RU2457832C2 - Состав на основе тровентола - Google Patents

Состав на основе тровентола Download PDF

Info

Publication number: RU2457832C2
Authority: RU; Russia
Prior art keywords: troventol; aerosol; propellant; composition according; amount
Prior art date: 2005-09-25

Application number

RU2008115918/15A

Other languages

English (en)

Russian (ru)

Other versions

RU2008115918A (ru

Inventor

Амар ЛУЛЛА (IN)

Амар Лулла

Гина МАЛХОТРА (IN)

Гина Малхотра

Original Assignee

Сипла Лимитед

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-25

Filing date

2006-09-25

Publication date

2012-08-10

2006-09-25 Application filed by Сипла Лимитед filed Critical Сипла Лимитед

2009-10-27 Publication of RU2008115918A publication Critical patent/RU2008115918A/ru

2012-08-10 Application granted granted Critical

2012-08-10 Publication of RU2457832C2 publication Critical patent/RU2457832C2/ru

Links

239000000203 mixture Substances 0.000 title claims abstract description 85
PIQNXFBDPDECGD-DGPRCEOPSA-M [(1S,5R)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-(hydroxymethyl)-2-phenylbutanoate iodide Chemical compound [I-].C([C@H]1CC[C@H]([N+]1(C)C)C1)C1OC(=O)C(CO)(CC)C1=CC=CC=C1 PIQNXFBDPDECGD-DGPRCEOPSA-M 0.000 title claims abstract description 54
239000000443 aerosol Substances 0.000 claims abstract description 49
239000003814 drug Substances 0.000 claims abstract description 47
239000004094 surface-active agent Substances 0.000 claims abstract description 35
239000003380 propellant Substances 0.000 claims abstract description 27
239000006184 cosolvent Substances 0.000 claims abstract description 19
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 15
208000009079 Bronchial Spasm Diseases 0.000 claims abstract description 9
239000003937 drug carrier Substances 0.000 claims abstract description 7
239000000945 filler Substances 0.000 claims abstract description 6
239000003963 antioxidant agent Substances 0.000 claims abstract description 4
239000000126 substance Substances 0.000 claims abstract description 4
LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims description 29
-1 rimeterol Chemical compound 0.000 claims description 20
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 17
YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims description 15
229940124597 therapeutic agent Drugs 0.000 claims description 14
PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 13
235000019404 dichlorodifluoromethane Nutrition 0.000 claims description 13
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 13
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 10
239000000787 lecithin Substances 0.000 claims description 10
235000010445 lecithin Nutrition 0.000 claims description 10
229940067606 lecithin Drugs 0.000 claims description 10
DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 claims description 9
229940071648 metered dose inhaler Drugs 0.000 claims description 8
239000000546 pharmaceutical excipient Substances 0.000 claims description 8
208000014181 Bronchial disease Diseases 0.000 claims description 7
206010006482 Bronchospasm Diseases 0.000 claims description 7
229940124630 bronchodilator Drugs 0.000 claims description 7
235000014113 dietary fatty acids Nutrition 0.000 claims description 7
229930195729 fatty acid Natural products 0.000 claims description 7
239000000194 fatty acid Substances 0.000 claims description 7
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 7
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 5
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 5
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 5
239000005642 Oleic acid Substances 0.000 claims description 5
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 5
239000000168 bronchodilator agent Substances 0.000 claims description 5
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 5
KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 claims description 4
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 4
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 4
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RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims description 4
PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Polymers CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 4
239000008186 active pharmaceutical agent Substances 0.000 claims description 4
UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 claims description 4
RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims description 4
229960000396 atropine Drugs 0.000 claims description 4
229940088679 drug related substance Drugs 0.000 claims description 4
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 4
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 4
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 4
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 4
238000002360 preparation method Methods 0.000 claims description 4
ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 4
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims description 4
ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims description 4
XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims description 3
229920001213 Polysorbate 20 Polymers 0.000 claims description 3
239000004147 Sorbitan trioleate Substances 0.000 claims description 3
239000013543 active substance Substances 0.000 claims description 3
150000001298 alcohols Chemical class 0.000 claims description 3
229940124599 anti-inflammatory drug Drugs 0.000 claims description 3
239000000739 antihistaminic agent Substances 0.000 claims description 3
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 3
150000002148 esters Chemical class 0.000 claims description 3
229960002848 formoterol Drugs 0.000 claims description 3
BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims description 3
229960001888 ipratropium Drugs 0.000 claims description 3
OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 claims description 3
239000003921 oil Substances 0.000 claims description 3
235000019198 oils Nutrition 0.000 claims description 3
XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 claims description 3
229960004448 pentamidine Drugs 0.000 claims description 3
229920000642 polymer Polymers 0.000 claims description 3
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 3
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 3
229960000391 sorbitan trioleate Drugs 0.000 claims description 3
235000019337 sorbitan trioleate Nutrition 0.000 claims description 3
229960000195 terbutaline Drugs 0.000 claims description 3
230000001225 therapeutic effect Effects 0.000 claims description 3
JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims description 2
AKNNEGZIBPJZJG-MSOLQXFVSA-N (-)-noscapine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2[C@@H]1[C@@H]1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-MSOLQXFVSA-N 0.000 claims description 2
UBLVUWUKNHKCJJ-ZSCHJXSPSA-N (2s)-2,6-diaminohexanoic acid;1,3-dimethyl-7h-purine-2,6-dione Chemical compound NCCCC[C@H](N)C(O)=O.O=C1N(C)C(=O)N(C)C2=C1NC=N2 UBLVUWUKNHKCJJ-ZSCHJXSPSA-N 0.000 claims description 2
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 claims description 2
YREYLAVBNPACJM-UHFFFAOYSA-N 2-(tert-butylamino)-1-(2-chlorophenyl)ethanol Chemical compound CC(C)(C)NCC(O)C1=CC=CC=C1Cl YREYLAVBNPACJM-UHFFFAOYSA-N 0.000 claims description 2
LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 claims description 2
LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
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MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 claims description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 2
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims description 2
229920002307 Dextran Polymers 0.000 claims description 2
239000004338 Dichlorodifluoromethane Substances 0.000 claims description 2
IJVCSMSMFSCRME-KBQPJGBKSA-N Dihydromorphine Chemical compound O([C@H]1[C@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-KBQPJGBKSA-N 0.000 claims description 2
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AKNNEGZIBPJZJG-UHFFFAOYSA-N alpha-noscapine Natural products CN1CCC2=CC=3OCOC=3C(OC)=C2C1C1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-UHFFFAOYSA-N 0.000 claims description 2
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150000001735 carboxylic acids Chemical class 0.000 description 1
210000000748 cardiovascular system Anatomy 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
210000003169 central nervous system Anatomy 0.000 description 1
NFCRBQADEGXVDL-UHFFFAOYSA-M cetylpyridinium chloride monohydrate Chemical compound O.[Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 NFCRBQADEGXVDL-UHFFFAOYSA-M 0.000 description 1
230000008859 change Effects 0.000 description 1
238000002144 chemical decomposition reaction Methods 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 description 1
230000001713 cholinergic effect Effects 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
235000019504 cigarettes Nutrition 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
206010013781 dry mouth Diseases 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
238000011049 filling Methods 0.000 description 1
229960000289 fluticasone propionate Drugs 0.000 description 1
WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 description 1
239000007789 gas Substances 0.000 description 1
150000008282 halocarbons Chemical class 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
230000002102 hyperpolarization Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
231100001231 less toxic Toxicity 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000003509 long acting drug Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
238000002483 medication Methods 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
239000011859 microparticle Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
210000000663 muscle cell Anatomy 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
230000007310 pathophysiology Effects 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
230000007096 poisonous effect Effects 0.000 description 1
108020001213 potassium channel Proteins 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
230000005070 ripening Effects 0.000 description 1
210000003079 salivary gland Anatomy 0.000 description 1
230000028327 secretion Effects 0.000 description 1
208000013220 shortness of breath Diseases 0.000 description 1
230000000391 smoking effect Effects 0.000 description 1
210000002460 smooth muscle Anatomy 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000012453 solvate Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
JNYAEWCLZODPBN-CTQIIAAMSA-N sorbitan Polymers OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
230000008961 swelling Effects 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
230000009967 tasteless effect Effects 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
150000003611 tocopherol derivatives Chemical class 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
230000003313 weakening effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Pulmonology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Otolaryngology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

RU2008115918/15A 2005-09-25 2006-09-25 Состав на основе тровентола RU2457832C2 (ru)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN884/MUM/2005		2005-09-25
IN884MU2005		2005-09-25

Publications (2)

Publication Number	Publication Date
RU2008115918A RU2008115918A (ru)	2009-10-27
RU2457832C2 true RU2457832C2 (ru)	2012-08-10

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ID=37450755

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Application Number	Title	Priority Date	Filing Date
RU2008115918/15A RU2457832C2 (ru)	2005-09-25	2006-09-25	Состав на основе тровентола

Country Status (2)

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RU (1)	RU2457832C2 (fr)
WO (1)	WO2007034207A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2019147154A1 (fr) *	2018-01-23	2019-08-01	Александр Григорьевич ЧУЧАЛИН	Composition pharmaceutique (variantes) utilisation de la composition pharmaceutique (variantes)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2126248C1 (ru) *	1992-12-09	1999-02-20	Берингер Ингельхейм Фармасьютикалз, Инк.	Жидкая фармацевтическая композиция в форме аэрозоля
EP1340492A1 (fr) *	2002-03-01	2003-09-03	CHIESI FARMACEUTICI S.p.A.	Formulations d'aérosol pour l'administration par voie pulmonaire de medicaments avec effet systémique

2006
- 2006-09-25 WO PCT/GB2006/003538 patent/WO2007034207A2/fr not_active Ceased
- 2006-09-25 RU RU2008115918/15A patent/RU2457832C2/ru active

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2126248C1 (ru) *	1992-12-09	1999-02-20	Берингер Ингельхейм Фармасьютикалз, Инк.	Жидкая фармацевтическая композиция в форме аэрозоля
US5955058A (en) *	1992-12-09	1999-09-21	Boehringer Ingelheim Pharmaceuticals, Inc.	Stabilized medicinal aerosol solution formulations containing ipratropium bromide
EP1340492A1 (fr) *	2002-03-01	2003-09-03	CHIESI FARMACEUTICI S.p.A.	Formulations d'aérosol pour l'administration par voie pulmonaire de medicaments avec effet systémique

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Title
AULTON M.E. Pharmaceutics The Science of Dosage Form Design, «Churchill Livingstone» 2002, с.473-478. *
МАШКОВСКИЙ М.Д. Лекарственные средства. - М.: Новая волна, 2001, т.1, с.214-215. *
Недогода С.В. Фармакотерапия хронической обструктивной болезни легких [он-лайн], [найдено 22.06.2010]. Nayak V.G. et al «Quantitative Determination of Troventol from Aerosols by Reversed Phase Liquid Chromatography» Drug Development and Industrial Pharmacy, 1994, v.20, issue 8, 1485-1491. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2019147154A1 (fr) *	2018-01-23	2019-08-01	Александр Григорьевич ЧУЧАЛИН	Composition pharmaceutique (variantes) utilisation de la composition pharmaceutique (variantes)

Also Published As

Publication number	Publication date
WO2007034207A2 (fr)	2007-03-29
RU2008115918A (ru)	2009-10-27
WO2007034207A3 (fr)	2007-07-12

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RU2179037C2 (ru)	2002-02-10	Баллон для доставки фармацевтического состава, дозирующий ингалятор
JP3675474B2 (ja)	2005-07-27	医薬
RU2327450C2 (ru)	2008-06-27	Фармацевтические продукты и композиции, содержащие специфические антихолинергические средства, агонисты бета-2 и кортикостероиды
CA2477881C (fr)	2011-02-01	Preparation superfine de formoterol
US7601336B2 (en)	2009-10-13	Pharmaceutical aerosol composition
EP0920302B2 (fr)	2006-06-21	Composition aerosol pharmaceutique
CA2352483C (fr)	2009-01-20	Composition pharmaceutique en aerosol contenant hfa 227 et hfa 134a
JPH10506887A (ja)	1998-07-07	医薬品
MX2011012783A (es)	2012-06-28	Administracion respiratoria de agentes activos.
HK1221654A1 (zh)	2017-06-09	用於呼吸递送三种或更多种活性剂的组合物、方法和系统
EP2311793A1 (fr)	2011-04-20	Crystalline levosalbutamol sulphate (Form II)
CN105338967A (zh)	2016-02-17	包含布地奈德和福莫特罗的药物组合物
RU2457832C2 (ru)	2012-08-10	Состав на основе тровентола
WO2001028535A2 (fr)	2001-04-26	Formulations pharmaceutiques
EP2167042B1 (fr)	2015-09-09	Aerosols pharmaceutiques comprenant du fluticasone
US9808423B2 (en)	2017-11-07	Preparation of suspension aerosol formulations
RU2098082C1 (ru)	1997-12-10	Аэрозольная лекарственная композиция для ингаляций (варианты)
RU2440972C2 (ru)	2012-01-27	Кристаллический сульфат левосальбутамола, способ его получения и фармацевтическая композиция, содержащая его
WO2009090009A1 (fr)	2009-07-23	Formulation pharmaceutique comprenant un médicament anticholinergique
US20110182830A1 (en)	2011-07-28	Inhalation drug products, systems and uses
ZA200704378B (en)	2008-07-30	Pharmaceutical compounds and compositions
KR20060135873A (ko)	2006-12-29	살메테롤 흡입 제제
AU4382701A (en)	2001-07-19	Pharmaceutical aerosol composition

RU2457832C2 - Состав на основе тровентола - Google Patents

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Links

Classifications

Landscapes

Applications Claiming Priority (2)

Publications (2)

Family

ID=37450755

Family Applications (1)

Country Status (2)

Cited By (1)

Citations (2)

Patent Citations (3)

Non-Patent Citations (3)

Cited By (1)

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