RU2376011C1 - Agent for care of peripheral joints and backbone area - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention is related to chemical-pharmaceutical industry, namely to development of agent with active transdermal transfer of chondroprotectors for care of joints area in case of osteoarthrosis (arthrosis), osteochondrosis of backbone, inhuries of joints in posttraumatic period, for prevention of age and traumatic degenerative-dystrophic diseases of joints on the basis of natural vegetable components.

EFFECT: agent in the form of nutrient cream-balm moderates progressing of osteoarthrosis, osteochondrosis, stimulates process of articular cartilage recovery, prevents further cartilaginous tissue, normalises composition and generation of intraarticular liquid, improves its lubricating properties, improves mobility and functions of injured joints, activates blood circulation in the area of injured joint, improves nutrition to area of articular cartilage and gives anti-inflammatory effect.

6 cl, 3 ex, 2 dwg

Description

The invention relates to the chemical and pharmaceutical industry, in particular to the creation of agents with active transdermal transfer of chondroprotectors to care for the joint area with osteoarthritis (arthrosis), osteochondrosis of the spine, joint injuries in the post-traumatic period, to prevent age-related and traumatic degenerative joint diseases based on natural plant components.

In the modern treatment regimen for osteoarthritis and other joint diseases, an important place is given to chondroprotectors. They, along with non-steroidal anti-inflammatory drugs (NSAIDs), are the basis for the therapeutic treatment of patients with osteoarthrosis.

The main chondroprotectors are glucosamine sulfate and chondroitin sulfate. They are natural components of articular cartilage, are part of the proteoglycans and glycosaminoglycans of cartilage. The most important aspect of the pathogenesis of osteoarthritis is the formation of proteoglycan deficiency (E.M. Neyko, I.Yu. Golovach, 2000), which consists in the depolymerization of protein-polysaccharide complexes with the formation of smaller compounds that leave the cartilage. At the same time, the function of chondrocytes is also disturbed, they synthesize less stable proteoglycans, the loss of physiological properties of cartilage develops, which is accompanied by the formation of erosion and cracks in the cartilage.

Glucosamine sulfate and chondroitin sulfate are used in the treatment of osteoarthritis and similar diseases as natural metabolites as agents that can have a protective effect against cartilage.

Chondroitin sulfate is formed in the body from glucosamine, its molecule is 100-200 times larger than its predecessor. The polyanion molecule of chondroitin sulfate is an integral part of the aggrecan structure and is responsible for the cellular and physicochemical properties of cartilage. In addition, chondroitin sulfate serves as the basis for the synthesis of hyaluronic acid, which provides the lubricant necessary for the functioning of the joints.

In patients with osteoarthritis, the metabolism of chondroitin sulfate is impaired, clusters of pathological chondrocytes produce an inferior basic substance of cartilage.

Studies on the pharmacological effects of chondroitin sulfate have established the presence of anti-inflammatory activity. An additional factor explaining the anti-inflammatory effect of chondroitin sulfate may be its antithrombotic effect. It has been shown that chondroitin sulfate can inhibit the formation of fibrin thrombi in the synovial and subchondral microvasculature due to its structural proximity to heparin.

Chondroitin sulfate and glucosamine not only have a symptomatic effect, but are also able to favorably affect the metabolism of cartilage, restoring its structure and normalizing metabolism. Ultimately, these chondroprotectors do have a protective effect on articular cartilage, prevent its destruction and contribute (at least partially) to its restoration.

Glucosamine treatment makes it possible to get the effect after 2-4 weeks.

The use of chondroitin sulfate (the recommended daily intake is 1000-1500 mg) is especially indicated in elderly patients with concomitant atherosclerosis, obesity, impaired lipid metabolism, metabolic syndrome, concomitant diabetes mellitus, due to the presence of an antithrombotic heparin-like effect and a decrease in cholesterol and lipoproteins. Compared to glucosamine, the effect of chondroitin sulfate occurs somewhat later.

The combined use of chondroitin sulfate and glucosamine provides a more rapid saturation of the body with chondroprotectors compared to the action of one component, as well as a more pronounced clinical effect. Their joint prescription is indicated if it is necessary to strengthen the action when the effect of one drug is insufficient. This approach makes it possible to reduce the dose of each drug.

Thus, the latest research has allowed, taking into account all the requirements of evidence-based medicine, to confirm the clinical significance of chondroprotectors in the treatment of osteoarthritis. Chondroitin sulfate and glucosamine sulfate, used as the basis for long-term basic therapy for patients with osteoarthritis, can significantly change the course of the disease.

A known external medicine is Chondroxide ointment based on chondroitin sulfate at a concentration of 5% and a transdermal transfer enhancer dimethyl sulfoxide at a concentration of 10% (Radar, Doctor, 2006, p.771).

Chondroxide normalizes the metabolism in hyaline tissue, stimulates regenerative (regenerative) processes in the articular cartilage, has an analgesic and anti-inflammatory effect, slows the progression of osteoarthritis and osteochondrosis. Chondroxide contains a natural component - chondroitin sulfate, obtained from cattle tissue. Chondroitin sulfate is a high molecular weight mucopolysaccharide that slows down bone resorption and reduces calcium loss. Chondroitin sulfate improves calcium and phosphorus metabolism in the cartilage, accelerates the process of its repair, inhibits the degeneration (destruction) of the cartilage, inhibits the collapse of the connective tissue, inhibits the enzymes that cause damage to the cartilage, stimulates the synthesis of glucosaminoglycans, and promotes the regeneration (restoration) of the joint bag and cartilage surfaces of joints, increases the production of intraarticular fluid. This leads to a decrease in soreness and an increase in the mobility of the affected joints. Dimethyl sulfoxide, which is part of the ointment, promotes better penetration of chondroitin sulfate through cell membranes into the tissues, has some anti-inflammatory, analgesic and fibrinolytic effects. Ointment is used to treat and prevent osteochondrosis, osteoarthritis of the peripheral joints and spine.

But the dimethyl sulfoxide included in the recipe is allowed to be used only in pharmaceutical preparations to a limited extent due to its specific toxicity.

In addition, the ointment base does not contribute to the deep penetration of active substances into tissues, their effect remains superficial, does not have good absorption, leaves a greasy film on the surface of the skin, which disrupts its natural respiration.

The objective of the present invention is to provide a safe agent with a more effective transepidermal transfer of several chondroprotectors and an active complex effect aimed at various pathogenesis links in the prevention of osteochondrosis, osteoarthrosis and restoration of peripheral joints and spine.

The technical result consists in the fact that the agent in the form of a nourishing cream-balm slows down the progression of osteoarthrosis, osteochondrosis, stimulates the restoration of articular cartilage, prevents further destruction of the cartilage tissue, normalizes the composition and production of intraarticular fluid, improves its lubricating property, improves the mobility and function of the affected joints , activates blood circulation in the affected joint, improves nutrition in the articular cartilage and has an anti-inflammatory effect vie.

The problem is solved as follows.

The proposed tool for the care of the peripheral joints and spine, including a complex of chondroprotectors, characterized in that it includes: a liposome concentrate with an antioxidant complex containing soy phospholipids, ethyl alcohol, troxerutin, sorbitol, glycerin, dihydroquercetin, vitamin PP (nicotinamide), 2 -ethyl-6-methyl-3-hydroxypyridine succinate, 1-hydroxy germatran, 6-ethoxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline, tocopherol linoleate, magnesium ascorbyl phosphate, preservative and deionized water ; microemulsion concentrate of organosilicon liquids containing organosilicon liquids, vegetable oils, soy phospholipids, vitamin E hydroxyethylated, glycerin, sorbitol, 2-ethyl-6-methyl-3-hydroxypyridine succinate, 1-hydroxy germatran, preservative and deionized water; an emulsion with a complex of nourishing vegetable oils; diethylene glycol monoethyl ether; 20-50% aqueous solution of bile; sodium hyaluronate mol. weighing 50-100 thousand. Daltons and a complex perfumed thickener containing deionized water, glycerin, a thickener preservative and perfume with the following components in wt.%:

liposome concentrate with antioxidant complex 2.0-7.0 microemulsion concentrate organosilicon liquids 2.0-7.0 emulsion with a complex of nutrients vegetable oils 45.0-60.0 chondroprotective complex 3.0-10.0 diethylene glycol monoethyl ether 3.0-10.0 20-50% aqueous solution of bile 0.05-0.5 molecular sodium hyaluronate weighing 30-100 thousand. Daltons 0.05-0.5 complex perfumed thickener rest

Liposomal concentrate with antioxidant complex contains soy phospholipids, ethyl alcohol, troxerutin, sorbitol, glycerin, dihydroquercetin, vitamin PP (nicotinamide), 2-ethyl-6-methyl-3-hydroxypyridine succinate, 1-hydroxy germatran, 6-ethoxy-2 2,4-trimethyl-1,2,3,4-tetrahydroquinoline, tocopherol linoleate, magnesium ascorbyl phosphate, preservative and deionized water with the following components in wt.%:

soybean phospholipids 6.0-16.0 ethanol 6.0-14.0 troxerutin 0.01-4.0 sorbitol 2.0-5.0 glycerol 2.0-5.0 dihydroquercetin 0.01-0.5 vitamin PP (nicotinamide) 0.01-0.2 2-ethyl-6-methyl-3-hydroxypyridine succinate 0.05-0.2 1-hydroxy germatran 0.05-0.2 6-ethoxy-2,2,4-trimethyl-1,2,3,4- tetrahydroquinoline 0.05-0.5 tocopherol linoleate 0.05-0.5 magnesium ascorbyl phosphate 0.05-0.5 preservative 0.3-1.0 deionized water up to 100

The microemulsion concentrate of organosilicon liquids contains organosilicon liquids, vegetable oils, soybean phospholipids, vitamin E hydroxyethylated, glycerin, sorbitol, 2-ethyl-6-methyl-3-hydroxypyridine succinate, 1-hydroxy germatran, preservative and deionized water with the following components in weight .%:

organosilicon liquids 20.0-35.0 vegetable oils 5.0-15.0 soybean phospholipids 1.0-4.0 vitamin E ethoxylated 0.3-0.8 glycerol 2.0-5.0 sorbitol 2.0-5.0 2-ethyl-6-methyl-3-hydroxypyridine succinate 0.05-0.5 1-hydroxy germatran 0.05-0.2 preservative 0.3-1.0 deionized water up to 100

The emulsion with a complex of nourishing vegetable oils contains Maccadamia oil, castor oil, Shea butter, isopropyl palmitate, diisopropyl adipate, diisopropyl sebacate, emulsifier, cetyl alcohol, surfactant, Boswellia Serato extract, 6-ethoxy-2,2,4-trimethyl-1, 2,3,4 tetrahydroquinoline, preservative and deionized water in the following components in wt.%:

macadamia oil 4.0-6.0 castor oil 1.0-4.0 Shea Butter 1.0-2.0 isopropyl palmitate 2.0-6.0 diisopropyl adipate 1.0-5.0 diisopropyl sebacate 1.0-5.0 emulsifier 4.0-8.0 cetyl alcohol 2.5-5.0 Surfactant 0.6-1.2 Boswellia Serato Extract 1.0-5.0 6-ethoxy-2,2,4-trimethyl-1,2,3,4- tetrahydroquinoline 0.1-0.2 preservative 0.35-1.2 deionized water up to 100

The complex of chondroprotectors is a mixture of chondroitin sulfate (chloride), glucosamine sulfate (chloride), acetyl glucosamine in the following components in the indicated concentration ranges of each chondroprotector in wt.% In 100 g of product:

chondroitin sulfate (chloride) 2.0-8.0 glucosamine sulfate (chloride) 1.0-8.0 glucosamine acetyl 0.1-1.0

The complex perfumed thickener contains deionized water, glycerin, a thickener, polyacrylamide, preservative and perfume with the following components in wt.%:

glycerin 3.0-6.0 thickener 0.2-0.5 polyacrylamide 2.0-5.0 preservative 0.3-1.0 perfume 0.1-0.5 deionized water rest

Diethylene glycol monoethyl ether (ethoxydiglycol) is a highly purified molecular distillation product with a purity of at least 99.5%.

The bile solution is an aqueous 20-50% solution and contains bile selected from bear, bovine, goose, duck or chicken.

Sodium hyaluronate (hyaluronic acid) is low molecular weight with a molecular weight of not more than 30-100 thousand Daltons.

The invention is illustrated by the following examples.

Technological recipe for preparation means.

The main technological stages.

I. Preparation of an aqueous solution of chondroprotectors with bile.

II. Preparation of emulsion cream.

III. Cooking Cream-Balm nourishing.

Example 1

When preparing an aqueous solution of chondroprotective agents with bile in a separate reactor with stirring while heating to 55-60 ° C, dissolve in 100.0 g of ethoxyglycol and 169.7 g of deionized water with 3.2 g of preservative (Sepicide HB2), the total weight of chondroprotectors (60, 0 g of chondroitin sulfate, 30.0 g of glucosamine sulfate, 10.0 g of acetyl glucosamine) and after they are completely dissolved, 1.0 g of bile solution (50%) is charged.

II. To prepare the emulsion cream, the oil and water phases are separately prepared.

The aqueous phase is prepared in a separate main reactor. To do this, while stirring in 262.6 g of deionized water, pre-prepared dispersions of hydroxyethyl starch (Natrosol 250) (4.5 g) in glycerol (50.0 g) and a dispersion of 1.0 g of sodium hyaluronate in deionized water (19.0 g) are added ), heated to 70-75 ° C and stirred until a homogeneous viscous mass for 15-25 minutes.

The oil phase is prepared in a separate container.

Composition of the oil phase: 30.0 g Macadamia oil, 20.0 g castor oil, 10.0 g Shea butter, 25.0 g isopropyl myristate, 15.0 g diisopropyl adipate, 15.0 g diisopropyl sebacate, 0.5 g 6-ethoxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline, 0.5 g nipazole, 20.0 g Boswellia Serato extract, 25.0 g Ceralus N (emulsifier), 15.0 g Montanov 202 (emulsifier), 15.0 g of cetyl alcohol (Lanette 16), 5.0 g of Laureth-9 (surfactant).

Then, while mixing with a planetary mixer, the oil phase that was previously prepared and heated to a temperature of 70-75 ° C is slowly added to the aqueous phase and then dispersed at high speed (at least 1500 rpm) for 1-2 minutes, then reduce the speed and with stirring planetary mixer is cooled to 35-40 ° C.

After preparation of the emulsion cream and its cooling to 40 ° C, 4.0 g of preservative (Sepicide HB2) are added and, with vigorous stirring (at least 1500 rpm), the biomass is dispersed for 1-2 minutes.

III. When preparing the Cream-Balm feed in the main reactor with an emulsion cream (537.1 g) prepared in stage II, with the planetary stirrer stirring at room temperature (not higher than 30-40 ° С), we add in small portions sequentially from auxiliary containers 372.9 g of a solution of chondroprotectors with bile, 20.0 g of liposomal concentrate, 20.0 g of microemulsion concentrate of organosilicon liquids and perfume (qs), the mass is mixed until homogeneous, using a vacuum we free from air bubbles formed in manufacturing processes. After obtaining a homogeneous mass, with vigorous stirring, add 50.0 g of thickener (Sepigel 305). Mixing time is 15-20 minutes.

Ready Cream-Balm nourishing is a creamy balsamic type homogeneous mass.

Example 2

I. When preparing an aqueous solution of chondroprotective agents with bile in a separate reactor with stirring while heating to 55-60 ° C, dissolve in 30.0 g of ethoxyglycol and 162.5 g of deionized water with 3.2 g of preservative (Sepicide HB2), the total weight of chondroprotectors ( 25.0 g of chondroitin sulfate, 5.0 g of glucosamine sulfate) and after they are completely dissolved, 10.0 g of bile solution (50%) is charged.

II. To prepare the emulsion cream, the oil and water phases are separately prepared.

The aqueous phase is prepared in a separate main reactor. To do this, while stirring in 251.3 g of deionized water, pre-prepared dispersions of hydroxyethyl starch (Natrosol 250) (2.0 g) in glycerol (60.0 g) and a dispersion of 5.0 g of sodium hyaluronate in deionized water (60.0 g) are added ), heated to 70-75 ° C and stirred until a homogeneous viscous mass for 15-25 minutes.

The oil phase is prepared in a separate container.

Composition of the oil phase: 10.0 g Macadamia oil, 5.0 g castor oil, 5.0 g Shea butter, 30.0 g isopropyl myristate, 20.0 g diisopropyl adipate, 20.0 g diisopropyl sebacate, 1.5 g 6-ethoxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline, 0.5 g nipazole, 50.0 g, Boswellia Serato extract, 30.0 g Ceralus N (emulsifier), 20.0 g of Montanov 202 (emulsifier), 25.0 g of cetyl alcohol (Lanette 16), 5.0 g of Laureth-9 (surfactant).

Then, while mixing with a planetary mixer, the oil phase that was previously prepared and heated to a temperature of 70-75 ° C is slowly added to the aqueous phase and then dispersed at high speed (at least 1500 rpm) for 1-2 minutes, then reduce the speed and with stirring planetary mixer is cooled to 35-40 ° C.

After preparation of the emulsion cream and its cooling to 40 ° C, 4.0 g of preservative (Sepicide HB2) are added and, with vigorous stirring (at least 1500 rpm), the biomass is dispersed for 1-2 minutes.

III. When preparing the Cream-Balm feed into the main reactor with emulsion cream (599.3 g), prepared according to stage II, with stirring with a planetary mixer at room temperature (not higher than 30-40 ° C), we make small portions in series from auxiliary containers 235.7 g of a solution of chondroprotective agents with bile, 70.0 g of liposomal concentrate, 70.0 g of microemulsion concentrate of organosilicon liquids and perfume, the mass is mixed until homogeneous, using a vacuum, we free from air bubbles formed during all production. After obtaining a homogeneous mass, with vigorous stirring, add 20.0 g of thickener (Sepigel 305). Mixing time is 15-20 minutes.

Ready Cream-Balm nourishing is a creamy balsamic type homogeneous mass.

Example 3

I. When preparing an aqueous solution of chondroprotective agents with bile in a separate reactor, with stirring while heating to 55-60 ° C, dissolve in 60.0 g of ethoxyglycol and 220.0 g of deionized water with 3.2 g of preservative (Sepicide HB2), 20.0 g of glucosamine sulfate, 10.0 g of acetyl glucosamine and after they are completely dissolved, 5.0 g of bile solution (50%) is charged.

II. To prepare the emulsion cream, the oil and water phases are separately prepared.

The aqueous phase is prepared in a separate main reactor. To do this, while stirring in 267.5 g of deionized water, pre-prepared dispersions of hydroxyethyl starch (Natrosol 250) (5.0 g) in glycerol (50.0 g) and a dispersion of 2.0 g of sodium hyaluronate in deionized water (40.0 g) are added ), heated to 70-75 ° C and stirred until a homogeneous viscous mass for 15-25 minutes.

The oil phase is prepared in a separate container.

Composition of the oil phase: 30.0 g Macadamia oil, 20 g, castor oil, 5.0 g Shea butter, 25.0 g isopropyl myristate, 15.0 g diisopropyl adipate, 15.0 g diisopropyl sebacate, 1.0 g 6 -ethoxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline, 0.5 g Nipazole, 10.0 g Boswellia Serato extract, 20.0 g Ceralus N (emulsifier), 10.0 g Montanes 202 (emulsifier), 20.0 g of cetyl alcohol (Lanette 16), 5.0 g of Laureth-9 (surfactant).

Then, while mixing with a planetary mixer, the oil phase that was previously prepared and heated to a temperature of 70-75 ° C is slowly added to the aqueous phase and then dispersed at high speed (at least 1500 rpm) for 1-2 minutes, then reduce the speed and with stirring planetary mixer is cooled to 35-40 ° C.

After preparation of the emulsion cream and its cooling to 40 ° C, 4.0 g of preservative (Sepicide HB2) are added and, with vigorous stirring (at least 1500 rpm), the biomass is dispersed for 1-2 minutes.

III. When preparing the Cream-Balm feed into the main reactor with emulsion cream (541.0 g), prepared according to stage II, with stirring with a planetary mixer at room temperature (not higher than 30-40 ° C), we add in small portions sequentially from auxiliary containers 345.0 g of a solution of chondroprotective agents with bile, 50.0 g of liposomal concentrate, 30.0 g of microemulsion concentrate of organosilicon liquids and perfume (qs), the mass is mixed until uniform, using a vacuum we free from air bubbles formed in manufacturing processes. After obtaining a homogeneous mass, with vigorous stirring, add 30.0 g of thickener (Sepigel 305). Mixing time is 15-20 minutes.

Ready Cream-Balm nourishing is a creamy balsamic type homogeneous mass.

A comparative assessment was made of the effect of the proposed new agent (Cream-Balm nourishing) and the known Chondroxide ointment on the intensity of transport of chondroprotectors (CP) through the skin of animals.

Special devices were made - chambers, including 4 containers of the same volume-cells A, B, C, D, which can be separated by membranes or skin preparations isolated from one animal (Fig. 1). The intensity of transport through the skin of two substances is compared, one of which passes from cell A to B, and the other from cell C to D. A prerequisite for such a comparison is that the skin preparation is isolated from a certain part of the body of one animal and is of sufficient size, to overlap both transitions. Skin preparations of mice of the BALB genetic line, including layers of the epidermis and dermis, were prepared immediately before the experiment.

In order to prepare skin preparations, the back skin area of adult male mice weighing 20-22 g of the BALB genetic line, inaccessible to the paws of animals, 2 × 4 cm in size was treated with hair removal cream and washed from the remnants of the cream. After 2 days, the skin was checked for damage or scratches. Then, the animals selected for the experiment were euthanized by displacement of the cervical vertebrae and a skin area with removed hair was separated. The skin preparation was washed from contaminants and blood, fascia and connective tissue were mechanically removed, a layer of adipose tissue was removed, and the remaining layers of the epidermis and dermis were washed with saline. The skin area thus treated was placed in a Hanks solution (X) (pH 7.0) containing all the components necessary for respiration and nutrition of the skin cells for several hours, and immediately placed in the chambers for the experiment, and then the chamber was placed in a thermostat at 37 ° C.

Since the direct spectrophotometric determination of CP by light absorption in the UV region was ineffective under the conditions of our experiments, we used the method of staining ChIS with a cationic dye - toluidine blue (TS), which is not affected by the presence of proteins in solutions and is weakly affected by the presence of nucleic acids (Schiff reaction). Since TS molecules are actively bound by polysaccharides and interact with each other on the surface of polysaccharides. In this case, the absorption spectrum and the intensity of light absorption by the dye in the visible region change. By changing the intensity of absorption of visible light by the dye, when it is bound to a polysaccharide (CP), the amount of polysaccharide in solution can be determined.

Comparison of the amounts of polysaccharides (CPs) penetrating through the skin into the body of an animal from the agent of the present patent (Cream-Balm nourishing) and Chondroxide ointment.

The product (Nourishing Cream-Balm, which includes 5% of the chondroprotective complex and 6% ethoxydiglycol) is placed in cell A. Chondroxide ointment is placed in cell C, which contains 5% chondroitin sulfate and 10% dimethyl sulfoxide. Cells B and D contain solutions of X. The whole system is placed in a thermostat and, at certain intervals, aliquots of solutions are taken from cells B and D, which are transferred to the cells of the spectrophotometer in which the TS solution of known concentration and optical density is located. The solutions are thoroughly mixed and their optical density in the visible region is determined at a wavelength of 590 nm (at the peak of absorption of the native TC). When polysaccharides got into the solutions located in cells B and D through skin preparations, when TC was added to these solutions, the light absorption spectrum was changed by the dye, and the light absorption by the dye was reduced at 590 nm. These changes are strictly proportional to the concentration of polysaccharides (CP). For each experimental point in figure 2, the arithmetic mean value (M) and the standard deviation (b) were determined. The significance of differences in the difference of sample means was determined using Student's criterion Tst (N. A. Plokhinsky. Algorithms for biometric calculations. M., Moscow State University, 1976). According to the criterion used, the differences of these points reach the first threshold of the probability of error-free forecasts t1. Differences between all other compared points in the control and the experiment reach the highest degree of probability t3. Recalculation of the change in the optical density of the dye (Fig. 2) by the number of polysaccharides associated with it indicates that for 1 hour 1 cm ^{2 of} skin passes approximately 0.71 mg of polysaccharides (CP) from cream-balm nourishing and approximately 0.57 mg of polysaccharides (CP ) from Chondroxide ointment. Thus, Cream-Balm that nourishes by a comparable indicator is approximately 20-30% more active than Chondroxide ointment.

The proposed tool was also tested on a group of patients with osteoarthrosis (arthrosis), osteochondrosis of the spine, on patients with joint injuries in the post-traumatic period and on a group of patients to prevent age-related and traumatic degenerative joint diseases.

Clinical trials have shown that the claimed tool in the form of Cream-Balm slows the progression of osteoarthrosis, osteochondrosis, stimulates the restoration of articular cartilage, prevents further destruction of cartilage tissue, normalizes the composition and production of intraarticular fluid, improves its lubricating properties, improves mobility and function of the affected joints, activates blood circulation in the affected joint, improves nutrition of the articular cartilage and has an anti-inflammatory effect. It is also noted: after daily use of the Cream-Balm twice a week later, uncomfortable painful manifestations in the knee and ankle areas decrease, pain during walking disappears and swelling subsides.

Claims (6)

1. A tool for the care of the peripheral joints and spine, including a complex of chondroprotectors, characterized in that it includes a liposome concentrate with an antioxidant complex containing soy phospholipids, ethyl alcohol, troxerutin, sorbitol, glycerin, dihydroquercetin, vitamin PP (nicotinamide), 2 -ethyl-6-methyl-3-hydroxypyridine succinate, 1-hydroxy germatran, 6-ethoxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline, tocopherol linoleate, magnesium ascorbyl phosphate, preservative and deionized water ; microemulsion concentrate of organosilicon liquids containing organosilicon liquids, vegetable oils, soy phospholipids, vitamin E hydroxyethylated, glycerin, sorbitol, 2-ethyl-6-methyl-3-hydroxypyridine succinate, 1-hydroxy germatran, preservative and deionized water; an emulsion with a complex of nourishing vegetable oils; diethylene glycol monoethyl ether; 20-50% aqueous solution of bile; sodium hyaluronate mol. weighing 50-100 thousand. Daltons and a complex perfumed thickener containing deionized water, glycerin, a thickener preservative and perfume with the following components, wt.%:
liposome concentrate with antioxidant complex 2.0-7.0 microemulsion concentrate organosilicon liquids 2.0-7.0 emulsion with a complex of nutrients vegetable oils 45.0-60.0 chondroprotective complex 3.0-10.0 diethylene glycol monoethyl ether 3.0-10.0 20-50% aqueous solution of bile 0.05-0.5 molecular sodium hyaluronate weighing 30-100 thousand. Daltons 0.05-0.5 complex perfumed thickener rest 2. The tool according to claim 1, in which the liposome concentrate with an antioxidant complex contains soy phospholipids, ethyl alcohol, troxerutin, sorbitol, glycerin, dihydroquercetin, vitamin PP (nicotinamide), 2-ethyl-6-methyl-3-hydroxypyridine succinate, 1 -hydroxy germatran, 6-ethoxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline, tocopherol linoleate, magnesium ascorbyl phosphate, preservative and deionized water with the following content of components, wt.%:
soybean phospholipids 6.0-16.0 ethanol 6.0-14.0 troxerutin 0.01-4.0 sorbitol 2.0-5.0 glycerol 2.0-5.0 dihydroquercetin 0.01-0.5 Vitamin PP (Nicotinamide) 0.01-0.2 2-ethyl-6-methyl-3-hydroxypyridine succinate 0.05-0.2 1-hydroxy germatran 0.05-0.2 6-ethoxy-2,2,4-trimethyl-1,2,3,4- tetrahydroquinoline 0.05-0.5 tocopherol linoleate 0.05-0.5 magnesium ascorbyl phosphate 0.05-0.5 preservative 0.3-1.0 deionized water up to 100 3. The tool according to claim 1, in which the microemulsion concentrate of organosilicon liquids contains organosilicon liquids, vegetable oils, soy phospholipids, vitamin E ethoxylated, glycerin, sorbitol, 2-ethyl-6-methyl-3-hydroxypyridine succinate, 1-hydroxy germatran, preservative and deionized water in the following components, wt.%:
organosilicon liquids 20.0-35.0 vegetable oils 5.0-15.0 soybean phospholipids 1.0-4.0 vitamin E ethoxylated 0.3-0.8 glycerol 2.0-5.0 sorbitol 2.0-5.0 2-ethyl-6-methyl-3-hydroxypyridine succinate 0.05-0.5 1-hydroxy germatran 0.05-0.2 preservative 0.3-1.0 deionized water up to 100 4. The tool according to claim 1, in which the emulsion with a complex of nutritional vegetable oils contains McCadamia oil, castor oil, Shea butter, isopropyl palmitate, diisopropyl adipate, diisopropyl sebacate, emulsifier, cetyl alcohol, surfactant, Boswellia Serato extract, 6-ethoxy- 2,2,4-trimethyl-1,2,3,4 tetrahydroquinoline, preservative and deionized water in the following components, wt.%:
macadamia oil 4.0-6.0 castor oil 1.0-4.0 Shea Butter 1.0-2.0 isopropyl palmitate 2.0-6.0 diisopropyl adipate 1.0-5.0 diisopropyl sebacate 1.0-5.0 emulsifier 4.0-8.0 cetyl alcohol 2.5-5.0 Surfactant 0.6-1.2 Boswellia Serato Extract 1.0-5.0 6-ethoxy-2,2,4-trimethyl -1,2,3,4-tetrahydroquinoline 0.1-0.2 preservative 0.35-1.2 deionized water up to 100 5. The tool according to claim 1, in which the complex of chondroprotectors is a mixture of chondroitin sulfate (chloride), glucosamine sulfate (chloride), acetyl glucosamine in the following components in the indicated concentration ranges of each chondroprotector, wt.% In 100 g of product:
chondroitin sulfate (chloride) 2.0-8.0 glucosamine sulfate (chloride) 1.0-8.0 glucosamine acetyl 0.1-1.0 6. The tool according to claim 1, in which the complex perfumed thickener contains deionized water, glycerin, a thickener, polyacrylamide, preservative and fragrance in the following components, wt.%:
glycerol 3.0-6.0 thickener 0.2-0.5 polyacrylamide 2.0-5.0 preservative 0.3-1.0 perfume 0.1-0.5 deionized water rest

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