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RU2699789C1 - Method for producing nanocapsules of dry extract of muirapuama (ptychopetatum olacoides) - Google Patents

Method for producing nanocapsules of dry extract of muirapuama (ptychopetatum olacoides) Download PDF

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RU2699789C1
RU2699789C1 RU2019106746A RU2019106746A RU2699789C1 RU 2699789 C1 RU2699789 C1 RU 2699789C1 RU 2019106746 A RU2019106746 A RU 2019106746A RU 2019106746 A RU2019106746 A RU 2019106746A RU 2699789 C1 RU2699789 C1 RU 2699789C1
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Александр Александрович Кролевец
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Abstract

FIELD: nanotechnologies; medicine; food industry.
SUBSTANCE: method of producing nanocapsules of muirapuama dry extract is characterized by that nanocapsules are coated with guar gum, dry extract of muirapuama, wherein the dry extract of muirapuama is added to a suspension of guar gum in ethanol in presence of 0.01 g of glycerol ester with one or two molecules of edible fatty acids and one or two molecules of citric acid as a surfactant while stirring at 900 rpm, then fluorobenzene is added, obtained suspension of nanocapsules is filtered and dried at room temperature, wherein weight ratio of core : shell is 1:1, 1:2 or 1:3.
EFFECT: disclosed is a method of producing nanocapsules of dry extract of muirapuama.
1 cl, 3 ex

Description

Изобретение относится к области нанотехнологии, медицины, фармакологии и пищевой промышленности.The invention relates to the field of nanotechnology, medicine, pharmacology and the food industry.

Ранее были известны способы получения микрокапсул.Previously known methods for producing microcapsules.

В пат. 2173140 МПК A61K 009/50, A61K 009/127 Российская Федерация опубликован 10.09.2001 предложен способ получения кремнийорганолипидных микрокапсул с использованием роторно-кавитационной установки, обладающей высокими сдвиговыми усилиями и мощными гидроакустическими явлениями звукового и ультразвукового диапазона для диспергирования.In US Pat. 2173140 IPC A61K 009/50, A61K 009/127 Russian Federation published September 10, 2001. A method for producing silicon-organolipid microcapsules using a rotary-cavitation unit with high shear forces and powerful sonar and ultrasonic sonar phenomena for dispersion is proposed.

Недостатком данного способа является применение специального оборудования - роторно-кавитационной установки, которая обладает ультразвуковым действием, что оказывает влияние на образование микрокапсул и при этом может вызывать побочные реакции в связи с тем, что ультразвук разрушающе действует на полимеры белковой природы, поэтому предложенный способ применим при работе с полимерами синтетического происхождения.The disadvantage of this method is the use of special equipment - a rotary cavitation unit, which has an ultrasonic effect, which affects the formation of microcapsules and can cause adverse reactions due to the fact that ultrasound destructively affects polymers of a protein nature, therefore, the proposed method is applicable when work with polymers of synthetic origin.

В пат. 2359662 МПК A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 опубликован 27.06.2009 Российская Федерация предложен способ получения микрокапсул хлорида натрия с использованием распылительного охлаждения в распылительной градирне Niro при следующих условиях: температура воздуха на входе 10°С, температура воздуха на выходе 28°С, скорость вращения распыляющего барабана 10000 оборотов/мин. Микрокапсулы по изобретению обладают улучшенной стабильностью и обеспечивают регулируемое и/или пролонгированное высвобождение активного ингредиента.In US Pat. 2359662 IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 published on 06/27/2009 The Russian Federation proposed a method for producing sodium chloride microcapsules using spray cooling in a Niro spray cooling tower under the following conditions: inlet air temperature 10 ° C, outlet air temperature 28 ° C, the rotation speed of the spray drum 10,000 rpm. The microcapsules of the invention have improved stability and provide controlled and / or prolonged release of the active ingredient.

Недостатками предложенного способа являются длительность процесса и применение специального оборудования, комплекс определенных условий (температура воздуха на входе 10°С, температура воздуха на выходе 28°С, скорость вращения распыляющего барабана 10000 оборотов/мин).The disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of certain conditions (air temperature at the inlet 10 ° C, air temperature at the outlet 28 ° C, rotation speed of the spray drum 10,000 rpm).

Наиболее близким методом является способ, предложенный в пат.2134967 МПК A01N 53/00, A01N 25/28 опубликован 27.08.1999 Российская Федерация (1999). В воде диспергируют раствор смеси природных липидов и пиретроидного инсектицида в весовом отношении 2-4:1 в органическом растворителе, что приводит к упрощению способа микрокапсулирования.The closest method is the method proposed in Pat.2134967 IPC A01N 53/00, A01N 25/28 published on 08.27.1999 Russian Federation (1999). A solution of a mixture of natural lipids and a pyrethroid insecticide in a weight ratio of 2-4: 1 in an organic solvent is dispersed in water, which simplifies the microencapsulation method.

Недостатком метода является диспергирование в водной среде, что делает предложенный способ неприменимым для получения микрокапсул водорастворимых препаратов в водорастворимых полимерах.The disadvantage of this method is dispersion in an aqueous medium, which makes the proposed method inapplicable for producing microcapsules of water-soluble preparations in water-soluble polymers.

Техническая задача - упрощение и ускорение процесса получения нанокапсул, уменьшение потерь при получении нанокапсул (увеличение выхода по массе).The technical task is to simplify and accelerate the process of obtaining nanocapsules, reduce losses in obtaining nanocapsules (increase in yield by mass).

Решение технической задачи достигается способом получения нанокапсул, отличающийся тем, что в качестве оболочки нанокапсул используется альгуаровая камедь, а в качестве ядра - сухой экстракт муира пуамы, при получении нанокапсул методом осаждения нерастворителем с применением фторбензола в качестве осадителя.The solution to the technical problem is achieved by the method of producing nanocapsules, characterized in that alguar gum is used as the shell of the nanocapsules, and dry extract of muira puama is used as the core when nanocapsules are prepared by the non-solvent precipitation method using fluorobenzene as the precipitant.

Отличительной особенностью предлагаемого метода является получение нанокапсул методом осаждения нерастворителем с использованием фторбензола в качестве осадителя, а также использование гуаровой камеди в качестве оболочки частиц и сухого экстракта муира пуамы - в качестве ядра.A distinctive feature of the proposed method is the preparation of nanocapsules by non-solvent deposition using fluorobenzene as a precipitant, as well as the use of guar gum as a particle shell and a dry extract of muira puama as a core.

Результатом предлагаемого метода являются получение нанокапсул сухого экстракта муиры пуамы.The result of the proposed method is the preparation of nanocapsules of dry extract of muira puama.

ПРИМЕР 1. Получение нанокапсул сухого экстракта муиры пуамы, соотношение ядро:оболочка 1:3.EXAMPLE 1. Obtaining nanocapsules of dry extract of muira puama, the ratio of core: shell 1: 3.

1,5 г сухого экстракта муиры пуамы добавляют в суспензию 4,5 г гуаровой камеди в этаноле в присутствии 0,01 г препарата Е472с (сложный эфир глицерина с одной-двумя молекулами пищевых жирных кислот и одной-двумя молекулами лимонной кислоты, причем лимонная кислота, как трехосновная, может быть этерифицирована другими глицеридами и как оксокислота - другими жирными кислотами. Свободные кислотные группы могут быть нейтрализованы натрием) в качестве поверхностно-активного вещества при перемешивании 900 об/мин. Далее приливают 8 мл фторбензола. Полученную суспензию отфильтровывают и сушат при комнатной температуре.1.5 g of a dry extract of Muira puama is added to a suspension of 4.5 g of guar gum in ethanol in the presence of 0.01 g of the preparation E472c (glycerol ester with one or two molecules of food fatty acids and one or two molecules of citric acid, with citric acid as tribasic, it can be esterified with other glycerides and as an acid with other fatty acids. Free acid groups can be neutralized with sodium) as a surfactant with stirring at 900 rpm. Then pour 8 ml of fluorobenzene. The resulting suspension is filtered and dried at room temperature.

Получено 6 г порошка нанокапсул. Выход составил 100%.Received 6 g of nanocapsule powder. The yield was 100%.

ПРИМЕР 2. Получение нанокапсул сухого экстракта муиры пуамы, соотношение ядро:оболочка 1:1.EXAMPLE 2. Obtaining nanocapsules of dry extract of muira puama, the ratio of core: shell 1: 1.

2 г сухого экстракта муиры пуамы добавляют в суспензию 2 г гуаровой камеди в этаноле в присутствии 0,01 г препарата Е472с в качестве поверхностно-активного вещества при перемешивании 900 об/мин. Далее приливают 8 мл фторбензола. Полученную суспензию отфильтровывают и сушат при комнатной температуре.2 g of dry extract of Muira puama is added to a suspension of 2 g of guar gum in ethanol in the presence of 0.01 g of the preparation E472c as a surfactant with stirring at 900 rpm. Then pour 8 ml of fluorobenzene. The resulting suspension is filtered and dried at room temperature.

Получено 4 г порошка нанокапсул. Выход составил 100%.Received 4 g of nanocapsule powder. The yield was 100%.

Пример 3 Получение нанокапсул сухого экстракта муиры пуамы, соотношение ядро:оболочка 1:2,Example 3 Obtaining nanocapsules of dry extract of muira puama, the ratio of core: shell 1: 2,

2 г сухого экстракта можжевельника добавляют в суспензию 4 г гуаровой камеди в этаноле в присутствии 0,01 г препарата Е472с в качестве поверхностно-активного вещества при перемешивании 900 об/мин. Далее приливают 8 мл фторбензола. Полученную суспензию отфильтровывают сушат при комнатной температуре.2 g of a dry extract of juniper is added to a suspension of 4 g of guar gum in ethanol in the presence of 0.01 g of the preparation E472c as a surfactant with stirring at 900 rpm. Then pour 8 ml of fluorobenzene. The resulting suspension is filtered off and dried at room temperature.

Получено 4 г порошка нанокапсул. Выход составил 100%.Received 4 g of nanocapsule powder. The yield was 100%.

Claims (1)

Способ получения нанокапсул сухого экстракта муира пуамы, характеризующийся тем, что в качестве оболочки нанокапсул используют гуаровую камедь, в качестве ядра - сухой экстракт муиры пуамы, при этом сухой экстракт муиры пуамы добавляют в суспензию гуаровой камеди в этаноле в присутствии 0,01 г сложного эфира глицерина с одной-двумя молекулами пищевых жирных кислот и одной-двумя молекулами лимонной кислоты в качестве поверхностно-активного вещества при перемешивании 900 об/мин, далее приливают фторбензол, полученную суспензию нанокапсул отфильтровывают и сушат при комнатной температуре, при этом массовое соотношение ядро : оболочка составляет 1:1, 1:2 или 1:3.A method for producing nanocapsules of a dry extract of puira muira, characterized in that guar gum is used as a shell of nanocapsules, a dry extract of puama muira is used as a core, and a dry extract of puami muira is added to a suspension of guar gum in ethanol in the presence of 0.01 g of ester glycerol with one or two molecules of food fatty acids and one or two molecules of citric acid as a surfactant with stirring at 900 rpm, then fluorobenzene is added, the resulting suspension of nanocapsules from filtered and dried at room temperature, while the mass ratio of the core: shell is 1: 1, 1: 2 or 1: 3.
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RU2730847C1 (en) * 2020-03-16 2020-08-26 Александр Александрович Кролевец Method of producing dry aloe extract nanocapsules
RU2744739C1 (en) * 2020-06-25 2021-03-15 Александр Александрович Кролевец Method of obtaining nanocapusles of the dry boswellia extract

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2730847C1 (en) * 2020-03-16 2020-08-26 Александр Александрович Кролевец Method of producing dry aloe extract nanocapsules
RU2744739C1 (en) * 2020-06-25 2021-03-15 Александр Александрович Кролевец Method of obtaining nanocapusles of the dry boswellia extract

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