RU2537031C2 - Method of treating cystitis - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to methods of treating cystitis of various origins. Increasing the clinical effectiveness and reducing a probability of recurrences are ensured by administering therapeutically active and gel preparations possessing a high adhesion to urothelium walls. The method involves instilling sodium alginate in the form of Colegel gel containing the therapeutically active preparations dioxidine, lidocaine, deoxyribonucleate, sodium hyaluronate in a therapeutically effective amount with the instillation procedure suggested to be performed according to the schedule specified depending on the cystitis origin. If observing chronic bacterial recurrent cystitis, the following schedule is presented: instillations of Colegel-ADL from the 1^st to 10^th therapeutic day daily, instillations of Colegel-DNK-L from the 11^th to 20^th therapeutic day every second day, 2-month instillation of Colegel-Hyal once a week. Treating radiation and interstitial cystitis requires the following therapeutic schedule: instillations of Colegel-ADL from the 1^st to 20^th day, while Colegel-DNK-L and Colegel-Hyal are instilled once twice a week from the 21^st to 56^th day alternated every second day. The presented therapeutic schedules using the given therapeutically active preparations enabling relieving pain, reducing a rate and a length of recurrent cystitis.

EFFECT: using these therapeutic schedules is high-efficient and safe.

1 ex

Description

The invention relates to medicine, namely to methods for treating bacterial recurrent cystitis.

A known method of treating cystitis, including intravesical administration of an elastic viscous buffered physiological solution of sodium hyaluronate (P.V. Glybochko, Yu.G. Alyaev, Z.K. Gadzhieva, Mirkin Y.B. Application of hyaluronic acid in the treatment of chronic cystitis. EF. Urology. 5/2011, pp. 30-35).

The disadvantage of this method is that the solution of sodium hyaluronate does not have a long-term effect, since the drug has poor adhesion to urothelium of the bladder and is removed from the body shortly after administration, it is necessary to repeatedly carry out a rather complicated (only medical staff) and painful procedure for the patient.

A known local method, including intravesical therapy of chronic cystitis (RF Patent No. 2270678, IPC A61K 31/495), which consists in the intravesical administration of a 0.5% dioxidine solution with the simultaneous administration of Enterosgel.

The disadvantage of this method is the weak adhesion of the injected dioxidine solution to the walls of urothelium, as well as the need for the introduction of Enterosgel, which can reduce the concentration of dioxidine.

The objective of the invention is to remedy these disadvantages, increase the effectiveness of treatment and reduce the likelihood of relapse due to the introduction of therapeutically active and gel preparations with increased adhesion to the walls of urothelium.

To solve this problem, it was proposed in the treatment of chronic bacterial recurrent cystitis to instill the Kolegel-ADL gel preparation from 1 to 10 days of treatment daily, then to instill Kolegel-DNA-L from 11 to 20 days every other day.

The proposed treatment regimen using these therapeutically active drugs can reduce pain symptoms, reduce the frequency and duration of cystitis relapses.

The implementation of the method shown in specific clinical examples.

Example 1

Patient A., 34 years old, has recurrent bacterial cystitis since she was 20 years old, the relapse rate increased from 1-2 per year, to 10-12 relapses per year, the intensity of relapse on a visual analogue scale reached 7 points, the duration was 5-7 days. During relapse in the general analysis of urine, leukocytes of 30–40 were detected in s / s, urine culture - E. coli 5 * 10 ⁵ .

The treatment was carried out according to the proposed method.

In a previously emptied bladder, therapeutically active drugs are injected through a catheter via a syringe according to the following scheme:

1-10 day - "Kolegel-ADL" on the 1st instillation of 20 ml daily.

11-20 day - "Kolegel-DNA-L" on the 1st instillation of 20 ml every other day.

After a course of intravesical therapy, no relapse of cystitis was observed for 1.5 years. General urine analysis: leukocytes 1-2 in n / a. (normal), urine culture - no growth.

According to the proposed method, treatment was performed in 21 patients. All patients after treatment according to the proposed schemes noted a decrease in discomfort and burning in the urethra during the first week of treatment. The frequency of urination as a result of treatment decreased by an average of 33% in the first three weeks of treatment. The number of nightly urination in patients also decreased significantly by an average of 3 times.

During treatment by the proposed method, stabilization of the glucosamine layer is observed in patients, the treatment is highly effective and safe.

Claims (1)

A method of treating chronic bacterial recurrent cystitis, including the installation of the Kolegel-ADL gel preparation from 1 to 10 days of treatment daily, then Kolegel-DNA-L is installed from 11 to 20 days every other day.