristic phenomenon of solubilization, gelation, which contributes to the formation of a hydrogel when mixing granular powder with water. This increases the bioavailability of the introduced components and improves organoleptic properties. In addition, the acidic environment of aqueous solutions of pectins reduces the microbial contamination of dosage forms. Pectin is able to bind heavy metal ions, which is of great importance for the stabilization of the dosage form.

Gums are natural products derived from plant materials. Gum is a thick, rapidly hardening sap that protrudes on the surface of trees when bark is damaged.

Gum is a wood glue sticking to plant wounds. Guar gum is a thickener and stabilizer of E 412, used in the food, cosmetic and pharmaceutical industries. Guar gum is a natural product that is made from the endosperm of a guar plant, or pea tree. The seeds of this bean plant contain about 70% gum. Guar gum has a neutral taste and low calorie content. The main property is to swell and create very viscous solutions in hot and cold water. It is the most economical thickener and stabilizer in the modern food industry. Guar gum is used in the food industry to regulate viscosity; to stabilize emulsions; to give products a creamy consistency; to increase the elasticity of products; in dairy products - to retain moisture, to give a creamy structure to low-calorie foods; in frozen foods - to prevent the growth of ice crystals; to increase the volume of production in the manufacture of cheese; in confectionery - as a dough improver; in instant products - to give a uniform consistency; in meat products - to increase the viscosity of minced meat, reduce moisture loss; to increase the shelf life of products. Guar gum is part of various dietary supplements and drugs. This type of gum has the following effects on the body: normalizes intestinal permeability; has a laxative effect; cleanses the body of toxins; helps to reduce appetite; lowers cholesterol.

Xanthan gum (syn: xanthan) is a natural compound, a polysaccharide with the general formula (C ₃₅ H ₄₉ O ₂₉ ) _n , obtained by fermentation using the bacterium Xanthomonas campestris. In the life cycle of bacteria, it serves as protection against viruses and drying out, so it can be used in cosmetics to moisturize the skin. It is approved for use in the Russian Federation as a food supplement E 415 (Conclusion of the Research Institute of Nutrition RAMS No. 72 / Э-414 / и-04 dated 12.02.2004). Xanthan gum is used in food systems as a thickener, gelling agent and stabilizer. It is soluble in cold and hot water, milk, as well as in salt and sugar solutions. Xanthan molecules adsorb water to form a three-dimensional network of xanthan double helices, similar in structure to a gel, but with a lower viscosity. In this regard, xanthan is usually used as a thickener or stabilizer, and not a gelling agent.

The feasibility of introducing citric acid into the composition is due to the fact that, according to published data, citrate stimulates bone growth and also activates metabolic processes in the body [14].

The invention is illustrated by the following examples.

Example 1. Obtaining the proposed composition of dietary supplements.

The composition is obtained by mixing in the claimed amounts of components taken in accordance with the recipe presented in the table. 1, in the following sequence:

- the extracts of stevia leaves, callisia of aromatic and white willow bark, obtained by aqueous extraction are mixed until homogeneous, then glucosamine and citric acid are added to the resulting mixture;

- in a separate container, fillers are mixed together - isomalt, pectin, gum, inulin;

- powder mixtures are combined and mixed until smooth with the addition of flavoring.

The resulting mixture in an amount of 1 tsp. (4-5 g) immediately before use, diluted with hot water (70-100) ° C, the mixture is kept for 10-15 minutes, then mixed until smooth. The finished product is a low-calorie (100-150 kcal) drink, it is consumed in a warm form, it is allowed to use it in a chilled form.

Example 2 Test Results.

The product prepared according to Example 1 was tested on 6 volunteers in the medical and diagnostic center of Sakura LLC (Essentuki). The product was used for 30 days 1-2 times a day with meals, in the recommended dose - 1 teaspoon at a time. Reviews were recorded on the main consumer properties of the developed dietary product, general health, some functional

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parameters, in particular, from the digestive system and the musculoskeletal system.

As the tests showed, the overall health of the volunteers improved, the number of complaints about the psychosomatic state decreased, the organoleptic, taste properties of the product were evaluated positively, there were no complaints from patients about the negative and side properties of the product, course use of the developed composition quickly and beneficially affected the basic functions of the gastrointestinal tract. intestinal tract, eliminated the signs of dysbiosis, prolonged use of the composition made it possible to improve the functional state ence other body systems, musculoskeletal, immune system, enhance the resistance to adverse environmental factors and abnormalities in the diet.

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Table 1 - Examples of prescriptions composition

Claims (2)

Dietary composition for normalizing intestinal microflora based on a mixture of prebiotics, including citric acid as monomer substances, disaccharides as dimeric substances, inulin, natural gum as polymeric substances; pectin, plant extracts and flavoring, characterized in that the composition contains extracts of stevia leaves as plant extracts, aqueous extracts of callis shoots of fragrant and white willow bark, the composition additionally contains glucosamine, and isomalt as disaccharide, in the following ratio of components, mass. %: Stevia leaf extract 19.0-21.0 Fragrant Callisia Shoot Extract 10.0-14.0 White Willow Bark Extract 0.5-5.5 Glucosamine 5.0-17.0 Isomalt 20.0-22.0 Pectin 18.0-20.0 Inulin 0.5-5.0 Citric Acid 0.5-1.9 Flavoring 0.1-0.3 Gum the rest is up to 100%