RU2486912C1 - Agent for vaginal douche in first stage of treatment of vaginal thrush (vaginal yeast) - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, particularly to an agent for vaginal douche in the first phase of treatment of thrush (vaginal yeast). The agent for vaginal douche in the first phase of treatment for thrush (vaginal yeast), which represents a powder containing kitchen salt, baking powder and dry extract of chamomile (Matricaria chamomilla L) in the specific ingredient percentage.

EFFECT: agent is effective for vaginal douche in the first phase of treatment of thrush (vaginal yeast), eliminates the risk of a local allergic reaction.

Description

The invention relates to medicine, in particular to means for douching the vagina.

The state of the barrier properties of the vaginal mucosa is determined by the composition of its microflora, which depends on the acidity of the secretion of the vaginal glands. Normally, the pH of the vagina is 3.9-4.4, the environment of the vagina is acidic and inhibits the reproduction of pathogenic microflora. In the vaginal secretion, the Na content is 93.3 mmol / L, Cl - 92.3 mmol / L, which provides physiological indicators of the osmolarity of the vaginal secretion. Normally, in the vagina of an adult woman, lactobacilli dominate, which, by breaking down the glycogen of epithelial cells, produce lactic acid and hydrogen peroxide, which inhibit the growth of pathogenic microflora. In violation of the normal composition of the bacterial flora, vaginal diseases develop.

Candidiasis colpitis (thrush) is a disease that affects 25% to 40% of the adult female population. Called by fungi of the genus Candida. It manifests itself in the form of itching, "curdled" discharge, pH - 3.0-3.5.

Treatment of candidal colpitis is based on the use of topical antifungal drugs, topical anti-inflammatory drugs, immunotherapy, normalization of the vaginal microflora (restoration of the lactobacillus pool), and normalization of pH (alkalization using soda baths).

Known pharmaceutical composition for the treatment of urogenital infections [Pat. RU No. 2401102 from 2010]. This pharmaceutical composition contains an antiseptic, a dietary supplement, a component that provides the natural acidity of the vagina, an antifungal agent, anesthetic and a base.

Known pharmaceutical composition for the treatment of candidal vulvovaginitis [Pat. RU No. 2354385 of 2009]. The invention is a pharmaceutical composition made in a dosage form suitable for topical application, which contains at least one antimycotic from the groups: azoles, allylamines, polyenes, nitrofurans, as well as a prebiotic with a degree of polymerization from 2 to 30 or a combination of prebiotics, mixed at a certain content of components in wt.% per unit dosage form.

The disadvantage of the composition is its implementation in the form of a suppository, which complicates the hygienic cleaning of the vagina from the discharge and microorganisms during the procedure. Also, the composition of the product does not take into account the pH and osmolarity of the vaginal secretion in the first phase of treatment.

The objective of the present invention is to develop a means for douching the vagina in the first phase of treatment of candidal colpitis (thrush).

The technical result consists in hygienic cleaning of the vagina from the discharge and microorganisms during the procedure and, in addition, the risk of developing a local allergic reaction is eliminated.

The problem is solved by creating a means for douching the vagina in the first phase of treatment of candidal colpitis (thrush) in the form of a powder containing sodium chloride, baking soda and dry extract of chamomile (Matricaria chamomilla L) with the following components, in wt.%:

table salt 21.8 baking soda 77,2 dry extract of chamomile pharmacy (Matricaria chamomilla L) 1,0.

For douching, water decoctions and infusions of plant herbs are traditionally used. In this case, the active components of plant materials enter the solution. Pharmaceutical chamomile (Matricaria chamomilla L) and calendula (Calendula officinalis) are often used as medicinal raw materials for the preparation of aqueous solutions (infusions and decoctions) for douching.

Chamomile pharmacy (Matricaria chamomilla L) deservedly has a reputation for female medicine (one of the popular names for this plant is “uterine grass”).

Chemical composition. Flower baskets contain 0.2-0.8% of essential oil, which includes chamazulene С14Н16 (thick blue liquid), terpene С10Н16, sesquiterpene С15Н24 (about 10%), sesquiterpene alcohols (about 20%) C15H24O2 and C15H26O2, cadinene C15H26O (tricyclic alcohol), as well as caprylic, nochilic and isovaleric acids. In addition to essential oil, the following are distinguished from flower baskets: apiin C26H28O14, which splits upon hydrolysis into apigenin C15H10O5, glucose and apiosis; querimetrin C21H20O12, hydrolyzed to quercetin C15H10O5 and glucose; prochamazolen matricin C17H22O5; the lactone of the guayanolid group - matricarin C17H25O5; umbelliferone and its methyl ether - herniarin; dioxicoumarins: triacanthin C30H62, nicotinic acid, taraxasterol C30H50O; choline, phytosterol and its glucoside, salicylic acid, glycerides of fatty acids (oleic, palmitic and stearic), vitamin C, carotene, bitterness, mucus and gum.

The action of chamomile pharmacy is due to the complex of substances contained in it, especially chamazulene and mitricin. Chamazulen gives a pronounced anti-inflammatory effect: enhances regenerative processes, weakens allergic reactions.

The composition of the claimed funds is designed so that when preparing an aqueous solution for douching, a solution is obtained that corresponds to the osmolarity of the vaginal secretion, the use of which allows you to normalize the pH of the vaginal secretion during douching, and helps to restore the normal microflora of the vagina, provides hygienic cleaning of the vagina from the discharge and microorganisms during time of the procedure, creates optimal conditions for the action of medicinal herbs, eliminates the risk of Vitia local allergic reaction.

When preparing an aqueous solution of the indicated product, the douching solution has optimal osmolarity (in 120 ml of the solution, the concentration of Na ions is 93.3 mmol / L, Cl - 92.3 mmol / L). The pH of this solution is 8.0-9.0, which allows its use in the first phase of treatment of candidal colpitis to optimize the pH of the vaginal secretion, which usually is pH 3.0-3.5 in this pathological condition. At the same time, the antiseptic and anti-inflammatory properties of chamomile (Matricaria chamomilla L) are preserved.

Based on these components, a powder is prepared which is a mixture of the components in the indicated quantitative values. An aqueous solution is prepared by dissolving 3 grams of the product in 120 ml of pure water (solution temperature 34-36 degrees) and then douching is carried out using a modified device with a volume of 120 ml.

In the period from January 30, 2012 to March 16, 2012, the claimed drug was tested in the Gynecological Department of the Novosibirsk City Perinatal Center. In the department, 63 patients were diagnosed with acute candidal colpitis, confirmed by smear microscopy. Of the total number of 63 patients, depending on the duration and severity of the symptoms of the disease, 34 patients were prescribed specific systemic antimycotic therapy in combination with immunomodulators (group No. 1) in combination with douching, 29 patients received local use of antimycotics (group No. 2) in combination with douching agent.

In the treatment phase of the disease in groups No. 1 and No. 2, douching twice a day for 7 days was carried out by the composition of the drug. The general course of douching for each patient was 14 days.

On the 4th day of treatment, all patients of group No. 1 noted the absence of complaints and the absence of signs of yeast infection during smear microscopy, in contrast to the standard 7-day period for normalizing these parameters when using traditional candidiasis colpitis therapy using systemic antimycotic and immunocorrective therapy. In group No. 2, in 28 patients (97%), symptoms were stopped by the 4th day of treatment and the microscopic picture of smears normalized. One patient of group No. 2 (3%) required additional administration of systemic antimycotics and immunomodulators in connection with the progression of symptoms. On the 7th day of treatment using the composition of the drug, stable normalization of the indices occurred in all 63 patients. No side effects of douching were noted. According to microscopic examination, all patients showed an I-II degree of purity of the vaginal flora.

The use of an aqueous solution of this agent helps restore normal vaginal microflora, provides hygienic cleaning of the vagina from the discharge and microorganisms during the procedure, creates optimal conditions for the action of medicinal herbs, eliminates the risk of developing a local allergic reaction.

Claims (1)

The means for douching the vagina in the first phase of treatment of candidal colpitis (thrush), characterized in that it is a powder containing sodium chloride, baking soda and dry extract of chamomile (Matricaria chamomilla L) with the following components, wt.%:
table salt 21.8 baking soda 77,2 dry extract of chamomile pharmacy (Matricaria chamomilla L) 1,0