RU2286328C1 - Method for preparing 4,7-dialkyl(benzyl)idene-2,10-dodecadienes - Google Patents

Abstract

FIELD: organic chemistry, chemical technology.

SUBSTANCE: method involves carrying out the interaction of alkyl(benzyl)allene of the general formula (R-=^.=) wherein R means n-C₅H₁₁, n-C₆H₁₃, -CH₂Ph with EtMgBr, Mg, Cp₂TiCl₂, crotyl bromide and CuCl in argon atmosphere in tetrahydrofuran medium. The total reaction time is 18-22 h and the total yield of end products is 63-81%. Invention provides the development of method for synthesis of 4,7-dialkyl(benzyl)idene-2,10-dodecadienes.

EFFECT: improved method of synthesis.

1 tbl, 1 ex

Description

The present invention relates to organic chemistry, in particular to a method for producing 4,7-dialkyl (benzyl) ide-2,10-dodecadienes of the general formula (1):

где R=н-C₅H₁₁, н-C₆H₁₃, CH₂Ph

where R = n-C ₅ H ₁₁ , n-C ₆ H ₁₃ , CH ₂ Ph

The proposed compounds can be used in fine organic synthesis, in the production of plasticizers, additives, polymeric materials, aromatic components, as well as in the synthesis of biologically active preparations.

A known method ([1], Takahashi T., Kotora M., Kasai K., Suzuki N. // Organometallics, 1994, 13, 4183) for producing 4,5,6,7-tetraalkyl-1,4,6,9 -decatetraenes (2) by the interaction of zirconacyclopentanes with allyl chloride in the presence of stoichiometric amounts of CuCl according to the scheme:

The known method does not allow to obtain 4,7-dialkyl (benzyl) ide-2,10-dodecadienes (1).

The known method ([2], Dzhemilev U.M., Ibragimov A.G., Azhgaliev M.N., Musloukhov PP // Izv. AN Ser. Chem., 1995, No. 8, p. 1561) of obtaining 5,6-dialkyl (aryl) -1,9-decadienes (3) by cross-coupling of 1,4-dialuminium compounds with allyl halides under the action of copper catalysts according to the scheme:

In a known manner, 4,7-dialkyl (benzyl) iden-2,10-dodecadiene (1) cannot be obtained.

Thus, in the literature there is no information on the selective synthesis of 4,7-dialkyl (benzyl) ide-2,10-dodecadiene (1).

A new method is proposed for producing 4,7-dialkyl (benzyl) iden-2,10-dodecadienes (1).

The essence of the method is. the interaction of alkyl (benzyl) allenes of the general formula R- = · =, where R = n-C ₅ H ₁₁ , n-C ₆ H ₁₃ , CH ₂ Ph, with ethyl magnesium bromide and activated magnesium (Mg, powder), taken in the ratio R - = · =: EtMgBr: Mg = 10: (10-14) :( 5-7) mmol, preferably 10: 12: 6 mmol, in the presence of a titanacenedichloride catalyst (Cp ₂ TiCl ₂ ) in an amount of 0.3-0.7 mmol, preferably 0.5 mmol, in an argon atmosphere at room temperature (~ 20 ° C) and atmospheric pressure in THF for 8-12 hours, preferably 10 hours, followed by the addition of CuCl catalyst to the reaction mass at a temperature of -20 ° C in an amount of ve 1.8-2.2 mmol, preferably 2 mmol and crotyl bromide in an equimolar amount with respect to EtMgBr. Subsequent stirring of the reaction mass for 10 hours at a temperature of ~ 20 ° C. Receive 4,7-dialkyl (benzyl) iden-2,10-dodecadiene (1) with a total yield of 63-81%. The reaction proceeds according to the scheme:

[Ti] = Cp ₂ TiCl ₂ ; R = n-C ₅ H ₁₁ , n-C ₆ H ₁₃ , CH ₂ Ph

The target product 4,7-dialkyl (benzyl) iden-2,10-dodecadiene (1) is formed only with the participation of alkyl (benzyl) allenes, EtMgBr and crotyl bromide.

Changing the ratio of the starting reagents and catalysts in the direction of their increase relative to the starting allene does not lead to a significant increase in the yield of the target product (1). A change in the ratio of the starting reagents and the catalyst in the direction of their decrease relative to the starting allene leads to a significant decrease in the yield of the target product (1).

Reactions were carried out using THF as a solvent. In other solvents (for example, aliphatic or aromatic), the reaction does not proceed.

Significant differences of the proposed method:

1. In the proposed method, alkyl (benzyl) allens, EtMgBr and crotyl bromide are used as starting compounds. In a known method, the compound (3) is obtained from 1,4-diallyuminium compounds.

The proposed method has the following advantages:

1. The method allows to obtain with high selectivity 4,7-dialkyl (benzyl) ide-2,10-dodecadiene (1), the synthesis of which is not described in the literature.

The method is illustrated by the following examples:

EXAMPLE 1. In a 50 ml glass reactor mounted on a magnetic stirrer in an argon atmosphere, 12 mmoles of freshly prepared EtMgBr in a THF solution, 6 mg at. Mg (powder), 10 mmol of 1,2-octadiene and 0.5 mmol of Cp ₂ TiCl ₂ , stirred for 10 hours at room temperature (~ 20 ° C), at a temperature of -20 ° C, 2 mmol of CuCl and 12 mmol of crotyl bromide are added, stirred 10 hours at a temperature of ~ 20 ° C. At the end of the reaction, the catalysis is treated with 5% HCl, extracted with ether, dried with MgSO ₄ . After removal of solvent, the residue was distilled in vacuo, 7,10-di (but-2-enyl) hexadeca-6,10-diene (1) was isolated in 74% yield. Spectral characteristics of 7,10-di (but-2-enyl) hexadeca-6,10-diene (1):

IR spectrum, ν / cm ^-1 : 3030, 2950, 2860, 1650, 1490, 1450, 1390, 1000, 910, 890, 720. ¹ H NMR spectrum (δ, ppm): 0.78-0.90 (t 6H, J = 6.0 Hz, CH ₃ ); 1.21-1.35 (m, 12H, CH ₂ ); 1.55-1.68 (d, 6H, CH ₃ -C = C); 1.85-2.25 (m, 8H, CH ₂ -C = C); 2.76-2.89 (d, 4H, C = C-CH ₂ -C = C); 5.0-5.55 (m, 6H, H ₂ C - H C = C). ¹³ C NMR spectrum (δ, ppm): 14.05 C (1, 16); 17.67 C (20, 24); 22.81 C (2, 15); 28.61 C (8, 9); 28.89 C (5.12); 29.69 C (4, 13); 30.87 C (3, 14); 50.48 C (17, 21); 122.25 C (19, 23); 123.85 C (6, 11); 127.69 C (18, 22); 137.15 C (7, 10). Mass spectrum, m / z: M ⁺ 330.

Other examples confirming the method are given in table. one.

Table 1 №№ Allen,
R- =

:CuCl, ммольMolar ratio
R- = · =: EtMgBr: Mg: Cp ₂ TiCl ₂ :

: CuCl, mmol Reaction time, hour Yield (1),% one 2 3 four 5 one. HC ₅ H ₁₁ - =
n-amylallen 10: 12: 6: 0.5: 12: 2 twenty 74 2. - "- 10: 14: 6: 0.5: 14: 2 twenty 72 3. - "- 10: 10: 6: 0.5: 10: 2 twenty 66 four. - "- 10: 12: 7: 0.5: 12: 2 twenty 77 5. - "- 10: 12: 5: 0.5: 12: 2 twenty 68 6. - "- 10: 12: 6: 0.7: 12: 2 twenty 81 7. - "- 10: 12: 6: 0.3: 12: 2 twenty 63 8. - "- 10: 12: 6: 0.5: 12: 2 22 78 9. - "- 10: 12: 6: 0.5: 12: 2 eighteen 69 10. - "- 10: 12: 6: 0.5: 12: 1.8 twenty 70 eleven. - "- 10: 12: 6: 0.5: 12: 2.2 twenty 79 12. nC ₆ H ₁₃ - = · =
n-hexylallen 10: 12: 6: 0.5: 12: 2 twenty 72 13. PhCH ₂ - = · = Benzylallen 10: 12: 6: 0.5: 12: 2 twenty 65

Reactions were carried out at room temperature (20-21 ° C) in THF.

Claims (1)

The method of obtaining 4,7-dialkyl (benzyl) ide-2,10-dodecadienes of the general formula (1)

where R is n-C ₅ H ₁₁ , n-C ₆ H ₁₃ , CH ₂ Ph characterized in that the alkyl (benzyl) allen of the general formula (R- = · =), where R is n-C ₅ H ₁₁ , n-C ₆ H ₁₃ , CH ₂ Ph, is reacted with ethyl magnesium bromide (EtMgBr) and metallic magnesium in a molar ratio of R- = · =: EtMgBr: Mg, equal to 10: (10-14) :( 5-7), in the presence of a titanacenedichloride catalyst (Cp ₂ TiCl ₂ ), taken in an amount of 0.3-0.7 mmol in an argon atmosphere at room temperature and atmospheric pressure in THF as a solvent for 8-12 hours, followed by the addition of a catalyst of copper monochloride (CuCl) at a temperature of -20 ° C, taken in an amount of 18-22 mol.% in relation to allene and crotyl bromide in an amount equimolar to EtMgBr and stirring the reaction mixture for 10 hours at room temperature.