RU2526165C1 - Resource-saving method of production of dry extract from ceylon cinnamon bark - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: method comprises extraction, filtration, evaporation, and is characterised in that extraction is carried out in two stages with 30% aqueous solution of ethanol at a temperature 70°C of each stage, with the exposure of 1 hour, the extract is purified by an alcohol method at a temperature of 4°C, then the resulting product is filtered from the pectin precipitate and the filtrate is evaporated to dry residue.

EFFECT: improved method.

Description

FIELD OF THE INVENTION

The invention relates to the pharmaceutical industry, in particular to the production of an agent used in the treatment of diabetes mellitus.

State of the art

An analogue of the claimed product and method is the method described in the Russian patent document RU 2161039 C1. A method of treating insulin-dependent diabetes mellitus (type 1) is to administer insulin and take an anti-diabetic drug collection containing nettle, astragalus, wormwood, sweet clover, dandelion and blueberry leaf in a specific ratio. In the course of treatment, the dose of insulin is gradually reduced by 0.3-0.5 IU of insulin per month until the replacement therapy is completely canceled. Medicinal herbs enriched with chromium ions are additionally introduced into the composition of the drug collection: real ginseng, prickly eleutherococcus, high aralia, high temptation, acanthopanax flower, kalopanaks seven-bladed, licorice, atractylode ovoid, flax seed, burdock roots, highlander caravans are mane, black nightshade, Amur velvet forehead, Manchurian walnut leaves, creeping dust, real bedstraw, field yarrow, eastern chastushka, winterhub umbellate, bean shell, wiki seeds, corn branches, hops, rhizomes of the Fisher fighter, thin-leaved source, shallow-leaved codonopsis, fragrant bought, tansy cinquefoil, Canadian small-leaved, Oldgem noricum, walnut-leaved leaves, pavoiformes, Lindley sapling, gastrodiacepha rhizopoda, rossyny rossa, rossa olezyn, roguena rossa common blueberries, common blackheads, field yarns, coconut poria, pakhima hoelyan, Chinese cinnamon, common lingonberries, marsh blueberries, dogwood, Chinese pit, scutellaria lysky, Chinese chrysanthemum, Chinese smoked, Chinese dereza, Japanese honeysuckle, gingerbread cardamom, fox-shaped pueraria, digitalis, dioscorea, nodule asparagus, in this case dioecious nettle, membranous Astragalus, Siverswort wormwood, honey clover and yellow clover are used.

The use of this collection in this course of treatment leads to a positive therapeutic effect.

The disadvantage of this product is the presence in its composition of a large number of components, which complicates the stage of collecting its plant components, preparation and increases the risk of side effects.

The prototype is a composition for the prevention or alleviation of multiple risk factor syndrome described in the Russian patent RU 2003121228, which includes at least one component selected from the group consisting of a hydrophobic licorice extract, yellow root extract (turmeric), clove extract and cinnamon extract.

This prototype allows you to get the product from affordable plant materials.

The disadvantage of this prototype is the lack of standardization in the content of active substances, in particular substances of the polyphenolic group, responsible for the sugar-lowering effect.

Disclosure of invention

The objective of the invention is the creation of resource-saving technology for obtaining a dry extract from the ceylon cinnamon bark containing a polyphenolic complex of substances responsible for the sugar-lowering effect. Unlike infusions and decoctions, dry extracts have several advantages: 1 - racks during storage, since they do not contain moisture; 2 - convenient for transportation; 3 - standardized by the content of active substances; 4 - the ability to receive other dosage forms based on them (tablets, capsules).

The proposed product is obtained from the raw materials of ceylon cinnamon bark, which meets the requirements of GOST 29049-91 “Spices. Cinnamon. Specifications "and GOST 28875-90" Spices. Acceptance and analysis methods. "

The dry extract of cinnamon cinnamon bark is obtained according to the following technology: pieces of bark rolled up into tubes are crushed to a particle size of 5 mm. Next, the extraction is carried out in two stages:

1 - crushed raw materials are placed in the extractor vessel and an extractant is added to it, which is a 30% aqueous solution of ethyl alcohol heated to 70 ° C in the ratio of 1 mass part of the raw material per 10 mass parts of the extractant and incubated for 1 hour at 70 ° C with constant stirring. Next, the extract is drained, filtered to separate the particles of raw materials.

2 - Next, a fresh extractant is poured into the extractor with a meal of the first stage, in the ratio of 1 mass part of meal to 10 mass parts of extractant heated to a temperature of 70 ° C, incubated for 1 hour at a temperature of 70 ° C with constant stirring. Then the second extract is drained and filtered to separate the particles of raw materials.

Next, both extracts are mixed with each other and the process of purification from pectins is carried out as follows: a 95% aqueous solution of ethyl alcohol is added to the mixture of extracts in a ratio of 1 part of extract 3 parts of an alcohol solution, the resulting mixture is cooled to 4 ° C, stirred and maintained at this temperature 48 hours. Next, the pectin precipitate is filtered off, and the filtrate is evaporated in vacuo at an absolute pressure of 0.2-0.3 technical atmosphere, to a dry residue.

The resulting dry extract of Ceylon cinnamon is packaged in standard pharmaceutical packaging.

We have conducted research on the costs of extraction at various degrees of grinding of raw materials.

For this, extraction was carried out from raw materials ground to a particle size of 10 mm, 5 mm, 3 mm and 1 mm. With the exposure time of each stage of extraction from 0.5 hours to 15 hours. As a result of the experiment, it was found that extraction from large particles (10 mm) has lower efficiency due to the large diffusion path of the extracted substance from the particle array to its surface. Extraction from small particles (1 mm, 3 mm) is less effective due to the large yield of pectins, which increase the viscosity of the extract and significantly complicate filtration and, as a result, reduce the yield of extractive substances.

With a degree of grinding of 5 mm, the yield of solids is maximum, which allows us to conclude that the optimum degree of grinding of raw materials is close to 5 mm. Obtaining particles of this size is less energy intensive than obtaining particles of 3 mm or 1 mm, but allows a sufficient extraction process.

An extraction time of 0.5 hours is not enough to fully recover the product. Long exposure during extraction leads to an increased yield of pectins, which complicate the process, reduce the yield of the product, and also increase the cost of maintaining the temperature of the extractor. The most effective was an exposure time of 1 hour, at which a sufficient amount of recoverable substances was extracted, and the filtering process with a high content of pectins was not complicated.

The effect of the concentration of ethanol in the extractant was studied in the concentration range from 0% to 95% ethanol. When extracted into pure water or at low ethanol concentrations (10%, 20%), a large yield of pectins occurs, which complicate the subsequent stages of the process. At high concentrations of ethanol (40% -95%), the partial effectiveness of the extractant decreases. Thus, ethanol is a constraining differential factor for the extraction of pectins. The experimental results allow us to conclude that the most efficient extraction process occurs when using an extractant with an ethanol content of 30% by mass.

Thus, the invention allows to obtain a dry extract containing the sum of polyphenolic substances with insulin-like action, stable during storage and convenient to use. Moreover, the proposed technology for the production of dry extract allows more economical use of energy spent on extraction, and to ensure a sufficient yield of biologically active substances.

Claims (1)

A method of obtaining a dry extract of ceylon cinnamon, including extraction, filtration, evaporation, characterized in that the extraction is carried out in two stages with a 30% aqueous solution of ethanol at a temperature of 70 ° C each stage, with an exposure of 1 hour, the extract is purified by the alcohol method at a temperature of 4 ° C then the resulting product is filtered from pectin sludge and the filtrate is evaporated to a dry residue at an absolute pressure of 0.2-0.3 atm technical.