RU2221579C2 - Method for treating mastitis in cows - Google Patents

Abstract

FIELD: veterinary science, animal science. SUBSTANCE: one should intracisternally introduce specific bacteriophages (staphylococcal, streptococcal, proteic, clebsiellosis, pasteurellosis and escherichiosis) 3-4 times at interval of 22-26 h at the dosage of 40-50 ml into sick udder's portion, and into area of external inguinal nodes - subcutaneously at interval of 46-48 h, also, one should introduce placental extract at the dosage of 40-50 ml 3-4 times. The method increases body immune reactivity, causes lactogenic effect, enhances regenerative capacity of udder's tissues and antimicrobial action upon microflora of mammary gland secreta. EFFECT: shortened terms and higher efficiency of therapy.

Description

 The invention relates to veterinary obstetrics and can be used to treat mastitis in cows.

 There is a method of treating mastitis cows with an antimicrobial drug staphylococcal bacteriophage when it is interstitially administered at a dose of 50 ml to each affected lobe once for 3 days [1, 2].

 However, the drug does not have an immunostimulating effect and the therapeutic effect is low, especially with aseptic mastitis.

 In this regard, the treatment of various forms of mastitis requires a comprehensive treatment method, including the use of antimicrobial and biogenic substrates.

 The purpose of the invention is to reduce the time and increase the effectiveness of the treatment of mastitis in cows.

 This goal is achieved by the fact that a biogenic stimulant - placenta extract is injected subcutaneously in the area of the external inguinal lymph nodes 3-4 times with an interval of 46-48 hours, and antimicrobial bacteriophages (staphylococcal, streptococcal, proteus, klebsiellosis, escherichiosis and pasteurellosis) - intra once for 3-4 days. The dose of drugs is 40-50 ml, depending on the body weight of the animals.

 The tests of the placenta extract and specific bacteriophages in the treatment of 32 mastitis cows showed high therapeutic efficacy.

 The course of treatment with this drug began after an external clinical study of the udder and staging mastidine, bromothymol and sedimentation tests.

 The method is as follows: with the appearance of clinical signs of mastitis in cows and with a positive result of laboratory tests, the placenta extract is injected into the area of the external inguinal lymph nodes in a dose of 40-50 ml, depending on the live weight of the animal, 3-4 times with an interval of 46- 48 hours. Bacteriophages (staphylococcal, streptococcal, protean, Klebsiellosis, pasteurellosis and Escherichiosis) are administered three to four times with an interval of 22-26 hours at a dose of 40-50 ml.

 The use of bacteriophages in a dose of less than 40 ml does not have the necessary therapeutic effect, and a dose of more than 50 ml causes irritation of the tissues of the udder.

 Three-time administration of bacteriophages and two-time administration of the placenta extract provided a favorable outcome and led to recovery in 22 animals. After the first administration preparations, the edema of the udder subsided, and soreness decreased. After the second injection of bacteriophages, the clinical signs of mastitis completely disappeared, however, laboratory tests yielded a positive result. And after the third injection of bacteriophages, reactions with mastidine, bromothymol and a sedimentation assay, as well as bacteriological examination of milk, gave negative results. After the second administration of the placenta extract, milk production was fully restored.

 In five animals, the healing process was sluggish. To restore milk production, 4 injections of drugs were required.

 In five cases out of 32, the use of drugs led to animal recovery, but milk production did not recover.

 Using the proposed method allows to reduce the treatment of mastitis in cows, to achieve a stable therapeutic effect.

Sources of information
1. Niyaz N.M. The basics of obtaining staphylococcal bacteriophage for the treatment of mastitis in cows. Dis. can Vet.Science, Moscow, 1988, p. 73.

 2. Niyaz N.M. The study of phage sensitivity of staphylococcus strains of various origin / Mosk. vet. Academy named after K.I. Scriabin, M., 1987 .-- 6 p. - Dep. in VNIITEISKH, VII, 1986, 99 BC-86.

Claims (1)

A method of treating mastitis in cows, including the introduction of an intracisternally into the diseased portion of the udder of a drug, characterized in that a complex of bacteriophages, including staphylococcal, streptococcal, proteic, Klebsiellosis, pasteurellosis and Escherichiosis, which is administered three to four times with an interval of 22- 26 hours at a dose of 40-50 ml, and a placenta extract is injected subcutaneously at an interval of 46-48 hours three to four times at a dose of 40-50 ml into the area of the external inguinal nodes.