RU2306938C1 - Method for preventing and treating inflammatory diseases of cavitary organs of reproduction in animals - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: the present innovation deals with introducing foam-producing suppositories into organ's cavity, these suppositories contain potassium iodide, furacillin, citric acid, calcium stearate, sodium bicarbonate and 20% alcoholic solution of MGD-2 emulsifier, moreover, before cavitary introduction it is necessary to additionally introduce not less than 100.0 ml warm 0.9%-common salt solution intracavitarily and composition of foam-producing suppositories should be additionally supplemented with levomycetin, metronidasol and ascorbic acid at the following ratio of components, g (weight%): potassium iodide 1.5 (7.4), furacillin 0.5 (2.5), levomycetin 2.0 (9.8), metronidasol 2.0 (9.8), ascorbic acid 2.5-5.0 (12.3-24.6), citric acid 1.0-2.0 (4.9-9.8), calcium stearate 0.2 (1.0), sodium bicarbonate 6.3-7.8 (31.1-38.5), 20%-alcoholic solution of MGD-2 emulsifier 1.8 (8.9).

EFFECT: higher efficiency of prophylaxis and therapy.

Description

The present invention relates to veterinary medicine, specifically to methods and drugs for the prevention and treatment of acute and chronic endometritis, vaginitis and other diseases in cows.

According to the patent of the Russian Federation No. 2267308, 2006 [3], a method is known in which preparations containing medicinal, foaming and other ground substances are introduced into the cavity of a diseased organ in the following ratio of components, g (wt.%): Potassium iodide - 1, 5 (6.8), furatsilin - 0.7 (3.2), trichopol - 2.0 (3.6), calcium carbonate - 2.6 (11.8), sodium bicarbonate - 9.0 (41, 0), calcium stearate - 0.2 (0.9), table salt - 1.0 (4.6), citric acid - 3.0 (3.6), 20% freshly prepared alcoholic solution of the emulsifier MGD-2 - 1.2 (5.5), lidocaine hydrochloride - 0.8 (3.6).

The disadvantages of this method include the following: a) an insufficient set of drugs; b) citric acid has almost no healing properties; c) lidocaine hydrochloride is an expensive and scarce substance, the appropriateness of its use is poorly substantiated.

The purpose of the invention is to increase the therapeutic effectiveness of the drug by increasing the number of drugs.

This goal is achieved by the fact that at least 100.0 ml of a warm 0.9% sodium chloride solution and a foaming preparation prepared from a mixture of substances crushed to an amorphous state are introduced into the cavity of a diseased organ in the following weight and percentage ratio of components (table):

Table Weight and percentage of the mixture №№ Name of substance Permissible fluctuations g the weight.% g the weight.% g the weight.% one Potassium iodide 1,5 7.4 1,5 7.4 1,5 7.4 2 Furatsilin 0.5 2,5 0.5 2,5 0.5 2,5 3 Chloramphenicol 2.0 9.8 2.0 9.8 2.0 9.8 four Metronidazole (Trichopolum) 2.0 9.8 2.0 9.8 2.0 9.8 5 Ascorbic acid 2,5 12.3 3.8 18.8 5,0 24.6 6 Citric Acid 2.0 9.8 1,5 7.4 1,0 4.9 7 Calcium stearate 0.2 1,0 0.2 1,0 0.2 1,0 8 Sodium bicarbonate 7.8 38.5 7.0 34,4 6.3 31.1 9 20% alcohol solution of the emulsifier MGD-2 or another equivalent 1.8 8.9 1.8 8.9 1.8 8.9 Total 20.3 100.0 20.3 100.0 20.3 100.0

The technology for preparing a mixture of substances and stamping foaming candles from it includes the following steps:

a) separate grinding to an amorphous state of crystalline substances, sieving them and other components of the mixture through a sieve with cells up to 0.3 mm;

b) mixing in the mixer the prescribed amount of sodium bicarbonate, calcium stearate, citric acid, ascorbic acid, a 20% freshly prepared alcohol solution of the MGD-2 emulsifier or another equivalent to obtain a uniformly moistened mass, drying it with a thin layer at a temperature of 20-25 ° From up to 24 hours, sifting through a sieve, grinding the lumps remaining in the sieve;

c) mixing in a mixer until a homogeneous mass of potassium iodide, furatsilin, chloramphenicol, metronidazole (trichopolum);

d) thorough mixing in the mixer of mixtures of items "b" and "c";

d) a homogeneous amorphous mixture is carefully poured into the hopper of a hydraulic or other press with mold cells and the candles are pressed at a pressure of about 600 kg / cm ² ;

f) each candle having a cylindrical shape with rounded ends, a dense consistency, smooth surfaces of light yellow color, is placed in the nest of the bag made of plastic film, its open part is closed with a thermal seam, the packages are placed in a cardboard box, and instruction is given in it (recommendations) on the use of the drug.

Note: a) instead of furatsilin, you can use furazolidone, instead of chloramphenicol - chloramphenicol stearate, synthomycin: b) a mixture of solids can be packaged in 20.3 g in separate nests of a film of polyethylene, their open sides are closed with a heat seal so that tightness is maintained. When used, the contents of the nest are placed in a device for introducing foaming solutions into the cavity, dissolved with a 0.9% warm solution of sodium chloride.

Pharmacodynamics of the ingredients of the drug:

- Potassium iodide - odorless white crystalline hygroscopic powder, easily soluble in water (1: 0.75), does not contain free iodine, does not irritate nerve endings and mucous membrane cells, does not have a bactericidal effect. After rapid absorption in the body, the animal changes to form various iodine compounds. They are part of the thyroid hormones, act in the focus of inflammation bactericidal, anti-inflammatory, promote resorption and neutralization of inflammatory products [2, p.323];

- furatsilin - yellow or greenish-yellow powder, sparingly soluble in water [1: 4200, 1, p. 299], but better in 0.9% (isotonic, physiological) sodium chloride solution [1: 420, 2, s .433], in a liquid medium it acts detrimental to gram-positive and gram-negative bacteria [1, p. 300; 2, p. 433];

- chloramphenicol - a bitter-tasting crystalline powder, white or white with a slight yellowish-greenish tint, slightly soluble in water, is a broad-spectrum antibiotic, is effective against many gram-positive and gram-negative bacteria, rickettsia, spirochetes, some large viruses, acts on bacterial strains, penicillin resistant.

The mechanism of action of chloramphenicol is associated with impaired protein synthesis in microbial cells, the resistance of microbes to chloramphenicol develops relatively slowly [1, p. 251];

- metronidazole (Trichopolum) - a white or slightly greenish crystalline powder, sparingly soluble in water, has a strong destructive effect on protozoa (Trichomonas, etc.) and on anaerobic bacteria [1, p.343-344];

- ascorbic acid (vitamin "C") - colorless crystals that are easily soluble in water (1: 5), are well preserved in dry form.

After absorption in the body, it takes part in interstitial respiration, is related to enzymes and hormones, promotes the production of intercellular bonding agents, has a very significant antihemorrhagic effect, reduces the porosity of the vascular walls, prevents the development of an infectious onset, acts antitoxically, and increases the body's resistance to infections and intoxications, activates the growth of granulation tissue in places of inflammatory processes, improves heart function, has diuretic and de toxic effect. When interacting with sodium bicarbonate in a humid environment, the reaction proceeds according to the following scheme:

To neutralize 10.0 g of ascorbic acid (m. M. 176,13) it is necessary to take 4.8 g of sodium bicarbonate (m. M. 84);

- citric acid (m. m. 192,13) - coarse-grained powder, soluble in water, interacts with sodium bicarbonate in a liquid medium according to the following scheme:

Sodium citrate has an alkaline reaction, interacts with the acidic substances of the inflammatory exudate, like sodium ascorbate, neutralizes them, when interacting with capillary blood calcium, forms salts that deprive it of its ability to coagulate, and promotes the flow of arterial blood into the inflamed area [2, p.349] ;

- calcium stearate, MGD-2 emulsifier, or another, but equivalent in action, are used in the preparation as form-forming substances and as substances that prevent the rapid decay of foam;

- sodium bicarbonate (m. m. 84) - a white crystalline powder, odorless, readily soluble in water (1:12) with the formation of an alkaline reaction solution, when interacting with acids in a humid environment forms foamy solutions.

To neutralize one unit of citric acid (m. M. 192,13) it is necessary to take at least 2.3 parts of sodium bicarbonate, one part of ascorbic acid (m. M. 176,13) - half of one part of it.

After absorption into the animal’s blood, sodium bicarbonate is part of the buffer systems, neutralizes the acidic substances of the inflammatory exudate, softens the action of its toxic substances, and has anti-inflammatory and antiparasitic effects [2, p. 341-343];

- table salt is very hygroscopic - it is injected in the form of a warm 0.9% (isothermal, physiological) solution into the cavity of the diseased organ before the introduction of the foaming agent - it is easily absorbed by the mucous membranes, the mineral substances contained in it participate in the regulation of osmotic pressure, have an effect to enhance the activity of protective devices of the body, improve the solubility and effectiveness of the antimicrobial action of furatsilin [1, p. 106; 2, p. 346-347].

Indications for use:

- prevention of the development of postpartum endometritis. After delivery and separation of the placenta, a 0.9% warm solution of sodium chloride and one candle or a solution of a mixture of foaming substances in a warm 0.9% sodium chloride solution are introduced into the uterine cavity;

- treatment of postpartum endometritis. A warm 0.9% solution of sodium chloride and 1-2 candles are injected into the uterine cavity through the open cervix, and if necessary, the treatment is repeated after 48 and 72 hours.

Preliminary tests of the effectiveness of foaming candles and mixtures gave quite encouraging results.

Literature

1. Mashkovsky M.D. Medicines M.: Medicine, 1987, vol. 1 and 2. Pages are indicated in the text.

2. Brains I.E. Pharmacology. M .: Selkhozizdat, 1954, p. Are indicated in the text.

3. Moiseev O.N., Klimenko A.I., Klimenko R.V., Drobin Yu.D., Tikhenko G.A. A method for the prevention and treatment of certain diseases of animal reproductive organs. RF patent No. 2267308, m.cl. A61D 7/00 et al., 2006.

Claims (1)

A method for the prevention and treatment of inflammatory diseases of the abdominal reproductive organs in animals, including the introduction into the body cavity of foaming suppositories containing potassium iodide, furatsilin, citric acid, calcium stearate, sodium bicarbonate and 20% alcohol solution of the MGD-2 emulsifier, characterized the fact that before introducing foaming candles into the body cavity of the animal, at least 100.0 ml of warm 0.9% sodium chloride solution is additionally introduced into the body cavity, and additionally into the composition of the foaming candles chloramphenicol, metronidazole and ascorbic acid are introduced in the following ratio of components, g (wt.%): potassium iodide - 1.5 (7.4), furatsilin - 0.5 (2.5), chloramphenicol - 2.0 (9, 8), metronidazole - 2.0 (9.8), ascorbic acid - 2.5-5.0 (12.3-24.6), citric acid - 1.0-2.0 (4.9-9 , 8), calcium stearate - 0.2 (1.0), sodium bicarbonate 6.3-7.8 (31.1-38.5), 20% alcohol solution of the emulsifier MHD-2 - 1.8 ( 8.9).