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RU2219176C2 - Derivatives of 2-aminopyridine, pharmaceutical composition based on thereof and method for its preparing - Google Patents

Derivatives of 2-aminopyridine, pharmaceutical composition based on thereof and method for its preparing Download PDF

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RU2219176C2
RU2219176C2 RU2001111815/04A RU2001111815A RU2219176C2 RU 2219176 C2 RU2219176 C2 RU 2219176C2 RU 2001111815/04 A RU2001111815/04 A RU 2001111815/04A RU 2001111815 A RU2001111815 A RU 2001111815A RU 2219176 C2 RU2219176 C2 RU 2219176C2
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phenyl
pyridyl
derivatives
quinolyl
thiazolyl
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RU2001111815A (en
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Венделин ФРИК (DE)
Венделин Фрик
Райнхард КИРШ (DE)
Райнхард Кирш
Хайнер ГЛОМБИК (DE)
Хайнер Гломбик
Хуберт ХОЙЕР (DE)
Хуберт Хойер
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Авентис Фарма Дойчланд Гмбх
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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Abstract

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new derivatives of 2-aminopyridines of the formula (I)
Figure 00000002
wherein C means unsubstituted or substituted phenyl, pyridyl, thienyl, thiazolyl, quinolyl, quinoxaline-2-yl or their benzoanellated derivatives; D means unsubstituted or substituted phenyl, pyridyl, thienyl, pyrimidyl, indolyl, thiazolyl, imidazolyl, quinolyl, triazolyl, oxazolyl, isoxazolyl or their benzoanellated derivatives under condition that C and D have no the following values simultaneously: C phenyl and D phenyl, C phenyl and D pyridyl, C pyridyl and D phenyl, C pyridyl and D pyridyl; R1-R4 mean hydrogen atom, NO2 or NH2. Compounds of the formula (I) elicit hypolipidemic activity and can be used in medicine for treatment of lipid metabolism disorders. EFFECT: improved preparing method, valuable medicinal properties of compounds. 4 cl, 1 tbl, 66 ex

Description

Текст описания в факсимильном виде (см. графическую часть) Тк Description text in facsimile form (see graphic part) Tk

Claims (4)

1. Производные 2-аминопиридинов формулы I1. Derivatives of 2-aminopyridines of the formula I
Figure 00000033
Figure 00000033
 где С - фенил, пиридил, тиенил, тиазолил, хинолил, хиноксалин-2-ил или их бензоаннелированные производные, причем ароматический или гетероароматический остаток может быть замещен -NO2-группой или (C1-C8)-алкилом;where C is phenyl, pyridyl, thienyl, thiazolyl, quinolyl, quinoxalin-2-yl or their benzo-cannulated derivatives, wherein the aromatic or heteroaromatic residue may be substituted with an —NO 2 group or (C 1 -C 8 ) -alkyl; D - фенил, пиридил, тиенил, пиримидил, индолил, тиазолил, имидазолил, хинолил, триазолил, оксазолил, изоксазолил или их бензоаннелированные производные, причем ароматический или гетероароматический остаток может быть одно- или двукратно замещен хлором, СF3, (C1-C8)-алкилом, (C1-C8)-алкоксилом, (C0-C6)-алкилпиридилом или (C0-C6)-алкил-фенилом, причем фенильный остаток может быть замещен галогеном,D is phenyl, pyridyl, thienyl, pyrimidyl, indolyl, thiazolyl, imidazolyl, quinolyl, triazolyl, oxazolyl, isoxazolyl or their benzo-canned derivatives, and the aromatic or heteroaromatic residue may be substituted once or twice with chlorine, CF 3 , (C 1 -C 8 ) -alkyl, (C 1 -C 8 ) -alkoxyl, (C 0 -C 6 ) -alkylpyridyl or (C 0 -C 6 ) -alkyl-phenyl, wherein the phenyl moiety may be substituted with halogen, при условии, что С и D не имеют одновременно следующие значения:provided that C and D do not simultaneously have the following meanings: С = фенил и D = фенил, С = фенил и D = пиридил, С = пиридил и D = фенил, С = пиридил и D = пиридил;C = phenyl and D = phenyl, C = phenyl and D = pyridyl, C = pyridyl and D = phenyl, C = pyridyl and D = pyridyl; R1, R2, R3 и R4 независимо друг от друга - водород, -NO2 или NH2.R 1 , R 2 , R 3 and R 4 independently of one another are hydrogen, —NO 2 or NH 2 . 2. Соединения формулы I по п.1, отличающиеся тем, что С - фенил, пиридил, тиенил, тиазолил, хинолил, хиноксалин-2-ил, причем ароматический или гетероароматический остаток может быть замещен (C1-C8)-алкилом; D - фенил, пиридил, тиенил, пиримидил, индолил, тиазолил, имидазолил, хинолил, триазолил, оксазолил, изоксазолил, причем ароматический или гетероароматический остаток может быть одно- или двукратно замещен хлором, (C1-C8)-алкилом, при условии, что С и D не имеют одновременно следующие значения: С = фенил и D = фенил, С = фенил и D = пиридил, С = пиридил и D = фенил, С = пиридил и D = пиридил; R1, R2, R3 и R4 независимо друг от друга - водород, -NO2 или NH2.2. The compounds of formula I according to claim 1, characterized in that C is phenyl, pyridyl, thienyl, thiazolyl, quinolyl, quinoxalin-2-yl, wherein the aromatic or heteroaromatic residue may be substituted with (C 1 -C 8 ) -alkyl; D is phenyl, pyridyl, thienyl, pyrimidyl, indolyl, thiazolyl, imidazolyl, quinolyl, triazolyl, oxazolyl, isoxazolyl, and the aromatic or heteroaromatic residue may be substituted once or twice with chlorine, (C 1 -C 8 ) -alkyl, provided that C and D do not simultaneously have the following meanings: C = phenyl and D = phenyl, C = phenyl and D = pyridyl, C = pyridyl and D = phenyl, C = pyridyl and D = pyridyl; R 1 , R 2 , R 3 and R 4 independently of one another are hydrogen, —NO 2 or NH 2 . 3. Фармацевтическая композиция, проявляющая гиполипидемическую активность и содержащая одно или несколько соединений по п.1 или 2.3. A pharmaceutical composition exhibiting lipid-lowering activity and containing one or more compounds according to claim 1 or 2. 4. Способ получения фармацевтической композиции с гиполипидемической активностью, отличающийся тем, что одно или несколько соединений формулы I по п.1 или 2 смешивают с фармацевтически приемлемым носителем и эту смесь готовят в виде пригодной для введения формы.4. A method of obtaining a pharmaceutical composition with lipid-lowering activity, characterized in that one or more compounds of formula I according to claim 1 or 2 is mixed with a pharmaceutically acceptable carrier and this mixture is prepared in a form suitable for administration.
RU2001111815/04A 1998-10-02 1999-09-18 Derivatives of 2-aminopyridine, pharmaceutical composition based on thereof and method for its preparing RU2219176C2 (en)

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Application Number Priority Date Filing Date Title
DE19845402A DE19845402B4 (en) 1998-10-02 1998-10-02 Heterocyclic substituted propanolamine derivatives, process for their preparation, pharmaceutical compositions containing them and their use
DE19845402.3 1998-10-02

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2363699C2 (en) * 2005-02-28 2009-08-10 Джапан Тобакко Инк. New aminopyridin derivative with inhibition activity in relation to syk

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19845406C2 (en) * 1998-10-02 2001-10-18 Aventis Pharma Gmbh Substituted 1,3-diaryl-2-pyridin-2-yl-3- (pyridin-2-ylamino) propanol derivatives, process for their preparation, medicaments containing these compounds and their use
DE10064402A1 (en) * 2000-12-21 2002-06-27 Aventis Pharma Gmbh New diphenyl-azetidinone derivatives useful for the treatment of hyperlipidemia, arteriosclerosis and hypercholesterolemia
HUP0401073A2 (en) * 2000-12-21 2004-09-28 Aventis Pharma Deutschland Gmbh. Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
NZ531292A (en) * 2001-08-22 2005-08-26 Aventis Pharma Gmbh Combination products of aryl-subsituted propanolamine derivatives with other active ingredients and the use thereof
DE10219987A1 (en) * 2002-05-03 2004-04-08 Aventis Pharma Deutschland Gmbh Optically active β-amino ketones, optically active 1,3-amino alcohols and process for their preparation
US7161008B2 (en) * 2002-05-03 2007-01-09 Sanofi - Aventis Deutschland GmbH Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
CA2794018C (en) * 2010-03-24 2016-05-10 Medical University Of South Carolina Compositions and methods for the treatment of degenerative diseases
EP3593802A3 (en) 2010-05-26 2020-03-25 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
EA030839B1 (en) 2011-10-28 2018-10-31 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
WO2013063526A1 (en) 2011-10-28 2013-05-02 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
JP2016514684A (en) 2013-03-15 2016-05-23 ルメナ ファーマシューティカルズ エルエルシー Bile acid recirculation inhibitors for the treatment of primary sclerosing cholangitis and inflammatory bowel disease
CN105228615A (en) 2013-03-15 2016-01-06 鲁美纳医药公司 Be used for the treatment of the bile acid recycling inhibitors of Barrett esophagus and gastroesophageal reflux disease
US11238759B1 (en) 2015-10-29 2022-02-01 Ward-Kraft, Inc. Single ply wristband with printable coating
US11232719B1 (en) 2019-09-04 2022-01-25 Ward-Kraft, Inc. Single ply wristband with printable coating
AU2020221834B2 (en) 2019-02-12 2025-10-23 Mirum Pharmaceuticals, Inc. Genotype and dose-dependent response to an ASBTI in patients with bile salt export pump deficiency
USD988404S1 (en) 2020-02-14 2023-06-06 Rekon, Llc Wristband label form with single strap wristbands
USD941917S1 (en) 2020-02-18 2022-01-25 Ward-Kraft, Inc. Combination wristband label form with extender
USD967253S1 (en) 2020-02-26 2022-10-18 Ward-Kraft, Inc. Wristband form with extender

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1240354A3 (en) * 1981-02-09 1986-06-23 Пфайзер Инк (Фирма) Method of producing pyrbuterol dihydrochloride
EP0345591A1 (en) * 1988-06-10 1989-12-13 F. Hoffmann-La Roche Ag Propanol amine derivatives
WO1998034920A1 (en) * 1997-02-05 1998-08-13 Bayer Aktiengesellschaft 2-amino substituted pyridines for use in the treatment of arteriosclerosis and hyperlipoproteinaemia

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT869121E (en) * 1997-04-04 2004-10-29 Aventis Pharma Gmbh PROPANOLAMINE HIPOLIPIDEMIC DERIVATIVES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1240354A3 (en) * 1981-02-09 1986-06-23 Пфайзер Инк (Фирма) Method of producing pyrbuterol dihydrochloride
EP0345591A1 (en) * 1988-06-10 1989-12-13 F. Hoffmann-La Roche Ag Propanol amine derivatives
WO1998034920A1 (en) * 1997-02-05 1998-08-13 Bayer Aktiengesellschaft 2-amino substituted pyridines for use in the treatment of arteriosclerosis and hyperlipoproteinaemia

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2363699C2 (en) * 2005-02-28 2009-08-10 Джапан Тобакко Инк. New aminopyridin derivative with inhibition activity in relation to syk

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