RU2354352C1 - Woman intimate hygiene preparation - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: invention refers to cosmetic industry, particularly to woman intimate hygiene preparation containing chlorophyll-carotene mixture and phytosterol as an active vegetative component, sodium soap base as a shaping component, as well as wax taken in certain ratio.

EFFECT: preparation is characterised with antibacterial activity improved by long-term exposure of active components; does not cause irritation of mucous membrane and skin.

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Description

The invention relates to the field of intimate hygiene of women and is a solid soap used mainly during the menstrual cycle, as well as during pregnancy and the postpartum period.

Known means for intimate hygiene of women, including an active herbal component and other additives, in particular mimosa extract, EP 1348439.

This tool is not effective enough because it does not contain surfactants, which can be alkaline salts of fatty acids that form a soap base.

Also known is a composition for female sexual hygiene comprising an extract of milk from an animal family of horses in combination with therapeutically acceptable additives; this composition may be a soap, RU 2005133972.

However, as an active component, milk extract is ineffective, in addition, horse milk is in many cases a very strong allergen and causes serious side effects -

inflammation, swelling, etc.

Known means for the hygiene of women, containing an active plant component in the form of a fraction of labdanic alcohols obtained during the processing of coniferous greenery, a formative component in the form of beeswax in the following ratio of components:

fraction of labdanic alcohols obtained during the processing of coniferous wood greenery - 1-10, the forming component is the rest, RU 2149640.

This technical solution is made as a prototype of the present invention.

In the “critical days”, as well as in the prenatal and postpartum periods, female excretions from the genital tract are a good breeding ground for the intensive reproduction of pathogenic microbes such as staphylococci, streptococci, grams (+) and (-) sticks, fungi, which can lead to complicated course of the postpartum period.

It was revealed that during this period, 90% of women in the genital area have a significant number of staphylococci, streptococci and pathogenic sticks, and 33% also show yeast-like fungi.

A necessary and sufficient from a hygienic point of view is the reduction of pathogenic flora to the level of single microorganisms.

However, labdanic alcohols have relatively low antibacterial activity.

As rightly noted in RU 2138279, labdanic (dicyclic) diterpene alcohols are natural compounds whose “activity is not known” and has a narrow focus, mainly with respect to influenza viruses.

In addition, labdanic alcohols irritate the mucous membranes and skin. The healing effect of the Labdan alcohol fraction was not detected.

The above does not allow us to consider the tool according to RU 2149640 effective for the hygiene of women in general and especially in the periods indicated above.

It should also be noted that when using wax as a forming component, its content is from 90 to 99%.

Such a large amount of wax causes its introduction into the pores of the skin, which causes clogging of these pores with all the negative consequences: the development of anaerobic infection, impaired outflow of body fluids, impaired lipid balance, etc.

Another disadvantage of the prototype is the lack of cleaning properties, since it does not contain components with a sorbing and surface-active effect.

The present invention is to provide a means for intimate hygiene of women, especially during the menstrual cycle, pregnancy, prenatal and postpartum periods, which would have high antibacterial activity, would not have an irritating effect on the mucous membranes and skin. In addition, the problem is solved to improve the cleaning properties and increase the duration of exposure to active components.

According to the invention, an agent for intimate hygiene of women containing an active plant component and wax contains chlorophyllocarotin paste and phytosterol as the active plant component in the following ratio, wt.%:

Chlorophyllocarotene Paste 4-13 Phytosterol 0.3-3.0 Wax 0.05-0.2 Forming component in the form soap base rest.

In this tool used chlorophyllocarotene paste obtained from green spruce and / or pine. Chlorophyllocarotene paste used in a specific example is produced by KLM (Moscow Region, Dolgoprudny).

When the content of chlorophyllocarotene paste is below 4 wt.%, The antibacterial effect is not sufficiently pronounced. When its content exceeds 13 wt.%, The product does not have the hardness necessary for soap.

Phytosterol is used as β-sitosterol (C ₂₉ H ₅₀ O) isolated from cottonseed oil. It is also possible to use C ₂₈ - and O ₂₉ - sterols isolated from ferns or conifers.

These phytosterols are precursors of progesterone, a female sex hormone. With a phytosterol content of less than 0.3 wt.%, The effect is not pronounced, with a phytosterol content of more than 3.0 wt.%, The risk of allergic reactions increases.

Beeswax in this composition, unlike the prototype, is not a form-forming component, but rather provides the formation of a very thin protective film on the skin and mucous membranes. When the wax content is less than 0.05 wt.%, The effect of the protective film is practically not observed, when the wax content is more than 0.2 wt.%, Undesirable clogging of pores occurs.

The forming component, which also has a sorbing and cleaning effect, is a sodium soap base.

The applicant has not identified any technical solutions identical to the claimed composition, which determines the compliance of the invention with the criterion of "novelty."

Unlike the prototype, the present invention has high antibacterial activity, without causing irritation of the mucous membranes and skin. The presence of phytosterol, a precursor to progesterone, has an immunostimulating effect and enhances the overall activity of the drug. A thin protective film of wax does not cause clogging of pores, but it helps to retain active components (chlorophyllocarotin paste, phytosterol) and thereby increase the duration of their exposure. In addition, this protective film protects the external genitalia and skin from the effects of pathogenic secretions in case of inflammatory processes in the vagina, cervical canal, uterus and other internal organs.

The applicant has not identified sources of information that would contain information about the influence of the distinguishing features of the invention on the achieved result, which determines, according to the applicant, the invention meets the criterion of "inventive step".

Clinical testing of the means (soap) was carried out in the antenatal clinic No. 30 of the maternity hospital No. 6 named after Professors Snegirev, St. Petersburg, ul. Mayakovsky, d.5.

The patients were divided into four groups, each of which had 12 people - 3 pregnant women, 3 - after childbirth (puerperas), 3 -

gynecological patients, 3 - clinically healthy, with a preventive purpose.

The first three groups used soap with the following ratio of components, wt.% (Table 1):

Table 1 Chlorophyllocaro-
mud paste Phytosterol Wax Sodium soap base First group four 0.3 0.05 95.65 Second group 8 1,5 0.1 90,4 Third group 13 3.0 0.2 83.8

The fourth control group used Forest soap.

Testing was carried out for 10 days in each group.

Each patient of the group before the start of testing and after it was taken from the external genitalia and perineum. In all patients, the state of the perineum - the anogenital zone - was assessed before and after the study.

When patients subjectively evaluated the quality of the soap of the present invention, the following reviews were received: the vast majority of patients considered the appearance of a special soap necessary and timely to maintain proper hygiene during pregnancy, the postpartum period and as a prophylactic. As a rule, when using soap, there is a significant improvement in well-being: “heaviness” and itching in the perineal region disappear, the amount of secretions decreases, and a feeling of dryness and freshness appears.

Unpleasant sensations - burning and tingling were noted by two puerperas, one of them in the third group, the second in the control.

A number of women reported that they “liked” the soap, while offering to increase the size of the pieces, give them a more aesthetic shape and improve the smell.

Microbiological control was carried out by quantitative seeding and determining the nature of microorganisms, including those unfavorable from the point of view of the condition of the skin and mucous membranes (Staphylococcus spp., Streptococcus spp., Candida spp., Various gram-positive and gram-negative bacilli); bacterioscopic and bacteriological methods were used. Before and after using the soap, smears were taken from the examined patients from the surface of the anogenital zone, in which the main significant microorganisms were revealed after staining.

The seeds of the anogenital zone before and after using the claimed funds were studied by seeding on general, elective and differential diagnostic nutrient media, followed by microscopy of Gram stained smears. Staphylococci, streptococci, and yeast-like fungi of the genus Candida were identified before the genus.

Before using the soap, the contamination with staphylococci was 1.0 × 10 ² -1.0 × 10 ⁴ / tampon (90% of patients); streptococci - 1.0 × 10 ³ -1.0 × 10 ⁵ / tampon (70% of patients); Gr (-) sticks - 6.0 × 10 ² -1.0 × 10 ⁴ / swab (90% of patients); Gr (+) sticks - 1.0 × 10 ⁴ / tampon (30%) of patients); yeast-like fungi of the genus Candida - 1.0 × 10 ⁴ / tampon (30%) of patients).

After using soap, a significant decrease in the degree of microbial contamination was observed in all examined patients.

There was a (average) decrease in the amount of:

Staphylococcus: in the first group 2 times, in the second - 8 times, in the third - 7 times, in the fourth (control) - 1.5 times;

Streptococcus: in the first group, 4,000 times, in the second - 10,000 times, in the third - 9,000 times, in the fourth - 1,000 times;

Gr (-) sticks: in the first group 6,000 times, in the second - 10,000 times, in the third - 10,000 times, in the fourth - 5,000 times;

Gr (+) sticks: approximately 10 times in the first three groups, 5 times in the fourth group;

Mushrooms of the genus Candida: in the first group 3 times, in the second - 10 times, in the third - 5 times, in the fourth - 3 times.

Similar results were obtained during clinical trials in the laboratories of the Department of Obstetrics and Gynecology and the Department of Microbiology, Virology and Immunology of St. Petersburg State Medical University. ac. I.P. Pavlova, St. Petersburg, st.L. Tolstoy, 6/8.

Claims (1)

A means for intimate hygiene of women, containing an active plant component and wax, characterized in that it contains chlorophyllocarotin paste and phytosterol as an active plant component, and a sodium soap base as a forming component, in the following ratio, wt.%:
chlorophyllocarotin paste 4-13 phytosterol 0.3-3.0 wax 0.05-0.2 formative component in the form soap base rest