RU2227744C2 - "antiches" anti-pruritus preparation - Google Patents
"antiches" anti-pruritus preparation Download PDFInfo
- Publication number
- RU2227744C2 RU2227744C2 RU2002118366/15A RU2002118366A RU2227744C2 RU 2227744 C2 RU2227744 C2 RU 2227744C2 RU 2002118366/15 A RU2002118366/15 A RU 2002118366/15A RU 2002118366 A RU2002118366 A RU 2002118366A RU 2227744 C2 RU2227744 C2 RU 2227744C2
- Authority
- RU
- Russia
- Prior art keywords
- preparation
- lipoic acid
- pruritus
- antiches
- polcortolone
- Prior art date
Links
- 208000003251 Pruritus Diseases 0.000 title abstract description 6
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 claims abstract description 9
- 235000019136 lipoic acid Nutrition 0.000 claims abstract description 9
- 229960002663 thioctic acid Drugs 0.000 claims abstract description 9
- 239000003908 antipruritic agent Substances 0.000 claims description 3
- 239000005556 hormone Substances 0.000 claims description 3
- 229940088597 hormone Drugs 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000843 powder Substances 0.000 abstract description 3
- XGMPVBXKDAHORN-RBWIMXSLSA-N Triamcinolone diacetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](OC(C)=O)[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O XGMPVBXKDAHORN-RBWIMXSLSA-N 0.000 abstract 2
- 229960004320 triamcinolone diacetate Drugs 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 10
- 229940079593 drug Drugs 0.000 description 8
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 4
- 230000007803 itching Effects 0.000 description 4
- 206010019799 Hepatitis viral Diseases 0.000 description 3
- 238000006748 scratching Methods 0.000 description 3
- 230000002393 scratching effect Effects 0.000 description 3
- 201000001862 viral hepatitis Diseases 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 201000009053 Neurodermatitis Diseases 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 230000001139 anti-pruritic effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000036269 ulceration Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000002322 anti-exudative effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Изобретение относится к медицине, ветеринарии и может быть использовано в качестве противозудного, противовоспалительного, противоаллергического и антиэкссудативного средства, а также в качестве биологически активной добавки к пище домашних животных (собак и кошек).The invention relates to medicine, veterinary medicine and can be used as an antipruritic, anti-inflammatory, anti-allergic and antiexudative agent, as well as a biologically active food supplement for pets (dogs and cats).
Известно применение гормона полькортолон в качестве противозудного средства (Регистр лекарственных средств России РЛС - Дотоктор. - М.: РЛС-2000, 2 изд., 1999, с.760).The use of the hormone polcortolone as an antipruritic is known (Russian Medicines Radar Register - Dotoktor. - M .: Radar 2000, 2nd ed., 1999, p. 760).
Недостатки - побочные действия: ожирение, отеки, необходимость использования дополнительных препаратов и витаминов, так как он выводит из организма кальций и Д3, животные неохотно принимают данный препарат.Disadvantages - side effects: obesity, swelling, the need to use additional drugs and vitamins, since it removes calcium and D3 from the body, animals are reluctant to take this drug.
Изобретение направлено на решение задач: профилактика побочных действий, удобство применения, хорошая переносимость препарата животными.The invention is aimed at solving problems: prevention of side effects, ease of use, good tolerance of the drug by animals.
Указанные задачи достигаются за счет средства, включающего полькортолон, липоевую кислоту и сахарную пудру в определенном процентном соотношении.These tasks are achieved at the expense of funds, including polcortolone, lipoic acid and powdered sugar in a certain percentage.
Липоевая кислота обладает гепатопротекторным действием и липостатическим действием.Lipoic acid has a hepatoprotective effect and lipostatic effect.
Глюкоза хорошо связывает билирубин, чем достигается повышение эффективности лечения, особенно вирусного гепатита.Glucose binds bilirubin well, thereby increasing the effectiveness of treatment, especially viral hepatitis.
Наличие липоевой кислоты и сахарной пудры увеличивает эффективность целевого продукта полькортолона, так как позволяет достичь тех же результатов при меньшей дозе гормона.The presence of lipoic acid and powdered sugar increases the effectiveness of the target product of polcortolone, as it allows you to achieve the same results with a lower dose of the hormone.
Одновременно с лечебным эффектом достигается профилактика основных побочных явлений: отеков, ожирении и др.Along with the therapeutic effect, prevention of the main side effects is achieved: edema, obesity, etc.
Средство готовят следующим образом. Таблетки полькортолона и липоевой кислоты размельчают и смешивают с сахарной пудрой в следующем соотношении, мас.%:The tool is prepared as follows. Tablets of polcortolone and lipoic acid are crushed and mixed with powdered sugar in the following ratio, wt.%:
Полькортолон 0,013-0,025 (8-15 мг)Polcortolone 0.013-0.025 (8-15 mg)
Липоевая кислота 0,083-0,166 (50-100 мг)Lipoic acid 0.083-0.166 (50-100 mg)
Сахарная пудра ОстальноеPowdered sugar rest
Порошок расфасовывают в пакеты по 60 г.The powder is packaged in bags of 60 g.
Рекомендуют использовать один пакет в течение двух недель по 3-5 г один раз в день в течение двух первых суток, далее по 1-3 г в день в течение 10-14 дней в сухом виде или растворяя в воде или в пище. При необходимости курс повторяют после двухнедельного перерыва.It is recommended to use one packet for two weeks, 3-5 g once a day for the first two days, then 1-3 g per day for 10-14 days in dry form or dissolved in water or in food. If necessary, repeat the course after a two-week break.
Примеры конкретного выполнения.Examples of specific performance.
Пример 1.Example 1
Кокер-спаниель, девочка, 5 лет. Зуд, расчесы и изъязвления по телу. Болеет 1 месяц. Грибкового заболевания не обнаружено. В анамнезе: вирусный гепатит.Cocker Spaniel, girl, 5 years old. Itching, scratching, and ulceration of the body. It is sick 1 month. Fungal disease was not detected. History: viral hepatitis.
Диагноз: нейродермит.Diagnosis: neurodermatitis.
Назначен препарат "Античес" в дозе 1/2 чайной ложки в течение двух дней, далее по 1/4 чайной ложки в течение двух недель.The preparation "Antiches" was prescribed in a dose of 1/2 teaspoon for two days, then 1/4 teaspoon for two weeks.
Зуд пропал в течение первых суток, расчесы и изъязвления исчезли в течение недели. В течение 1 года рецидивов нет.The itching disappeared during the first day, scratching and ulceration disappeared within a week. There is no relapse within 1 year.
Пример 2.Example 2
Кот, 3 года. Зуд по всему телу, расчесы на груди, шее, мокнущая экзема на спине. Болен 2 недели, в контакте с другими животными не был, грибок не обнаружен.Cat, 3 years old. Itching throughout the body, scratching on the chest, neck, weeping eczema on the back. Sick for 2 weeks, was not in contact with other animals, the fungus was not detected.
Диагноз: нейродермит.Diagnosis: neurodermatitis.
Назначен препарат "Античес" в дозе 1/4 чайной ложки в течение 2 дней, затем по 1/8 чайной ложки в течение 10 дней.The drug "Antiches" was prescribed in a dose of 1/4 teaspoon for 2 days, then 1/8 teaspoon for 10 days.
Зуд исчез полностью на второй день. Через 10 дней кот был здоров. В течение года рецидивов нет.The itching disappeared completely on the second day. After 10 days, the cat was healthy. There are no relapses during the year.
Предлагаемое средство можно использовать для лечения экземы, в том числе мокнущей и других кожных аллергических заболеваний. Особенно эффективно это средство для лечения вирусного гепатита (кожная форма), так как глюкоза, содержащаяся в нем, хорошо связывает билирубин.The proposed tool can be used to treat eczema, including weeping and other skin allergic diseases. This drug is especially effective for treating viral hepatitis (skin form), since the glucose contained in it binds bilirubin well.
По сравнению с прототипом, животные лучше принимают этот препарат из-за отсутствия специфичного запаха как в сухом, так и в разведенном виде, так как препарат хорошо растворяется в воде.Compared with the prototype, animals take this drug better due to the lack of a specific smell both in dry and in diluted form, since the drug is highly soluble in water.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2002118366/15A RU2227744C2 (en) | 2002-07-08 | 2002-07-08 | "antiches" anti-pruritus preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2002118366/15A RU2227744C2 (en) | 2002-07-08 | 2002-07-08 | "antiches" anti-pruritus preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2002118366A RU2002118366A (en) | 2004-03-20 |
| RU2227744C2 true RU2227744C2 (en) | 2004-04-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002118366/15A RU2227744C2 (en) | 2002-07-08 | 2002-07-08 | "antiches" anti-pruritus preparation |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2227744C2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2367426C1 (en) * | 2008-07-29 | 2009-09-20 | Александр Анатольевич Смирнов | Medicine for treatment of inflammatory and alergic skin diseases of cats and dogs ''stop-zud-1'' |
| RU2392932C2 (en) * | 2008-07-29 | 2010-06-27 | Александр Анатольевич Смирнов | Stop-zud-2 agent for treating inflammatory and allergic skin disease in cats and dogs |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2071343C1 (en) * | 1993-02-26 | 1997-01-10 | Научно-исследовательский институт фармакологии Томского научного центра РАМН | Method of preparing substance showing antiulcer activity and pharmaceutical composition based on thereof |
| RU2072860C1 (en) * | 1992-08-26 | 1997-02-10 | Тюменский медицинский институт | Method of treatment or early lipid metabolism disturbance in patient with diabetes of the 1-type |
| RU2164802C1 (en) * | 2000-02-28 | 2001-04-10 | Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова | Agent for treatment of patients with hepatitis and fibrosis symptoms |
-
2002
- 2002-07-08 RU RU2002118366/15A patent/RU2227744C2/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2072860C1 (en) * | 1992-08-26 | 1997-02-10 | Тюменский медицинский институт | Method of treatment or early lipid metabolism disturbance in patient with diabetes of the 1-type |
| RU2071343C1 (en) * | 1993-02-26 | 1997-01-10 | Научно-исследовательский институт фармакологии Томского научного центра РАМН | Method of preparing substance showing antiulcer activity and pharmaceutical composition based on thereof |
| RU2164802C1 (en) * | 2000-02-28 | 2001-04-10 | Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова | Agent for treatment of patients with hepatitis and fibrosis symptoms |
Non-Patent Citations (1)
| Title |
|---|
| Регистр лекарственных средств России РЛС - Доктор. - М.: РЛС - 2000, 2 изд. 1999, с.760. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2367426C1 (en) * | 2008-07-29 | 2009-09-20 | Александр Анатольевич Смирнов | Medicine for treatment of inflammatory and alergic skin diseases of cats and dogs ''stop-zud-1'' |
| RU2392932C2 (en) * | 2008-07-29 | 2010-06-27 | Александр Анатольевич Смирнов | Stop-zud-2 agent for treating inflammatory and allergic skin disease in cats and dogs |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2002118366A (en) | 2004-03-20 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20040709 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20070709 |